DavidMingdarWuMDPhD

Ophthalmology • Boston, MA

Retinal Disease

Assistant Professor of Ophthalmology / Vitreoretinal Surgery

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Office
Massachusetts Eye and Ear Infirmary
Retina Service - 243 Charles Street
Boston, MA 02114
Phone+1 617-573-3492

Fax+1 617-573-3698

Summary

Dr. David Wu is a vitreoretinal surgeon and scientist with Mass Eye and Ear’s Retina Service who sees patients and conducts retina research in Boston. He specializes in diseases of the retina, including retinal detachments, diabetic retinopathy, retinal vascular occlusions, epiretinal membranes, macular holes, age-related macular degeneration (AMD), retinal arterial and venous occlusions, and diabetic retinopathy. He has a particular interest in the repair of complex retinal detachments, including those secondary to proliferative vitreoretinopathy and diabetic-related traction.

Dr. Wu earned his MD/PhD from the University of Michigan Medical School and trained at the University of Michigan’s W.K. Kellogg Eye Center for his Ophthalmology Residency and a Medical Retina/Research Fellowship. He then completed his Vitreoretinal Surgery fellowship at the Doheny Eye Institute / University of Southern California and Los Angeles County Hospital (USC+LAC). He subsequently joined Mass Eye and Ear, building a respected clinical and surgical practice and a reputation as an educator and scientist before joining the faculty at the Wilmer Eye Institute/Johns Hopkins School of Medicine. He returns to Boston as the Joan Whitten Miller scholar in retina.

Dr. Wu is one of the few vitreoretinal surgeons with expertise in cutting-edge molecular techniques to advance research from bench to bedside. Clinically, he has been voted one of Boston Magazine’s Top Doctors since 2017. He is passionate about ophthalmology education and has won teaching awards for training students and residents through his career. In the laboratory, he has been funded by the NIH as well as private foundations and is the co-inventor of a gene therapy vector with the potential to treat AMD and retinal degenerations. He has presented nationally and internationally on retina surgery and retinal laboratory science, publishing multiple research and clinical manuscripts as well as book chapters.

Education & Training

University of Southern California/LAC+USC Medical CenterFellowship, Surgical Retina and Vitreous, 2010 - 2012
University of Michigan Health SystemResidency, Ophthalmology, 2006 - 2009
Grand Rapids Medical Education and Research Center/ Michigan State University (St Mary's)Internship, Transitional Year, 2005 - 2006
University of Michigan Medical SchoolClass of 2005
University of Michigan School of Public HealthPh.D., Neuroscience (Neuroscience Graduate Program), 1998 - 2003
University of Michigan, College of Literature, Sciences, and the ArtsB.S., Inteflex Program, With distinction, 1993 - 1997

Certifications & Licensure

CA State Medical License 2010 - 2026
MA State Medical License 2012 - 2025
MI State Medical License 2005 - 2025
MD State Medical License 2019 - 2021
American Board of Ophthalmology Ophthalmology

Awards, Honors, & Recognition

Award for Excellence in Resident Training Doheny Eye Institute/Keck School of Medicine, 2011
Selected to present at the AUPO Resident & Fellow Research Forum 2009
Walter R. Parker Award for Best Resident Teaching Second Place 2009
Fellow Heed and Society of Heed Fellows, 2009
George Slocum Award for Best Resident Research First place 2008
Walter R. Parker Award for Best Resident Teaching First Place 2008
James M. LaBerge Research Award 2008
George Slocum Award for Best Resident Research Third Place 2007
Selected to attend the Heed Foundation Resident Retreat 2007
Dean's Award for Research Excellence 2005
Duncan McCarthy Award Michigan Society for Neuroscience, 2003
Benjamin W. Zweifach Award The Microcirculatory Society, 2003
Best Graduate Student Poster Award Michigan Society for Neuroscience, 2002
Fundamentals in Vision Research Course (20 students from across the country selected to participate) National Eye Institute, 2002
Medical Student Geriatrics Scholar John A. Hartford/American Federation for Aging, 1997
Fight for Sight Medical Student Research Fellowship (awarded this fellowship, but declined it to accept Hartford Scholar award) 1997
Angell Scholar University of Michigan, 1996
Class Honors University of Michigan, 1995
Summer Biomedical Research Fellowship Program University of Michigan Medical School, 1994
International Science and Engineering Fair - Expense paid trip, poster presentation 1993
Southeastern Michigan Science Fair - First Place 1993
First Place Resident Research Competition Michigan Society of Eye Physicians and Surgeons
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Publications & Presentations

PubMed

15 citations
Association of the Affordable Care Act Medicaid Expansion with Dilated Eye Examinations among the United States Population with Diabetes.
Evan M. Chen, Grayson W. Armstrong, Jacob T. Cox, David M. Wu, Donald R. Hoover
Ophthalmology. 2020-07-01
143 citations
AAV cis-regulatory sequences are correlated with ocular toxicity
Wenjun Xiong, David M. Wu, Yunlu Xue, Sean K. Wang, Michelle Chung
Proceedings of the National Academy of Sciences of the United States of America. 2019-03-19
18 citations
AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa.
Yunlu Xue, Sean K. Wang, Parimal Rana, Emma R. West, Christin M Hong
Elife. 2021-04-13

Journal Articles

The electrotonic architecture of the retinal microvasculature: modulation by angiotensin II
Zhang T. Wu DM. Xu G. Puro DG., J Physiology, 1/1/2011
Diabetes-induced inhibition of voltage-dependent calcium channels in the retinal microvasculature: role of spermine
Matsushita K. Fukumoto M. Kobayashi T. Kobayashi M. Ishikazi E. Minami M. Katsumura K. Liao SD. Wu DM. Zhang T. Puro DG., IOVS, 1/1/2010
Long-term follow-up of a family with dominant X-linked retinitis pigmentosa
Wu, DM. Khanna, H. Atmaca-Sonmez, P. Sieving PA. Branham K. Othman M. Swaroop A. Daiger SP. Heckenlively JR., Eye, 1/1/2010
Electrotonic transmission within pericyte-containing retinal microvessels
Wu DM. Minami M. Kawamura H. Puro DG., Microcirculation, 1/1/2006
Effects of angiotensin II on the pericyte-containing microvasculature of the rat retina
Kawamura H. Kobayashi M. Li Q. Yamanishi S. Katsumura K. Minami M. Wu DM. Puro DG., J Physiology, 1/1/2004
Cholinergic regulation of pericyte-containing retinal microvessels
Wu DM. Kawamura H. Sakagami K. Kobayashi M. Puro DG., Am J Physiol Heart Circ Physiol, 1/1/2003
ATP: a vasoactive signal in the pericyte-containing microvasculature of the rat retina
Kawamura H. Sugiyama T. Wu DM. Kobayashi M. Yamanishi S. Katsuymura K. Puro DG., J Physiology, 1/1/2003
Cones regenerate from retinal stem cells sequestered in the inner nuclear layer of adult goldfish retina
Wu DM. Schneiderman T. Burgett J. Gokhale P. Barthel L. Raymond PA., IOVS, 1/1/2001
Dopamine activates ATP-sensitive K+ currents in rat retinal pericytes
Wu DM. Kawamura H. Li Q. Puro DG., Visual Neurosci, 1/1/2001
Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy
Sieving PA. Chaudhry P. Kondo M. Provenzano M. Wu D. Carlson TJ. Bush RA. Thompson DA., Proceedings of the National Academy of Sciences, 1/1/2001
Nitric oxide/cGMP-induced inhibition of calcium and chloride currents in retinal pericytes
Sakagami K. Kawamura H. Wu DM. Puro DG., Microvascular Research, 1/1/2001
Physiology of rat retinal pericytes: modulation of ion channel activity by serum-derived molecules
Sakagami K. Wu DM. Puro DG., J Physiology, 1/1/1999
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Press Mentions

Current Practice Preferences and Safety Protocols for Intravitreal Injection of Anti-Vascular Endothelial Growth Factor AgentsMarch 22nd, 2020
AbstractsFebruary 19th, 2021