DemetriosThomasBraddockMD

PubMed

• 870 citations
  Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
  Anila K. Madiraju, Derek M. Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T. Braddock
  Nature. 2014-06-26
• 607 citations
  MicroRNA silencing for cancer therapy targeted to the tumour microenvironment
  Christopher J. Cheng, Raman Bahal, Imran A. Babar, Zachary Pincus, Francisco N. Barrera
  Nature. 2015-02-05
• 33 citations
  Clinical and Biochemical Phenotypes in a Family With ENPP1 Mutations
  Anupam Kotwal, Alejandro Ferrer, Rajiv Kumar, Ravinder J. Singh, Vishakantha Murthy
  Journal of Bone and Mineral Research. 2020-04-01

Journal Articles

• "In vivo correction of anaemia in Beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery"  
  Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, Lopez-Giraldez F, Ricciardi A, Beloor J, K..., Nature Communications, 1/26/2016
• "pHLIP® targeting of PNA to silence MicroRNA in tumors"  
  Cheng, C.J., Bahal, R., Babar, I.A., Pincus, Z., Barrera, F., Liu, C., Svoronos, A., Braddock, D.T., Glazer, P.M., Engelman, D.M., Saltzman, W.M., Slack, F.J., Nature, 1/5/2015
• "ENPP1-Fc Fusion Protein Prevents Mortality and Vascular Calcifications in Rodent Model of Generalized Calcification of Infancy"  
  Albright, R.A., Stabach, P., Cao, W., Kavanagh, D., Mullen, I., Braddock, A.A., Covo M.S., Tehan, M., Yang, G., Cheng, Z., Bouchard, K., Zhao-Xue, Y., Thorn, S., Wang,..., Nature Communications, 1/1/2015
• "The Molecular Basis of Purinergic Signal Metabolism by Ecto-Nucleotide Phosphatase/Phosphodiesterases 4 and 1 and Implications in Stroke"  
  Albright, R.A., Ornstein, D.L., Cao, W., Chang, W.C., Robert, D., Tehan, M., Stabach, P. R., Hoyer, D., Liu, L., Yang, G., De La Cruz, E. M., Braddock, D.T., J Biol Chem, 1/7/2014
• "Desmoplastic Melanoma: A 12-year experience with sentinel lymph node biopsy"  
  Broer, P.N., Walker, M.E., Goldberg, C., Buonocore, S., Braddock, D.T., Lazova, R., Narayan, D., Ariyan, S., Eur J. Surg Oncol., 1/1/2013
• "NPP4 is a procoagulant enzyme on the surface of vascular endothelium"  
  Albright, R.A., Chang, W.C., Robert, D., Ornstein, D.L., Cao, W., Redick, M.E., Young, J.I., De La Cruz, E. M., Braddock, D.T., Blood, 1/1/2012
• "Kinetic Analysis of Autotaxin Reveals Substrate-specific Catalytic Pathways and a Mechanism for Lysophosphatidic Acid Distribution"  
  Saunders, L. P., Wenxiang Cao, W., Chang, W. C., Albright, W.A., Braddock, D. T.,* De La Cruz, E.M., Journal of Biological Chemistry, 1/1/2011
• "Autotaxin and lipid signaling pathways as anticancer targets"  
  Braddock, D.T., Current Opinion in Investigational Drugs, 1/1/2010
• "Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice"  
  Li, S., Ezhevsky, S., Dewin A., Cato, M.H., Scortegagna, M., Bhoumik A., Breitwieser W., Braddock, D., Eroshkin, A., Qi, J., Chen, M., Kim, J.-Y., Jones, S., Jones, N...., Genes and Cancer, 1/1/2010
• "Quantitative Characterization of the Interactions between c-myc Transcriptional Regulators FUSE, FBP and FIR"  
  Hsiao, H.-H., Nath, A., Lin, C.-Y., Folta-Stogniew, E.J., Rhoades, E. and Braddock, D.T., Biochemistry, 1/1/2010
• "Histopathologic and Molecular Aspects of CD56+ Natural Killer/T-Cell Lymphoma of the Testis"  
  Ornstein, D.L, Bifulco. C.B., Braddock D.T., and Howe, J.G., Int J Surg Pathol, 1/1/2008
• "Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition"  
  Crichlow, G. V., Zhou, H., Hsiao, H-H, Frederick, K. B., Debrosse, M., Yang, Y., Folta-Stogniew, E. J., Chung., H-J, Fan, C., De La Cruz, E. M., Levens, D.L., Lolis E...., EMBO, 1/1/2008
• "Small molecule inhibitors of Autotaxin inhibit melanoma cell migration and invasion"  
  Saunders, L.P., Ouellette, A., Bandle, R., Chang, W.C., Zhou, H., Misra, R.N., De La Cruz, E. M. and Braddock, D.T., Molecular Cancer Therapeutics, 1/1/2008
• "Benzoylanthranilic Acid Inhibitors of FBP Binding to the c-myc Promoter"  
  Huth, J.R., Liping, Y., Collins, I., Mack, Mendoza, R., Isaac, B., Braddock, D.T., Muchmore, S.W., Comess, K.M., Fesik, S.W., Clore, G.M., Levens, D., Hajduk, P.J., J. Med. Chem., 1/1/2004
• "The Solution Structure of a Complex between the KH3 domain of hnRNP K and Single Stranded DNA"  
  Braddock, D.T., Baber, J. L., Levens, D., and Clore, G. M., EMBO, 1/1/2002
• "Solution Structure and Dynamics of a Specific Complex Between the KH3 and KH4 Domains of FBP and the Single Stranded Far Upstream Element of C-Myc"  
  Braddock, D.T., Louis, J. M., Baber, J. L., Levens, D., and Clore, G. M., Nature, 1/1/2002
• "Rapid Identification of Medium to Large Scale Interdomain Motion in Modular Proteins using Dipolar Couplings"  
  Braddock,D.T., Cai, M., Baber, J. L., Huang, Y., and Clore, G. M., J. Am. Chem. Soc, 1/1/2001
• "Model for the molecular mechanism of HIV-associated neurological damage and dementia"  
  Caffrey, M., Braddock, D.T., Louis J.M., Abu-Asab, M.A., Kingma, D., Liotta, L., Tresser, N., Tsokos, M., Wingfield, P., and Clore, G.M., Journal of Biological Chemistry, 1/1/2000
• "Treatment of autoimmune premature ovarian failure"  
  Kalantaridou, S.N., Braddock, D.T., Patronas, N.J., and Nelson, L.M., Human Reproduction, 1/1/1999
• "Adrenal lymphocytic infiltration and adrenocortical tumors in a patient with 21-hydroxylase deficiency"  
  Merke D.P., Bornstein S.R., Braddock D., Chrousos G., New England Journal of Medicine, 1/1/1999
• "Structure-function relationships in side chain lactam cross-linked peptide models of a conserved N-terminal domain of apolipoprotein E"  
  Benzinger TLS, Braddock D.T., et. al, Biochemistry, 1/1/1998
• "A Conserved Anionic N Terminal Domain of Human Apolipoprotein E Increases the Binding of LDL to Cell Surface Receptors: Structure Function Relationships in Peptide Mo...  
  Braddock, D. T., Mercurius, K. O., Subramanian, R. M., Davies, P. F., Meredith, S. C., Biochemistry, 1/1/1996
• "Structural and Thermodynamic Characterization of a Bioactive Peptide Model of Apolipoprotein E: Side Chain Lactam Bridges To Constrain the Conformation"  
  Luo, P., Braddock, D. T., Subramanian, R. M., Meredith, S. C., and Lynn, D. G., Biochemistry, 1/1/1994
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Books/Book Chapters

• Proteomics in Cancer Research 
  Chapter: Structural Proteomics: High Throughput Determination of Whole Organismal Genomes 
  Braddock, D. T.Editors: Daniel C. Liebler.Wiley Press, Hoboken, NJ2005
• Molecular Biology of Atherosclerosis 
  Chapter: Secondary Structure of the Exon 3 Encoded Domain of Apolipoprotein E 
  Braddock, D. T., Kovatsits, P. G., and Meredith, S. C.Editors: Attie, A. D..Elsevier Science Publishing Co. Inc.1990