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Office
740 Rose St
Lexington, KY 40536Phone+1 859-323-5661Fax+1 859-257-5477
Education & Training
University of Virginia Medical CenterResidency, Neurology, 1976 - 1979
University of Wisconsin Hospitals and ClinicsResidency, Internal Medicine, 1974 - 1976
University of WisconsinPhD, Biochemistry, 1968 - 1975
University of Wisconsin School of Medicine & Public HealthClass of 1974
Certifications & Licensure
KY State Medical License 1980 - 2025
WI State Medical License 1975 - 2005
LA State Medical License 1979 - 1987- American Board of Psychiatry and Neurology Neurology
Clinical Trials
- Early Treatment of Amyotrophic Lateral Sclerosis (ALS) With Nutrition and Non-Invasive Positive Pressure Ventilation Start of enrollment: 2004 Aug 01
- Longitudinal Study of Outcomes Measures in ALS Trials Start of enrollment: 2013 Jul 01
- Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study Start of enrollment: 2017 Aug 21
Publications & Presentations
PubMed
- A 40-week phase 2B randomized, multicenter, double-blind, placebo-controlled study evaluating the safety and efficacy of memantine in amyotrophic lateral sclerosis.Salman Bhai, Todd Levine, Dan Moore, Robert Bowser, Andrew J Heim
Muscle & Nerve. 2025-01-01 - Reply to Glycemic Index/Load Effect on ALS Progression: Potential Interaction with Riluzole.Ikjae Lee, Hiroshi Mitsumoto, Seonjoo Lee, Edward Kasarskis, Michael Rosenbaum
Annals of Neurology. 2024-07-01 - 6 citationsHigher Glycemic Index and Glycemic Load Diet Is Associated with Slower Disease Progression in Amyotrophic Lateral Sclerosis.Ikjae Lee, Hiroshi Mitsumoto, Seonjoo Lee, Edward Kasarskis, Michael Rosenbaum
Annals of Neurology. 2024-02-01
Journal Articles
- Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral SclerosisSabrina Paganoni, Michael A Elliott, Samuel Maiser, Margaret A Owegi, Stephen A Goutman, Carlayne E Jackson, Jeffrey D Rothstein, Edward J Kasarskis, Liberty Jenkins, ..., The New England Journal of Medicine
- ALS Mutations of FUS Suppress Protein Translation and Disrupt the Regulation of Nonsense-Mediated DecayEdward Kasarskis, MD, Proceedings of the National Academy of Sciences
Press Mentions
UK Pathology Resident Exhibits Photography Collection to Honor Friend with ALSNovember 21st, 2022
ALS-Causative Mutations in FUS/TLS Confer Gain- and Loss-of-Function by Altered Association with SMN and U1-snRNPJanuary 27th, 2020
49ers’ Dwight Clark Tragedy: Can Football Cause ALS?March 20th, 2017- Join now to see all
Grant Support
- Early Treatment Of ALS With Nutrition And NippvNational Center For Research Resources2005–2007
- Early Treatment Of ALS With Nutrition And NippvNational Institute Of Neurological Disorders And Stroke2004–2007
- Phase III Trial Of Minocycline In Amyotrophic Lateral SclerosisNational Center For Research Resources2004–2007
- Assessment Of Caloric Needs In Amyotrophic Lateral Sclerosis (ALS)National Center For Research Resources2004–2005
- Celebrex In ALSNational Center For Research Resources2004
- Upper And Lower Anthropometry To Assess The Progression Of Weakness In ALSNational Center For Research Resources1996–1997
- Laser Microprobe Analysis Of Neuronal MercuryNational Institute Of Neurological Disorders And Stroke1988–1990
- Zinc Nutrition And Alcohol--Effect On Fetal BrainNational Institute On Alcohol Abuse And Alcoholism1985–1987
- Role Of Zinc At The Hippocampal Mossy Fiber SynapseNational Institute Of Neurological Disorders And Stroke1985–1987
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