Edward L Nelson MD FACP

PubMed

• 2 citations
  A Therapeutic Vaccine Targeting Rat BORIS (CTCFL) for the Treatment of Rat Breast Cancer Tumors.
  Dmitri Loukinov, Amanda Laust Anderson, Mikayel Mkrtichyan, Anahit Ghochikyan, Samuel Rivero-Hinojosa
  International Journal of Molecular Sciences. 2023-03-22
• 3 citations
  Nanoparticle vaccines can be designed to induce pDC support of mDCs for increased antigen display.
  Nina Butkovich, Jo Anne Tucker, Aaron Ramirez, Enya Li, Vijaykumar S Meli
  Biomaterials Science. 2023-01-17
• 2 citations
  Evaluating Anti-tumor Immune Responses of Protein Nanoparticle-Based Cancer Vaccines.
  Enya Li, Nina Butkovich, Jo A Tucker, Edward L Nelson, Szu-Wen Wang
  Methods in Molecular Biology. 2023-01-01

Journal Articles

• HER2/neu: an increasingly important therapeutic target. Part 3: clinical applications and investigations  
  Nelson, E.L., Clinical Investigation (2014), 4(9), 791–823
• HER2/neu: an increasingly important therapeutic target. Part 2: Distribution of HER2/neu overexpression and gene amplification by organ, tumor site and histology  
  Nelson, E.L., Clinical Investigation (2014), 4(8), 705–728
• HER2/neu: An increasingly important therapeutic target: Part 1 Basic Biology & Therapeutic Armamentarium  
  Nelson E.L, Clin. Invest. (2014) 4(7),649–671
• VRP immunotherapy targeting neu: treatment efficacy and evidence for immunoediting in a stringent rat mammary tumor model.  
  Laust A.K., Wang K., Sur B.W.R., Hubby B., Smith J.F., Nelson E.L, Breast Cancer Res Treat, Mar 10, 2007, doi:10.1007/s10549-007-9517-8, Dec 2007, 106 (3):371-82. PMID
• Restricted and selective tropism of a Venezuelan equine encephalitis virus-derived replicon vector for human dendritic cells.  
  Nishimoto K.P., Laust A, Wang K, Van C., Kamrud K.I., Fralish B., Smith J.F., Nelson E.L, Viral Immunol 20, 88-104. PMID: 17425424
• Fluorescence Activated Cell Sorting (FACS) Using RNALater to Minimize RNA Degradation and Perturbation of mRNA Expression from Cells Involved in Initial Host Microbe I...  
  Nishimoto K.P., Newkirk D, Hou S, Fruehauf J, Nelson E.L, Journal of Microbiological Methods Ap 2007, doi:10.1016/j.mimet.2007.03.022. PMID: 17512621
• Prenatal Stress Associated with Insulin Resistance in Young Adults.  
  Entringer S, Wüst S, Kumsta R, Layes I, Nelson EL, Hellhammer DH, and Wadhwa PD, Am J Obstet Gynecol. March 6, 2008, doi: 10.1016/j.ajog.2008.03.006
• Stress, Immunity, and Cervical Cancer: Biobehavioral Outcomes of a Randomized Clinical Trial.  
  Nelson E.L, Wenzel LB, Osann K, Dogan Ates A, Chantana N, Reina-Patton A, Laust AK, Nishimoto KP, Chicz-DeMet A, du Pont N, Monk BJ, Clin Cancer Res. April 1, 2008;14(7):2111-18. PMID: 18381952
• Immunophototherapy, Combined Photodynamic Therapy and Intratumoral Administration of Dendritic Cells: Evidence for Retention of Dendritic Cell Functional Status and Im...  
  Sur B.W.R., Nguyen P., Sun C.H., Tromberg B. J., Nelson E.L, Photochemistry & Photobiology April 23, 2008 doi: 10.1111/j.1751-1097.2008.00356.x. PMID: 18435703
• Influence of Prenatal Psychosocial Stress on Cytokine Production in Adult Women.  
  Entringer S, Kumsta R, Nelson EL, Hellhammer DH, Wadhwa PD, and Wüst S, Dev Psychobiol. 2008 Aug 5;50(6):579-587. PMID: 18683180
• A Human Dendritic Cell Subset Receptive to the Venezuelan Equine Encephalitis Virus-Derived Replicon Particle Constitutively Expresses IL-32.  
  Nishimoto K.P., Laust A.K., Nelson E.L, Journal of Immunology, Sept 15 2008, 181: 4010–4018. PMID: 18768856
• C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells.  
  Fraser D.A., Laust A.K., Nelson E.L., and Tenner A.J, J Immunol. 2009 Nov 15;183(10):6175-85. Epub 2009 Oct 28. PMID: 19864605
• Fabrication and biological evaluation of uniform extracellular matrix coatings on discontinuous photolithography generated micropallet arrays.  
  Gunn N.M., Bachman M., Li G.P., Nelson E.L, J Biomed Mater Res A. 2010 Nov;95(2):401-12. PMID: 20648537
• Targeted messenger RNA Profiling of Transfected Breast Cancer Gene in a Living Cell.  
  Nawarathna, D., Chang R., Nelson E. and Kumar Wickramasinghe H, Anal Biochem. 2010 Aug 17. doi:10.1016/j.ab.2010.08.014 PMID: 20723536
• Ferromagnetic Micropallets for Magnetic Capture of Single Adherent Cells.  
  Gunn NM, Chang R, Westerhof T, Li G.P., Mark Bachman M., Nelson E.L, Langmuir 10/2010 doi: 10.1021/la101960v. PMID: 20968293
• Longitudinal Modulation of Immune System Cytokine Profile During Pregnancy.  
  Denney J.M., Nelson E., Wadhwa P., Waters T.M., Mathew L., Chung E.K., Goldenberg R.L. Culhane J.F, Cytokine 11/2010 doi:10.1016/j.cyto.2010.11.005 PMID: 21123081
• Recruitment and Retention Results for a Population-based Cervical Cancer Biobehavioral Clinical Trial.  
  Osann K., Wenzel L., Dogan A., Hsieh S., Chase D.M., Sappington S., Monk B.J., Nelson E.L, Gynecologic Oncology 121 (2011), pp. 558-564
• B-1 Cell Lymphoma in Mice Lacking the Steroid and Xenobiotic Receptor, SXR.  
  Casey S.C., Nelson E.L., Turco G., Janes M.R., Fruman D.A., and Blumberg B, Mol Endocrinol. 2011 Jun;25(6):933-43
• Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma.  
  Mkrtichyan M., Ghochikyan A., Davtyan H., Movsesyan N., Loukinov D., Lobanenkov V., Cribbs D.H., Laust A.K., Nelson E.L. and Agadjanyan M.G, Cell Immunol. 2011 May 12. PMID: 21641588
• Glass Micropallets for adherent cell analysis and recovery.  
  N. M. Gunn, T. Westerhof, G.P. Li, E. L. Nelson and M. Bachman, MicroTAS
• Granulocyte-macrophage stimulating factor (GM-CSF) increases circulating dendritic cells but does not abrogate suppression of adaptive cellular immunity in patients wi...  
  Martinez M, Ono N, Planutiene M, Planutis K, Nelson E.L., Holcombe R.F, Cancer Cell International 2012, 12:2 doi:10.1186/1475-2867-12-2. PMID: 22270330
• Longitudinal Change in Telomere Length and the Chronic Stress Response in a Randomized Pilot Biobehavioral Clinical Study: Implications for Cancer Prevention.  
  Biegler K.A., Anderson A.K.L., Wenzel L.B., Osann K., Nelson E.L, Cancer Prev Res 2012, Jul 24 doi:10.1158/1940-6207.CAPR-12-0008
• Separation and Purification of Plasmid DNA Using Continuous Elution Electrophoresis: Isolation of individual components from mixtures of plasmids.  
  Prieto DA, Harvey LK, and Nelson EL, BioTechniques 2000 29(6):1204-1206. PMID: 11126121
• Juvenile Aponeurotic Fibroma with Disseminated Fibrosarcoma.  
  Lafferty KA, Nelson EL, Demuth RJ, Miller SH, Harrison MW, J Hand Surg (Am) 1986; 11:737-40. PMID: 3760506
• Wound Healing and the Shaw Scapel.  
  Millay DM, Cook TA, Brummett RE, Nelson EL, O'Neill PL, Arch Otol Head Neck Surg 1987; 113:282-85. PMID: 3814370
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Books/Book Chapters

• Handbook of Cancer Vaccines in Cancer Drug and Discovery Series. 
  Chapter: Alphaviral-based Strategies for Immmunotherapy of Cancer 
  Edward L. Nelson & Jonathan SmithEditors: Lyerly, M. Morse and T. Clay.Human Press

Abstracts/Posters

• Assessing quality of life and biomarkers in cervical cancer survivors.
  Biegler, K., Wenzel, L., Osann, K., McClure, L., Monk, B., & Nelson, E, International Society of Quality of Life Research meeting, New Orleans, LA
• The Venezuelan Equine Encephalitis Replicon Vector System Has Selective and Restricted Tropism for a Sub-set of Immature Myeloid Dendritic Cells.
  Nishimoto KP. Laust AK, Nelson EL, ISBTc Annual Meeting, Los Angeles, CA
• Stress, Immunity, and Cervical Cancer: Quality of Life Associated Immune Modulation.
  Nelson EL, Wenzel LB, Osann K, Dogan-Ates A, Laust AK, Nishimoto KP, Chantana N, Reina-Patton A, duPont N; Monk BJ, Chicz-Demet A, Journal of Immunotherapy. 29(6):668, ISBTc Annual Meeting, Los Angeles, CA
• Optical Monitoring of Tumor Angiogenesis by Modulated Imaging: Preliminary Results from In vitro Rat Tumor Model.
  JG Kim, J Lee, EL Nelson, DJ Cuccia, A Cerussi, AJ Durkin, M Brenner, BJ Tromberg, AFMR Annual Western Regional Meeting, Carmel, CA
• IL-32 Expression is Associated with a Unique Subset of Human Dendritic Cells Receptive to the Venezuelan Equine Encephalitis Virus-derived Replicon Vector.
  Nishimoto K.P., Hou S. Dinarello C.A., Nelson E.L, FOCIS, San Diego, CA
• Constitutive Expression of IL-32 characterizes a Unique Subset of Human Dendritic Cells Receptive to the Venezuelan Equine Encephalitis Virus-Derived Replicon Vector.
  Nelson E.L., Nishimoto K.P., Hou S., Dinarello C.A, 15th Annual Conference of the International Cytokine Society, San Francisco, CA
• A Phase I Trial of Systemic or Intralesional GM-CSF in Clinically Resectable Pancreatic Adenocarcinoma.
  Nelson E.L., Imagawa D.K., Bhela S., Nishimoto K.P. Change K., Holcombe RF, 22nd ISBTc Annual Meeting, Boston, MA
• Integrating Analysis of Chronic Stress Biomarkers into the Biobehavioral Model for Cancer Survivorship with a Focus on T Helper Immunologic Status for Generation of Me...
  Nelson E.L., Wenzel L.B., Osann K, Ates A., Laust A.K., Nishimoto K.P., Chicz-Demet A., duPont N, Monk B.J, Society for Integrative Oncology, San Franciso, CA
• Applications of a Novel Nanotechnology and Advanced Optical Imaging for Investigating Tumor Cellular Profiles and the Analysis of Rare Cell Subsets
  Nelson EL, Gunn N, Brachman M, Cerussi A, Krasieva T, Tromberg BJ, Beckman Laser Institute LAMMP
• Lessons Learned in Recruitment and Retention to a Randomized Psychosocial Telephone Counseling (PTC) Intervention for Cervical Cancer Survivors.
  Wenzel L.B., Osann K, McClure L., Ates A.,Chantana N., Campos S., Chase D., Monk B.J. Nelson E.L, APOS 5th Annual Conference, Irvine, CA, USA
• Micropallet Technology for Investigating Tumor Cellular Profiles and Analysis of Rare Cell Subsets.
  Gunn N, Brachman M, Li G.P., Nelson E.L, BioMed2008 3rd Frontiers in Biomedical Devices Conference, Irvine, California, USA
• A Phase I clinical trial of single dose GM-CSF as a immunomodulatory biological adjuvant in clinically-staged, respectable pancreatic adenocarcinoma.
  Nelson E.L., Imagawa D.K., Xiaohui Z., Bhela S., Lee J.G., Chang K.J., Wenzel L.W., Holcombe R.H, AACR Annual Meeting LB-308, San Diego CA
• The Pallet Array: A Novel Nanotechnology for Investigating Tumor Cellular Profiles and the Analysis of Rare Cell Subsets.
  Gunn N., Nelson E.L., Brachman M., Li G.P, Lifechips 2009 Symposium, The University of California, Irvine, Irvine, CA, USA
• Granulocyte-macrophage stimulating factor (GM-CSF) increases circulating dendritic cells, but does not abrogate suppression of adaptive cellular immunity in patients w...
  Martinez M., Reihanifam N., Bhela S., Planutiene M., Planutis K., Nelson E.L., Holcombe R.F, Annual AACR meeting, Denver CO
• Fabrication of Polymer Micropallet Arrays.
  Brachman M., Gunn N., Li G.P., Nelson E.L, 2nd International Conference from Nanoparticles and Nanomaterials to Nanodevices and Nanosystems, Rhodes, Greece
• Application of a Novel Nanotechnology for Molecular Profiling of Tumor Cellular Elements.
  Nelson E.L., Brachman M., Li G.P., Gunn N, 10th annual PI meeting for the Innovative Molecular Analysis Technologies, Bethesda MD
• VRP Targeting of Rat Neu in a Rat Mammary Tumor Model: Therapeutic Efficacy, Effectors, Evidence for Immunologic Selection.
  A. K. Laust, K. Wang, Nelson EL, ISBTc Annual Meeting, Los Angeles, CA
• Micropallet Arrays for Detection of Rare Subpopulations of Adherent Cells.
  Gunn N, Brachman M, Li G.P., Nelson E.L, MicroTAS, International Convention Center, Jeju Island, Korea
• Stress Immunity and Cervical Cancer: Biobehavioral Outcomes of a Randomized Trial.
  Wenzel L., Nelson E.L., Osann K., Monk B, Second Annual NIH Translational Science Meeting, Vienna, VA
• Multivalent VRP-based anti-tumor immunotherapy is an effective therapeutic strategy in a rat model of breast cancer.
  Laust A.K., Mkrtichyan M., Davtyan H., Khlgatyan J., Ghochikyan A., Liu H., Agadjanyan M.G., Nelson E.L, 2010 AACR Annual Meeting, Washington DC
• Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is effective against metastatic disease.
  Mkrtichyan M., Loukinov D., Movsesyan M., Davtyan H., Laust A.K., Lobanenkov V., Nelson E.L., Ataullakhanov R., Ghochikyan A., Agadjanyan M.G, 2010 AACR Annual Meeting, Washington DC
• Cancer Trial Recruitment and Retention: Lessons Learned from Multi-ethnic Cervical Cancer Survivorship Trials.
  Wenzel, L., Osann, K., Chase, D., Biegler, K., Hsieh, S., Monk, B.J., and Nelson, E.L, NCI-ASCO Cancer Trial Accrual Symposium: Science and Solutions, Bethesda, MD
• Therapeutic Replicon-based immunotherapy targeting the breast cancer tumor antigens Neu & BORIS: advantages and constraints.
  Laust A.K., Mkrtichyan M., Davtyan H., Khlgatyan J., Ghochikyan A., Liu H., Agadjanyan M.G., Nelson E.L, 2010 ASCO Annual Meeting, Chicago, IL
• Capturing gynecologic symptoms and sexual problems in cervical cancer survivors.
  Biegler KA, Wenzel L., Osann K., Hsieh S, Sappington S., Marquez, D, Chase D., Monk B, Nelson E.L, APOS 8th Annual Conference, Anaheim CA
• Biobehavioral Factors and Telomere Length in Cervical Cancer Survivors.
  Biegler KA, Wenzel L, Osann K, Hsieh S, Nelson E, American Psychosomatic Society Annual Meeting, San Antonio, Texas
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Lectures

• The Micropallet Array (aka Bio-Pod) Technology: An Ongoing Translational Saga. 
  Chao Family Comprehensive Cancer Center Conference, Rancho Mirage, CA
• Finding Your Niche. 
  Annual Meeting Society for Immunotherapy of Cancer, Bethesda, MD
• Hidden Jewel of Our Community. 
  Orange County Hispanic Chamber of Commerce, UCI and UCIMC, Orange CA
• Micropallet Arrays (aka the BioPod): a novel technology providing an opportunity to examine tumor cellular profiles one cell at a time. 
  Ludwig Maximillian Universitat, Munich Germany
• Part of your community you can be proud of. 
  International Waldenstrom Macroglobulinemia Support Foundation, UCI, UCIMC, CA
• Concept to Clinical Translation: The journey of the micropallet array. 
  3rd International Symposium on LifeChips, UCI Henry Samueli School of Engineering, 2220 Engineering
• Quality Improvement Measures for Hematology/Oncology. 
  Department of Medicine Grand Rounds, UCIMC Orange CA
• Quality Improvement Measures & Lessons Learned in an Academic Hematology/Oncology Practice. 
  MOASC General Meeting, Irvine CA
• Where we are and where we are going? 
  1st Annual Breast Cancer Awareness Panel, Passionately Pink, UCI, Breast Cancer 2011; Irvine CA
• Breast Cancer Management: Updates, Advances, & New Options. 
  Temple Community Hospital Los Angeles, CA
• Stress Mediated Effects on Cancer Biology – A Primer on Cancer Biology and Plausible Mechanisms. 
  American Psychosomatic Association Annual Meeting, Portland, OR
• Integrative Oncology at UCIMC Cancer Center. 
  Susan & Henry Samueli Center for Integrative Medicine Advisory Board
• Application of a Novel Nanotechnology for Molecular Profiling of Tumor Cellular Elements. 
  10th annual PI meeting for the Innovative Molecular Analysis Technologies
• Tumor Cellular Profiles: A Window into Biology. 
  10th annual PI meeting for the Innovative Molecular Analysis Technologies
• Micropallet Arrays (aka the BioPod): a novel technology providing a new window into cellular biology. 
  Beckman Center for Academy of Sciences, Irvine, CA
• Micropallet Array Technology for Analysis of Adherent Cells. 
  Prostate Cancer Workshop, Chao Family Comprehensive Cancer Center, Aliso Creek Inn, Aliso Creek, CA
• A New Genetic Vaccine Therapy for Breast Cancer. 
  California Breast Cancer Research Program 4th Symposia, San Diego, CA
• Venezuelan Equine Encephalitis Replicon (VRP) Based Anti-tumor Immunotherapy. 
  UCI Molecular Genetics Seminar Series, Irvine CA
• The Mind/Body Connection & Oncology Patients. 
  KS Inflammatory Breast Cancer Foundation, Long Beach, CA
• A Novel Microtechnology, aka BioPod, and Advanced Imaging: Application for the Study of Stem Cells. 
  LifeChips/CIRM/CFCCC Stem Cell Workshop, UCI
• Of Rats and Humans: Two Tales of Anti-Tumor Immunity. 
  Cancer Research Institute, 2008 Campuswide Symposium in Basic Cancer Research, UCI
• Psychoneuroimmunology (PNI) & Cancer: Is there a mind-body connection? 
  Oncology Association of Naturopathic Physicians, Philadelphia, PA
• Dendritic Cells: Targets for Immunotherapy. 
  Pfizer Global Development, New London CT
• Stress, Immunity, and Cervical Cancer: Results of A Randomized Clinical Trial. 
  Chao Family Comprehensive Cancer Annual Retreat
• Ramping up the body’s self-defense system. 
  Chao Family Comprehensive Cancer Center, Symposium on Breast Cancer, Irvine, CA
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Other

• A Case Report of a 33 Year Old Female with Concomitant Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) and Diffuse Large B-Cell Lymphoma. 
  Moore J.C., Zhao X. Nelson E.L, Journal of Medical Case Reports 2008, 2:70
  http://www.jmedicalcasereports.com/content/2/1/70
• A question of attitude The link between chronic stress and a marker of old age is being disentangled. 
  Nelson EL, The Economist
  http://www.economist.com/node/18526881
• HER 2/neu Target Antigen and Use of Same to Stimulate an Immune Response. 
  Nelson EL, U.S. Patent No. 7,446,185
• Novel Vector for Polynucleotide Vaccines. 
  Nelson EL, US Application No. 09/242,202 and European Patent 0920522
• Methods and compositions for Making Dendritic Cells from Expanded Populations of Monocytes and for Activating T Cells. 
  Nelson EL, U.S. Patent No. 6,479,286 B1
• What the Hell is a Telomere? 
  Nelson EL, Lisa Bernhard & Matthew Zachery, Stupid Cancer Show
  http://www.blogtalkradio.com/stupidcancershow/2012/07/17/what-the-hell-is-a-telomere
• New insights into telomeres, stress, and cancer risk. 
  Nelson EL, Carrie Printz. Cancer Volume 117, Issue 12, page 2585, 15
• Chronic Stress and Aging. 
  Nelson EL, Nora Nagatani
  http://noranagatani.com/?tag=edward-nelson
• Update on Telomere Research 
  Nelson EL, Oncology Times
  AACR Annual Meeting, Cynthia Washam
• Stress can raise your risk of cancer, other diseases. 
  Nelson EL, Judy Siegal-Itzkovich, The Jerusalem Post
• Stress shortens your telomeres in cancer. 
  Nelson EL, Cancer Watch
  http://www.canceractive.com/cancer-active-page-link.aspx?n=3070&Title=Cancer%20Watch%20March%202011#
• Telomeres tell the tale of stress relief in cancer patients. 
  Nelson EL, FierceBiomarkers, Howard Lovy
  http://www.fiercebiomarkers.com/story/telomeres-tell-tale-stress-relief-cancer-patients/2011-04-26#i
• Chronic stress of cancer causes accelerated telomere shortening. 
  Nelson EL, eCancerTV
  http://ecancer.org/tv/pubdate/921
• How Stress Makes You Look Older. 
  Nelson EL, Denny Watkins Men’s Health
  http://blogs.menshealth.com/health-headlines/chillax/2011/04/10
• Methods and compositions for Making Dendritic Cells from Expanded Populations of Monocytes and for Activating T Cells. 
  Nelson EL, U.S. Patent No. 6,479,286 B1
• Stress relief helps cancer patients, Signs of the Times. 
  Nelson EL
  http://www.sott.net/article/226761-Stress-relief-helps-cancer-patients
• Cancer study shows chronic stress speeds telomere shortening. 
  Nelson EL, Kathleen Blanchard RN
  http://www.emaxhealth.com/1020/cancer-study-shows-chronic-stress-speeds-telomere-shortening
• Stress Reduction in Cancer Patients May Pay Off. 
  Nelson EL, Kathleen Doheny? WebMD Health News
  http://www.webmd.com/cancer/news/20110401/stress-reduction-in-cancer-patients-may-pay-off
• Chronic stress of cancer causes accelerated telomere shortening. 
  Nelson EL, PhysOrg online journal
  http://phys.org/news/2011-04-chronic-stress-cancer-telomere-shortening.html
• Phone counseling helpful after cervical cancer. 
  Nelson EL, Reuters Health. American Society of Clinical Oncology Cancer Net News
• UCI finds phone counseling impacts cancer survivors. 
  Nelson EL, Advance for Nurses Southern California Vol 5, No. 11, pg 21
• Phone counseling study highlights ‘Mind-Body’ connection for surviving cancer. 
  Nelson EL
  http://www.DailyIndia.com
• Phone counseling study highlights ‘Mind-Body’ connection for surviving cancer. 
  Nelson EL, Asian News International
• Phone counseling improves quality of life, immune systems of cervical cancer survivors. 
  Nelson EL, Press Release. Today at UCI
• HER 2/neu Target Antigen and Use of Same to Stimulate an Immune Response. 
  Nelson EL, U.S. Patent No. 7,446,185
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