EdwardCrandallMDPhD

PubMed

• 153 citations
  Astrocytic tight junctions control inflammatory CNS lesion pathogenesis
  Sam Horng, Anthony Therattil, Sarah Moyon, Alexandra Gordon, Karla Kim
  The Journal of Clinical Investigation. 2017-07-24
• 25 citations
  Regulation of intracellular pH in alveolar epithelial cells.
  Richard L. Lubman, Edward D. Crandall
  The American Journal of Physiology. 1992-01-01
• 717 citations
  Induction of Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells by Transforming Growth Factor-β1 : Potential Role in Idiopathic Pulmonary Fibrosis
  Brigham C. Willis, Janice M. Liebler, Katherine Luby-Phelps, Andrew G. Nicholson, Edward D. Crandall
  The American Journal of Pathology. 2005-05-01

Journal Articles

• p300/Beta-catenin interactions regulate adult progenitor cell differentiation downstream of Wnt5a/protein kinase C (PKC)  
  Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Phan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z, J Biol Chem, 1/1/2016
• National Institutes of Health workshop on alveolar epithelial transport-basic science to clinical medicine  
  Crandall ED, Matthay M, Am J Resp Crit Care Med, 1/1/2001
• Influence of lipophilicity on Beta-blocker permeation across rat alveolar epithelial cell monolayers  
  Saha P, Kim KJ, Yamahara H, Crandall ED, Lee VHL, J Cont Rel, 1/1/1994
• Studies on the mechanisms of active ion fluxes across alveolar epithelial cell monolayers  
  Kim KJ, Suh DJ, Lubman RL, Danto SI, Borok Z, Crandall ED, J Tiss Cult Meth, 1/1/1992
• Disequilibrium phenomena in CO2 transport and exchange  
  Bidani A, Crandall ED, Appl Cardiopulm Pathophysiol, 1/1/1987
• Effects of intra- and extra-cellular carbonic anhydrase on CO2 excretion and intravascular pH equilibrium in the isolated perfused rat lung  
  Geers C, Heming TA, Gros G, Bidani A, Crandall ED, Prog Resp Res, 1/1/1986
• Water and nonelectrolyte transport across alveolar epithelium  
  Crandall ED, Am Rev Respir Dis, 1/1/1983
• Role of alveolar epithelium in lung fluid balance  
  Crandall ED, Ann Int Med, 1/1/1983
• Analysis of distribution of water flow across alveolar epithelium  
  Kim KJ, Crandall ED, Am Inst Chem Eng Symp Ser, 1/1/1983
• Analysis of pulmonary vascular carbonic anhydrase activity  
  Bidani A, Crandall ED, Am Inst Chem Eng Symp Ser, 1/1/1983
• Analysis of the effects of hematocrit on pulmonary CO2 transfer  
  Bidani A, Crandall ED, J Appl Physiol, 1/1/1982
• Kinetics of CO2 in blood  
  Crandall ED, Prog Resp Res, 1/1/1981
• Organ and species differences in tissue vascular carbonic anhydrase activity  
  O'Brasky JE, Crandall ED, J Appl Physiol, 1/1/1980
• Post-capillary pH disequilibrium after gas exchange in isolated perfused liver  
  O'Brasky JE, Mauro T, Crandall ED, J Appl Physiol, 1/1/1979
• HCO3-/C1- exchange across the human erythrocyte membrane: effects of pH and temperature  
  Obaid AL, Crandall ED, J Memb Biol, 1/1/1979
• Kinetics of viscosity changes in sickle hemoglobin solutions  
  Fieschko J, Meadow W, Crandall ED, Litt M, Forster RE, J Lab Clin Med, 1/1/1978
• Slow post-capillary pH changes in blood in anesthetized animals  
  Bidani A, Crandall ED, J Appl Physiol, 1/1/1978
• Slow post-capillary changes in blood pH in vivo: titration with acetazolamide  
  Bidani A, Crandall ED, J Appl Physiol, 1/1/1978
• Bicarbonate-chloride exchange in erythrocyte suspensions: stopped-flow pH electrode measurements  
  Crandall ED, Obaid AL, Forster RE, Biophys J, 1/1/1978
• A pressure- and flow-insensitive reference electrode liquid junction  
  Crandall ED, DeLong J, J Appl Physiol, 1/1/1976
• Pulmonary gas exchange  
  Forster RE, Crandall ED, Ann Rev Physiol, 1/1/1975
• Time course of exchange between red cells and extracellular fluid during CO2 uptake  
  Forster RE, Crandall ED, J Appl Physiol, 1/1/1975
• Serum sodium response to hyperglycemia  
  Crandall ED, New Engl J Med, 1/1/1974
• On some rapid ion exchanges across the red cell membrane  
  Crandall ED, Forster RE, Adv Chem, 1/1/1973
• Kinetic analysis of calcium transport across the placenta  
  Ramberg C, Delivoria-Papadopoulos M, Crandall ED, Kronfeld D, J Appl Physiol, 1/1/1973
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Books/Book Chapters

• Nanoparticles in the Lung: Environmental Exposure and Drug Delivery 
  Chapter: Interactions with alveolar epithelium. 
  Page 107 - 131Fazlollahi F, Kim YH, Sipos A, Borok Z, Kim KJ, Crandall EDEditors: Tsuda A, Gehr P.CRC Press, Boca Raton, FL2015
• Claudins 
  Chapter: Claudins and barrier function of the lung. 
  Page 177 - 194Flodby P, Borok Z, Crandall ED, Kim KJEditors: Yu ASL.Elsevier, Philadelphia, PA2010
• Encyclopedia of Respiratory Medicine 
  Chapter: Epithelial Cells-Type I 
  Page 133 - 137Borok Z, Crandall EDEditors: Laurent J, Shapiro S.Elsevier, Oxford, England2006
• Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels 
  Chapter: Inorganic Cation Inhibition of Sodium Conductance in Adult Rat Lung Type II Pneumocytes 
  Page 181 - 182Kim KJ, Borok Z, Crandall ED, Kemp PJEditors: Suketa Y, Carafoli E, Lazdunski M, Mikoshiba K, Okada Y, Wright EM.Elsevier, Amsterdam, Holland2000
• Pulmonary Edema 
  Chapter: Na, K-ATPase and the Clearance of Pulmonary Edema Fluid. 
  Page 477 - 499Ingbar D, Wendt CH, Crandall EDEditors: Matthay M, Ingbar D.Marcel Dekker, New York, NY1998
• Pulmonary Edema 
  Chapter: Role of Active Sodium Transport in Reabsorption of Pulmonary Edema. 
  Page 95 - 112Lubman RL, Crandall EDEditors: Weir EK, Reeves JT.Futura, New York, NY1998
• Respiratory Drug Delivery 
  Chapter: Role of Endocytic Pathways in Alveolar Epithelial Transport of Macromolecules 
  Page 153 - 159Kim KJ, Crandall EDEditors: Dolby R, Byron P, Farr S.Interpharm Press, Buffalo Grove, IL1996
• Fluid and Solute Transport in the Airspaces of the Lungs 
  Chapter: Specialized Alveolar Epithelial Transport Processes 
  Page 219 - 247Kim KJ, Crandall EDEditors: Effros RM, Chang HK.Marcel Dekker, New York, NY1993
• Fluid and Solute Transport in the Airspaces of the Lungs 
  Chapter: Mechanisms of pH Homeostasis in Alveolar Epithelium 
  Page 123 - 150Lubman RL, Crandall EDEditors: Effros RM, Chang HK.Marcel Dekker, New York, NY1993
• The Lung-Scientific Foundations 
  Chapter: Alveolar Epithelial Barrier Properties 
  Page 273 - 287Crandall ED, Kim KJEditors: Crystal RG, West JB.Raven, New York, NY1991
• Respiratory Physiology: An Analytical Approach 
  Chapter: Quantitative Aspects of Capillary CO2 Exchange 
  Page 371 - 419Bidani A, Crandall EDEditors: Chang HK, Paiva M.Marcel Dekker, New York, NY1989
• Acute Lung Injury 
  Chapter: Active Transport and Permeability of the Alveolar Epithelium in the Lung 
  Page 45 - 63Acute Lung InjuryEditors: Kazemi H, Hyman A, Kadowitz P.PSG Publishing, Littleton, CO1986
• Current Medicine, Volume 3 
  Chapter: Recent Advances in Pulmonary Disease 
  Page 183 - 217Bellamy PE, Crandall EDEditors: Gitnick G.Year Book, Chicago, IL1986
• Techniques in Respiratory Physiology, Part II 
  Chapter: Techniques in Mathematical Modelling of Capillary Gas Exchange 
  Page 1 - 27Bidani A, Crandall EDEditors: Otis AB.Excerpta Medica, Amsterdam, Holland1984
• Biology and Chemistry of the Carbonic Anhydrases 
  Chapter: Kinetic Parameters and Activity of Pulmonary Vascular Carbonic Anhydrase 
  Page 565 - 567Bidani A, Crandall EDEditors: Tashian R, Hewitt-Emmett D.New York Academy of Sciences, New York, NY1984
• Current Medicine, Volume 2 
  Chapter: Selected Developments in Pulmonary Disease 
  Page 221 - 252Bellamy PE, Crandall EDEditors: Gitnick G.John Wiley, New York, NY1984
• Current Medicine, Volume 1 
  Chapter: Pulmonary Disease 
  Page 235 - 286Bellamy PE, Crandall EDEditors: Gitnick G.John Wiley, New York, NY1983
• Textbook of Medical-Surgical Nursing 
  Chapter: Physiology and Selected Sections on Pathophysiology 
  Crandall ED, Fisher ABEditors: Brunner L, Suddarth D.Lippincott, Philadelphia, PA1980
• Biophysics and Physiology of Carbon Dioxide 
  Chapter: Contribution of Red Cell-Plasma H+ Disequilibrium to Alveolar-Blood PCO2 Differences during Rebreathing. 
  Page 356 - 358Crandall ED, Bidani AEditors: Bauer C, Gros G, Bartels H.Springer-Verlag, New York, NY1980
• Biophysics and Physiology of Carbon Dioxide 
  Chapter: Intravascular End Capillary CO2-H+ Disequilibrium. 
  Page 306 - 314Crandall ED, Bidani A, O'Brasky JEEditors: Bauer C, Gros G, Bartels H.Springer-Verlag, New York, NY1980
• Biophysics and Physiology of Carbon Dioxide 
  Chapter: Chloride and Bicarbonate Movements across the Red Blood Cell Membrane. 
  Page 285 - 290Forster RE, Obaid AL, Crandall ED, Itada NEditors: Bauer C, Gros G, Bartels H.Springer-Verlag, New York, NY1980
• Chemical Engineering in Medicine and Biology 
  Chapter: A study of respiratory gas transport in pulmonary capillaries. 
  Page 447 - 475Crandall ED, Flumerfelt RWEditors: Hershey D.Plenum Press, New York, NY1967
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Abstracts/Posters

• Single-cell RNA sequencing of Aquaporin 5 (Aqp5)-Positive Epithelial Cells in Adult Mouse Lung Reveals Heterogeneity of Type I Cells and Facilitates Identification of ...
  Horie M, Sunohara M, Castaldi A, Wang H, Ji Y, Li F, Kage H, Crandall ED, Flodby P, Zhou B, Borok Z, Am J Resp Crit Care Med, 1/1/2019
• Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Alveolar Epithelial Cells.
  Sipos A, Kim KJ, Borok Z, Sioutas C, Cradall ED, Am J Resp Crit Care Med, 1/1/2019
• Nanoparticle Fate in Alveolar Epithelial Cells: Uptake, Distribution and Exocytosis.
  Crandall ED, Sipos A, Kim KJ, Borok Z, Flodby UP, 2nd Pan American Congress of Physiological Sciences, Havana, Cuba, 1/1/2019
• Interactions of inhaled nanoparticles with rat alveolar epithelial cell monolayers.
  Interactions of inhaled nanoparticles with rat alveolar epithelial cell monolayers., FASEB J, 1/1/2018
• Alveolar epithelial cell processing of nanoparticles: distribution between cytosolic and vesicular compartments.
  Sipos A, Kim KJ, Chow RH, Borok Z, Crandall ED, Am J Resp Crit Care Med, 1/1/2018
• Inducible alveolar epithelial type II cell (AT2)-specific Grp78 knockout mice develop endoplasmic reticulum (ER) stress and reversible pulmonary fibrosis.
  Zhou B, Wang H, Liu X, Flodby P, Crandall ED, Lee A, Borok Z, Am J Resp Crit Care Med, 1/1/2018
• Fate of nanoparticles in alveolar epithelial cells: uptake, autophagy, distribution and lysosomal exocytosis.
  Sipos A, Kim KJ, Flodby UP, Chow R, Borok Z, Crandall ED, 9th International Nanotoxicology Conference, Dusseldorf, Germany, 1/1/2018
• Cldn18-/-mice reveal novel role for YAP signaling in regulation of distal lung epithelial stem/progenitor cell homeostasis.
  Borok Z, Zhou B, Flodby P, Castillo DR, Luo J, Yu FX, McConnell A, Varghese BA, Li G, Conti PS, Liu Y, Sunohara M, Liebler JM, Yang C, Marconett C, Laird-Offringa IA, ..., FASEB J, 1/1/2017
• Mechanisms of nanoparticle flow across alveolar epithelial cells.
  Sipos A, Chow RH, Borok Z, Kim KJ, Crandall ED, Am J Resp Crit Care Med, 1/1/2017
• Mice with mutant E1A-binding protein-300 kD (p300(S89A)) are protected from bleomycin-induced lung fibrosis.
  Sunohara M, Sasaki T, Flodby P, Zhou B, Crandall ED, Kahn M, Borok Z, Am J Resp Crit Care Med, 1/1/2017
• Claudin-18 is a novel regulator of organ size and distal lung epithelial stem/progenitor cell homeostasis.
  Zhou B, Flodby P, Castillo DR, Luo J, Yu FX, McConnell A, Varghese B, Li G, Conti PS, Liu Y, Sunohara M, Liebler JM, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z, Am J Resp Crit Care Med, 1/1/2017
• Effects of nanoparticle size and surface charge on uptake into rat alveolar epithelial cells.
  Sipos A, Peti-Peterdi J, Chow RH, Borok Z, Kim KJ, Crandall ED, FASEB J, 1/1/2016
• Alveolar epithelial type II cell-specific deletion of foxo1 results in increased stem/progenitor cell proliferation in vitro.
  Yeragunta Y, Ran D, Rieger ME, Liebler JM, Flodby P, Zhou B, Crandall ED, Borok Z, Am J Resp Crit Care Med, 1/1/2016
• Endoplasmic reticuum (ER) stress exacerbates pulmonary fibrosis in inducible alveolar epithelial type II cell-specific Grp78 knockout mice.
  Flodby P, Li C, Wang H, Liu Y, Rieger M, Kahn M, Beers MF, Lee AS, Minoo P, Crandall ED, Borok Z, Zhou B, Am J Resp Crit Care Med, 1/1/2016
• Mechanisms of uptake/egress and intracellular fate of nanoparticles in primary rat alveolar epithelial cell monolayers (RAECM).
  Sipos A, Peti-Peterdi J, Chow RH, Borok Z, Kim KJ, Crandall ED, Am J Resp Crit Care Med, 1/1/2016
• Expression of Homeodomain-only protein (HOPX) in normal lung.
  Liebler JM, Marconett CN, Wang H, Liu Y, Flodby P, Laird-Offringa IA, Minoo P, Crandall ED, Borok Z, Zhou B, Am J Resp Crit Care Med, 1/1/2016
• Ex vivo lung volume measurement using high resolution micro-computerized tomography.
  Luo J, Varghese B, Skorka T, Zhou B, Crandall ED, Conti PS, Borok Z, Am J Resp Crit Care Med, 1/1/2016
• Mouse alveolar epithelial type I cell isolation using magnetic sorting.
  Sunohara M, Kage H, Zhou B, Liebler JM, Flodby P, Crandall ED, Borok Z, Am J Resp Crit Care Med, 1/1/2016
• Computerized tomographic-based quantification of regional volume in murine lung specimens.
  Varghese B, Luo J, Skorka T, Zhou B, Flodby P, Crandall ED, Conti P, Borok Z, J Nucl Med, 1/1/2016
• Effects of endoplasmic reticulum (ER) stress on epithelial injury and fibrosis in alveolar epithelial type II cell (AT2)-specific Grp78 knockout mice.
  Zhou B, Flodby P, Wang H, Liu Y, Minoo P, Crandall ED, Lee A, Borok Z, FASEB J, 1/1/2015
• Key role of autophagy in processing of intracellular nanoparticles in alveolar epithelial cells.
  Sipos A, Peti-Peterdi J, Chow RH, Borok Z, Kim KJ, Crandall ED, Am J Resp Crit Care Med, 1/1/2015
• Integrative analysis of microRNA and mRNA expression reveals a role for glucocorticoid signaling during adult human alveolar epithelial cell differentiation.
  Rieger ME, Zhou B, Marconett CN, Dubourd M, Pandit K, Siegmund KD, Crandall ED, Kaminshi N, Fabbri M, Laird-Offringa IA, Borok Z, Am J Resp Crit Care Med, 1/1/2015
• Combinations of lung differentiation markers distinguish subpopulations of alveolar epithelial cells during early and late transdifferentiation.
  Liebler JM, Rieger ME, Juul N, Beard LL, Wang HJ, Flodby P, Crandall ED, Borok Z, Zhou B, Am J Resp Crit Care Med, 1/1/2015
• Role of DNA methylation in regulation of CLDN18.1 gene expression in lung adenocarcinoma.
  Luo J, Zhou B, Marconett CN, Yang C, Tran E, Crandall ED, Laird-Offringa IA, Borok Z, Am J Resp Crit Care Med, 1/1/2015
• Lung epithelial cell-specific knockout of Grp78 perturbs the unfolded protein response and affects lung maturation.
  Flodby P, Li C, Liu Y, Wang H, Marconett CN, Lee AS, Minoo P, Crandall ED, Borok Z, Zhou B, Am J Resp Crit Care Med, 1/1/2015
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Lectures

• Alveolar epithelial transport in claudin-18 knockout mice. 
  Estoril, Portugal - 1/21/2012
• Lung interactions with nanoparticles: injury, uptake and trafficking. 
  Denver, CO - 1/16/2011
• Lung Interactions with Nanoparticles. 
  Denver, CO - 1/16/2011
• Alveolar epithelial interactions with environmental and engineered nanomaterials. 
  Denver, CO - 1/13/2011
• Cellular and molecular biology of the pulmonary alveolar epithelium in health and disease. 
  Innsbruck, Austria - 1/13/2009
• Development, differentiation and function of alveolar epithelial type I cells. 
  San Diego, CA - 1/23/2005
• Fluid Transport Across the Perinatal and Adult Lung Epithelium. 
  San Diego, CA - 1/23/2005
• Nasal and pulmonary delivery: technology and future directions. 
  San Francisco, CA - 1/9/2005
• Molecular Engineering. 
  Barcelona, Spain - 1/16/2003
• Improved models for studies of alveolar epithelial barrier. 
  Rome, Italy - 1/27/1999
• Alveolar Ion Transport. 
  Chicago, IL - 1/29/1998
• Geriatrics in the pulmonary and critical care medicine curriculum. 
  St. John, VI - 1/17/1998
• Therapeutic Applications. 
  Stockholm, Sweden - 1/30/1997
• Pathogenesis and treatment of pulmonary edema. 
  Sedalia, CO - 1/5/1996
• Role of ion pumps in reabsorption of edema fluid. 
  Sedalia, CO - 1/1/1996
• Alveolar epithelial ion and fluid transport. 
  Seattle, WA - 1/22/1995
• Pulmonary delivery physiology/pathophysiology. 
  Munich, Germany - 1/20/1995
• Transport properties of the alveolar epithelial barrier. 
  Munich, Germany - 1/1/1995
• Healthcare reform and the pulmonologist. 
  Boston, MA - 1/23/1994
• Lung Ion and Macromolecular Transport. 
  New Orleans, LA - 1/31/1993
• In vitro models for drug evaluation and testing. 
  San Diego, CA - 1/6/1993
• Alveolar ion transport mechanisms. 
  Glasgow, Scotland - 1/5/1993
• Lung Cells: Epithelial Ion Transport. 
  Anaheim, CA - 1/8/1992
• Pulmonary/Adult. 
  Carmel, CA - 1/7/1992
• Pulmonary Vascular/Lung Injury and Inflammation. 
  Palm Springs, CA - 1/26/1991
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Other

• Fluid Balance Across Alveolar Epithelium. 
  Crandall ED, American Thoracic Society
  New York, NY - 1/1/1983
• Adaptive control of a continuous stirred tank reactor. 
  Crandall ED, Ph.D. Thesis, Department of Chemical Engineering, Northwestern University
  Chicago, IL - 1/1/1964
• An application of a model-reference adaptive control system to a rigid body missile. 
  Crandall ED, Report SM-44723, Douglas Aircraft Company
  Santa Monica, CA - 1/1/1963
• Cricondentherms and cricondenbars: their prediction for binary hydrocarbon systems. 
  Crandall ED, M.S. Thesis, Department of Chemical Engineering, Northwestern University
  Chicago, IL - 1/1/1962
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