DennisJSelkoeMD

The Vincent and Stella Coates Professor of Neurologic Diseases, Harvard Medical School; Co-Director, Center for Neurologic Diseases, Department of Neurology Brigham and Women’s Hospital.

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Office
60 Fenwood Road
BTM 10 - 10002S
Boston, MA 02115
Phone+1 617-525-5260

Education & Training

Beth Israel Deaconess Medical Center/Harvard Medical SchoolResidency, Neurology, 1974 - 1975
Beth Israel Deaconess Medical Center/Harvard Medical SchoolResidency, Neurology, 1972 - 1973
University of Pennsylvania Health SystemInternship, Internal Medicine, 1969 - 1970
University of Virginia School of MedicineClass of 1969

Certifications & Licensure

MA State Medical License 1974 - 2025
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

Elected Member Institute of Medicine, 2005
Super Doctor SuperDoctors.com
Whos Who in Medicine and Healthcare Marquis Whos Who

Publications & Presentations

PubMed

Parkinson disease-associated toxic exposures selectively up-regulate vesicular glutamate transporter vGlut2 in a model of human cortical neurons.
Karis A Clark, Andrew J White, Wojciech Paslawski, Kellianne D Alexander, Shaoning Peng
Molecular Biology of the Cell. 2025-02-01
The case for regulatory approval of amyloid-lowering immunotherapies in Alzheimer's disease based on clearcut biomarker evidence.
Paul Aisen, Randall J Bateman, Damian Crowther, Jeff Cummings, John Dwyer
Alzheimer's & Dementia. 2025-01-01
The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1.
Lei Liu, Stephanie A Schultz, Adriana Saba, Hyun-Sik Yang, Amy Li
Alzheimer's & Dementia. 2024-12-01

Journal Articles

MicroRNA-132 Provides Neuroprotection for Tauopathies via Multiple Signaling Pathways
Dennis Selkoe, MD, Acta Neuropathologica

Authored Content

CMS Made the Wrong Decision on Aduhelm. But There Might Be a Silver LiningApril 2022

Press Mentions

There Is No ‘Amyloid Cabal’ in Alzheimer’s ResearchFebruary 14th, 2025
An Open Letter to Dennis J. Selkoe, M.D.December 20th, 2024
Eisai to Present Dual-Acting Lecanemab Three Year Efficacy and Safety Data and Discuss Long-Term Outcomes of Continued Treatment at the Alzheimer's Association International Conference 2024July 22nd, 2024
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Grant Support

Structure-Function Relationships In Presenilin/Y-SecretaseNational Institute On Aging2008–2011
PROTEIN-PROTEIN Interactions In The Biology Of Beta-AppNational Institute On Aging2008–2011
Presenilin Biology And The Mechanism Of Alzheimer'S DiseaseNational Institute On Aging2008–2011
Administrative And Educational CoreNational Institute On Aging2008–2011
Aging In The Brain: The Role Of The Fibrous ProteinsNational Institute On Aging2007–2011
Pathogenic Mechanisms Of Cell-Derived Abeta OligomersNational Institute On Aging2006–2011
Alpha-Synuclein, PUFA And Membrane Vesicles In Health And Parkinson'S DiseaseNational Institute Of Neurological Disorders And Stroke2007–2010
Amyloid B-Protein And Immune Markers In Human BloodNational Center For Research Resources2007–2008
Purification And Reconstitution Of Active Gamma Secretase ComplexNational Institute On Aging2007
Administrative CoreNational Institute On Aging2007
PROTEIN-PROTEIN Interactions In The Biology Of Beta APPNational Institute On Aging2003–2007
Presenilin Biology And Mechanism Of Alzheimer'S DiseaseNational Institute On Aging2003–2007
Alpha-Synuclein, PUFA And Membrane Vesicles-Health/PdNational Institute Of Neurological Disorders And Stroke2006
Aging In The Brain-Role Of The Fibrous ProteinsNational Institute On Aging2003–2006
Amyloid Precursor Protein In Human BloodNational Center For Research Resources2004–2005
Aging In The Brain-Role Of The Fibrous ProteinsNational Institute On Aging2002
Mechanism And Inhibition Of Native Amyloid Beta Aggregation In CellsNational Institute On Aging1999–2002
Presenilin Genotype To Phenotype Conversion And Gamma SecretaseNational Institute On Aging1998–2002
Presenilin Biology &The Mechanism Of Alzheimers DiseaseNational Institute On Aging1998–2002
Protein/Protein Interactions In The Biology Of Beta AmylNational Institute On Aging1999–2001
Aging In The Brain--Role Of The Fibrous ProteinsNational Institute On Aging1992–2000
Purification /Reconstitution Of Active Gamma SecretaseNational Institute On Aging1999
Protein/Protein Interactions In The Biology Of Beta APPNational Institute On Aging1995–1998
Regulation Of Amyloid Beta Production In Health And Alzheimer'S DiseaseNational Institute On Aging1994–1998
Leadership And Excellence In Alzheimers DiseaseNational Institute On Aging1994
Aging In The Brain: Role Of The Fibrous ProteinsNational Institute On Aging1991–1993
Leadership And Excellence In Alzheimer'S DiseaseNational Institute On Aging1988–1993
Molecular Pathology Of Alzheimer Paired Helical FilamentNational Institute On Aging1987–1989
Aging In The Brain--Role Of The Fibrous ProteinsNational Institute On Aging1985–1989
Purification Of Paired Helical FilamentsNational Institute On Aging1985–1988
Molecular Pathology Of Alzheimer Paired Helical FilamentNational Institute Of Neurological Disorders And Stroke1985–1986
Molecular Pathology Of Alzheimer Paired Helical FilamentNational Institute Of Neurological Disorders And Stroke1985