Douglas Scott Tyler MD FACS

PubMed

• Impact of pre-existing cancer diagnoses on burn injury survival and morbidity.
  Phillip Keys, Kassandra Corona, Sheldon McCown, Lyndon Huang, Elvia Villarreal
  Burns. 2025-04-01
• Circulating Tumor DNA in High-Risk Stage II/III Cutaneous Melanoma: A Feasibility Study.
  Kristen E Rhodin, Margaret H O'Connor, Aaron Therien, Shayna Hollander, Viviana Geron
  Annals of Surgical Oncology. 2025-03-27
• In Search of the Shot to Kill Cancer: Possibilities and Limitations.
  Margaret H O'Connor, Douglas S Tyler, Georgia M Beasley
  Annals of Surgical Oncology. 2025-03-01

Journal Articles

• Comparing Survival Outcomes and Costs Associated with Radical Cystectomy and Trimodal Therapy for Older Adults with Muscle-Invasive Bladder Cancer  
  Jacques G Baillargeon, Douglas S Tyler, Stephen B Williams, Anthony J Senagore, Todd A Swanson, Ashish M Kamat, Eduardo Orihuela, JAMA
• Development of myofibrosarcoma after removal of longstanding chemotherapy port  
  Rice C, Wyble A, Qiu S, Silva M, Tyler DS, Phillips L, and Chao C, Journal of Surgery and Research, 1/1/2018
• Who did the case? Perceptions on resident operative participation  
  Perone JA, Fankhouser GT, Adhikari D, Mehta HB, Woods MB, Strohmeyer JH, Tyler DS, and Brown KM, American Journal of Surgery, 1/1/2017
• It depends on your perspective: resident satisfaction with operative experience  
  Perone JA, Fankhouser GT, Adhikari D, Mehta HB, Woods MB, Tyler DS, and Brown KM, American Journal of Surgery, 1/1/2017
• Safety and feasibility of minimally invasive inguinal lymph node dissection in patients with melanoma (SAFE-MILND): report of a prospective multi-institutional trial  
  Jakub JW, Terando AM, Sarnaik A, Aryian CE, Faires MB, Zani S, Neuman HB, Wasif N, Farma JM, Averbook BJ, Bilimoria KY, Grotz TE, Allred JB, Suman VJ, Brady MS, Tyler ..., Annals of Surgery, 1/1/2017
• Multi-center study of the prognostic value of sentinel lymph node biopsy in the management of recurrent melanoma  
  Beasley G, Hu Y, Youngwirth L, Scheri R, Salama A, Rossfeld K, Gardezi S, Agnese D, Howard H, Tyler DS, Slingluff C, and Terando A, Annals of Surgical Oncology, 1/1/2017
• Increased utilization of positron emission tomography-computed tomography (PET/CT) imaging and its economic impact for patients diagnosed with bladder cancer  
  Huo J, Chu Y, Chamie K, Smaldone MC, Boorjian SA, Baillargeon JG, Kuo YF, Kerr P, O'Malley J, Orhuela E, Tyler DS, Freedland SJ, Giordano S, Vikram R, Kamat AM, and Wi..., Clinical Genitourinary Cancer, 1/1/2017
• Can binimetinib, encorafenib, and masitinib be more efficacious than currently available mutation-based targeted therapies for melanoma treatment?  
  Turner MC, Rossfeld K, Salama AK, Tyler DS, and Beasley G, Expert Opinion in Pharmacotherapy, 1/1/2017
• Laparoscopic skill assessment of practicing surgeons prior to enrollment in a surgical trial of a new laparoscopic procedure  
  Zendejas B, Jakub JW, Terando AM, Sarnaik A, Ariyan CE, Faries MB, Zani S, Neuman HB, Wasif N, Farma JM, Averbook BJ, Bilimoria KY, Tyler DS, Brady MS, Farley DR, Surgical Endoscopy, 1/1/2017
• Survival differences among bladder cancer patients according to gender: critical evaluation of radical cystectomy use and delay to treatment  
  Williams SB, Huo J, DafashyT, Ghaffary C, Baillargeon JG, Morales E, Kim S, Kuo YK, Orihuela E, Tyler DS, Freedland SJ, and Kamat AM, Urologic Oncology, 1/1/2017
• Cancer and all-cause mortality in bladder cancer patients undergoing radical cystectomy:development and validation of a nomogram for treatment decision-making  
  Williams SB, Huo J, Chu Y, Baillargeon JG, Daskivich T, Kuo YF, Kim SP, Orhuela E, Tyler DS, Freedland SJ, and Kamat AM, Urology, 1/1/2017
• Computed tomography-based limb volume measurements for isolated limb infusion in melanoma  
  Brys AK, Bhatti L, Bashir MR, Jaffe TA, Beasley GM, Nath NS, Salama AK, Tyler DS, and Mosca PJ, Annals of Surgical Oncology, 1/1/2016
• Minimally invasive pancreaticoduodenectomy does not improve use or time to initiation of adjuvant chemotherapy in patients with pancreatic adenocarcinoma  
  Nussbaum DP, Adam MA, Youngwirth L, Ganapathi AM, Roman SA, Tyler DS, Sosa JA, and Blazer DG III, Annals of Surgical Oncology, 1/1/2016
• What is the OPTimal way to manage in transit disease?  
  Olino K and Tyler DS, Annals of Surgical Oncology, 1/1/2016
• Finish line or beginning? Welcome the new board certified surgical oncologists  
  Tyler DS, and Michelassi FA, Annals of Surgical Oncology, 1/1/2016
• Feeding jejunostomy tube placement during resection of gastric cancers  
  Sun Z, Shenoi MM, Nussbaum DP, Keenan JE, Gulack BC, Tyler DS, Speicher PJ, and Blazer DG III, Journal of Surgical Research, 1/1/2016
• Training high volume melanoma surgeons to perform a novel minimally invasive inguinal lymphadenectomy: report of a prospective multi-institutional trial  
  Jakub JW, Terando AM, Sarnaik A, Ariyan CE, Faries MB, Zani S, Neuman HB, Nabil Wasif H, Farma JM, Averbook BJ, Bilimoria KY, Allred JB, Suman VJ, Grotz TE, Zendejas B..., Journal of the American College of Surgeons, 1/1/2016
• Commentary sidebar Commentary on Grunhagen DJ, and Verhoef C Isolated limb perfusion for stage III melanoma: is there still a role in the present era of effective sy...  
  Tyler DS, Oncology, 1/1/2016
• The role of CT-guided percutaneous drainage of loculated air collections: An institutional experience  
  Patel BN, Morgan M, Tyler DS, Paulson E, Jaffee T, Abdominal Imaging, 1/1/2015
• Long-term oncologic outcomes after neoadjuvant radiation therapy for retroperitoneal sarcomas  
  Nussbaum DP, Speicher PJ, Gulack BC, Ganapathi AM, Englum BR, Kirsch DG, Tyler DS, and Blazer DG III, Annals of Surgery, 1/1/2015
• Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma  
  Turley RS, Toshimitsu H, Padussis JC, Fontanella A, Deng W, Augustine CK, Dewhirst M, Davies MA, and Tyler DS, Annals of Surgery, 1/1/2015
• In-transit melanoma metastases: incidence, prognosis and the role of lymphadenectomy  
  Beasley GM and Tyler DS, Annals of Surgical Oncology, 1/1/2015
• A multicenter phase I dose escalation trial to evaluate the Safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using ...  
  Beasley GM, Speicher PJ, Augustine CK, Dolber PC, Peterson B, Sharma K, Mosca PJ, Royal R, Ross M, Zager JS, and Tyler DS, Annals of Surgical Oncology, 1/1/2015
• Quality of life after isolated limb infusion for in-transit melanoma of the extremity  
  Jiang BS, Speicher PJ, Thomas S, Mosca PJ, Abernethy AP, and Tyler DS, Annals of Surgical Oncology, 1/1/2015
• Burden of disease predicts response to isolated limb infusion with melphalan and Actinomycin D in melanoma  
  Muilenburg DJ, Beasley GM, Thompson ZJ, Lee JH, Tyler DS, and Zager JS, Annals of Surgical Oncology, 1/1/2015
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Books/Book Chapters

• Surgical Oncology Clinics of North America: Melanoma. 
  Chapter: Regional therapies for in-transit disease. 
  Page 309 - 322Speicher PJ, Meriwether CH, and Tyler DSEditors: Berger AC.W. B. Saunders, Philadelphia, PA2015
• Gastrointestinal Surgery: Management of Complex Perioperative Complications. 
  Chapter: Duodenal stump blowout. 
  Page 147 - 158Speicher PJ, Barbas AS, Li GZ, and Tyler DSEditors: Pawlik TM, Merchant N, and Maithel SK.Springer, New York, NY2015
• Surgery: Complications, Risks, and Consequences. 
  Chapter: Lymphatic surgery. 
  Page 115 - 532Thompson J, Giuliano A, Mabry H, Hansen N, Rees G, Tyler DS, and Coventry BEditors: Coventry B.Insite Productions, Kent Town, South AustraliaEdition 1st,2014
• Surgery: Complications, Risks, and Consequences. 
  Chapter: Specialized cancer procedures and surgery. 
  Page 201 - 218Thompson J, Coventry B, Tyler DS, and Kroon HMEditors: Coventry B.Insite Productions, Kent Town, South AustraliaEdition 1st,2014
• Contemporary surgical management of liver, biliary tract, and pancreatic disease. 
  Chapter: Cystic neoplasms of the pancreas. 
  Page 469 - 490Ceppa EP and Tyler DSEditors: Blazer DG, Kuo PC, Pappas TN, and Clary BM.World Scientific Books, Singapore2014
• Contemporary surgical management of liver, biliary tract, and pancreatic disease. 
  Chapter: Unusual pancreatic neoplasms. 
  Page 523 - 532Padussis JC and Tyler DSEditors: Blazer DG, Kuo PC, Pappas TN, and Clary BM.World Scientific Books, Singapore2014
• Genomics and Personalized Medicine 
  Chapter: Molecular therapeutics of melanoma. 
  Page 967 - 976Augustine CK, Freedman J, Beasley GM, and Tyler DSEditors: Willard H, and Ginsberg J.Elsevier Academic Press, Oxford, EnglandEdition 2nd,2013
• Patient Surveillance After Cancer Treatment. 
  Chapter: Stomach carcinoma surveillance counterpoint: USA. 
  Page 109 - 112Coleman A and Tyler DSEditors: Johnson FE, Maehara Y, Browman GP, Margenthaler JA, Audisio RA, Thompson JF, Johnson DY, Earle GC, and Virgo KS.Humana Press, New York, NY2013
• Surgical Oncology Clinics of North America: Melanoma. 
  Chapter: Regional treatment strategies for in-transit melanoma metastatasis. 
  Page 79 - 103Turley RS, Raymond AK, and Tyler DSEditors: Gershenwald J.W. B. Saunders, Philadelphia, PA2011
• Intraoperative Irradiation – Techniques and Results. 
  Chapter: Retroperitoneal sarcomas. 
  Page 353 - 386Czito B, Donohue J, Willett CG, Tyler DS, Petersen IA, Krempien R, Hu KS, Calvo FA, Callister MD, Alektiar KM, Eble M, and Alvarez AEditors: Gunderson LL, Willett CG, Harrison LB, and Calvo FC.Springer-Verlag, New York, NYEdition 1st,2011
• Small intestine and carcinoma of the colon and rectum. 
  Chapter: Small intestine and carcinoma of the colon and rectum. 
  Page 1172 - 1193Padussis J, Beasley G, McMahon N, Tyler DS, and Ludwig, KEditors: Kufe DW, Pollock RE, Weichselbaum RR, Bast RC, Holland JF, and Frei E.BC Decker, Philadelphia, PAEdition 8th,2010
• Gastrointestinal Bleeding: a Practical Approach to diagnosis and management. 
  Chapter: Management of Dieulafoy's Lesions. 
  Page 31 - 37Faes SK, Untch BR, Edwards C, Turner J, Poleski M, and Tyler DSEditors: Branch S, Pappas TN, and Pryor A.Springer-Verlag, New York, NYEdition 1st,2010
• Cutaneous Melanoma. 
  Chapter: Isolated limb infusion for melanoma. 
  Page 541 - 560Beasly GM, Kroon HM, Ross MI, Kam P, Thompson JF, and Tyler DSEditors: Balch CM, Houghton AN, Sober AJ, Soong S, Atkins MA, and Thompson J.Quality Medical Publishing, St. Louis, MOEdition 5th,2009
• Cutaneous Melanoma. 
  Chapter: Axillary and epitrochlear lymph node dissection for melanoma. 
  Page 447 - 455McMasters K, Wong SL, Tyler DS, Balch CM, and Thompson JFEditors: Balch CM, Houghton AN, Sober AJ, Soong S, Atkins MA, and Thompson J.Quality Medical Publishing, St. Louis, MOEdition 5th,2009
• Advanced Therapy in Surgical Oncology. 
  Chapter: Surgical treatment of carcinoid tumors of the gastrointestinal tract. 
  Page 248 - 255Onaitis M, and Tyler DSEditors: Curley SA, Pollock RE, Ross MI, and Perrier ND.BC Decker, Philadelphia, PAEdition 1st,2008
• Current clinical and research approaches to optimizing regional chemotherapy: Novel strategies generated through a better understanding of drug pharmacokinetics, drug resistance, and the development of clinically relevant animal models. 
  Chapter: Current clinical and research approaches to optimizing regional chemotherapy: Novel strategies generated through a better understanding of drug pharmacokinetics, drug resistance, and the development o 
  Page 731 - 758Beasly-Switzer G, Kahn L, and Tyler DSEditors: Wanebo HJ.W. B. Saunders, Philadelphia, PA2008
• Pancreatic Cancer. MD Anderson Solid Tumor Oncology Series. 
  Chapter: Neoadjuvant therapy for resectable pancreatic cancer. 
  Page 549 - 562Petersen RP, Bendell J, Czito B, and Tyler DSEditors: Lowy AM, Leach SD, and Philip PA.Springer-Verlag, New York, NYEdition 1st,2008
• Holland-Frei Cancer Medicine. 
  Chapter: Neoplasms of the small bowel, vermiform appendix and peritoneum. 
  Page 1359 - 1368Grubbs E, and Tyler DSEditors: Kufe DW, Pollock RE, Weichselbaum RR, Bast RC, Holland JF, and Frei E.BC Decker, Philadelphia, PAEdition 7th,2006
• Conn’s Current Therapy 2006 
  Chapter: Malignant melanoma. 
  Page 997 - 1003Tyler DS, and Seigler HFEditors: Rakel RE and Bope ET.W. B. Saunders Co., Philadelphia, PAEdition 58th,2006
• Conn’s Current Therapy 2005 
  Chapter: Malignant melanoma. 
  Page 936 - 941Tyler DS, and Seigler HFEditors: Rakel RE and Bope ET.W. B. Saunders, Philadelphia, PAEdition 57th,2005
• American Society of Clinical Oncology 2005 Educational Book 
  Chapter: Controversies in the use of adjuvant therapy for patients with pancreatic cancer. 
  Page 308 - 312Wolff RA, Tyler DS, and Lu DS2005
• Pancreatic Cancer. 
  Chapter: Clinical management of periampullary tumors. 
  Page 703 - 714White RR, Clary B, Pappas TN, and Tyler DSEditors: Von Hoff DD, Evans DB, and Hruban RH.Jones and Bartlett Publishers, Sudbury, MA2005
• Current Problems in Surgery: Immunotherapy of Surgical Malignancies. 
  Chapter: Immunologic therapies for gastrointestinal malignancies. 
  Page 86 - 99Kalady M, Onaitis M, Abdel Wahab O, and Tyler DSEditors: Clay TM, Lyerly HK, and Morse MA.Mosby, Inc., St. Louis, MO2004
• Seminars in Colon and Rectal Surgery: Retrorectal lesions. 
  Chapter: Sarcomas of the Pelvis. 
  Page 33 - 40White RR and Tyler DSEditors: Ludwig, K.W. B. Saunders, Philadelphia, PA2004
• Surgical Oncology Clinics of North America: Therapy for Pancreatic cancer. 
  Chapter: Neoadjuvant therapy for pancreatic cancer: The Duke experience. 
  Page 675 - 684White RR and Tyler DSEditors: Hoffman J.W. B. Saunders, Philadelphia, PA2004
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Abstracts/Posters

• Glutathione S transferase as a marker of metastatic potential in malignant melanoma.
  Yoo JS, Yoshimoto Y, Peterson P, Pruitt SK, Ali-Osman F, and Tyler DS, Journal of the American College of Surgeons, 1/1/2005
• Measuring utilities for temporary health states in pancreatic cancer.
  Purcell GP, Martin GR, and Tyler DS, Journal of the American College of Surgeons, 1/1/2003
• Transfection with RNA Encoding a Dominant Positive Toll-like Receptor 4 (TLR4) Construct Induces Maturation of Human Monocyte-Derived Dendritic Cells (DC) in the Absen...
  Cisco R, Abdel-Wahab Z, Dannull J, Tyler DS, and Pruitt SK, Journal of the American College of Surgeons, 1/1/2003
• In-transit melanoma: The role of alkylating agent resistance in regional therapy.
  Grubbs E, Friedman H, Colvin M, Kalady M, Abdul-Wahab O, Pruitt SK, and Tyler DS, Journal of the American College of Surgeons, 1/1/2002
• Preferences affect treatment decisions for pancreatic cancer.
  Purcell GP, White RR, and Tyler DS, Journal of the American College of Surgeons, 1/1/2002
• Quality of life following low anterior resection vs. abdominoperineal resection for rectal cancer: A case for sphincter preservation.
  Wilkins K, Fields R, Onaitis M, Kalady M, Seigler H, Tyler DS, Mantyh C, and Ludwig K, Journal of the American College of Surgeons, 1/1/2002
• RNA electroporation of dendritic cells results in superior antigen presentation and improved generation of specific effector T cells.
  Kalady M, Onaitis M, Padilla K, Emani S, Tyler DS, and Pruitt SK, Surgical Forum, 1/1/2001
• Both degree and timing of maturation of dendritic cells are critical for optimal T cell presenting capacity.
  Onaitis M, Kalady M, Padilla K, Emani S, Tyler DS, and Pruitt SK, Surgical Forum, 1/1/2001
• Utilities for temporary health states in pancreatic cancer.
  Purcell GP, Odunze MJ, and Tyler DS, Surgical Forum, 1/1/2001
• The role of the adaptor protein CRKL in insulin-like growth factor receptor signaling.
  Hartwig M, Onaitis M, Pendergast AM, and Tyler DS, Surgical Forum, 1/1/2000
• Novel alterations of the adaptor protein CRKL in lung cancer.
  Onaitis M, Harpole D, Hartwig M, D'Amico T, Joshi MB, Pendergast AM, and Tyler DS, Surgical Forum, 1/1/2000
• Molecular mechanisms underlying cellular motility: negative regulation through phosphorylation of the adaptor protein CRKL.
  Tyler DS, Hata A, Kherani A, Onaitis M, Zipfel P, and Pendergast AM, Surgical Forum, 1/1/1999
• Commercially-available surgical gowns do not prevent penetration by HIV-1.
  Shadduck PP, Tyler DS, Lyerly HK, Sebastian M, Farnitano C, Fitzpatrick K, Langlois AJ, and Moylan J, Surgical Forum, 1/1/1990
• The anti-retroviral effects of lymphokine activated killer cells.
  Tyler DS, Stanley SD, Bumpas EA, Bartlett JA, Bolognesi DP, and Weinhold KJ, Surgical Forum, 1/1/1989
• Direct ADCC: Evidence of circulating antibody armed cytotoxic CD16+ NK/K cells in patients infected with HIV-1.
  Tyler DS, Nastala CL, Lyerly HK, Matthews TJ, Bolognesi DP, and Weinhold KJ, Surgical Forum, 1/1/1988
• Alterations in anti-HIV immune cytolysis is independent of viral envelope glycosylation.
  Lyerly HK, Skinner MA, Tyler DS, Nastala CL, Matthews TJ, Bolognesi DP, and Weinhold KJ, Surgical Forum, 1/1/1988
• Indefinite survival of skin allografts in cyclosporine treated rats.
  Towpik E, Kupiec-Weglinski JW, Schneider TM, Tyler DS, and Tilney NL, Surgical Forum, 1/1/1985
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Lectures

• Optimizing outcomes in colorectal surgery: cost and clinical analysis of robotic versus laparoscopic approaches to colon surgery. 
  Houston, TX - 1/6/2018
• A history of the Department of Surgery at the University of Texas Medical Branch 
  Galveston, TX - 1/30/2017
• What operation should be performed after neoadjuvant chemoradiation for rectal cancer. 
  Yokohama, Japan - 1/28/2017
• Interviewing: pearls for a successful job interview. 
  Birmingham, AL - 1/22/2017
• Optimizing regional therapy in melanoma: development of a novel regional therapy clinical trial. 
  San Antonio, TX - 1/7/2017
• Current approaches to localized of pancreatic cancer. 
  Kawasaki Medical School, Kurashiki, Japan - 1/1/2017
• Current updates in the management of malignant melanoma. 
  University of Texas Medical Branch, Galveston, TX - 1/24/2016
• Motivating faculty using a WRVU based compensation model. 
  Washington, DC - 1/16/2016
• Current advances in melanoma. 
  University of Texas Medical Branch, Galveston, TX - 1/9/2016
• Integrating immunotherapies with regional therapies. 
  Boston, MA - 1/6/2016
• Lessons learned in building a translational research program: evolution of regional chemotherapy strategies for advanced extremity melanoma 
  University of Texas MD Anderson Cancer Center, Houston, TX - 1/12/2015
• University of Texas Medical Branch Department of Surgery. Where we have been and where are we going? 
  Galveston, TX - 1/11/2015
• Current status of regional therapy for melanoma 
  Austin, TX - 1/5/2015
• Current advances in melanoma 
  Austin, TX - 1/3/2015
• Building a translational research program: evolution of regional chemotherapy strategies for advanced extremity melanoma. 
  University of Texas Medical Branch, Galveston, TX - 1/27/2014
• The American Board of Surgery certification process for complex general surgical oncology. 
  Phoenix, AZ - 1/15/2014
• Regional therapy for melanoma - Isolated limb perfusion, isolated limb infusion, and local therapies for in-transit melanoma. 
  Cincinnati, OH - 1/14/2014
• Pancreatic neuroendocrine tumors. 
  Durham, NC - 1/6/2014
• How do I prepare for a job interview? 
  San Diego, CA - 1/2/2014
• Defining tumor-host interactions in regional treatment of advanced extremity melanoma. 
  Washington, DC - 1/28/2013
• Definition of borderline vs locally advanced vs unresectable pancreatic cancer: how do we decide? 
  Cary, NC - 1/23/2013
• Neoadjuvant chemoradiation vs surgery for resectable pancreatic cancer? 
  Cary, NC - 1/23/2013
• Update on the current management of malignant melanoma. 
  Milwaukee, WI - 1/21/2013
• Update on regional therapy clinical trials for advanced extremity melanoma. 
  Indian Wells, CA - 1/16/2013
• Therapeutic approaches for patients with advanced melanoma. 
  Duke University Medical Center. Durham, NC - 1/15/2013
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Other

• Management of In-transit melanoma. In: Melanoma: From Early Detection to Treatment. 
  Speicher P, Tyler DS, and Mosca P, InTech Open Access books
  http://www.intechopen.com/articles/show/title/management-of-in-transit-malignant-melanoma
  1/1/2013
• Pancreatic cancer: manuscript accompanying clinical practice guidelines. 
  Tempero M, and Tyler DS (The Writing Committee for the Guideline Panel), National Comprehensive Cancer Network
  1/1/2003
• Breast disease: Implications for primary care. 
  Mather SH, Bastian L, Glazebrook K, Havlin KA, Jens G, and Tyler DS, Department of VA Birmingham Regional Medical Education Center, Office of Public Health & Environment
  1/1/1995