EduardoDavidLeonardoMD

PubMed

• 1 citations
  Inhibition of norepinephrine signaling during a sensitive period disrupts locus coeruleus circuitry and emotional behaviors in adulthood.
  Qingyuan Meng, Alvaro L Garcia-Garcia, Alex Dranovsky, E David Leonardo
  Scientific Reports. 2023-02-22
• 6 citations
  Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior.
  Muhammad O Chohan, Jared M Kopelman, Hannah Yueh, Zeinab Fazlali, Natasha Greene
  Molecular Psychiatry. 2022-03-01
• 51 citations
  Early life stress delays hippocampal development and diminishes the adult stem cell pool in mice.
  Mary Youssef, Piray Atsak, Jovani Cardenas, Stylianos Kosmidis, E. David Leonardo
  Scientific Reports. 2019-03-11

Journal Articles

• Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-induced Impairments in Dendritic Spines and Fear Responses  
  Besnard, A., Langberg, T., Levinson, S., Chu, D., Vicidomini, C., Scobie, K.N., Dwork, A.J., Arango, V., Rosoklija, G.B., Mann, J.J., Hen, R., Leonardo, E.D., Boldrini..., Cell Reports, 1/12/2018
• Ablation of proliferating neural stem cells during early life is sufficient to reduce adult hippocampal neurogenesis  
  Youssef, M., Krish, V.S., Kirshenbaum, G.S. Atsak, P., Lass, T.J., Lieberman, S.R., Leonardo, E.D., Dranovsky, A., Hippocampus, 1/1/2018
• Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT1A receptor dependent manner  
  Garcia-Garcia, A.L., Canetta, S., Stujenske, J.M., Burghardt, N.S., Ansorge, M.S., Dranovsky, A., Leonardo, E.D., Molecular Psychiatry, 1/1/2017
• Serotonin signaling through Prefrontal Cortex 5-HT1A receptors during adolescence can determine baseline mood-related behaviors  
  Garcia-Garcia, A.L., Meng, Q., Canetta, S., Gardier, A.M., Guiard, B.P., Kellendonk, C., Dranovsky, A., Leonardo, E.D., Cell Reports, 1/1/2017
• An opening for humor in Melancholy  
  Leonardo, E.D., Dranovsky, A., Nature Neuroscience, 1/1/2017
• 5-HT1A agonist properties contribute to a robust response to Vilazodone in the novelty suppressed feeding paradigm  
  Garcia-Garcia, A.L., Navarro-Sobrino, M., Pilosof, G., Banerjee, P., Dranovsky, A., Leonardo E.D., Int. J Neuropsychopharmacol, 1/1/2016
• 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking  
  You, I.J., Wright, S.R., Garcia-Garcia, A.L., Tapper, A.R., Gardner, P.D., Koob, G.F., Leonardo, E.D., Bohn, L.M., Wee, S., Neuropsychopharmacology, 1/1/2016
• Hippocampal Subfields and Major Depressive Disorder  
  Samuels, B.A., Leonardo, E.D., Hen, R., Biological Psychiatry, 1/1/2015
• Developmental effects of serotonin 1A autoreceptor on anxiety and social behavior  
  Donaldson, Z.R., Calizo, L.H., Piel, D.A., Santos, T.L., Richardson-Jones, J., Leonardo, E.D., Beck, S.G., Champagne, F.A., Hen, R, Neuropsychopharmacology, 1/1/2014
• 5-HT1A receptors in mood and Anxiety: Recent insights into autoreceptor vs heteroreceptor function  
  Garcia-Garcia, A., Newman-Tancredi, A., and Leonardo, E.D., Psychopharmacology, 1/1/2014
• Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior  
  Altieri, S.C., Garcia-Garcia, A.L., Leonardo, E.D., Andrews A.M., ACS Chemical Neuroscience, 1/1/2013
• Is there a role for adult hippocampal stem cells and their progeny in response to chronic stress?  
  Dranovsky A., Leonardo E.D., Behavioral Brain Research, 1/1/2012
• Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety  
  Richardson-Jones, J.W., Craige, C.P., Nguyen, T.H., Kung, H.F., Gardier, A.M., Dranovsky, A., David, D.J., Guiard, B.P., Beck, S.G., Hen, R., and Leonardo, E.D., Journal of Neuroscience, 1/1/2011
• Antidepressants recruit new neurons to improve stress response regulation  
  Surget, A., Tanti, A., Leonardo, E.D., Langueray, A., Rainer, Q., Touma, C., Palme, R., Griebel, G., Ibarguen-Vargas, Y., Hen, R., Belzung, C., Molecular Psychiatry, 1/1/2011
• Flexible Accelerated STOP TetO-knockin (FAST): A versatile and efficient new gene modulating system  
  Tanaka, K.J., Ahmari, S.E., Leonardo, E.D., Richardson-Jones, J.W., Budreck, E.C., Scheiffele, P., Sugio, S., Inamura, N., Ikenaka, K., and Hen, R., Biological Psychiatry, 1/1/2010
• 5-HT1A autoreceptors determine vulnerability to stress and response to antidepressants  
  Richardson-Jones, J.W., Craige, C.P., Guiard, B.P., Stephen, A.K., Metzger, K.L., Kung, H.F., Gardier, A.M., Dranovsky, A., David, D.J., Beck, S.G., Hen, R., and Leona..., Neuron, 1/1/2010
• Vertebrate homologues of UNC-5 are candidate Netrin receptors  
  Leonardo, E.D., Hinck, L., Masu, M., Keino-Masu, K., Ackerman, S. and Tessier-Lavigne, M., Nature, 1/1/1997
• Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system  
  Serafini, T., Colamarino, S.A., Leonardo, E.D., Wang, H., Beddington, R., Skarnes, W.C. and Tessier-Lavigne, M., Cell, 1/1/1996
• Deleted in colorectal carcinoma encodes a netrin receptor  
  Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E.D., Chan, S., Culotti, J. and Tessier-Lavigne, M., Cell, 1/1/1996
• A new vector for cloning large eukaryotic DNA segments in Escherichia coli  
  Leonardo E.D., and Sedivy, J.M., Bio/Technology, 1/1/1990
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Books/Book Chapters

• Psychiatry 
  Chapter: Neurobiology of Anxiety Disorders 
  Page 320 - 340Meaney, M.J., Liebowitz, M.L., Leonardo, E.D.Editors: Allan Tasman, Jerald Kay, Jeffrey A. Lieberman, Michael First, and Michelle Riba.Wiley-BlackwellEdition 4th,2015
• Anxiety Disorders: Theory, Research and Clinical Practice 
  Chapter: Animal Models of Anxiety Disorders: Behavioral and Genetic Approaches 
  Page 156 - 168Richardson-Jones, J.W., Leonardo, E.D., Hen, R., and Ahmari, S.E.Editors: Helen Blair Simpson.Cambridge University Press2010
• Clinical Manual of Anxiety Disorders 
  Chapter: Social Phobia 
  Page 63 - 86Schneier, F.R., Luterek, J.A., Heimberg, R.G., and Leonardo, E.Editors: Dan J. Stein.American Psychiatric Publishing, Inc.2004
• Guidebook to the Extracellular Matrix, Anchor and Adhesion Proteins 
  Chapter: DCC Family 
  Page 179 - 182Leonardo E.D., Tessier-Lavigne, M., Culotti, J.G.Editors: Thomas Kreis and Ron Vale.Oxford University Press1999
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Lectures

• Serotonin signaling through Prefrontal Cortex 5-HT1A receptors during adolescence can bi-directionally determine baseline Mood-related behaviours 
  Cork, Ireland - 1/1/2018
• Lifelong Mood and Anxiety Setpoints 
  1/1/2017
• Setting Lifelong Mood and Anxiety Setpoints: Insights from Studies in Mice 
  1/1/2014
• Contribution of Serotonin 1A Auto and Heteroreceptors to Anxiety, Depression, and the Antidepressant Response 
  Montpellier, France - 1/1/2012
• Vilazodone: Serotonin 1A Receptor Partial Agonist and Reuptake Inhibitor 
  Chicago, IL - 1/28/2010
• The Nature of the Nurture: Gene-Environment Interactions in Psychiatry 
  Colegio Medico del Peru, Lima, Peru - 1/1/2010
• The role of 5-HT1A Auto and Heteroreceptors in Anxiety and Depression 
  1/1/2010
• Antidepressant Mechanisms and Neurogenesis 
  Jackson Laboratories, Bar Harbor, ME - 1/1/2007
• Gene-Environment Interactions in Psychiatry 
  1/1/2004
• Molecular studies of Axonal Chemorepulsion 
  Instituto Santiago Ramon y Cajal, Madrid, Spain - 1/1/1995
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Other

• Genetics of Affective and Anxiety Disorders 
  Leonardo, E. D., and Hen, R., Annual Review of Psychology
  1/1/2006
• Molecular Studies of Axonal Chemorepulsion 
  Leonardo ED, University of California
  1/1/1997
• Guidance of Developing Axons by Netrin-1 and its Receptors 
  Leonardo, E.D., Hinck, L., Masu, M., Keino-Masu, K., Fazeli, A., Stoeckli, E.T., Ackerman, S.A., Weinberg, R.A., and Tessier-Lavigne, M., Cold Spring Harbor Symposia on Quantitative Biology
  1/1/1997