DevrajBasuMDPhD, FACS

Otolaryngology (ENT) • Philadelphia, PA

Head & Neck Microvascular Surgery, Head & Neck Oncologic Surgery

Associate Professor, Otorhinolaryngology/Head & Neck Surgery, Perelman School of Medicine

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Office
3400 Spruce St
Fl 5
Philadelphia, PA 19104
Phone+1 215-662-2777

Summary

I see patients at the Hospital of the University of Pennsylvania, where I am an Associate Professor with 11 years of experience as an oncologic and reconstructive surgeon. I use open, endoscopic, robotic, and laser procedures to treat neoplasms of the larynx, pharynx, oral cavity, nasal cavity, paranasal sinuses, salivary glands, parapharyngeal space, and skin. I am also experienced in thyroid and parathyroid surgery.

My research group focuses on squamous cell carcinomas of the head and neck, with emphasis on the rapidly growing HPV+ subtype of this disease. This NIH-funded work seeks to address show cancers evade therapy by exploiting aspects of normal human development and devises strategies to improve drug responses by modulating the developmental plasticity inherent in malignant cells. In doing so, our goals are to increase survival for the worst head and neck cancers and alter management for readily curable ones in order to abate treatment toxicity. My dual clinical and scientific roles drive optimal research use of resected cancers to serve these long-term goals.

Education & Training

The Wistar InstitutePost-Doctoral Fellowship, 2007 - 2012
University of Pennsylvania Health SystemFellowship, Head & Neck Surgical Oncology/Microvascular Reconstruction, 2006 - 2007
Washington University/B-JH/SLCH ConsortiumResidency, Otolaryngology - Head and Neck Surgery, 2002 - 2006
Washington University/B-JH/SLCH ConsortiumInternship, Otolaryngology - Head and Neck Surgery, 2001 - 2002
Washington University in St. Louis School of MedicineClass of 2001
Washington University in St. LouisPh.D., Immunology, 2001
Brown UniversitySc.B., Biology, magna cum laude, 1990 - 1994
Brown UniversityBS, Biology, Magna Cum Laude, 1994

Certifications & Licensure

MO State Medical License 2004 - 2025
PA State Medical License 2006 - 2024
American Board of Otolaryngology - Head and Neck Surgery Otolaryngology

Awards, Honors, & Recognition

Member American Head and Neck Society
Fellow Triological Society
Member American Association for Cancer Research
Candidate Thesis Honorable Mention Award Triological Society, 2017
Vice Presidential Citation The Triological Society, 2017
Joseph P. Atkins MD Resident Teaching Award 2014
Second Place AAO-HNSF Resident Research Award Competition, 2005
Albert Arnold Bennett Award in Biology Brown University, 1994
Sigma Xi Brown University, 1993
Fellow (FACS) American College of Surgeons
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Clinical Trials

A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001) Start of enrollment: 2017 May 02
Recruiting
Phase 1, Phase 2

Publications & Presentations

PubMed

The imprint of viral oncoproteins on the variable clinical behavior among human papilloma virus-related oropharyngeal squamous cell carcinomas.
Malay K Sannigrahi, Lovely Raghav, Ahmed Diab, Devraj Basu
Tumour Virus Research. 2024-12-01
1 citations
HPV16 genome structure analysis in oropharyngeal cancer PDXs identifies tumors with integrated and episomal genomes.
Claire D James, Raymonde O Otoa, Aya H Youssef, Christian T Fontan, Malay K Sannigrahi
Tumour Virus Research. 2024-12-01
Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability.
Malay K Sannigrahi, Lovely Raghav, Dominick J Rich, Travis P Schrank, Joseph A Califano
Biorxiv. 2024-11-04

Journal Articles

Shear Wave Elastography in the Evaluation of Thyroid Nodules and Correlation with Aggressive Features on Microscopy: A Case Report
Chen DW,1 Horst J, Basu D, Dalal S, Jhala D, Hyland KA, Consultant360, 1/1/2018
IL-6 mediates cross-talk between activated fibroblasts and tumor cells in the tumor microenvironment
Karakasheva TA, Lin EW, Tang Q, Qiao E, Waldron TJ, Soni M, Klein-Szanto AJ, Sahu V, Basu D, Ohashi S, Baba K, Giaccone ZT, Walker SR, Frank DA, Wileyto EP, Long Q, Du..., Cancer Research, 1/1/2018
IL-6 Mediates Cross-Talk Between Activated Fibroblasts and Tumor Cells in the Tumor Microenvironment
Devraj Basu, Eric W Lin, Clinical Cancer Research
Managing Head and Neck Malignancy Arising in a Field of Crohn's Inflammation
Yver C, Jhala D, Muir A, Basu D, ENT Journal, 1/1/2017
JARID1 Histone Demethylases: Emerging Targets in Cancer
Harmeyer KM, Facompre ND, Herlyn M, Basu D, Trends Cancer, 1/1/2017
Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma
Natsuizaka M, Whelan K, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran P, Long A, Sahu V, Darling D, Que J, Yang Y, Katz J, Wileyto E, Basu D, Kita Y, Natsugoe S, N..., Nature Communications, 1/1/2017
Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
Zhang G, Frederick DT, Wu L, Wei Z, Krepler C, Srinivasan S, Chae YC, Xu X, Choi H, Dimwamwa E, Ope O, Shannan B, Basu D, Zhang D, Guha M, Xiao M, Randell S, Sproesser..., J Clin Invest, 1/1/2016
JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers
Facompre ND, Harmeyer KM, Sole X, Kabraji S, Belden Z, Sahu V, Whelan K, Tanaka K, Weinstein GS, Montone KT, Roesch A, Gimotty PA, Herlyn M, Rustgi AK, Nakagawa H, Ram..., Cancer Res, 1/1/2016
Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor suppressor activities
Kagawa S, Natsuizaka M, Whelan KA, Facompre N, Naganuma S, Ohashi S,Kinugasa G, Egloff AM, Basu D, Gimotty PA, Klein-Szanto AJ, Bass A, 12, Wong K, Diehl JA, Rustgi AK..., Oncogene, 1/1/2015
CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer
Karakasheva TA, Waldron TJ, Eruslanov E, Kim SB, Lee JS, O'Brien S, Hicks PD, Basu D, Singhal S, Malavasi F, Rustgi AK, Cancer Res, 1/1/2015
Comparative secretome analysis of epithelial and mesenchymal subpopulations of head and neck squamous cell carcinoma identifies S100A4 as a potential therapeutic target
Rasanen K, Sriswasdi S, Valiga A, Tang HY, Zhang G, Perego M, Somasundaram R, Li L, Speicher K, Klein-Szanto A, Basu D, Rustgi AK, Speicher DW, Herlyn M, Mol Cell Proteomics, 1/1/2013
EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas
Basu D, Bewley AF, Sperry SM, Montone KT, Gimotty PA, Rasanen K, Facompre ND, Weinstein GS, Nakagawa H, Diehl JA, Rustgi AK, Herlyn M, Mol Cancer Ther, 1/1/2013
A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT competent cells that express the ZEB transcription factors
Ohashi S, Natsuizaka M, Naganuma S, Kagawa S, Kimura S, Itoh H, Kalman RA, Nakagawa M, Darling DS, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Herlyn M, Nakagawa H., Cancer Res, 1/1/2011
Transoral Robotic Surgery (TORS)
O'Malley BW, Weinstein GS, Blanco R, Basu D, Murray S, 1/1/2011
Evidence for mesenchymal-like subpopulations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity
Basu D, Ngyen TK, Montone KT, Zhang BS, Wang L, Diehl JA, Rustgi AK, Lee JT, Weinstein GS, Herlyn M, Oncogene, 1/1/2010
Transoral robotic surgery: radical tonsillectomy
Weinstein GS, O'Malley BW Jr, Snyder W, Sherman E, Quon H, Arch Otolaryngol Head Neck Surg, 1/1/2007
Buccal salivary cysts in association with a congenital parotid salivary fistula
Basu D, White FV, Molter DW, Int J Pediatr Otorhinolaryngol Extra, 1/1/2006
Determinants of Success in Endoscopic CSF Leak Repair
Basu D, Haughey BH, Hartman JM, Otolaryngol Head Neck Surg, 1/1/2006
Molecular basis for recognition of an arthritic peptide and a foreign epitope on distinct MHC molecules by as single TCR
Basu D, Horvath S, Matsumoto I, Fremont DH, Allen PM, J Immunol, 1/1/2000
Antigen-dependent intrathecal antibody synthesis in the normal rat brain: tissue entry and local retention of antigen-specific B cells
Knopf PM, Harling-Berg CJ, Cserr HF, Basu D, Sirulnick EJ, Nolan SC, Park JT,Keir G,Thompson EJ,Hickey WF, J Immunol, 1/1/1998
In vivo antagonism of a T cell response by an endogenous ligand
Basu D, Williams CB, Allen PM, Proc Natl Acad Sci, 1/1/1998
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Books/Book Chapters

Differential Diagnosis in Otolaryngology: Head and Neck Surgery
Chapter: Differential Diagnosis of Salivary Gland Disturbance and Halitosis
Haddad C, Basu DEditors: W. Stewart.Thieme2010

Lectures

Identifying adverse molecular features of HPV+ head and neck cancers using patient-derived models.
2019 ASCO Annual Meeting - 6/1/2019
Leveraging patient-derived models of HPV+ head and neck cancer
Virginia Commonwealth University School of Dentistry, Richmond, VA - 1/1/2018
Genetic Determinants of PDX Growth in HPV+ Head and Neck Cancer
Scottsdale, AZ - 1/1/2018
Overcoming targeted therapy resistance in head and neck cancer
San Diego, CA - 1/1/2017
Targeting Quiescent Tumor Cells in Head and Neck Cancer
Department of Otolaryngology, University of Texas Southwestern, Dallas, Texas - 1/1/2017
Advancing Translational Models of HPV-Related Head and Neck Malignancy
Department of Otolaryngology, University of Texas Southwestern, Dallas, Texas - 1/1/2017
Application of PDX Technology to Model Human Papilloma Virus-associated Head and Neck Cancer
Seattle, Washington - 1/1/2016
Transition Between Two Distinct Stem Cell-Like States in Head and Neck Cancer is Mediated by JARID1B
Breckenridge, Colorado - 1/1/2016
Cancer Stem Cell Plasticity in the HNSCC Treatment Response
Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO - 1/1/2015
Targeting the Heterogeneity and Plasticity among Oral Cancer Stem Cells
Dept. Head and Neck Surgery, MD Anderson Cancer Center, Houston, TX - 1/1/2015
A G0-Like Cell State as a Barrier to HNSCC Stem Cell Eradication
Boston, MA - 1/1/2015
Understanding Head and Neck Cancer Stem Cell Heterogeneity
Mary Babb Randolph Cancer Center, West Virginia University - 1/1/2014
Two Distinct Quiescent Tumor Cell Phenotypes Within Head and Neck Squamous Cell Carcinomas
Toronto, ON - 1/1/2012
Targeting a treatment-resistant, mesenchymal-like subpopulation within head and neck squamous cell carcinomas
COSM, Las Vegas, NV - 1/1/2010
Biologic Features of Advanced Sinonasal Malignancy: Carcinomas with Neuroendocrine Differentiation
Philadelphia, PA - 1/1/2009
Managing surgical margins in head and neck cancer
Department of Otolaryngology-HNS, University of Pittsburgh School of Medicine, Pittsburgh, PA - 1/1/2007
The surgeon's perspective on management of parotid neoplasms
Toronto, Canada - 1/1/2006
Detection of occult bone metastasis from head and neck squamous cell carcinoma: impact of PET/CT imaging
Chicago, Illinois - 1/1/2006
Determinants of Success in Endoscopic CSF Leak Repair
Los Angeles, CA - 1/1/2005
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