DouglasBCinesMD

Director, Coagulation Laboratory Hosp University PA

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University of Pennsylvania Health SystemFellowship, Endocrinology, Diabetes, and Metabolism, 1975 - 1977
University of North Carolina HospitalsResidency, Internal Medicine, 1972 - 1975
New York University School of MedicineClass of 1972

PubMed

68 citations
Cerebrovascular Thromboprophylaxis in Mice by Erythrocyte-Coupled Tissue-Type Plasminogen Activator
Kristina Danielyan, Kumkum Ganguly, Bi-Sen Ding, Dmitriy N. Atochin, Sergei Zaitsev
Circulation. 2008-09-30
38 citations
The Glycocalyx Protects Erythrocyte-Bound Tissue-Type Plasminogen Activator from Enzymatic Inhibition
Kumkum Ganguly, Juan-Carlos Murciano, Randal Westrick, John Leferovich, Douglas B. Cines
The Journal of Pharmacology and Experimental Therapeutics. 2007-04-01
149 citations
Prophylactic fibrinolysis through selective dissolution of nascent clots by tPA-carrying erythrocytes.
Juan-Carlos Murciano, Sandra Medinilla, Donald Eslin, Elena N. Atochina, Douglas B. Cines
Nature Biotechnology. 2003-08-01

Journal Articles

Neutrophil Alpha-Defensins Promote Thrombosis in Vivo by Altering Fibrin Formation, Structure and Stability
Victoria Stepanova, Douglas B Cines, Blood
Dynamic Intercellular Redistribution of HIT Antigen Modulates Heparin-Induced Thrombocytopenia
Douglas B Cines, Mortimer Poncz, Blood
Polyreactive IgM Initiates Complement Activation by PF4/heparin Complexes Through the Classical Pathway
Grace M Lee, Michael Frank, Mortimer Poncz, Jennifer B Gilner, Douglas B Cines, Gowthami M Arepally, Blood

Abstracts/Posters

A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in _-Granules and Is Functional In Vivo in a Murine Model of Thromb...
Douglas B. Cines, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

After One Week, Efgartigimod Helps 38% of ITP Patients Achieve Platelet Counts to Avoid BleedingDecember 11th, 2022
Doctors Hone in on Cause of Blood Clots Potentially Linked with Covid-19 VaccinesApril 17th, 2021
Doctors Home in on Cause of Blood Clots Potentially Linked with Covid-19 VaccinesApril 16th, 2021
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Training Grant In Hemostasis And ThrombosisNational Heart, Lung, And Blood Institute2001–2011
Urokinase, Defensin And Acute Lung InjuryNational Heart, Lung, And Blood Institute2005–2009
Nuclear Translocation Of Urokinase/Nucleolin ComplexesNational Heart, Lung, And Blood Institute2007–2008
Urokinase Kringle-Mediated Vascular RemodelingFogarty International Center2001–2003
Structure/Function Analysis Of The Urokinase ReceptorNational Heart, Lung, And Blood Institute1999–2002
Defensin And The Pathogenesis Of AtherosclerosisNational Heart, Lung, And Blood Institute1998–2002
Vascular Injury Response--Novel Mechanisms And TherapyNational Heart, Lung, And Blood Institute1996–1998
Structure Function Analysis Of The Endothelial Cell Urokinase ReceptorNational Heart, Lung, And Blood Institute1996–1997
Oxygen Regulation Of Placental Blood FlowNational Heart, Lung, And Blood Institute1993–1997
Immune Injury Of Human Endothelial CellsNational Heart, Lung, And Blood Institute1985–1987
Viral And Immune Injury To Vessel Wall CellsNational Heart, Lung, And Blood Institute1985–1986