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Office
5 E 98th St
# Mount
New York, NY 10029Phone+1 212-241-7975Fax+1 212-423-0508
Summary
- Internationally known for his research in Diabetes, Derek LeRoith, MD, PhD, is Professor of Medicine (Endocrinology, Diabetes and Bone Diseases) and Interim Chief of the Hilda & J. Lester Gabrilove Division of Endocrinology, Diabetes and Bones Diseases. Dr. LeRoith received his MD and PhD from the University of Capetown where he also completed his residency and both a research and clinical fellowship in Endocrinology. Prior to joining the faculty of the Icahn School of Medicine at Mount Sinai in 2005, Dr. LeRoith was Chief of the Diabetes Branch at the National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. This is the largest program devoted to the study of diabetes within the intramural program of the NIH. He was recruited to Mount Sinai to become the Chief of the Endocrine Division at Mount Sinai as well as the Director of the Metabolism Institute. In 2010 he became the Director of Research for the Division of Endocrinology before returning to his duties as chief in 2015.
Dr. LeRoith was the first to demonstrate the link between insulin and the insulin-like growth factor-1 (IGF-1) and cancer and is the current recipient of an three NCI grants to study the relationship between cancer and type 2 diabetes. He has published over 600 original research papers, reviews and editorials and edited a number of books on Diabetes and IGF-related topics. He is also the senior editor of a major textbook on Diabetes, now in its third edition, as well as Editor-in-Chief of Endocrine Practice, the official journal of the Ammerican Association of Clinical Endocrinologists.
Education & Training
- University of Cape Town Faculty of MedicineClass of 1967
Certifications & Licensure
- NY State Medical License 1980 - 2026
- MD State Medical License 1981 - 2006
- OH State Medical License 1983 - 1984
- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Endocrinology, Diabetes and Metabolism
Awards, Honors, & Recognition
- Elected Member The American Society for Clinical Investigation, 1988
Publications & Presentations
PubMed
- 176 citationsInduction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in miceXiaoling Xu, Shogo Kobayashi, Wenhui Qiao, Cuiling Li, Cuiying Xiao
The Journal of Clinical Investigation. 2006-07-03 - 148 citationsInsulin-Like Growth Factor-I Affects Perinatal Lethality and Postnatal Development in a Gene Dosage-Dependent Manner: Manipulation Using the Cre/loxP System in Transge...Jun-Li Liu, Alexander Grinberg, Heiner Westphal, Brian C. Sauer, Domenico Accili
Molecular Endocrinology. 1998-09-01 - 16 citationsDyslipidemia and glucose dysregulation in overweight and obese patients.Derek LeRoith
Clinical Cornerstone. 2007-01-01
Press Mentions
- Long Non-Coding RNA Gm15441 Attenuates Hepatic Inflammasome Activation in Response to PPARA Agonism and FastingNovember 17th, 2020
- Early Disruption of Nerve Mitochondrial and Myelin Lipid Homeostasis in Obesity-Induced DiabetesNovember 5th, 2020
- Insulin/IGF1 Signalling Mediates the Effects of β2‐Adrenergic Agonist on Muscle Proteostasis and GrowthApril 1st, 2020
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Committees
- member, AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY CLINICAL PRACTICE GUIDELINES FOR DEVELOPING A DIABETES MELLITUS COMPREHENSIVE CARE PLAN 2015
- member, 2011 AACE Medical Guidelines for Clinical Practice for Developing a Diabetes Mellitus Comprehensive Care Plan
- member, American Association of Clinical Endocrinologists and American College of Endocrinology - Clinical Practice Guidelines for Developing a Diabetes Mellitus Comprehensive Care Plan 2015
Professional Memberships
- Member
- Member
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