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Office
5323 Harry Hines Boulevard
Dallas, TX 75390Phone+1 214-648-3111
Summary
- My research laboratory studies women's cancers with an emphasis on endometrial cancer. We focus on the genetic and genomic basis of cancer, and how DNA errors promote the formation of cancer. Our goal is to apply insights from our research towards the development of new therapies, predictive biomarkers, and diagnostic methods for these extremely common yet understudied cancers and their early precursors. I also serve as a pathologist in the Obstetric and Gynecologic Pathology Division at UT Southwestern.
Education & Training
Brigham and Womens HospitalFellowship, Selective Pathology, 1998 - 1999- Brigham and Women's HospitalResidency, Pathology-Anatomic and Clinical, 1996 - 1998
University of Texas Southwestern Medical SchoolClass of 1996
Certifications & Licensure
TX State Medical License 2004 - 2026
MA State Medical License 1998 - 2005- American Board of Pathology Anatomic Pathology
Awards, Honors, & Recognition
- Elected Fellow, Section on Medical Sciences American Association for the Advancement of Science (AAAS), 2022
- Vernie A. Stembridge, M.D., Distinguished Chair in Pathology UT Southwestern Medical School, 2014
- Elected Member The American Society for Clinical Investigation, 2009
Publications & Presentations
PubMed
- 50 citationsPolymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load.Hao Dong Li, Ileana Cuevas, Musi Zhang, Changzheng Lu, Maksudul Alam
The Journal of Clinical Investigation. 2018-08-31 - 854 citationsFoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasisJihye Paik, Ramya Kollipara, Gerald C. Chu, Hongkai Ji, Yonghong Xiao
Cell. 2007-01-26 - 640 citationsLoss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.Norman E. Sharpless, Nabeel Bardeesy, Kee Ho Lee, Daniel R. Carrasco, Diego H. Castrillon
Nature. 2001-09-06
Journal Articles
- β-Catenin, PAX2 and PTEN panel in the diagnosis of endometrial precancers: a case-based reviewElena Lucas Hao Chen Subhransu S. Sahoo Kelley Carrick Jessica Grubman Wenxin Zheng Jonathan Hecht Diego H. Castrillon, Diagnostic Histpathology, 7/22/2023
- Foxo3 Promotes Apoptosis of B Cell Receptor–Stimulated Immature B Cells, Thus Limiting the Window for Receptor EditingBrian Skaug, Evan Barrios, Diego H Castrillon, The Journal of Immunology
Press Mentions
- Lkb1 Deficiency Confers Glutamine Dependency in Polycystic Kidney DiseaseFebruary 26th, 2020
Researchers Uncover Mutated Genes Involved in Lung Cancer; One Affects NonsmokersOctober 24th, 2017
Gene Inactivation Drives Spread of MelanomaJune 11th, 2012
Grant Support
- Mouse Models And Translational Studies Of Endometrial CancerNational Cancer Institute2010–2012
- LKB1 Tumor Suppressor And Human CancerNational Cancer Institute2009–2011
- Mentoring And Research In Mouse Models Of Cancer And InfertilityNational Center For Research Resources2007–2011
- Regulation Of Ovarian Follicle ActivationEunice Kennedy Shriver National Institute Of Child Health &Human Development2005–2009
- Feedback Regulation Of WNT SignalingNational Institute Of General Medical Sciences2007
- Use Of The Mouse For Prostate Cancer Gene DiscoveryNational Cancer Institute2003–2004
- Use Of The Mouse For Prostate Cancer Gene DiscoveryNational Cancer Institute2000–2003
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