DivaDDeLeonMDMSCE

PubMed

• 133 citations
  Re-evaluating “Transitional Neonatal Hypoglycemia”: Mechanism and implications for management
  Charles A. Stanley, Paul J. Rozance, Paul S. Thornton, Diva D. De León, Deborah L. Harris
  The Journal of Pediatrics. 2015-06-01
• 55 citations
  GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells.
  Amita Tiyaboonchai, Fabian L. Cardenas-Diaz, Lei Ying, Jean Ann Maguire, Xiuli Sim
  Stem Cell Reports. 2017-03-14
• 67 citations
  Neonatal Diabetes and Congenital Malabsorptive Diarrhea Attributable to a Novel Mutation in the Human Neurogenin-3 Gene Coding Sequence
  Sara E. Pinney, Jennifer Oliver-Krasinski, Linda M. Ernst, Nkecha Hughes, Puja Patel
  The Journal of Clinical Endocrinology and Metabolism. 2011-04-13

Journal Articles

• Genetic characteristics of patients with congenital hyperinsulinism  
  Vajravelu ME, De Leon DD, Curr Opin Pediatr, 1/1/2018
• Hyperinsulinism in the Neonate  
  Lord K, De Leon DD, Clin Perinatol, 1/1/2018
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  Nyirjesy SC, Sheikh S, Hadjiliadis D, De Leon DD, Peleckis AJ, Eiel JN, Kubrak C, Stefanosvski, D, Rubenstein RC, Rickels MR, Kelly A, Pediatr Diabetes, 1/1/2018
• Prevalence of adverse events in children with congenital hyperinsulinism treated with diazoxide  
  Herrera A, Vajravelu ME, Givler S, Mitteer L, Avitabile CM, Lord K, De Leon DD, J Clin Endocrinol Metab, 1/1/2018
• Continuous intragastric dextrose: a therapeutic option for refractory hypoglycemia in congenital hyperinsulinism  
  Vajravelu ME, Congdon M, Mitteer L, Koh J, Givler S, ShultsJ, De Leon DD, Horm Res Paediatr, 1/1/2018
• Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations  
  Tung JY, Boodhansingh K, Stanley CA, De Leon DD, Pediatr Diabetes, 1/1/2018
• A unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1-/- mouse model of KATP hyperinsulinism  
  Patel P, Charles L, Corbin J, Goldfine ID, Johnson K, Rubin P, De Leon DD, MAbs, 1/1/2018
• Congenital hyperinsulinism in infants with Turner syndrome: possible association with monosomy X and KDM6A haploinsufficiency  
  Gibson CE, Boodhansingh KE, Li C, Conlin L, Chen P, Becker SA, Bhatti T, Bamba V, Adzick NS, De Leon DD, Ganguly A, Stanley CA, Horm Res Paediatr, 1/1/2018
• Congenital hyperinsulinism and hypopituitarism attributable to a novel mutation in FOXA2  
  Vajravelu ME, Chai J, Krock B, Baker S, Langdon D, Alter C, De Le�n DD, J Clin Endocrinol Metab, 1/1/2018
• Population pharmacokinetics of exendin-(9-39) and clinical dose selection in patients with congenital hyperinsulinism  
  Ng CM, Tang F, Seeholzer S, Zou Y, De Leon DD, Br J Clin Pharmacol, 1/1/2018
• Reduced beta-cell secretory capacity in pancreatic insufficient, but not pancreatic sufficient, cystic fibrosis despite normal glucose tolerance  
  Sheikh S, Gudipaty L, De Le�n DD, Hadjiliadis D, Kubrak C, Rosenfeld NK, Nyirjesy S, Pelekis A, Malik S, Stefanovski D, Cuchel M, Rubenstein RC, Kelly A, Rickels MR, Diabetes, 1/1/2017
• Extreme caution on the use of sirolimus for the congenital hyperinsulinism in infancy patient  
  Banerjee I, De Leon D, Dunne MJ, Orphanet J Rare Dis, 1/1/2017
• Novel hypoglycemia phenotype in congenital hyperinsulinism due to dominant mutations of uncoupling protein 2  
  Ferrara CT, Boodhansingh KE, Paradies E, Giuseppe F, Steinkrauss LJ, Topor LS, Quintos JB, Ganguly A, De Leon DD, Palmieri F, Stanley CA, J Clin Endocrinol Metab, 1/1/2017
• GATA6 plays an important role in the induction of human definite endoderm, development of the pancreas, and functionality of pancreatic beta-cells  
  Tiyaboonchai A, Cardenas-Diaz FL, Ying L, Maguire JA, Sim X, Jobaliya C, Cagne AL, Kishore S, Stanescu DE, Hughes N, De Leon DD, French DL, Gadue P, Stem Cell Reports, 1/1/2017
• Functional and metabolic consequences of ATP-dependent potassium channel inactivation in human islets  
  Li C, Ackermann AM, Boodhansingh KE, Bhatti TR, Liu C, Schug J, Doliba N, Han B, Cosgrove KE, Banerjee I, Matschinsky FM, Nissim I, Kaestner KH, Naji A, Adzick NS, Dun..., Diabetes, 1/1/2017
• A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase  
  Barrosse-Antle M, Su C, Chen P, Boodhansingh K, Stanley CA, De Le�n DD, Li C, Pediatr Diabetes, 1/1/2017
• Congenital hypoglycemia disorders: new aspects of etiology, diagnosis, treatment and outcomes  
  De Leon DD, Stanley CA, Pediatr Diabetes, 1/1/2017
• Octreotide use and safety in infants with hyperinsulinism  
  McMahon AW, Wharton GT, Thornton P, De Le�n DD, Pharmacoepidemiol Drug Saf, 1/1/2017
• Adding glucagon-stimulated GH testing to the diagnostic fast increases the detection of GH-sufficient children  
  Hawkes CP, Grimberg A, Dzata VE, De Leon DD., Horm Res Paediatr, 1/1/2016
• Iatrogenic necrolytic migratory erythema in an infant with congenital hyperinsulinism  
  Coughlin CC, Roy SM, Arkin LM, Adzick NS, Yan AC, De Le�n DD, Rubin AI, Pediatr Dermatol, 1/1/2016
• Use of propranolol for treating hemangiomas in infants with previously diagnosed hypoglycemic conditions  
  Yang TB, McMahon P, De Leon DD, Treat JR, Pediatr Dermatol, 1/1/2016
• Late presentation of fulminant necrotizing enterocolitis in a child with hyperinsulinism on octreotide therapy  
  Hawkes CP, Adzick NS, Palladino AA, De Le�n DD, Horm Res Paediatr, 1/1/2016
• Congenital hyperinsulinism in children with paternal 11p uniparental isodisomy and Beckwith Wiedemann syndrome  
  Kalish JM, Boodhansingh KE, Bhatti TR, Ganguly A, Conlin LK, Becker SA, Givler S, Mighion L, Palladino AA, Adzick NS, De Leon DD, Stanley CA, Deardorff MA, J Med Genet, 1/1/2016
• Postprandial hypoglycemia in children after gastric surgery: clinical characterization and pathophysiology  
  Calabria AC, Charles L, Givler S, De Leon DD, Horm Res Paediatr, 1/1/2016
• Pharmacological correction of trafficking defects in ATP-sensitive potassium channels caused by sulfonylurea receptor 1 mutations  
  Martin GM, Rex EA, Devaraneni P, Denton JS, Boodhansingh KE, De Leon DD, Stanley CA, Shyng SL, J Biol Chem, 1/1/2016
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Books/Book Chapters

• Pediatric Endocrinology 
  Chapter: Hypoglycemia in the Newborn and Infant 
  De Le�n DD, Thornton PS, Stanley CA, Sperling MAEditors: Sperling MA.ElsevierEdition 4th,2014
• Pediatric Endocrinology: A Practical Clinical Guide 
  Chapter: Hypoglycemia 
  De Le�n DD and Stanley CAEditors: Radovick S and MacGillivray MH.Springer, New York, NY2013
• Frontiers in Diabetes 
  Chapter: Monogenic Hyperinsulinemic Hypoglycemia Disorders 
  De Leon DD, Stanley CAKarger, Basel, Switzerland2012
• Netter's Pediatrics (Netter Clinical Science) 
  Chapter: Hypoglycemia 
  Palladino AA and De Le�n DDEditors: Florin T and Ludwig S.Saunders2011
• The Inpatient Pediatrics Work-Up 
  Chapter: Hypoglycemia 
  Pinney SE, De Le�n DDEditors: Shah and Frank.Lippincott Williams & Wilkins2010
• The 5-Minute Pediatric Consult 
  Chapter: Hyperinsulinism 
  Bamba V and De Le�n DDEditors: Schwartz, MW.Lippincott Williams & Wilkins, Philadelphia, PAEdition 5th,2008
• Pediatric Endocrinology 
  Chapter: Hypoglycemia in Neonates and Infants. 
  De Le�n DD, Stanley CA, Sperling MAEditors: Sperling, MA.SaundersEdition 3rd,2008
• Fetal and Neonatal Physiology 
  Chapter: Growth Factor Regulation of Fetal Development 
  De Le�n D, Ham N, Katz LELEditors: Polin R and Fox.Edition 4th,2007
• When to Screen in Obstetrics and Gynecology. 
  Chapter: Screening for Hypoglycemia in Newborns 
  De Le�n DD and Stanley CAEditors: Wildschut, Weiner and Peters.Elsevier, Philadelphia, PAEdition 2nd,2006
• Requisites in Pediatrics - Endocrinology 
  Chapter: Disorders of Growth 
  De Le�n DD and Grimberg AEditors: Moshang T Jr.Mosby Publishing, St. Louis, MO2004
• Growth Factor Regulation of Fetal Growth 
  Chapter: Growth Factor Regulation of Fetal Growth 
  De Le�n DD, Cohen P, and Katz LEditors: Polin, Fox and Abman.SaundersEdition 3rd,2003
• The 5 Minute Pediatric Consult 
  Chapter: Hyperinsulinism 
  Ng D (De Le�n DD), Weinzimer SEditors: Schwartz MW.Lippincott Williams & Wilkins, Philadelphia, PA2002
• Frontiers in Diabetes: Monogenic Hyperinsulinemic Hypoglycemia Disorders 
  Chapter: Role of Incretin Hormones in Hyperinsulinemic Hypoglycemia 
  De Le�n DDEditors: Stanley CA and De Le�n DD.Karger, Basel, Switzerland2012
• Frontiers in Diabetes: Monogenic Hyperinsulinemic Hypoglycemia Disorders. 
  Chapter: Pathophysiology of Diffuse ATP-Sensitive Potassium Channel Hyperinsulinism 
  De Le�n DD, Stanley CAEditors: Stanley CA and De Le�n DD.Karger, Basel, Switzerland2012
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Abstracts/Posters

• Effects of GLP-1 and GIP on insulin secretion in insulin secretion in glucose intolerant, pancreatic insufficient cystic fibrosis.
  Eiel JN, Nyrjesy S, Pleckis AJ, De Leon DD, Hadjiliadis D, Kubrak C, Tami A, Sheikh S, Rubenstein RC, Kelly A, Rickels MR, American Diabetes Association 78th Scientific Sessions, Orlando, FL, 1/1/2018
• Continuous intragastric dextrose as an adjunctive therapy for refractory hypoglycemia in congenital hyperinsulinism.
  Vajravelu ME, Mitteer LM, Koh J, Givler SR, De Leon DD, 10th International Join Meeting of Pediatric Endocrinology, Washington, DC, 1/1/2017
• Incidence and pattern of hypoglycemia among at-risk newborns in a community hospital setting.
  Vajravelu ME, Hufnal C, Ferrigno N, Neumann D, De Leon DD, 10th International Join Meeting of Pediatric Endocrinology, Washington, DC, 1/1/2017
• Prolactin receptor immunoreactivity in pancreatic islets of human infants, children, and adults
  Arumugam R, Frank SJ, Jiang J, Zhang Y, Sorenson RL, Bhatti T, De Leon DD, Freemark M, Annual Meeting of the Endocrine Society, Orlando, FL, 1/1/2017
• Activity of xoma 358, an inhibitor of insulin action following short-term administration to congenital hyperinsulinism patients.
  Johnson KW, Neale AC, Gordon A, De Leon DD, Hussain K, Mohnike KL, Vukelich S, Roessig JM, Rubin PD, Annual Meeting of the Endocrine Society, Orlando, FL, 1/1/2017
• New criteria for indeterminate glucose tolerance in pancreatic insufficient cystic fibrosis based on defects in beta-cell secretory capacity.
  Nyrjesy S, Sheikh S, Hadjiliadis D, De Leon DD, Peleckis A, Eiel J, Kubrak C, Stefanovski D, Rubenstein R, Rickels M, Kelly A, Annual Meeting of the Endocrine Society, Orlando, FL, 1/1/2017
• Severe hyperinsulinism in infants with Beckwith-Wiedemann syndrome and heterozygous KATP channel mutations: more than focal or diffuse disease.
  Ackermann AM, Li C, Lord K, Boodhansingh KE, Kalish JM, Bhatti TR, States L, Adzick NS, Stanley CA, De Leon DD, 10th International Join Meeting of Pediatric Endocrinology, Washington, DC, 1/1/2017
• Effect of exendin-(9-39) on glucose and insulin responses to a mixed meal and a protein load in children with hyperinsulinism
  Stefanovski D, Vajrevelu ME, De Leon DD, 10th International Join Meeting of Pediatric Endocrinology, Washington, DC, 1/1/2017
• Additional type 2 diabetes genetic variants and CFRD
  Kilberg M, Chesi A, De Leon D, Hadjiliadis D, Rickels M, Sheikh S, Grant S, Rubenstein RC, Kelly A, Pediatr Pulmonol, Indianapolis, IN, 1/1/2017
• Lanreotide is a safe and effective treatment for congenital hyperinsulinism.
  Lord K, Stewart N, De Leon DD, 10th International Join Meeting of Pediatric Endocrinology, Washington, DC, 1/1/2017
• Hyperglucagonemia and incretin defects do not contribute to worsening glucose tolerance in pancreatic insufficient cystic fibrosis.
  Sheikh S, Nyirjesy SC, Hadjiliadis D, De Leon D, Peleckis A, Eiel JN, Kubrak C, Stefanovski D, Rubenstein RC, Rickels M, Kelly A, 10th International Join Meeting of Pediatric Endocrinology, Washington, DC, 1/1/2017
• Protein-induced hypoglycemia in KATP hyperinsulinism is mediated by the GLP-1 receptor
  Vajravelu ME, Lord K, Givler S, De Le�n DD, PAS Annual Meeting of the Society for Pediatric Research and the Pediatric Endocrine Society, Baltimore, MD, 1/1/2016
• High risk of diabetes and neurobehavioral deficits in individuals with surgically treated hyperinsulinism
  Lord K, Radcliffe J, Gallagher PR, Adzick NS, Stanley CA, De Leon DD, Annual Meeting of the Endocrine Society, San Diego, CA, 1/1/2015
• The use of glucagon in the treatment of congenital hyperinsulinism
  Lado JJ, Givler S, De Leon DD, Annual Meeting of the Society for Pediatric Research and the Pediatric Endocrine Society, San Diego, CA, 1/1/2015
• Iatrogenic necrolytic migratory erythema in an infant receiving glucagon therapy for congenital hyperinsulinism
  Roy SM, Coughlin CC, Adzick NS, Yan AC, Rubin AI, De Leon DD, Annual Meeting of the Endocrine Society, San Diego, CA, 1/1/2015
• The use of glucagon in the treatment of congenital hyperinsulinism.
  Lado JJ, Givler S, De Leon DD, Annual Meeting of the Eastern Society for Pediatric Research, Philadelphia, PA, 1/1/2015
• Additional type 2 diabetes genetic variants and CFRD
  Kilberg M, Chesi A, De Leon D, Hadjiliadis D, Rickels M, Sheikh S, Grant S, Rubenstein RC, Kelly A, The 31 Annual North American Cystic Fibrosis Conference, Indianapolis, IN, 1/2./2017
• Genetic risk scores for height and obesity in cystic fibrosis.
  Orenstein M, De Leon D, Sheik S, Grant S, Chesi A, Rickels M, Hadjiliadis D, Rubenstein R, Kelly A., Meeting of the Pediatric Endocrine Society and the Pediatric Academic Societies, Toronto, Canada, 1/4./2018
• Effect of GLP-1 and GIP on insulin secretion in glucose intolerant, pancreatic insufficient cystic fibrosis.
  Eiel JN, Nyirjesy SC, Peleckis A, De Leon DD, Hadjiliadis D, Kubrak C, Tami A, Sheikh S, Rubenstein RC, Kelly A, Rickels MR, 78th Scientific Sessions of the American Diabetes Association., Orlando, Florida, 1/21/2018
• Incidence and risk of celiac disease in individuals with type 1 diabetes over the lifespan - a population based cohort study using the health improvement network database
  Vajravelu ME, Keren R, Weber D, Verma R, De Leon D, Denburg M, 78th Scientific Sessions of the American Diabetes Association., Orlando, Florida, 1/22/2018
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Lectures

• Pitfalls in the evaluation, diagnosis and treatment of persistent hyperinsulinemic hypoglycemia 
  Cuzco, Peru - 1/1/2018
• Neonatal Hypoglycemia: Who should be investigated and evaluated 
  Asuncion, Paraguay - 1/1/2018
• Differential Diagnosis of Persistent Hypoglycemia in Pediatrics 
  Asuncion, Paraguay - 1/1/2018
• Functional and metabolomic consequences of KATP channel inactivation in human islets 
  Orlando, Florida - 1/1/2018
• Diazoxide-responsive hyperinsulinism 
  Hong Kong - 1/1/2018
• Update on hyperinsulinism: what neonatologists and general pediatricians should know 
  Hong Kong - 1/1/2018
• Latest advances in hyperinsulinism - new frontiers in genetic diagnosis and novel treatments 
  Hong Kong - 1/1/2018
• Glycogen storage disease - an update on diagnosis and management 
  Hong Kong - 1/1/2018
• Management after pancreatectomy - persistent hypoglycemia and hyperglycemia 
  Hong Kong - 1/1/2018
• Surgical vs. non-surgical decisions and options 
  Hong Kong - 1/1/2018
• Congenital hyperinsulinism in the 21st century: novel insights into the pathophysiology and the promise of new treatments 
  Alfred I. DuPont Hospital for Children, Wilmington, DE - 1/1/2018
• Congenital hyperinsulinism: therapeutic approach 
  Centro de Educaci�n e Investigaciones Cl�nicas. Buenos Aires, Argentina - 1/1/2017
• Cases I Learned From 
  Miami, Florida - 1/1/2017
• Neonatal Hypoglycemia: What's New? 
  Miami, Florida - 1/1/2017
• Emerging insights into the pathophysiology and treatment of hyperinsulinism 
  University of Florida College of Medicine, Jacksonville, Florida - 1/1/2017
• Human Hyperinsulinism Islets: a model for examining pathophysiology and identifying novel targets for therapy 
  Nemours Children's Specialty Care, Jacksonville, Florida - 1/1/2017
• Effect of exendin-(9-39) on glucose and insulin responses to a mixed meal and a protein load in children with hyperinsulinism 
  Washington, D.C - 1/1/2017
• Congenital hyperinsulinism: new treatments 
  Centro de Educaci�n e Investigaciones Cl�nicas. Buenos Aires, Argentina - 1/1/2017
• Neurodevelopmental Outcomes 
  Philadelphia, PA - 1/1/2016
• Diagnosis and Management of Hypoglycemia in Children 
  Maimonides Medical Center. Brooklyn, New York - 1/1/2016
• Hypoglycemia Disorders in Children 
  New Orleans, LA - 1/1/2016
• Congenital Hypeirnsulinism 
  University of California in San Francisco. San Francisco, CA - 1/1/2016
• Diazoxide-unresponsive Hyperinsulinism 
  Philadelphia, PA - 1/1/2016
• Congenital Hyperinsulinism: diagnosis, management and long-term outcomes 
  Boston, MA - 1/1/2016
• Approach to the Diagnosis and Management of Hyperinsulinism 
  Philadelphia, PA - 1/1/2016
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Other

• Update on Infant Care: Neonatal Hypoglycemia. 
  De Leon-Crutchlow DD, Simmons RA, Stanley CA, Washington University in St. Louis School of Medicine and St. Louis children's Hospital - CD
  1/1/2017
• Hypoglycemia in an infant: case challenge 
  Hatch-Stein J, De Le�n DD, Clinical Case, Medscape Pediatrics.
  http://www.medscape.com/viewarticle/828030
  1/1/2014
• Permanent Neonatal Diabetes Mellitus 
  De Le�n DD, Stanley CA, GeneReviews
  http://www.ncbi.nlm.nih.gov/books/NBK1447/
  University of Washington, Seattle - 1/1/2008
• The outcomes of congenital hyperinsulinism 
  De Le�n DD, Medscape
  1/6./2015
• Hypoglycemia in the newborn 
  De Le�n DD, Medscape
  1/16/2016
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