DennisJ.ChiaMD

PubMed

• 11 citations
  Peak Growth Hormone Response to Combined Stimulation Test in 315 Children and Correlations with Metabolic Parameters.
  Mabel Yau, Elizabeth Chacko, Molly O. Regelmann, Rachel A. Annunziato, Elizabeth Wallach
  Hormone Research in Paediatrics. 2019-01-01
• 87 citations
  Minireview: Mechanisms of Growth Hormone-Mediated Gene Regulation
  Dennis J. Chia
  Molecular Endocrinology. 2014-05-13
• 148 citations
  Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation.
  Joachim Woelfle, Dennis J. Chia, Peter Rotwein
  The Journal of Biological Chemistry. 2003-12-19

Journal Articles

• Minireview: Mechanisms of growth hormone regulated gene transcription  
  D.J. Chia., Mol Endocrinol, 1/1/2014
• Hepatic-specific accessibility of igf1 gene enhancers is independent of growth hormone signaling  
  M. Santhanam and D.J. Chia, Mol Endocrinol, 1/1/2013
• Biochemical characterization of diverse Stat5b-binding enhancers that medicate growth hormone-activated insulin-like growth factor-I gene transcription  
  B. Varco-Merth, K. Mirza, D.T. Alzhanov, D.J. Chia, P. Rotwein., PLoS One, 1/1/2012
• In vivo transcript profiling and phylogenetic analysis identifies SOCS2 as a direct STAT5b target in liver  
  O.M. Vidal, R. Merino, E. Rico-Bautista, L. Fernandez-Perez, D.J. Chia, J. Woelfle, M. Ono, B. Lenhard, G. Norstedt, P. Rotwein, A. Flores-Morales., Mol Endocrinol, 1/1/2007
• Stat5b-mediated inhibition of IGF Binding Protein-1 gene transcription: a mechanism for repression of gene expression by growth hormone  
  M. Ono, D.J. Chia, R. Merino-Martinez, A. Flores-Morales, T.G. Unterman, P. Rotwein., Mol Endocrinol, 1/1/2007
• Obesity and the metabolic syndrome in children  
  D.J. Chia and B. A. Boston., Adv Pediatr, 1/1/2006
• Mechanisms of growth hormone (GH) action: Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation  
  J. Woelfle, D.J. Chia, P. Rotwein., J Biol Chem, 1/1/2003
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Books/Book Chapters

• Neonatology: Clinical Practice and Procedures 
  Chapter: Thyroid 
  M. O. Regelmann, E. Graber, D. Chia, R. RapaportEditors: D.K. Stevenson, R.S. Cohen, P. Sunshine.McGraw-Hill2015
• Pediatric Endocrinology 
  Chapter: Laboratory methods in pediatric endocrinology 
  D. W. Chandler, D. J. Chia, J. Nakamoto, K.Y. Chun, S.H. Peskowitz, R. Rapaport.Editors: M.A. Sperling.Elsevier2014

Abstracts/Posters

• Sexual dimorphism in the association of single nucleotide polymorphisms of the Igf1 gene with serum IGF-1 levels in inbred mouse strains
  D.J. Chia, B. Pitera, J. Shu., 10th International Meeting of Pediatric Endocrinology, Washington, DC, 1/1/2017
• Investigation for differential DNA methylation at Igf1 gene regulatory regions in inbred mice strains with discrepant serum IGF-1 levels.
  B. Pitera, J. Shu, D. Chia, Pediatric Research Day, Children�s Hospital at Montefiore, 1/1/2016
• Evolving growth hormone deficiency
  L. Waldman, E. Graber, M. Goldis, D. Chia, M. Regelmann, M. Klein, E. Wallach, R. Rapaport., Pediatric Academic Societies� meeting, Vancouver, BC, 1/1/2014
• Late-onset severe congenital hypothyroidism due to dyshormonogenesis.
  E. Graber, M. Regelmann, D. Chia, M. Goldis, L. Waldman, M. Klein, E. Wallach, R. Rapaport., Pediatric Academic Societies� meeting, Vancouver, BC, 1/1/2014
• Arginine and Levo-Dopa stimulation in children: association of peak growth hormone response with body fat percentage.
  E. Chacko, M. Regelmann, R. Annunziato, E. Graber, A. Buono, E. Wallach, M. Klein, D. Chia, R. Rapaport., Annual Meeting of the Endocrine Society, Washington, DC, 1/1/2013
• I-imaging: a useful adjunct in the evaluation of infants with mild hyperthyrotropinemia.
  E. Graber, M.O. Regelmann, A. Buono, A. Khattab, M. Klein, D.J. Chia, E. Wallach, F. Greig, C. Davis, R. Annunziato, J. Machac, R. Rapaport., Annual Meeting of the Endocrine Society, San Francisco, CA, 1/1/2013
• FAIRE reveals tissue- and species-specific mechanisms of regulation of Igf1 transcription.
  M. Santhanam and D.J. Chia., Pediatric Research Day, Icahn School of Medicine at Mount Sinai, New York, NY, 1/1/2013
• Arginine and Levo-Dopa stimulation in children: timing of peak growth hormone response and correlation with body mass index in children.
  E. Chacko, E. Graber, E. Wallach, M. Regelmann, R. Annunziato, M. Klein, D. Chia, R. Rapaport., Pediatric Academic Societies� meeting, Boston, MA, 1/1/2012
• Pituitary volume correlates with IGF-1 but not with peak growth hormone response to stimulation.
  M.O. Regelmann, B. Delman, E. Chacko, E. Graber, E. Wallach, D. Chia, M. Klein, R. Annunziato, R. Rapaport., Pediatric Academic Societies� meeting, Boston, MA, 1/1/2012
• Arginine and Levo-Dopa stimulation in children: association of peak growth hormone response with Homeostatic Model Assessment and lipids.
  E. Chacko, E. Graber, E. Wallach, M. Regelmann, R. Annunziato, M. Klein, D. Chia, A. Khattab, G. Costin, R. Rapaport., Annual Meeting of the Endocrine Society, Houston, TX, 1/1/2012
• Hemoglobin A1c during growth hormone treatment in prepubertal children.
  M.O. Regelmann, L. Giserman, E. Chacko, E. Graber, A. Khattab, D. Chia, M. Klein, E. Wallach, R. Annunziato, R. Rapaport., Annual Meeting of the Endocrine Society, Houston, TX, 1/1/2012
• Chromatin activation of regulatory elements of the Igf1 gene is tissue-specific
  D.J. Chia and M. Santhanam., Annual Meeting of the Endocrine Society, Houston, TX, 1/1/2012
• The IGF-I gene carries chromatin marks of gene activation even in the absence of acute gene transcription
  D.J. Chia., Pediatric Research Day of the Mount Sinai School of Medicine, New York, NY, 1/1/2011
• Sex steroids: Better indices of pubertal suppression than gonadotropins in Histrelin treated patients?
  M. Klein, M. Regelmann, E. Chacko, S. Hyman, D. Chia, E. Wallach, R. Rapaport., Pediatric Academic Societies� meeting, Denver, CO, 1/1/2011
• Distinct epigenetic actions of growth hormone and Stat5b
  D.J. Chia, P. Rotwein., Fifth International Congress of the Growth Hormone Research Society and the IGF Society, New York, NY, 1/1/2010
• Biochemical charact-erization of growth hormone-regulated and Stat5b-binding transcriptional enhancers in the rat IGF-I locus.
  B.D. Varco-Merth, K.L. Mirza, D.J. Chia, P. Rotwein., Annual Meeting of the Endocrine Society, San Diego, CA, 1/1/2010
• Growth hormone induces IGF-I gene activation via acute chromatin modifications of promoter segments.
  D.J. Chia, J.J. Young, P. Rotwein., Annual Child Health Research Center Retreat, Seattle, WA, 1/1/2009
• Multiple Stat5 binding sites mediate GH-regulated IGF-I gene transcription.
  D.J. Chia, J.J. Young, P. Rotwein, Gordon Research Conference: Insulin-like growth factors in physiology and disease, Annual Meeting of The Endocrine Society, Ventura, CA, 2009; Washington, DC, 2009, 1/1/2009
• Identification of potential mechanisms for diminished insulin-like growth factor-I synthesis in growth hormone resistance
  D.J. Chia, J. Woelfle, J.J. Young, P. Rotwein., Annual Child Health Research Center Retreat, The Woodlands, TX, 1/1/2008
• Persistent hyperparathyroidism in an adolescent following bisphosphonate-induced hypocalcemia with treatment for hypercalcemia of malignancy.
  J.L. Austin, G. Wettach, D.J. Chia, Annual Meeting of The Endocrine Society, San Francisco, CA, 1/1/2008
• Growth hormone regulates IGF-I gene transcription by inducing Stat5b binding to multiple distinct domains.
  D.J. Chia, J. Woelfle, K.A. Woods, P. Rotwein, American Society for Clinical Investigation/American Association of Physicians Joint Meeting, Chicago, IL, 1/1/2007
• Identification of two distinct Stat5 binding domains of the rat IGF-I gene by interspecies homology.
  D.J. Chia, K.A. Woods, J. Woelfle, P. Rotwein., Gordon Research Conference: Insulin-like growth factors in physiology and disease, Annual Meeting of The Endocrine Society, Ventura, CA, 2007; Toronto, Ontario, 2007, 1/1/2007
• Identification of a second GH-stimulated Stat5 binding domain in the rat IGF-I gene.
  D.J. Chia, J. Woelfle, P. Moyano, M.B. Schlesinger-Massart, Y. Wang, H. Jiang, P. Rotwein., Annual Meeting of The Endocrine Society, San Diego, CA, 1/1/2005
• Mis-folding of a mutant Stat5b causes its accumulation in insoluble protein complexes and its diminished activation by growth hormone
  D.J. Chia, P. Moyano, P. Rotwein., Gordon Research Conference: Insulin-like growth factors in physiology and disease, Ventura, CA and the Annual Meeting of The Endocrine Society, San Diego, CA, 1/1/2005
• Growth hormone deficiency in a patient with the Richieri-Costa and Pereira Form of Acrofacial Dysostosis
  D.J. Chia, T. Cole, B. Boston., Annual Meeting of the Western Society for Pediatric Research, Carmel, CA, 1/1/2004
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Lectures

• Growth for the Primary Care Physician 
  Children's Hospital at Montefiore - 1/1/2017
• When I grow up� A discussion of growth in Turner Syndrome. 
  Bronx, NY - 1/1/2016
• Drugs of hypothalamic and pituitary hormones 
  Icahn School of Medicine at Mount Sinai - 1/1/2015
• Liver-specific differentially methylated domains of the IGF1 gene. 
  Children�s Hospital at Montefiore - 1/1/2015
• Epigenetic features of regulatory regions of the IGF1 gene. 
  Albert Einstein College of Medicine - 1/1/2015
• New genetic tools for evaluation of children with short stature in Towards identification of molecular mechanisms of idiopathic short stature 
  San Diego, CA - 1/1/2015
• Drugs of hypothalamic and pituitary hormones. 
  Icahn School of Medicine at Mount Sinai - 1/1/2014
• Disorders of calcium homeostasis 
  Icahn School of Medicine at Mount Sinai - 1/1/2014
• Obesity and Type 2 diabetes in children 
  Icahn School of Medicine at Mount Sinai - 1/1/2013
• Novel molecular mechanisms of short stature. 
  New York, NY - 1/1/2013
• Epigenetic regulation of IGF-1 
  Icahn School of Medicine at Mount Sinai - 1/1/2013
• Obesity and Type 2 diabetes in children. 
  Icahn School of Medicine at Mount Sinai - 1/1/2012
• The IGF system and mechanisms for poor growth 
  Icahn School of Medicine at Mount Sinai - 1/1/2012
• Epigenetic regulation of IGF-I expression 
  Icahn School of Medicine at Mount Sinai - 1/1/2011
• Disorders of calcium homeostasis. 
  Icahn School of Medicine at Mount Sinai - 1/1/2011
• Congenital adrenal hyperplasia 
  Alaska Native Medical Center, Bethel, AL - 1/1/2010
• Metabolic syndrome & Type 2 diabetes in children. 
  Alaska Native Medical Center, Bethel, AL - 1/1/2009
• Congenital hyperinsulinism. 
  Oregon Health & Science University - 1/1/2009
• Growth hormone regulation of insulin-like growth factors: Genetics and epigenetics. 
  Icahn School of Medicine at Mount Sinai - 1/1/2009
• Does my short child need growth hormone? 
  Southwest Washington Medical Center, Vancouver, WA - 1/1/2009
• Genetics and epigenetics of the IGF system 
  Oregon Health & Science University - 1/1/2009
• Mechanisms of transcriptional regulation of IGF-I by growth hormone 
  Oregon Health & Science University - 1/1/2008
• Mechanisms of growth hormone regulation of IGF-I gene transcription. 
  Honululu, HI - 1/1/2008
• Hormonal regulation of IGF-I expression 
  Portland, OR - 1/1/2007
• Endocrine sequelae in cancer survivors. 
  Oregon Health & Science University - 1/1/2007
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