EdaireChengMD

PubMed

• 2 citations
  Eosinophilic esophagitis, Barrett’s esophagus and esophageal neoplasms in the pediatric patient: a narrative review
  Annette L. Medina, David M. Troendle, Jason Y. Park, Ameet I. Thaker, Kerry B. Dunbar
  Translational Gastroenterology and Hepatology. 2021-07-25
• 3 citations
  Esophagitis Dissecans Superficialis in Children.
  Nonyelum Ebigbo, Jason Y. Park, Edaire Cheng, Bhaskar Gurram
  Journal of Pediatric Gastroenterology and Nutrition. 2021-04-28
• 5 citations
  Esophageal Fibrosis in Eosinophilic Gastrointestinal Diseases.
  Ameet I. Thaker, Diana Montoya Melo, Layla Z. Samandi, Rong Huang, Jason Y. Park
  Journal of Pediatric Gastroenterology and Nutrition. 2021-03-01

Journal Articles

• Obtaining Adequate Lamina Propria for Subepithelial Fibrosis Evaluation in Pediatric Eosinophilic Esophagitis  
  Wang J, Park JY, Huang R, Souza RF, Specher SJ, Cheng E, Gastrointestinal Endoscopy, 1/1/2018

Books/Book Chapters

• Eosinophilic Esophagitis 
  Chapter: "Relationship of Eosinophilic Esophagitis To Gastroesophageal Reflux" 
  Cheng E, Winter HS, Spechler SJEditors: Liacouras C, Markowitz J.Springer, New York2011

Abstracts/Posters

• EoE Esophageal Epithelial Cells Induce Th2 Polarizing Dendritic Cells.
  Melo D, Lu D, Xue Y, Oh S, Spechler SJ, Souza RF, Farrar D, Gill M, Cheng E, Journal of Pediatric Gastroenterology, Hepatology, and Nutrition, 1/1/2018
• JAK/STAT6 are Potential Therapeutic Targets for Esophageal Remodeling in EoE.
  Muir A, Menard-Katcher C, Lu D, Zhang X, Melo D, Pan Z, Spechler SJ, Souza RF, Cheng E, Journal of Pediatric Gastroenterology, Hepatology, and Nutrition, 1/1/2018
• Protein-Losing Enterophathies with Mucosal Eosinophilia - Menetrier's, CMV, EGE, Oh My!
  Kumar P, Park JY, Mehta M, Baldwin C, Cheng E, Journal of Pediatric Gastroenterology, Hepatology, and Nutrition, 1/1/2017
• Epithelial-Mesenchymal Transition in Barrett's Esophagus: The Role of HIF-1a, microRNA-200, SP1, and MAZ.
  Zhang Q, Su T, Zhang X, Yu C, Huo X, Pham T, Dunbar KB, Cheng E, Wang DH, Spechler SJ, Souza RF, Gastroenterology, 1/1/2017
• In Non-Neoplastic Barrett's Epithelial Cells, Acid and Bile Salts Induce Epithelial Mesenchymal Transition (EMT) through a Hif-Mediated Reduction in Microrna-200a and ...
  Su T, Zhang X, Yu C, Huo X, Pham T, Dunbar KB, Cheng E, Bajpai M, Das KM, Wang DH, Spechler SJ, Souza RF, Zhang Q, Gastroenterology, 1/1/2017
• Aspirin Prevents NF-kB Activation and CDX2 Expression Induced by Acid and Bile Salts in Esophageal Squamous Cells of Patients with Barrett's Esophagus.
  Huo X, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham T, Lynch JP, Wang DH, Bresalier RS, Spechler SJ, Souza RF, Gastroenterology, 1/1/2017
• In Esophageal Fibroblasts, TH2 Cytokines Induce Pro-Fibrotic Periostin Expression that can be Blocked by JAK-STAT6 Inhibitors.
  Cheng E, Zhang X, Zhang Q, Yu C, Huo X, Pham T, Dunbar KB, Wang DH, Spechler SJ, Souza RF, Gastroenterology, 1/1/2017
• In Children With Esophageal Eosinophilia, Most Esophageal Biopsies Contain Insufficient Lamina Propria to Evaluate for Fibrosis, and Fibrosis often Is Present When End...
  Wang J, Park JY, Souza RF, Spechler SJ, Cheng E, Gastroenterology, 1/1/2016
• Ruxolitinib, a Selective JAK1/2 Inhibitor, Blocks IL-13/STAT6 Signaling and Eotaxin-3 Expression in Esophageal Epithelial Cells and Fibroblasts: A Potential Agent to T...
  Zhang X, Wang DH, Huo X, Yu C, Zhang Q, Tamagawa Y, Ding P, Pham T, Dunbar KB, Spechler SJ, Souza RF, Cheng E, Gastroenterology, 1/1/2016
• Eotaxin-3 Expression by Esophageal Epithelial Cells Correlates Inversely With Acid Reflux in Patients With Symptomatic Esophageal Eosinophilia.
  Cheng E, Park JY, Albert DM, Wang J, Dunbar KB, Souza RF, Spechler SJ, Moawad FJ, Gastroenterology, 1/1/2016
• "In Children with Esophageal Eosinophilia, Most Esophageal Biopsies Contain Insufficient Lamina Propria to Evaluate for Fibrosis, and Fibrosis Often is Present When En...
  Cheng E, Digestive Disease Week - American Gastroenterological Association Meeting, San Diego, CA, 1/1/2016
• "Eotaxin-3 Expression by Esophageal Epithelial Cells Correlates Inversely with Acid Reflux in Patients with Symptomatic Esophageal Eosinophilia."
  Cheng E, Digestive Disease Week - American Gastroenterological Association Meeting, San Diego, CA, 1/1/2016
• BMP4 Induces SOX9 and Columnar Cytokeratin Expression in Esophageal Squamous Cells and Increases Proliferation in Barrett's Cells Through the p38MAPK Pathway: Potentia...
  Tamagawa Y, Ding P, Zhang Q, Pham TH, Cheng E, Ishimura N, Kinoshita Y, Spechler SJ, Souza RF, Wang DH, Gastroenterology, 1/1/2015
• The Induction of Acute Reflux Esophagitis in Humans Causes Hypocontractile Esophageal Motility Alterations.
  Dunbar KB, Huo X, Cheng E, Pham TH, Castell DO, Souza RF, Spechler SJ, Gastroenterology, 1/1/2015
• In Barrett's Epithelial Cells, Ursodeoxycholic Acid Activates p38 and Hastens Repair of DNA Damage Caused by Acidic Bile Salts.
  Huo X, Zhang X, Yu C, Zhang Q, Cheng E, Nadatani Y, Zaika A, El-Rifai W, Wang DH, Spechler SJ, Souza RF, Gastroenterology, 1/1/2015
• In Barrett's Epithelial Cells, Lipopolysaccharide (LPS) Induces TLR4 Signaling With Activation of the NLRP3 Inflammasome, Pro-Inflammatory Cytokine Secretion and Pyrop...
  Nadatani Y, Huo X, Zhang X, Yu C, Zhang Q, Cheng E, Watanabe T, Fujiwara Y, Wang DH, Arakawa T, Spechler SJ, Souza RF, Gastroenterology, 1/1/2015
• DeltaNp63 Upregulates Expression of Squamous Cytokeratins and Increases Proliferation in Squamous Cells, but Decreases Proliferation in Barrett's Cells: A Potential Ro...
  Tamagawa Y, Ding P, Zhang Q, Pham TH, Cheng E, Ishimura N, Kinoshita Y, Spechler SJ, Souza RF, Wang DH, Gastroenterology, 1/1/2015
• In Non-Neoplastic Barrett's Epithelial Cells, Acid and Bile Salts Activate VEGF Signaling to Induce Epithelial Mesenchymal Transition Through ZEB2, a Transcriptional R...
  Zhang Q, Zhang X, Yu C, Huo X, Nadatani Y, Pham TH, Cheng E, Bajpai M, Das KM, Wand DH, Spechler SJ, Souza RF, Gastroenterology, 1/1/2015
• A STAT6 Inhibitor (AS1517499) and a Tyrosine Kinase Inhibitor (Leflunomide) Block IL-13/STAT6 Signaling and Eotaxin-3 Expression in Esophageal Fibroblasts and Epitheli...
  Cheng E, Zhang X, Huo X, Yu C, Zhang Q, Nadatani Y, Tamagawa Y, Ding P. Wang DH, Pham TH, Dunbar KB, Spechler SJ, Souza RF, Gastroenterology, 1/1/2015
• Omeprazole and Fluticasone Inhibit IL-13-Stimulated Eotaxin-3 Expression by Esophageal Epithelial Cells Through Different Mechanisms and With Additive Effects: Rationa...
  Zhang X, Huo X, Yu C, Zhang Q, Nadatani Y, Tamagawa Y, Ding P, Wang DH, Pham TH, Dunbar KB, Spechler SJ, Souza RF, Cheng E, Gastroenterology, 1/1/2015
• The Prevalence of Lamina Propria and Subepithelial Fibrosis in Mucosal Biopsies with Esophageal Eosinophilia.
  Wang J, Park JY, Cheng E, Gastroenterology, Hepatology, and Nutrition, 1/1/2015
• "The Prevalence of Lamina Propria and Subepithelial Fibrosis in Mucosal Biopsies with Esophageal Eosinophilia."
  Cheng E, NASGPHAN (North American Society for Pediatric Gastroenterology, Hepatology and Nutrition) Annual Meeting, Washington, DC, 1/1/2015
• Cross-Talk Between HIF-2Alpha and NF-KappaB Mediates Pro-Inflammatory Cytokine Expression by Esophageal Squamous Cells Exposed to Acid and Bile Salts.
  Huo X, Zhang Q, Zhang X, Yu C, Cheng E, Wang DH, Spechler SJ, Souza RF, Gastroenterology, 1/1/2014
• Different Effects of Proton Pump Inhibitors (PPIs) on Eotaxin-3 Protein Expression by the Proximal and Distal Esophagus of Children With Esophageal Eosinophilia.
  Park JY, Zhang X, Nguyen N, Souza RF, Spechler SJ, Cheng E, Gastroenterology, 1/1/2014
• Non-Neoplastic, Barrett's Epithelial Cells That Express Oncogenic RAS Can Be Transformed Through Forced Expression of Constitutively Active STAT3.
  Yu C, Huo X, Zhang X, Theiss AL, Cheng E, Zhang Q, Wang DH, Lobie PE, Spechler SJ, Souza RF, Gastroenterology, 1/1/2014
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Lectures

• "Recent Changes Regarding PPIs and EoE" 
  Dallas, TX - 1/1/2018
• "Esophageal Remodeling in Eosinophilic Esophagitis" 
  Dallas, TX - 1/1/2018
• "JAK/STAT6 are Potential Therapeutic Targets for Esophageal Remodeling in EoE" 
  Hollywood, FL - 1/1/2018
• "EoE Esophageal Epithelial Cells Induce Th2-Polarizing Dendritic Cells" 
  Hollywood, FL - 1/1/2018
• "Pediatric Eosinophilic Esophagitis Pathogenesis and Clinical Practice: Scientific Updates from Digestive Diseases Week 2018" 
  Dallas, TX - 1/1/2018
• "Pediatric Eosinophilic Esophagitis: From Pathogenesis to Clinical Practice" 
  Washington, DC - 1/1/2018
• "Relationship between EoE and Other Forms of Esophagitis with Focus on PPI Responses" 
  Orlando, FL - 1/1/2018
• "In Esophageal Fibroblasts, Th2 Cytokines Induce Pro-Fibrotic Periostin Expression that Can Be Blocked by JAK-STAT6 Inhibitors." 
  Chicago, IL - 1/1/2017
• "GI Dopplegangers: GERD and EoE" 
  1/1/2016
• "Ruxolitinib, a selective Jak1/2 inhibitor, blocks IL-13/STAT6 signaling and eotaxin-3 expression in esophageal epithelial cells and fibroblasts: A potential agent to ... 
  San Diego, CA - 1/1/2016
• "What are the emerging treatment options in EoE?" 
  Monaco, Monaco - 1/1/2015
• "Microscopic Esophagitis: Is it Reflux or Eosinophilic?" 
  Washington, DC - 1/1/2015
• "EoE, GERD, and PPI-REE: the confounding trio." 
  New York, NY - 1/1/2015
• "The EoE Hunger Games: PPI-REE is Catching Fire!" 
  Washington, DC - 1/1/2015
• "Effect of Omeprazole on Eotaxin-3" 
  Monaco, Monaco - 1/1/2015
• "What Causes Dysphagia in EoE?" 
  Monaco, Monaco - 1/1/2015
• "A STAT6 inhibitor (AS1517499) and a tyrosine kinase inhibitor (leflunomide) block IL-13/STAT6 signaling and eotaxin-3 expression in esophageal fibroblasts and epithel... 
  Washington, DC - 1/1/2015
• "Omeprazole and fluticasone inhibit IL-13-stimulated eotaxin-3 expression by esophageal epithelial cells through different mechanisms and with additive effects: Ration... 
  Washington, DC - 1/1/2015
• "21-month-old boy with projectile vomiting." 
  1/1/2014
• "Th2 Cytokines and Periostin Induce Fibrogenesis in EoE" 
  Atlanta, GA - 1/1/2014
• "Different Effects of Proton Pump Inhibitors (PPIs) on Eotaxin-3 Protein Expression by the Proximal and Distal Esophagus of Children with Esophageal Eosinophilia" 
  Chicago, IL - 1/1/2014
• "Proton Pump Inhibitors Decrease Eotaxin-3 Expression in the Proximal Esophagus of Children with Esophageal Eosinophilia" 
  Dallas, TX - 1/1/2014
• "Th2 Cytokines Stimulate Eotaxin-3 Secretion by Esophageal Fibroblasts: An Effect that is Not Blocked by Omeprazole" 
  Dallas, TX - 1/1/2013
• "Controversies in the Management of Eosinophilic Esophagitis" 
  Chicago, IL - 1/1/2013
• "Controversies in Eosinophilic Esophagitis" 
  1/1/2013
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Other

• Eosinophilic Esophagitis. 
  Cheng E, Pediatric Society of Greater Dallas Fourth Quarter Newsletter
  1/1/2014