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Office
Physician Medical Terrace
1505 Wilson Terrace, Suite 370
Glendale, CA 91206Phone+1 818-539-1985Fax+1 818-539-1985
Summary
- EXPERT. Dr. Holmes is a dedicated breast surgeon and cancer researcher currently serving as Interim Director of the Margie Petersen Breast Center at St. John’s Health. Formerly, Dr. Holmes held the positions of Chief Breast Surgeon and Medical Director of the Los Angeles Center for Women’s Health, and Chief Breast Cancer Surgeon, and Breast Cancer Research Committee Co-Chair at the University of Southern California (U.S.C.) Kenneth Norris Comprehensive Cancer Center.
LEADER. Dr. Holmes serves in the leadership of several national surgical societies and is a frequent lecturer at national conferences. For example, as a member of the education committee of the American Society of Breast Surgeons, Dr. Holmes recently led the development of national surgical practice guidelines for the use of preoperative chemotherapy prior to breast cancer surgery. Dr. Holmes is a Fellow of the American College of Surgeons and was also recently selected as Board Chair and President of the TARGIT Collaborative Group, a national research and education organization.
INNOVATOR. Widely respected by colleagues for his innovative approach to breast cancer care, Dr. Holmes has gained worldwide acclaim for his pioneering research in intraoperative radiotherapy. He currently serves as National Co-Chair of the TARGIT U.S. Registry clinical trial, and is also National Principal Investigator of the FROST Trial, a clinical trial evaluating the use of cryoablation (tumor freezing) instead of surgery for the treatment of early stage breast cancer. In addition, he has been a pioneer in the field of minimally-invasive breast surgery, including intraoperative radiotherapy, cryoablation, and lymph node-sparing surgery.
ADVOCATE. Dr. Holmes is a strong advocate for individualized or personalized cancer therapy that adapts the extent of care to the severity of the cancer, avoiding unnecessary side effects.
Education & Training
- University of Southern California/LACUSC Medical CenterFellowship, Breast Fellowship, 2002 - 2003
- University of California San Francisco (East Bay)Residency, Surgery, 1999 - 2002
- Washington University/B-JH/SLCH ConsortiumResidency, Surgery, 1991 - 1997
- Tulane University School of MedicineClass of 1991
- Loyola University New OrleansBachelor, Biology, Summa Cum Laude, 1987
Certifications & Licensure
- CA State Medical License 1999 - 2025
- FL State Medical License 2021 - 2023
- DC State Medical License 1997 - 2000
- MD State Medical License 1998 - 2000
- VA State Medical License 1997 - 2000
- LA State Medical License 1991 - 1992
- American Board of Surgery Surgery
Awards, Honors, & Recognition
- Top Doctors Los Angeles Magazine, 2016
- Congressional Commendation 2012
- Pasadena Top Doc in Breast Surgery 2010
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Clinical Trials
- MarginProbe, a Device for Intraoperative Assessment of Margin Status in Breast Conservation Surgery Start of enrollment: 2008 Oct 01
- Intraoperative Radiation Therapy in Treating Patients With Breast Cancer Undergoing Breast-Conserving Surgery Start of enrollment: 2012 May 18
- Cryoablation of Small Breast Tumors in Early Stage Breast Cancer Start of enrollment: 2013 Nov 01
Publications & Presentations
PubMed
- 111 citationsA Consensus Definition and Classification System of Oncoplastic Surgery Developed by the American Society of Breast Surgeons.Abhishek Chatterjee, Jennifer Gass, Krishnabhai Patel, Dennis R. Holmes, Katherine Kopkash
Annals of Surgical Oncology. 2019-04-11 - 8 citationsThe prevention and treatment of breast cancer- related lymphedema: A review.Maureen P McEvoy, Ameer Gomberawalla, Mark Smith, Francesco M Boccardo, Dennis Holmes
Frontiers in Oncology. 2022-01-01 - 27 citationsFeatures associated with successful recruitment of diverse patients onto cancer clinical trials: report from the American College of Surgeons Oncology Group.Kathleen M. Diehl, Erin M. Green, Armin D. Weinberg, Wayne Frederick, Dennis R. Holmes
Annals of Surgical Oncology. 2011-06-17
Journal Articles
- Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A r...Vaidya JS, Bulsara M, Baum M, Wenz F, Massarut S, Pigorsch S, Alvarado M, Duoek M, Saunders C, Flyger HL, Eiermann W, Brew-Graves C, Williams N, Potyka I, Roberts N, B..., British Medical Journal, 9/19/2020
- Breast cancer care during a pandemic: an opportune time for cryoablation?Holmes, DR, Breast Cancer Research and Treatment, 6/11/2020
- Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the BreastRivera R, Banks A, Casillas-Lopez A, et al (Holmes DR), Breast Journal, 1/1/2016
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Books/Book Chapters
Abstracts/Posters
- Analysis of the impact of intraoperative margin assessment with adjunctive use of MARGINPROBE (R) vs. standard of care on tissue volume removed, results from a randomi...Holmes DR, Tafra L, Margin Probe Group, 13th Annual American Society of Breast Surgeons Annual Meeting, Phoenix, AZ, 1/4/2012
- Mammographic findings after intraoperative radiotherapy.Holmes D, Rivera R, Sheth P, Villegas-Mendez S, Smith-Bronson V, Radiotherapy and Oncology, 1/1/2011
- Beyond TARGIT: A pragmatic, risk-adaptive policy for expanding the indications for IORT in the management of invasive breast cancer.Holmes DR, Alvarado M, Harris H, Hoefer R, Small W, International Society of Intraoperative Radiotherapy, Tucson, AZ, 1/5/2010
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Lectures
- Personalized Approach to Breast Cancer Surgery.William Beaumont Hospital, Detroit, MI - 1/19/2016
- Oncoplastic Approaches to Intraoperative Radiotherapy.Dallas, TX - 1/15/2016
- Targeted Intraoperative Radiotherapy for the Management of Ductal Carcinoma In Situ of the Breast.Mannheim, Germany - 1/1/2016
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Other
- Are Double Mastectomies Necessary for Breast Cancer Patients?Holmes, DR, NBC Southern California
1/22/2013 - Interview about Hereditary Breast Cancer.Holmes, DR, KTLA5
http://drholmesmd.com/press/tv/
1/20/2013 - Breast Cancer Surgery Radio Clips from Dr. Holmes. Interview About Declining Cancer Death Rates in the USHolmes, DR
http://drholmesmd.com/press/radio/
1/17/2013 - Join now to see all
Press Mentions
- IceCure Medical to Provide Educational Support in a First-of-Its-Kind Cryotherapy Course at the American Society of Breast Surgeons' 24th Annual MeetingApril 24th, 2023
- Everyday Habits That Shorten Your Life, According to ScienceNovember 13th, 2021
- Experts Answer Most Searched Questions About Breast CancerOctober 20th, 2021
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Professional Memberships
- Member
- Member
- Member
External Links
- Main Websitehttp://www.drholmesmd.com
- Cryoablation Website http://www.cryoablation.com
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