DouglasJohnConradMD

PubMed

• 690 citations
  Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
  Jannet T. Huang, John S. Welch, Mercedes Ricote, Christoph J. Binder, Timothy M. Willson
  Nature. 1999-07-22
• 76 citations
  Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome.
  Robert A. Quinn, Vanessa V. Phelan, Katrine Whiteson, Neha Garg, Barbara A. Bailey
  The ISME Journal. 2016-06-01
• 41 citations
  High-Resolution Longitudinal Dynamics of the Cystic Fibrosis Sputum Microbiome and Metabolome through Antibiotic Therapy.
  Ruma Raghuvanshi, Karla Vasco, Yoshiki Vázquez-Baeza, Lingjing Jiang, James T. Morton
  Msystems. 2020-06-23

Journal Articles

• A phase 3, multi-center, multinational, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of levofloxacin inhalation solution (APT...  
  Flume PA, VanDevanter DR, Morgan EE, Dudley MN, Loutit JS, Bell SC, Kerem E, Fischer R, Smyth AR, Aaron SD, Conrad D, Geller DE, Elborn JS, Cyst Fibros, 1/1/2016
• Mass spectral similarity for untargeted metabolomics data analysis of complex mixtures  
  Garg N, Kapono C, Lim YW, Koyama N, Vermeij MJ, Conrad D, Rohwer F, Dorrestein PC, Int J Mass Spectrom, 1/1/2015
• A phase 3, open-label, randomized trial to evaluate the safety and efficacy of levofloxacin inhalation solution (APT-1026) versus tobramycin inhalation solution in sta...  
  Stuart Elborn J, Geller DE, Conrad D, Aaron SD, Smyth AR, Fischer R, Kerem E, Bell SC, Loutit JS, Dudley MN, Morgan EE, VanDevanter DR, Flume PA, J Cyst Fibros, 1/1/2015
• A Winogradsky-based culture system shows an association between microbial fermentation and cystic fibrosis exacerbation  
  Quinn RA, Whiteson K, Lim YW, Salamon P, Bailey B, Mienardi S, Sanchez SE, Blake D, Conrad D, Rohwer F, ISME J, 1/17/2014
• Mechanistic model of Rothia mucilaginosa adaptation toward persistence in the CF lung, based on a genome reconstructed from metagenomic data  
  Lim YW, Schmieder R, Haynes M, Furlan M, Matthews TD, Whiteson K, Poole SJ, Hayes CS, Low DA, Maughan H, Edwards R, Conrad D, Rohwer F, PloS One, 1/30/2013
• Toward implementation of quorum sensing autoinducers as biomarkers for infectious disease states  
  Struss AK, Nunes A, Waalen J, Lowery CA, Pullanikat P, Denery JR, Conrad DJ, Kaufmann GF, Janda KD, Anal Chem, 1/19/2013
• Metagenomics and metatranscriptomics: Windows on CF-associated viral and microbial communities  
  Lim YW, Schmieder R, Haynes M, Willner D, Furlan M, Youle M, Abbott K, Edwards R, Evangelista J, Conrad D, Rohwer F, J Cyst Fibros, 1/28/2012
• Long term effects of denufosol tetrasodium in patients with cystic fibrosis  
  Ratjen F, Durham T, Navratil T, Schaberg A, Accurso FJ, Wainwright C, Barnes M, Moss RB; TIGER-2 Study Investigator Group, J Cyst Fibros, 1/1/2012
• Case studies of the spatial heterogeneity of DNA viruses in the cystic fibrosis lung  
  Willner D, Haynes MR, Furlan M, Hanson N, Kirby B, Lim YW, Rainey PB, Schmieder R, Youle M, Conrad D, Rohwer F, Am J Respir Cell Mol Biol, 1/1/2012
• Spatial distribution of microbial communities in the cystic fibrosis lung  
  Willner D, Haynes MR, Furlan M, Schmieder R, Lim YW, Rainey PB, Rohwer F, Conrad D, ISME J, 1/1/2012
• Metagenomic analysis of respiratory tract DNA viral communities in cystic fibrosis and non-cystic fibrosis individuals  
  Willner D, Furlan M, Haynes M, Schmieder R, Angly FE, Silva J, Tammadoni S, Nosrat B, Conrad D, Rohwer F, PLoS One, 1/9/2009
• 16alpha-Bromoepiandrosterone (HE2000) limits non-productive inflammation and stimulates immunity in lungs  
  Nicoletti F, Conrad D, Wang A, Pieters R, Mangano K, van Heeckeren A, White SK, Frincke J, Reading CL, Auci DL, Stickney D, Clin Exp Immunol, 1/1/2009
• Sleep disruption in cystic fibrosis  
  Yue HJ, Conrad D, Dimsdale JE, Med Hypotheses, 1/5/2008
• The Clinical Use of Aerosolized Antibiotics  
  Conrad, DJ, Clinical Pulmonary Medicine, 1/1/2003
• Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition  
  Chu HW, Balzar S, Westcott JY, Trudeau JB, Sun Y, Conrad DJ, Wenzel SE, Clin Exp Allergy, 1/1/2002
• Peroxisome Proliferator-Activiated Receptor Regulates Airway Epithelial Cell Activation  
  Wang, C. C. A., Dai X., Luu B.Q., Conrad DJ, Amer J Resp Cell and Mol Biol, 1/1/2001
• Regulation of Human 12/15-Lipoxygenase by Stat6-Dependent Regulation  
  Conrad, DJ and Lu Min, Amer J Resp Cell and Mol Biol, 1/1/2000
• Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase  
  Huang JT, Welsh JS, Ricote M, Kelly C, Binder C, Willson TM, Kelly C, Witztum JL, Funk C, Conrad DJ, Glass C, Nature, 1/1/1999
• The Arachidonate 12/15 Lipoxygenases: A Review of Tissue Expression and Biologic Function  
  Conrad, DJ, Clin Rev Allery Immunol, 1/1/1999
• Recent advances in the understanding and treatment of cystic fibrosis  
  Resnikoff JR; Conrad DJ, Current Opinion in Pulmonary Medicine, 1/1/1998
• Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene  
  Kritzik MR; Ziober AF; Dicharry S; Conrad DJ; Sigal E, Biochim Biophys Acta, 1/26/1997
• Intraluminal water increases expression of plasmid DNA in rat lung  
  Sawa T; Miyazaki H; Pittet JF; Widdicombe JH; Gropper MA; Hashimoto S, Conrad DJ; Folkesson HG; Debs R; Forsayeth JR; et al, Human Gene Therapy, 1/20/1996
• 15-Lipoxygenase immunoreactivity in normal and asthmatic airways  
  Bradding P, Redington AE, Djukanovic R, Conrad DJ and Holgate ST, Am J Respir Crit Care Med, 1/1/1995
• Human 15-Lipoxygenase: Induction by Interleukin-4 and Insights into Positional Specificity  
  Sigal E, Sloan DL and Conrad DJ, J Lipid Med, 1/1/1993
• Microgranulomatous Aspergillosis After Shoveling Wood Chips: Report of a Fatal Outcome in a Patient with Chronic Granulomatous Disease  
  Conrad DJ, Warnock M, Blanc P, Cowan M and Golden JA, Am J Ind Med, 1/1/1992
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Books/Book Chapters

• Manual of Clinical Problems in Pulmonary Medicine 
  Chapter: Cystic Fibrosis 
  Page 378 - 382Conrad, DJEditors: Bordow RA, Ries AL, Morris TA.Lippincott, Williams and Wilkins2005
• Manual of Clinical Problems in Pulmonary Medicine 
  Chapter: Cystic Fibrosis. 
  Page 378 - 383Conrad, DJEditors: Bordow RA, Ries AL, Morris TA.Lippincott, Williams and Wilkins2001
• Advances in Prostaglandins, Thromboxane and Leukotriene Research 
  Chapter: Human 15-Lipoxygenase: A potential effector molecule for Interleukin-4. 
  Page 309 - 316Sigal E, Conrad DJRaven Press1994

Lectures

• "Clinical Implications of the CF Airway Metagenome" 
  Basel, Swizterland - 1/1/2016
• "The Airway Microbiome: Lessons from Cystic Fibrosis Studies" 
  Carmel, CA - 1/1/2016
• "Lung function modeling and smoothing splines" 
  1/1/2015
• "Practical approach to Clinical Cystic Fibrosis" 
  1/1/2015
• "Clinical Cystic Fibrosis" 
  1/1/2015
• "Adult Cystic Fibrosis Clinical Phenotyping: The Application of the Statistical Learning Algorithm, Random Forest, to the Generation and Description of Adult Clinical ... 
  1/1/2015
• "Viral Interactions in the Microbiome" 
  1/1/2014
• Topics and Advances in Pulmonary and Critical Care Medicine 
  University of California, San Diego, San Diego, California - 2/9/2013
• "CF Pulmonary Exacerbations" 
  1/1/2013
• "Bronchiectasis" 
  1/1/2013
• "Clinical Applications of Genetics and Genomics to CF" 
  1/1/2013
• "Ethical Issues in Transition from Pediatric to Adult Care Settings" 
  1/1/2013
• "Complex Clinical CF Phenotyping" 
  1/1/2013
• "Cystic Fibrosis: Evolutionary Perspectives of Mucoviscidosis" 
  1/1/2012
• "CF Airway Biofilm Quantification: A Clinical Perspective" 
  1/1/2011
• "Cystic Fibrosis in Adults and Bronchiectactic Disorders" 
  1/1/2010
• "Bronchiectatic Syndromes: Diagnosis and Management" 
  1/1/2010
• "Characterization and Implications of Bacteriophage Communities in the Airway Secretions from Normal Healthy Volunteers and Clinically Stable CF Patients" 
  1/25/2009
• "The CF Airway Metagenome: Clinical and Therapeutic Implications" 
  1/6/2009
• "Culture-Independent Microbiologic Analysis of CF Airway Secretions" 
  1/5/2009
• "CF 101" 
  1/1/2009
• "Lung Phenotypes using Longitudinal Pulmonary Function" 
  1/1/2009
• "The CF Microbiome" 
  1/1/2009
• "The Importance of Longitudinal Lung Function in Assess CF Disease Severity." 
  1/1/2009
• "Adult Cystic Fibrosis" 
  1/1/2007
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Other

• Arachidonate 15-Lipoxygenase: Immunocytochemical Localization in Blood and Airway Cells. 
  Nadel JA, Ueki IF, Schuster A, Conrad DJ and E Sigal, 1990 Transactions of the Association of American Physicians
  1/1/1990