DonaldWilliamKufeMD

Oncology • Boston, MA

Professor of Medicine, Dana-Farber Cancer Institute

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Office
450 Brookline Ave
D830
Boston, MA 02215
Phone+1 617-632-3141

Fax+1 617-632-2934

Education & Training

George Washington UniversityResidency, Internal Medicine, 1975 - 1977
Beth Israel Deaconess Medical CenterInternship, Transitional Year, 1970 - 1971
University of Rochester School of Medicine and DentistryClass of 1970

Certifications & Licensure

MA State Medical License 1977 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1982

Clinical Trials

Vaccine Therapy in Treating Patients With Metastatic Breast Cancer Start of enrollment: 1999 Mar 03
Completed
Phase 1
Vaccine Therapy in Treating Patients With Metastatic Prostate Cancer Start of enrollment: 1996 Dec 01
Completed
Phase 1

Publications & Presentations

PubMed

189 citations
Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179
Rehan Ahmad, Deepak Raina, Colin J. Meyer, Surender Kharbanda, Donald Kufe
The Journal of Biological Chemistry. 2006-11-24
75 citations
Expression of the multidrug resistance associated protein and P-glycoprotein in doxorubicin-selected human myeloid leukemia cells.
Christopher A. Slapak, Nobuyuki Mizunuma, Donald Kufe
Blood. 1994-11-01
143 citations
Induction of Antitumor Immunity by Vaccination of Dendritic Cells Transfected with MUC1 RNA
Shigeo Koido, Masahiro Kashiwaba, Dongshu Chen, Sandra J. Gendler, Donald Kufe
Journal of Immunology. 2000-11-15

Journal Articles

Targeting the Human MUC1-C Oncoprotein with an Antibody-Drug Conjugate
Qing Zhao, Donald Kufe, The Journal of Clinical Investigation

Abstracts/Posters

Development of Novel Second Generation DC/Tumor Fusion Vaccine in Lymphoma
Donald Kufe, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Transcriptome Sequencing Demonstrates Unique Signature Associated with Durable Clinical Response to DC/AML Fusion Vaccine
Donald Kufe, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
T Cells Educated By DC/AML Fusions in the Context of 4-1BB Costimulation As a Potent Strategy for Adoptive Cellular Therapy
Donald Kufe, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
CD155-Tigit Pathway Modulation in Dendritic Cell/Acute Myeloid Leukemia Fusion Vaccine Model
Donald Kufe, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Potent Synergy between Combination of Chimeric Antigen Receptor (CAR) Therapy Targeting CD19 in Conjunction with Dendritic Cell (DC)/Tumor Fusion Vaccine in Hematologi...
Donald Kufe, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/2019
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Lectures

A Novel Monoclonal Antibody Combination Plus DC/AML Fusion Vaccine Eradicates AML in an Immunocompetent Murine Model
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

Hillstream BioPharma Signs an Exclusive Option Agreement to Advance Next-Generation Anti-MUC1-C Agents for Drug Resistant CancersJanuary 31st, 2023

Grant Support

Functional Role Of The MUC1-C Oncoprotein In Non-Small Cell Lung CancerNational Cancer Institute2012
Adoptive Immunotherapy For Multiple Myeloma Using Educated T CellsNational Cancer Institute2010–2012
Early Clinical Trials Of New Anti-Cancer Agents With Phase I EmphasisNational Cancer Institute2008–2012
P5 - Adoptive Immunotherapy For Renal Carcinoma Usng Dendritic Cell/Tumor FusionsNational Cancer Institute2010–2011
Oncogenic Signaling By DF3/MUC1 In Human Breast CancerNational Cancer Institute2002–2011
Differentiating Agents In Hematologic MalignanciesNational Cancer Institute1986–2011
Adoptive Immunotherapy For Renal Carcinoma Using Dendritic Cell/Tumor FusionsNational Cancer Institute2009
Novel Immunotherapeutic Approaches For Ovarian CancerNational Cancer Institute2004–2008
Regulation Of Oxidative Stress Response By C-ABL And ARGNational Cancer Institute2003–2007
Phase I Trials Of New Anti-Cancer AgentsNational Cancer Institute2003–2007
Molecular Mechanisms Of ARA-C Therapy In ManNational Cancer Institute1987–2005
Development Of Myeloma VaccinesNational Cancer Institute1998–2002
Molecular Regulation Of Signaling By Ionizing RadiationNational Cancer Institute1996–2002
Phase I Trials Of New Anticancer AgentsNational Cancer Institute1994–2002
Oncogenic Signaling By The MUC1 Breast Carcinoma AntigenNational Cancer Institute2000–2001
Phosphorylation Of RAD51National Center For Research Resources1998–2001
Core--Cancer PharmacologyNational Cancer Institute2000
DF3/MUC1 Vaccine And Stamp Therapy For Breast CancerNational Cancer Institute1997–1998
Specialized Program Of Research Excellence/Breast CancerNational Cancer Institute1992–1994
Molecular Regulation Of C-Jun By Ionizing RadiationNational Cancer Institute1992–1994
Clonality In Acute Myeloid Leukemia And MyelodysplasiaNational Cancer Institute1991–1992
Immunodiagnostic Approaches To Human Breast CancerNational Cancer Institute1985–1990
Molecular Mechanisms Of ARA C Therapy In ManNational Cancer Institute1985–1986
Molecular Mechanisms Of 5-Fluorouracil ChemotherapyNational Cancer Institute1985–1986