DonaldHowardRubinMD

PubMed

• 9 citations
  Toxoplasmosis: The Heart of the Diagnosis.
  James England, Samuel S Bailin, Jeff R. Gehlhausen, Donald H. Rubin
  Open Forum Infectious Diseases. 2019-01-01
• 49 citations
  Drug Repurposing: New Treatments for Zika Virus Infection?
  Feixiong Cheng, James L. Murray, Donald H. Rubin
  Trends in Molecular Medicine. 2016-11-01
• 40 citations
  Systems Biology-Based Investigation of Cellular Antiviral Drug Targets Identified by Gene-Trap Insertional Mutagenesis.
  Feixiong Cheng, James L. Murray, Junfei Zhao, Jinsong Sheng, Zhongming Zhao
  Plos Computational Biology. 2016-09-15

Journal Articles

• Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity  
  LaFrance ME, Farrow MA, Chandrasekaran R2, Sheng J3, Rubin DH4, Lacy DB5., Proc Natl Acad Sci U S A., 7/2015
• Identification of the Epithelial Cell Receptor Responsible for Clostridium difficile TcdB-Induced Cytotoxicity  
  LaFrance M, Farrow MA, Chandrasekaran R, Sheng J, Rubin DH, Lacy DB, Proc. Nat’l. Acad. Sci, 1/1/2015
• A Role for H/ACA and C/D Small Nucleolar RNAs In Viral Replication  
  Murray JL, Sheng J, Rubin DH, Molecular Biotechnology, 1/1/2014
• Role of Connexin 43 in Helicobacter pylori VacA-Induced Cell Death  
  Radin JN, González-Rivera C, Frick-Cheng AE, Sheng J, Gaddy JA, Rubin DH, Algood HM, McClain MS, Cover TL, Infect Immun, 1/1/2014
• Identification of Cellular Proteins Required for Replication of Human Immunodeficiency Virus Type 1  
  Dziuba N, Ferguson NR, O'Brien WA, Sanchez A, Prussia AJ, McDonald NJ, Friedrich BM, Li G, Shaw MW, Sheng J, Hodge TW, Rubin DH, and Murray JL, AIDS Research and Human Retroviruses, 1/1/2012
• Inhibition of Influenza A Virus Replication by Antagonism of a PI3K-AKT-mTOR Pathway Member Identified by Gene Trap Insertional Mutagenesis  
  Murray JL, McDonald NJ, Sheng J, Shaw MW, Hodge TW, Rubin DH, O’Brien WA, Smee DF, Antiviral Chemistry & Chemotherapy Antivir Chem Chemother, 1/1/2012
• A Functional Role for ADAM10 in Human Immunodeficiency Virus Type-1 Replication in Human Macrophages  
  Friedrich, BM, Murray JL, Li G, Sheng J, Hodge TW, Rubin DH, O’Brien WA, Ferguson MR, Retrovirology, 1/1/2011
• Gene-Trap Mutagenesis Identifies Mammalian Genes Contributing to Intoxication by Clostridium perfringens E-Toxin  
  Ivie SE, Fennessey CM, Sheng J, Rubin DH, McClain MS, PLoS ONE , 1/1/2011
• The Rab9 GTPase is Critical for the Replication of HIV-1, Filoviruses, and Measles Virus  
  Murray JL, Morey NJ, Yilla M, Sheng J, Bellini WJ, Le Doux JM, Shaw MW, Luo C-C, Sanchez A, Rubin DH, Hodge TW, Virus. J Virol, 1/1/2006
• Discovery of Candidate Mammalian Genes That Participate in Lytic Virus Infection  
  Organ E, Sheng J, Ruley E, Rubin DH, BMC Cell Biology, 1/2/2004
• Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection  
  Sheng J, Organ EL, Hao C, Wells, KS, Ruley HE, Rubin DH, BMC Cell Biology, 1/1/2004
• Effects of transforming growth factor-a (TGF-a) in vitro and in vivo on reovirus replication  
  Organ EL, Nalbantyan CD, Nanney LB, Woodward SC, Sheng J, DuBois RN, Sutcliffe M, Coffey RJ, Rubin DH, DNA Cell Biol, 1/1/2004
• review of Fields Virology  
  Rubin DH, Clinical Journal of Infectious Disease, University of Chicago Press, 1/1/2002
• Mucosal T cell response to reovirus  
  Chen D, Rubin DH, Immunol. Res, 1/1/2001
• G1 cell cycle arrest induced by ligands of the reovirus type 3 receptor is secondary to inactivation of p21ras and mitogen-activated protein kinase  
  Saragovi HU, Rebai N, DiGuglielmo GM, Macleod R, Sheng J, Rubin DH, Greene MI, NA Cell Biol, 1/1/1999
• Lineage-specific differences among CD8+  
  Mora AL , Chen D, Boothby M, and Rubin DH, Eur J. Immunol, 1/1/1999
• Intraepithelial lymphocyte proliferation and CTL responses to enteric reovirus infection: a limited VB usage defines CTL response  
  Chen D, Lee F, Cebra JJ, Rubin DH, J. Virol, 1/1/1997
• Development, function, and trafficing of mucosal leukocytes in immunodeficient mice  
  Cuff CF, Rubin DH, Cebra JJ, Adv. Exp. Med. Biol, 1/1/1995
• Characterization of cytotoxic cells from reovirus infected severe combined immunodeficient (SCID) mice: activated cells express NK and LAK-like activity but fail to cl...  
  Taterka J, Cebra JJ, Rubin DH, J. Virol, 1/1/1995
• Spontaneous proliferation of Peyer's patch cells in vitro  
  Hooper DC, Rubin DH, Cebra JJ, Intern. Immunol, 1/1/1994
• Selective reovirus infection of murine hepatocarcinoma cells during cell division: a model of viral liver infection  
  Taterka J, Sutcliffe M, Rubin DH, J. Clin. Invest, 1/1/1994
• Developmental relationship between cytotoxic Alpha/beta TcR+ intraepithelial lymphocytes (IELs) and Peyer's Patch lymphocytes  
  Cuff CF, Cebra CK, Rubin DH, Cebra JJ, Eur. J. Immunol, 1/1/1993
• Functional and penotypic analyses of the mucosal immune response in mice: aaproaches to studying the immunogenicity of antigens applied by the enteric route  
  Cuff CF, Hooper DC, Kramer DR, Rubin DH, Cebra JJ, Vaccine Res., 1/1/1992
• Binding of type 3 reovirus by a domain of the sigma 1 protein important for hemagglutination leads to infection of murine erythroleukemia cells  
  Rubin DH, Wetzel D, Dworkin C, Williams WV, Cohen J, Dworkin C, Dermody TA, J. Clin. Invest, 1/1/1992
• Receptor utilization by reovirus type 3: Distinct binding sites on thymoma and fibroblast cell lines result in differential compartmentalization of virions  
  Rubin DH, DB Weiner, Greene MI, Williams WV, Micro. Pathogen, 1/1/1992
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Books/Book Chapters

• Infectious Diseases 
  Chapter: Roseoloviruses: Human herpesviruses 6 and 7 
  Page 1918 - 1922Neuzil KM, Rubin DHEditors: SL Gorback, JG Bartlet, NR Blacklow.W.B. Saunders Co., Philadelphia, PAEdition 3rd,2004
• Mucosal Immunology 
  Chapter: Functional aspects of the mucosal T-cell response 
  Page 643 - 653London SL, Rubin DHEditors: PL Ogra, J Mestecky, ME Lamm, W Strober, JR McGhee, J Bienenstock.Academic Press, Inc., New York, NY1999
• Current Topics in Microbiology & Immunology 
  Chapter: Mucosal immunity and reovirus infection 
  Page 163 - 177Major AS, Rubin DH, Cuff CEditors: KL Tyler and MBA Oldstone.Heidelberg, Germany1998
• Current Topics in Microbiology & Immunology 
  Chapter: Pathogenesis of reovirus gastrointestinal and hepatobiliary disease 
  Page 67 - 83Organ E, Rubin, DHEditors: KL Tyler and MBA Oldstone.Springer-Verlag, Heidelberg, Germany1998
• Infectious Diseases 
  Chapter: Human herpesvirus 6 and other newly recognized human herpesviruses 
  Page 2062 - 2067Neuzil KM, Rubin DHEditors: SL Gorbach, JG Bartlett, NR Blacklow.W.B. Saunders Co., Philadelphia, PA1997
• The Encyclopedia of Immunology 
  Chapter: Reovirus, Infection and Immunity 
  Page 1310 - 1311Cuff CF, Cebra JJ, Rubin DHEditors: I. Roitt and M Delves.Orlando, FL1992
• Gastroenterol. Clinics North Amer 
  Chapter: Viral gastrointestinal infections 
  Page 303 - 330Taterka JA, Cuff CF, Rubin DHEditors: R.P. MacDermott and C.O. Elson.W.B. Saunders Co., Philadelphia, PA1992
• Emergency Medicine 
  Chapter: Infections: General Considerations 
  Page 1069 - 1087Rubin DH, Friedland GEditors: May H.Little, Brown and Co., Boston, MA1992
• Emergency Medicine 
  Chapter: The Common Cold and Associated Illnesses 
  Page 1106 - 1109Dubin G, Rubin DHEditors: May H.Little, Brown and Co., Boston, MA1992
• Emergency Medicine 
  Chapter: Viral Replication and Antiviral Therapy 
  Page 1088 - 1095Frank I, Rubin DHEditors: May H.Little, Brown and Co., Boston, MA1992
• Immunology of Milk and the Neonate 
  Chapter: Protection of neonatal mice from fatal reovirus infection by immune serum and gut derived lymphocytes 
  Page 307 - 315Cuff CF, Cebra CK, Lavi E, Molowitz EH, Rubin DH and Cebra JJEditors: J. Mestecky.Plenum Press, New York, NY1991
• Fronteirs of Mucosal Immunology 
  Chapter: Reoviruses as probes of the mucosal humoral and cellular immune responses 
  Page 167 - 171Cebra JJ, Cuff CF, George A, Logan A, Rubin D, Schrader C. Taterka JA, Weinstein PEditors: M. Tsuchiya, Heatley R, and McI. Mowat A.Kluwer Academic Publishers, London, UK1991
• Advances in mucosal immunology: Proceeding of the Fifth International Congress of Mucosal Immunology 
  Chapter: Functional potential of gut T and B cell subsets from mucosally primed mice 
  Cebra JJ, Cuff CF, George A, Kerlin R, Logan A, Rubin D, Schrader C, Weinstein PEditors: MacDonald TT, Challacombe S, Bland P, Stokes CR, Mowat AMcI.Kluwer Academic Publisher, London, UK1990
• Immunology and Immunopathology of the Liver & Gastrointestinal Tract 
  Chapter: Viral gastrointestinal infections 
  Page 395 - 417Cuff CF, Rubin DHEditors: Targan S, Shanahan F.Igaku-Shoin, New York, NY1989
• Vaccines 88, modern approaches to new vaccines including prevention of AIDS 
  Chapter: Structure of the neutralization epitope of the reovirus type 3 hemagglutinin 
  Page 25 - 28Williams WV, Guy HR, D Weiner, D Rubin, MI GreeneEditors: R Chanock, F Brown, R Lerner, H Ginsberg.Cold Spring Harbor Press, New York, NY1988
• UCLA Symposia v 84, Technological Advances in Vaccine Development 
  Chapter: Determination of the neutralizing/cell-attachment epitope of reovirus type 3 
  Williams WV, Weiner DB, Rubin DH, Guy HR, Greene MIEditors: L Lasky, Alan R.Liss, Inc.1988
• Recent Advances in Mucosal Immunology 
  Chapter: Murine Peyer's patches are capable of generating a cytotoxic T cell (CTL) response to nominal antigens 
  Page 267 - 278London SD, Rubin DH, Cebra JJEditors: J Mestecky, JR McGhee, J Bienenstock, PL Ogra.Plenum Press, New York, NY1987
• Microenvironments in the lymphoid system 
  Chapter: Effect of avridine on enteric uptake and mucosal immunity to reovirus (1/Lang) 
  Page 579 - 590Anderson AO, Rubin DHEditors: GGB Klaus.Penum, New York, NY1985
• The Emergency 
  Chapter: Febrile emergencies 
  Page 517 - 564Rubin DH, Friedland GEditors: May H.Wiley and Sons, New York, NY1983
• Internal Medicine for Dentistry 
  Chapter: Viral gastroenteritis 
  Page 149 - 151Rubin DHEditors: LF Rose & D Kaye.CV Mosby, St. Louis, MO1983
• Fundamentals in Internal Medicine 
  Chapter: Viral gastroenteritis 
  Page 456 - 462Rubin DHEditors: D. Kaye.CV Mosby, St. Louis, MO1983
• Comprehensive Therapy 
  Chapter: Viral diseases: Infections of the gastrointestinal tract 
  Offit PA, Rubin, DH1982
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Abstracts/Posters

• Identification of a cellular receptor for Clostridium difficile toxin B
  LaFrance ME, Farrow MA, Sheng J, Rubin DH, Lacy DB, MEEGID, XII, Bangkok, Thailand, 1/12/2014
• Systems biology-based host-virus pathogen gene interaction network analysis
  Cheng F, Murray J, Sheng J, Zhao Z, Rubin DH, MEEGID, XII, Bangkok, Thailand, 1/11/2014
• Genes, Genes, Genes
  Rubin, DH, Infectious Disease Grand Rounds, Vanderbilt University Medical School, 1/5/2011
• Discovery of genes that play roles in virus replication: just what the doctor ordered
  DH Rubin, Mid-Atlantic Immunology meeting, Egg Harbor City, NJ, 1/1/2004
• Functional genomics: discovery of mammalians genes that participate in infectious diseases
  DH Rubin, Boehringer-Ingleheim; SeBio. Conference, Montreal, Canada, 2001; Birmingham, AL, 2001, 1/1/2001
• Functional genomics: discovery of mammalian genes that participate in virus infection
  DH Rubin, EL Organ, J Sheng, Infectious Disease Society of America, 1/1/1999
• Functional genomics: discovery of mammalian genes that participate in virus infection or cancer development
  DH Rubin, EL Organ, RN DuBois, E Ruley, The Impact of Emerging Technologies, Knoxville, TN, 1/1/1998
• 6th International dsRNA Meeting, 1/1/1997
• Chen D, Lee F, Cebra JJ, Rubin DH, J. Invest. Med, 1/1/1996
• U3 gene-trap retrovirus selection of cellular mutants resistant to lytic reovirus infection
  Organ E, Ruley E, Rubin DH, J. Invest. Med, 1/1/1996
• Reovirus replication in transforming growth factor-a (TGFa) transgenic mice: prolonged overexpression leads to enhanced virus replication and disease in the liver
  Coffey RJ, Sutcliffe M, Rubin DH, Clin. Res, 1/1/1994
• In vitro modeling of reovirus infection utilizing rat intestinal epithelial cells (RIE-1): transforming growth factor-a (tgfa) increased viral replication requires serum
  Organ E, DuBois RN, Coffey R, Rubin DH, Clin. Res, 1/1/1994
• Structural and Non-structural Reovirus Type 3 Polypeptides Expressed in Vaccinia Virus (VV) Stimulate Responses by T Cells from Reovirus Type l Infected Mice
  Hooper DC, Cuff CF, Joklik WK, Roner M, Rubin DH, and Cebra JJ, Clin. Res, 1/1/1992
• Binding of reovirus type 3 to the hemagglutinin receptor results in infection of murine erythroleukemia cells
  Rubin DH, Dworkin C, Dermody T, Williams WV, Cohen J, Clin. Res, 1/1/1991
• Preferential infectibility of reovirus type 1/L in rapidly growing vs. quiescent hepa 1/1A cultures
  Taterka J, Rubin DH, Amer. Gastroen. Assoc; Clin. Res, 1/1/1991
• Receptor utilization by reovirus type 3: Distinct binding sites on thymoma and fibroblast cell lines result in differential compartmentalization of virions
  Rubin DH, DB Weiner, Greene MI, Williams WV, , Clin. Res, 1/1/1991
• Reovirus type 1/L infects only a subset of murine hepatoma cells in tissue culture
  Taterka J, Rubin DH, Clin. Res, 1/1/1990
• Severe combined immune deficient mice infected with reovirus type 1 develop hepatitis associated with large numbers of live NK cells
  Taterka J, Cebra JJ, Rubin DH, Clin. Res, 1/1/1990
• Analysis of intraepithelial lymphocyte (IEL) populations following priming with reovirus
  Cuff CF, Rubin DH, Cebra JJ, 7th International Congress of Immunology, Berlin, Germany, 1/1/1989
• Protective effects of Peyer's patch lymphocytes, interepithelial lymphocytes, and immune serum against reovirus-induced encephalitis
  Cuff CF, Lavi E, Rubin DH, Cebra JJ, Clin. Res; FASEB Journal, 1/1/1989
• T cell recognition of an internal image idiotype from an anti-idiotypic autoantibody
  Williams WV, London SD, Rubin DH, Weiner DB, Greene MI, Amer. Rheumatism Association, 1/28/1988
• Liver disease is induced by reovirus serotypes 1 and 3 in the severe combined immunodeficient (scid) mouse
  Kost SI, George A, Cebra JJ, Rubin DH, Clin. Res, 1/1/1988
• Liver disease caused by reovirus serotypes 1 and 3 in the severe com­bined immunodeficient (scid) mouse is ameliorated by adoptive transfer of immune lymphocytes
  George A, Kost SI, Cebra JJ, Rubin DH, Clin. Res, 1/1/1988
• Reovirus type 1 and type 3 differ in their binding to isolated intestinal epithelial cells
  Weiner DB, Gaulton G, Girard K, Williams WV, McPhillips T, Rubin DH, Clin. Res, 1/1/1988
• Reovirus type 1 infection of liver cells in adult mice is dependent upon hepatocellular perturbation
  Piccoli D, Kost SI, Rubin DH, Clin. Res, 1/1/1988
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Lectures

• Non-protein coding mammalian genes associated with virus infection: Broad affects on virus replication MEEGID 
  New Orleans, LA - 1/31/2012
• Mammalian genes associated with intoxication of Clostridium (C) perfringens, e-toxin: Discovery of an intoxication pathway shared by viruses MEEGID 
  Amsterdam, The Netherlands - 1/7/2010
• Defining risk to pathogenic infections: utilizing the HAPMAP database and broad based screens to discover host susceptibility genes to infectious diseases 
  Bangkok,Thailand - 1/1/2006
• Functional genomics: genes that participate in lytic virus infection 
  Shenyang, China - 1/28/2005
• Discovery of genes that participate in the replication of intracellular pathogens 
  Shanghai, China - 1/27/2005
• Deep sea fishing in the very dead sea 
  1/9/2005
• Discovery of genes that participate in virus infection 
  Shanghai, China - 1/7/2005
• Discovery of genes that participate in virus infection: persistence in the face of adversity 
  Shanghai, China - 1/6/2005
• Discovery of genes that play roles in virus replication: just what the doctor ordered 
  Egg Harbor City, NJ - 1/27/2004
• Genes that participate in lytic virus infection 
  Alexandria, VA - 1/5/2004
• A functional genomics approach to define host susceptibility to infection. Sixth annual meeting of Molecular Epidemiology and Evolutionary Genetics of Infectious Dise... 
  Paris, France - 1/27/2002
• Host susceptibility to infection 
  1/19/2002
• Identification of host genes which interact with infectious agents to induce malignant phenotypes 
  Atlanta, GA - 1/5/2002
• Host susceptibility to intracellular pathogens: a functional genomics approach using Gene Trap 
  Atlanta, GA - 1/5/2002
• Gene-trap tagging of gene that confer resistance to infection 
  1/7/2001
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  Cocoyne, Mexico - 1/13/1997
• Viral Pathogenesis: Approaches to Unraveling Cellular Participants in Infection 
  Morgantown, WV - 1/30/1996
• Gene-trap selection of cells with an altered permissiveness to reovirus 
  1/24/1995
• Viral pathogenesis: Cellular and molecular aspects 
  1/19/1994
• Department of Obstetrics and Gynecology, Vanderbilt University Medical Center 
  1/3/1994
• HIV and Hepatitis B: more than you wish to know 
  1/29/1993
• Viral Immunology: mucosa and beyond 
  Philadelphia, PA - 1/16/1993
• Binding of reovirus type 3 to the hemagglutinin receptor results in infection of murine erythroleukemia cells 
  Boston, MA - 1/14/1992
• Reovirus as a probe of the mucosal immune system 
  West Point, PA - 1/2/1991
• Reovirus hepatitis in immunocompetent and severe combined immunodeficient (SCID) mice 
  Multiple Locations, 1990, 1991, 1992 - 1/19/1990
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Other

• Rotaviruses. In Decision Support in Medicine, Infectious Diseases 
  Modjarrad, K, Rubin DH, ePublication
  1/1/2013