Dimitris G. Placantonakis MD

PubMed

• Intraoperative Augmented Reality Visualization in Endoscopic Transsphenoidal Tumor Resection Using the Endoscopic Surgical Navigation Advanced Platform (EndoSNAP): A T...
  Lea B Tortolero, Sabastian A Hajtovic, Jose Gautreaux, Richard Lebowitz, Dimitris G Placantonakis
  Cureus. 2025-02-01
• 3 citations
  Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation.
  Shuai Wang, Tengfei Huang, Qiulian Wu, Huairui Yuan, Xujia Wu
  The Journal of Clinical Investigation. 2024-11-15
• Middle meningeal artery embolization and tranexamic acid therapy for subdural hematoma in a patient with hereditary hemorrhagic telangiectasia: illustrative case.
  Robert Kushmakov, Ilona Cazorla-Morales, Keith Brenner, David Araten, Maksim Shapiro
  Journal of Neurosurgery. Case Lessons. 2024-11-04

Journal Articles

• Low-grade astrocytoma mutations IDH1, P53 and ATRX cooperate to block differentiation of human neural stem cells via repression of SOX2  
  Modrek, A. S., Golub, D., Khan, T., Bready, D., Prado, J., Bowman, C., Deng, J., Zhang, G., Rocha, P., Raviram, R., Lazaris, H., Stafford, J., LeRoy, G., Kader, M., Dh..., Cell Reports, 1/1/2017
• Traumatic Brain Injury and Subsequent Glioblastoma Development: Review of the Literature and Case Reports  
  Tyagi, V., Theobald, J., Barger, J., Bustoros, M., Bayin, N.S., Modrek, A.S., Anderer, E., Donahue, B., Fatterpekar, G., & Placantonakis, D.G., Surgical Neurology International, 1/1/2016
• GPR133 (ADGRD1), an adhesion G protein-coupled receptor, is necessary for glioblastoma growth  
  Bayin, N.S., Frenster, J.D., Kane, J.R., Rubenstein, J., Modrek, A.S., Baitalmal, R., Dolgalev, I., Rudzenski, K., Snuderl, M., Golfinos, J.G., Doyle, W., Pacione, D.,..., Oncogenesis, 1/1/2016
• GPR133 promotes glioblastoma growth  
  Bayin, N.S., Frenster, J.D., Kane, J.R., Modrek, A.S., Shohdy, N., MacNeil, D.J., Zagzag, D., & Placantonakis, D.G., Neurosurgery, 1/1/2016
• Adult Primary Spinal Epidural Extraosseous Ewing's sarcoma: Review of the literature and case report  
  Bustoros, M., Cheddhi, T., Frenster, J., Modrek, A. S., Bayin, N.S., Snuderl, M., Rosen G., Schiff, P. B., & Placantonakis, D.G., Case Reports in Neurological Medicine, 1/1/2016
• SOX2 Antagonizes the Hippo Pathway to Maintain Stemness in Cancer Cells  
  Basu-Roy, U., Bayin, N. S., Rattanakorn, K., Han, E., Placantonakis, D. G., Mansukhani, A., & Basilico, C., Nature Communications, 1/1/2015
• Glioblastoma Stem Cells: Molecular Characteristics and Therapeutic Implications  
  Bayin, N.S., Modrek, A. S. & Placantonakis, D. G., World Journal of Stem Cells, 1/1/2014
• Heterogeneity and Diversity of Cancer Stem Cells in Glioblastoma  
  Bayin, N. S., & Placantonakis, D. G., International Journal of Stem Cell Research and Therapy, 1/1/2014
• Selective Lentiviral Gene Delivery into CD133-expressing human Glioblastoma Stem Cells  
  Bayin, N. S., Modrek, A., Dietrich, A., Abel, T., Song, H.-R., Schober, M., Buchholz, C., Chao, M., & Placantonakis, D. G., PLoSOne, 1/1/2014
• Non-Invasive Diagnosis and Management of Spontaneous Intracranial Hypotension in Patients with Marfan Syndrome: Case Report and Review of the Literature  
  Bassani, L., Graffeo, C. S., Behrooz, N., Tyagi, V., Wilson, T., Penaranda, S., Zagzag, D., Rifkin, D. B., Barcellos-Hoff, M. H., Fatterpekar, G., & Placantonakis, D. G., Surgical Neurology International, 1/1/2014
• Stem cells as the cell of origin in glioma  
  Modrek, A. S., Bayin, N.S. & Placantonakis, D. G., World Journal of Stem Cells, 1/1/2014
• Endoscopic Endonasal Resection of Suprasellar Meningiomas: The Importance of Case Selection and Experience in Determining Extent of Resection, Visual improvement and R...  
  Ottenhausen, M., Banu, M., Placantonakis, D. G., Tsiouris, A. J., Khan, O. H., Anand, V. K., & Schwartz, T. H., World Neurosurgery, 1/1/2014
• The transplanum transtuberculum approaches for suprasellar and sellar-suprasellar lesions Avoidance of CSF leak and lessons learned  
  Mascarenhas, L., Moshel, Y. A., Bayad, F., Szentirmai, O., Salek, A. A., Leng, L. Z., Hofstetter, C. P., Placantonakis, D. G., Tsiouris, A. J., Anand, V. K. & Schwartz TH, World Neurosurgery, 1/1/2013
• Neurosurgical management of spinal stenosis in a patient with fibrodysplasia ossificans progressiva: a case report  
  Grobelny, B., Rubin, D., Fleischut, P., Rubens, E., Mack, P., Fink, M., Placantonakis, D. & Elowitz, E., Journal of Neurosurgery (Spine), 1/1/2012
• Transsphenoidal resection of sellar tumors using high field intraoperative MRI  
  Szerlip, N. J., Zhang, Y.-C., Placantonakis, D. G., Goldman, M., Colevas, K. B., Rubin, D. G., Kobylarz, E., Karimi, S., Girotra, M. & Tabar, V., Skull Base, 1/1/2011
• Intracranial and Spinal Metastases from Eccrine Mucinous Carcinoma: A Case Report  
  Sheth, R. N., Placantonakis, D. G. & Gutin, P. H., Neurosurgery, 1/1/2010
• Bilateral Intracranial Electrodes for Lateralizing Intractable Epilepsy: Efficacy, Risk and Outcome  
  Placantonakis, D. G., Shariff, S., Lafaille, F., Labar, D., Harden, C., Hosain, S., Kandula, P., Schaul, N., Kolesnik, D. & Schwartz, T. H., Neurosurgery, 1/1/2010
• Article comment Clinical characteristics and surgical outcomes of patients presenting with meningiomas arising predominantly from the floor of the middle fossa  
  Placantonakis, D. G. & Gutin, P. H., Neurosurgery, 1/1/2010
• BAC transgenesis in human ES cells as a novel tool to define the human neural lineage  
  Placantonakis, D. G., Tomishima, M. J., Lafaille, F., Desbordes, S., Jia, F., Socci, N., Viale, A., Lee, H., Harrison, N., Tabar, V. & Studer, L., Stem Cells, 1/1/2009
• Article comment Monophasic but not biphasic pulses induce brain tissue damage during monopolar high-frequency deep brain stimulation  
  Placantonakis, D. G. & Boockvar, J., Neurosurgery, 1/1/2009
• Article comment Environmental cue-dependent dopaminergic neuronal differentiation and functional effect of grafted neuroepithelial stem cells in parkinsonian brain  
  Placantonakis, D. G. & Boockvar, J., Neurosurgery, 1/1/2009
• Localization in epilepsy  
  Placantonakis, D. G & Schwartz, T. H., Neurologic Clinics, 1/1/2009
• Enriched motor neuron populations derived from BAC-transgenic human embryonic stem cells  
  Placantonakis, D. G., Tomishima, M. J., Lafaille, F., Desbordes, S., Jia, F., Socci, N., Viale, A., Lee, H., Harrison, N., Studer, L. & Tabar, V., Clinical Neurosurgery, 1/1/2009
• Article comment Usefulness of intraoperative ultra low-field magnetic resonance imaging in glioma surgery  
  Placantonakis, D. G. & Gutin, P. H., Neurosurgery, 1/1/2008
• Article comment Feasibility of Polestar N20, an ultra-low-field intraoperative magnetic resonance imaging system in resection control of pituitary macroadenomas: less...  
  Placantonakis, D. G. & Gutin, P. H., Neurosurgery, 1/1/2008
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Books/Book Chapters

• The NYU-HJD Comprehensive Textbook 
  Chapter: Tumors of the spine. In Spinal Disorders and Treatments 
  Pacione, D., Kim, I., Placantonakis, D.G. & Frempong-Boadu, A.Editors: T. Errico & T. Cheriyan.Jaypee Brothers, New Delhi, India2015
• Molecular Pathology of Nervous System Tumors: Biological Stratification and Targeted Therapies 
  Chapter: Brain tumor stem cells. 
  Bayin, N. S., Modrek, A. & Placantonakis, D. G.Editors: M. A. Karajannis & D. Zagzag.Springer2015
• Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury 
  Chapter: Genetic identification of human embryonic stem cell-derived neural cell types using bacterial artificial chromosomes. 
  Tokcaer-Keskin, Z. & Placantonakis, D.G.Editors: M.A. Hayat.Springer, New York, NY2013
• Fundamentals of Operative Techniques in Neurosurgery 
  Chapter: Frameless stereotactic placement of temporal depth electrodes. 
  Placantonakis, D.G., Shariff S. & Schwartz, T.H.Editors: E.S. Connolly, G.M. McKhann, J. Huang, T.F. Choudhri & J. Mocco.Thieme Medical Publishers, New York, NYEdition 2nd,2010
• Operative Techniques in Epilepsy Surgery 
  Chapter: Depth electrodes in invasive epilepsy monitoring. 
  Placantonakis, D.G., Kandula, P. & Schwartz, T.H.Editors: G.H. Baltuch & J.-G. Villemure.Thieme Medical Publishers, New York, NY2009
• Regulatory Networks in Stem Cells 
  Chapter: Genetic manipulation of human embryonic stem cells. 
  Placantonakis, D. G., Tomishima, M. J., Lafaille, F. G. & Studer, L.Editors: R. Vinagolu & V. Mohan.Humana Press, Totowa, NJ2009
• Practical Endoscopic Skull Base Surgery 
  Chapter: Endoscopic Closure of Anterior Skull Base Defects. 
  Tabaee, A., Placantonakis, D., Schwartz, T. H. & Anand, V. K.Editors: V. K. Anand & T. H. Schwartz.Plural Publishing, San Diego, CA2006
• Surgical Recall 
  Chapter: Neurosurgery. 
  Placantonakis, D. G.Editors: L.H. Blackbourne.Matthews Medical Books2005
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Abstracts/Posters

• Low-grade astrocytoma core mutations IDH1, P53 and ATRX cooperate to block differentiation of human neural stem cells via epigenetic repression of SOX2.
  Modrek, A. S., Golub, D., Khan, T., Prado, J., Bowman, C., Deng, J., Zhang, G., Rocha, P., Raviram, R., Lazaris, H., Stafford, J., LeRoy, G., Kader, M., Dhaliwal, J., ..., 1/1/2017
• Patient-specific screening using high-grade glioma explants to determine potential radiosensitization by a TGF-beta small molecule inhibitor.
  Bayin, N.S., Ma, L., Baitalmal, R., Golfinos, J.G., Pacione, D., Snuderl, M., Zagzag, D., Barcellos-Hoff, M.H., & Placantonakis, D.G., AANS Annual Meeting, 1/1/2017
• The Posterior Nasoseptal Flap: A Novel Technique for Closure after Endoscopic Transsphenoidal Resection of Pituitary Adenomas.
  Barger, J., Siow, M., Kader, M., Phillips, K., Fatterpekar, G., Kleinberg, D., Zagzag, D., Sen, C., Golfinos, J.G., Lebowitz, R. & Placantonakis, D.G., AANS Annual Meeting; NASBS Annual Meeting, 1/1/2017
• Cadherin-coated emulsion droplets are a biomimetic scaffold for tumorspheres and cell migration.
  Nagendra, K., Frenster, J.D., McMullen, A., Placantonakis, D.G., & Brujic, J., ACS Colloids and Surface Chemistry Conference, 1/1/2017
• GPR133, an orphan adhesion G protein-coupled receptor, promotes hypoxia-driven tumor progression in glioblastoma.
  Frenster, J.D., Bayin, N.S., Alghamdi, A., Inocencio, J., Xu, Z., Kane, J.R., Rubenstein, J., Modrek, A.S., Baitalmal, R., Dolgalev, I., Rudzenski, K., Snuderl, M., Go..., ISSCR Annual Meeting; NYSTEM Annual Meeting; NYU Kimmel Center for Stem Cell Biology Annual Retreat, 1/1/2017
• Using Nanoflow LC-MS/MS to Study Metabolic Changes in Low Grade Astrocytoma.
  Neubert, T. A., Modrek, A, Deng, J., Zhang, G., & Placantonakis, D., Mol Cell Proteomics, 1/1/2017
• Low-grade astrocytoma core mutations IDH1, P53 and ATRX cooperate to block differentiation of human neural stem cells via epigenetic repression of SOX2.
  Modrek, A. S., Golub, D., Khan, T., Prado, J., Bowman, C., Deng, J., Zhang, G., Rocha, P., Raviram, R., Lazaris, H., Stafford, J., LeRoy, G., Kader, M., Dhaliwal, J., ..., NYSTEM Annual Meeting; Pediatric SNO Meeting, 1/1/2017
• A phase II, open-label, single arm, multicenter study of avelumab with hypofractionated re-irradiation in adult subjects with transformed IDH mutant glioblastomas.
  Chi, A.S., Eisele, S.C., Arrillaga-Romany, I., Batchelor, T.T., Taylor, J., Cloughesy, T., Patel, A., Delara, M., Latchman, S., Placantonakis, D.G., Pacione, D., Fatte..., SNO Annual Meeting, 1/1/2017
• K27M mutant gliomas are selectively killed by ONC201, a small molecule inhibitor of dopamine receptor D2.
  Chi, A.S., Stafford, J., Sen, N., Possemato, R.L., Placantonakis, D.G., Hidalgo, E.T., Harter, D.H., Wisoff, J.H., Golfinos, J.G., Arrillaga-Romany, I., Batchelor, T.T..., SNO Annual Meeting, 1/1/2017
• Detection of TERT mutations in cell-free circulating tumor DNA (ctDNA) of glioblastoma patients using droplet digital PCR.
  Cordova, C., Corless, B., Syeda, M., Patel, A., Delara, M., Eisele, S., Schafrick, J., Placantonakis, D.G., Pacione, D., Silverman, J.S., Fatterpekar, G., Shepherd, T...., SNO Annual Meeting, 1/1/2017
• Correlation between IDH mutation status, patient survival, and blood volume estimates in diffuse gliomas: a TCGA/TCIA project.
  Jain, R., Poisson, L., Littig, I., Neto, L., Wu, C.-C., Ng, V., Patel, S., Snuderl, M.,. Zagzag, D., Placantonakis, D.G., Golfinos, J.G., & Chi, A.S., SNO Annual Meeting, 1/1/2017
• Characterization of GPR133 expression in glioma subtypes.
  Kader, M., Frenster, J.D., Liechty, B., Modrek, A.S., Tsirigos, A., Golfinos, J.G., Eisele, S., Jain, R., Shepherd, T., Fatterpekar, G., MacNeil, D.J., Shohdy, N., Hua..., SNO Annual Meeting, 1/1/2017
• Peripheral blood DNA methylation profiles are indicative of IDH1/2 mutation status in adult patients with diffuse gliomas.
  Kloetgen, A., Serrano, J., Patel, S., Bowman, C.J., Shen, G., Zagzag, D., Karajannis, M., Golfinos, J.G., Placantonakis, D.G., Tsirigos, A., Chi, A.S., & Snuderl, M., SNO Annual Meeting, 1/1/2017
• MR Imaging phenotype correlates with extent of genome-wide copy number abundance in IDH mutated gliomas.
  Wu, C.-C., Jain, R, Patel, S., Neto, L., Zagzag, D., Placantonakis, D.G., Golfinos, J.G., Chi, A.S., & Snuderl, M., SNO Annual Meeting, 1/1/2017
• GPR133 promotes hypoxia-driven tumor progression in glioblastoma.
  Frenster, J.D., Bayin, N.S., Kane, J.R., Rubenstein, J., Modrek, A.S., Baitalmal, R., Dolgalev, I., Rudzenski, K., Snuderl, M., Golfinos, J.G., Doyle, W., Pacione, D.,..., SNO Annual Meeting, 1/1/2016
• GPR133, an adhesion G protein-coupled receptor, is necessary for glioblastoma growth.
  Bayin, N.S., Frenster, J., Kane, J.R., Modrek, A.S., Shohdy, N., MacNeil, D.J., Zagzag, D., & Placantonakis, D.G., 8th International Adhesion GPCR Workshop, 1/1/2016
• GPR133, a novel oncogene in glioblastoma, regulates tumor growth in hypoxia.
  Bayin, N.S., Frenster, J., Kane, J.R., Modrek, A.S., Shohdy, N., MacNeil, D.J., Zagzag, D., & Placantonakis, D.G., AANS Annual Meeting, 1/1/2016
• Tumorigenic Alterations by Mutant IDH1 in Early Gliomagenesis.
  Modrek, A. S., Khan, T., Golub, D., Kader, M., Zhang, G., Deng, J., Bowman, C., Bayin, N.S., Frenster, J., Lhakhang, T., Heguy, A., Dankert, J., Tsirigos, A., Snuderl,..., AANS/CNS Section on Tumors Meeting, 1/1/2016
• GPR133 promotes glioblastoma growth in hypoxia.
  Bayin, N.S., Frenster, J., Kane, J.R., Modrek, A.S., Shohdy, N., MacNeil, D.J., Zagzag, D., & Placantonakis, D.G., CNS Annual Meeting, 1/1/2016
• High grade glioma (HGG) patient-specific screening using organotypic cultures to determine potential radiosensitization by a TGF-beta small molecule inhibitor.
  Ma, L., Bayin, N. S., Placantonakis, D. G. & Barcellos-Hoff, M. H., RRS Annual Meeting, 1/1/2016
• High grade glioma (HGG) patient-specific screening using organotypic cultures to determine potential radiosensitization by a TGF-beta small molecule inhibitor.
  Ma, L., Bayin, N. S., Placantonakis, D. G. & Barcellos-Hoff, M. H., SNO Annual Meeting, 1/1/2016
• Astrocytoma mutations IDH1, p53 and ATRX cooperate to block differentiation of neural stem cells via Sox2.
  Modrek, A.S., Golub, D., Khan, T., Kader, M., Zhang, G., Deng, J., Bowman, C., Prado, J., Bayin, N.S., Frenster, J., Lhakhang, T., Heguy, A., Dankert, J., Tsirigos, A...., SNO Annual Meeting, 1/1/2016
• Hypoxia-Inducible Gene (HIG2) and Perilipin 2 are specific biomarkers of hypoxic tumor cells in glioma and stromal cells in CNS hemangioblastoma.
  Zagzag, D., Gagner, J.-P., Ortenzi, V., Bayin, N. S., Sarfraz, Y., Chiriboga, L., & Placantonakis, D. G., SNO Annual Meeting, 1/1/2015
• Tumorigenic Alterations by Mutant IDH1 in Early Gliomagenesis.
  Modrek, A. S., Khan, T., Kader, M., Bayin, N. S., Zhang, G., Neubert, T., & Placantonakis, D. G., SNO Annual Meeting, 1/1/2015
• GPR133 is enriched in Glioblastoma stem cells and regulates the response to hypoxia.
  Bayin, N.S., Kane, J.R., Modrek, A.S., Shohdy, N., MacNeil, D.J., Zagzag, D., & Placantonakis, D.G., SNO Annual Meeting, 1/1/2015
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Lectures

• Low-grade astrocytoma core mutations IDH1, P53 and ATRX cooperate to block differentiation of human neural stem cells via epigenetic repression of SOX2. 
  1/1/2017
• Chromatin and cell surface alterations in glioma. 
  NYU School of Medicine - 1/1/2017
• Glioma clinical trials: Lessons learned. 
  NYU School of Medicine - 1/1/2017
• Chromatin conformation remodeling by mutant IDH. 
  Washington University of Saint Louis - 1/1/2017
• The overlap in basic ideas in management of glioblastoma. 
  1/1/2016
• Tumorigenic Alterations by Mutant IDH1 in Early Gliomagenesis. 
  1/1/2016
• Pituitary tumors: Surgery and management. 
  NYU School of Medicine - 1/1/2016
• Brain and pituitary tumors. 
  NYU School of Medicine - 1/1/2016
• GPR133 promotes glioblastoma growth in hypoxia. 
  1/1/2016
• Models for low-grade and high-grade gliomas. 
  SUNY Downstate School of Medicine - 1/1/2016
• GPR133 (ADGRD1) is required for glioblastoma growth. 
  Leipzig, Germany - 1/1/2016
• Interactions between cancer stem cells and tumor microenvironment in glioblastoma. 
  Cold Spring Harbor Laboratories - 1/1/2015
• Glioblastoma Stem Cell Heterogeneity. 
  SUNY Upstate Medical Center - 1/1/2015
• Defining glioblastoma stem cell heterogeneity. 
  1/1/2015
• Gliomas: stem cells, origin, and drug-screening platforms. 
  Weill Cornell Medical College - 1/1/2014
• Gene therapy for malignant brain tumors. 
  NYU School of Medicine - 1/1/2014
• Pituitary Surgery. 
  NYU School of Medicine - 1/1/2014
• Cancer stem cells in low- and high-grade gliomas. 
  1/1/2014
• Brain tumor update. 
  1/1/2013
• Basics of Stem Cell Biology and Cell Sources. 
  1/1/2013
• Glioblastoma stem cell therapeutics. 
  SUNY Downstate School of Medicine - 1/1/2013
• Glioblastoma stem cell biology and therapeutics. 
  NYU School of Medicine - 1/1/2013
• Glioma stem cell biology and therapeutics. 
  NYU School of Medicine; Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center - 1/1/2012
• Neurosurgical management of brain tumors. 
  East Orange VA Hospital - 1/1/2012
• Specific targeting of glioblastoma stem cells with lentiviral vectors. 
  1/1/2012
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Other

• Brain tumors. (Radio appearance) 
  Placantonakis D, Sirius XM Doctor Radio
  1/1/2017
• On the role of gap junctional communication in inferior olivary oscillations. Doctoral dissertation. 
  Placantonakis, D. G.
  New York University, New York, NY - 1/1/2002