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3400 Civic Center BlvdPhiladelphia, PA 19104
Phone+1 215-615-5858
Dr. Cines is on Doximity
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Education & Training
University of Pennsylvania Health SystemFellowship, Endocrinology, Diabetes, and Metabolism, 1975 - 1977
University of North Carolina HospitalsResidency, Internal Medicine, 1972 - 1975
New York University School of MedicineClass of 1972
Certifications & Licensure
PA State Medical License 1975 - 2026
NJ State Medical License 2018 - 2023
NC State Medical License 1973 - 2002
American Board of Internal Medicine Internal Medicine- American Board of Internal Medicine Hematology
Awards, Honors, & Recognition
- Elected Member The American Society for Clinical Investigation, 1985
Publications & Presentations
PubMed
- Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia.Lubica Rauova, Khalil Bdeir, Ann H Rux, Manu Thomas Kalathottukaren, Jenna Oberg
Blood. 2025-03-25 - Complement activation as a biomarker for platelet-activating antibodies in heparin-induced thrombocytopenia.Sooho S Myoung, Samuel J Francis, Jonah Chen, Grace Lee, Lubica Rauova
Journal of Thrombosis and Haemostasis. 2025-03-01 - Structural and functional changes underlying activation of monocytes in heparin-induced thrombocytopenia.Izabella Andrianova, Vincent Hayes, Rustem I Litvinov, Chandrasekaran Nagaswami, Gowthami M Arepally
Journal of Thrombosis and Haemostasis. 2025-02-09
Journal Articles
- Neutrophil Alpha-Defensins Promote Thrombosis in Vivo by Altering Fibrin Formation, Structure and StabilityVictoria Stepanova, Douglas B Cines, Blood
- Dynamic Intercellular Redistribution of HIT Antigen Modulates Heparin-Induced ThrombocytopeniaDouglas B Cines, Mortimer Poncz, Blood
- Polyreactive IgM Initiates Complement Activation by PF4/heparin Complexes Through the Classical PathwayGrace M Lee, Michael Frank, Mortimer Poncz, Jennifer B Gilner, Douglas B Cines, Gowthami M Arepally, Blood
Press Mentions
After One Week, Efgartigimod Helps 38% of ITP Patients Achieve Platelet Counts to Avoid BleedingDecember 11th, 2022- Doctors Hone in on Cause of Blood Clots Potentially Linked with Covid-19 VaccinesApril 17th, 2021
- Doctors Home in on Cause of Blood Clots Potentially Linked with Covid-19 VaccinesApril 16th, 2021
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Grant Support
- Complement and thrombosis in HITDUKE UNIVERSITY2025–2028
- Training Grant In Hemostasis And ThrombosisNational Heart, Lung, And Blood Institute2001–2011
- Urokinase, Defensin And Acute Lung InjuryNational Heart, Lung, And Blood Institute2005–2009
- Nuclear Translocation Of Urokinase/Nucleolin ComplexesNational Heart, Lung, And Blood Institute2007–2008
- Urokinase Kringle-Mediated Vascular RemodelingFogarty International Center2001–2003
- Structure/Function Analysis Of The Urokinase ReceptorNational Heart, Lung, And Blood Institute1999–2002
- Defensin And The Pathogenesis Of AtherosclerosisNational Heart, Lung, And Blood Institute1998–2002
- Vascular Injury Response--Novel Mechanisms And TherapyNational Heart, Lung, And Blood Institute1996–1998
- Structure Function Analysis Of The Endothelial Cell Urokinase ReceptorNational Heart, Lung, And Blood Institute1996–1997
- Oxygen Regulation Of Placental Blood FlowNational Heart, Lung, And Blood Institute1993–1997
- Immune Injury Of Human Endothelial CellsNational Heart, Lung, And Blood Institute1985–1987
- Viral And Immune Injury To Vessel Wall CellsNational Heart, Lung, And Blood Institute1985–1986
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