DavidWilkesMD

Pulmonology • Indianapolis, IN

Critical Care Medicine

Executive Associate Dean for Research Affairs

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Office
Indiana University School of Medicine 340 W 10th Street
6200
Indianapolis, IN 46202
Phone+1 317-278-7020

Fax+1 317-278-8439

Education & Training

University of Texas Southwestern Medical CenterFellowship, Pulmonary Disease and Critical Care Medicine, 1989 - 1992
Temple University HospitalResidency, Internal Medicine, 1982 - 1985
Lewis Katz School of Medicine at Temple UniversityClass of 1982
Villanova UniversityB.S., Biology, 1974 - 1978

Certifications & Licensure

VA State Medical License 2016 - 2026
IN State Medical License 1992 - 2023
TX State Medical License 1986 - 1992
PA State Medical License 1983 - 1986
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

Certificate of Excellence, Chancellor’s Academic Honors Convocation Indiana University Purdue University, 2015
President’s Medal Indiana University, 2015
Award for Advancements in Science and Technology Center for Leadership Development, 2014
Alpha Omega Alpha 2014
Honorary Doctor of Science Wake Forest University, 2013
Who’s Who in the Life Sciences in Indiana Indianapolis Business Journal, 2011
Pedigo Lecturer, Department of Medicine Grand Rounds University of Louisville School of Medicine, 2009
Edward S. Cooper, M.D. Distinguished Lectureship, Department of Medicine Ground Rounds University of Pennsylvania School of Medicine, 2009
Renzetti Distinguished Lecturer, Department of Medicine Ground Rounds University of Utah School of Medicine, 2009
Award of Appreciation Central Indiana Sarcoidosis Support Group, 2008
Outstanding Faculty, Prestigious External Award Recognition Indiana University Purdue University, 2008
Bowman Society Lecturer Univ. Chicago School of Medicine, 2008
Latner Visiting Lecturer, Department of Surgery Univ. Toronto School of Medicine, 2008
Diversity Award Association of Professors of Medicine, 2007
Dudley F. Richardson, M.D. Lectureship University of Virginia School of Medicine, 2006
Who’s Who in Black Indianapolis 2003
Planning Committee Chair Award, Assembly on Allergy, Inflammation, and Immunology American Thoracic Society, 2002
Dr. Joseph T. Taylor Award for Distinguished Contributions to Indiana University Purdue University at Indianapolis 2002
Fellow American College of Physicians, 2001
Who’s Who of the American Thoracic Society 2001
Alvin S. Bynum Mentoring Award Indiana University Purdue University at Indianapolis, 2000
Fellow American College of Chest Physicians, 1999
Fundraising/Marketing Development Award American Lung Association of Indiana, 1997
Distinguished Award Center for Leadership Development, Inc., 1996
Most Outstanding Mentor Award: NIH Summer Student Research Program Indiana University School of Medicine, 1993
Harold Amos Medical Faculty Development Program Fellow Robert Wood Johnson Foundation, 1992
Fellowship, Outstanding Research Award Texas Thoracic Society, 1991
Outstanding Physician Award United States Air Force, R. L. Thompson Regional Hospital, 1987
Commendation Medal for Service United States Air Force, 1985
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Publications & Presentations

PubMed

10 citations
Obesity-related IL-18 Impairs T-Regulatory Cell Function and Promotes Lung Ischemia-Reperfusion Injury.
Tatiana Akimova, Tianyi Zhang, Lanette M Christensen, Zhonglin Wang, Rongxiang Han
American Journal of Respiratory and Critical Care Medicine. 2021-11-01
327 citations
Race and Genetic Ancestry in Medicine - A Time for Reckoning with Racism.
Luisa N. Borrell, Jennifer R. Elhawary, Elena Fuentes-Afflick, Jonathan Witonsky, Nirav R. Bhakta
The New England Journal of Medicine. 2021-01-06
11 citations
Acting Wisely: Eliminating Negative Bias in Medical Education-Part 2: How Can We Do Better?
Margaret Plews-Ogan, Taison Bell, Gregory C. Townsend, Randolph J. Canterbury, David S. Wilkes
Academic Medicine. 2020-12-01

Journal Articles

The HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury Induced Pulmonary Dysfunction
Weber D., Y.M. Allette, D.S. Wilkes, F.A. White, Antioxidants & Redox Signaling, 1/1/2015
Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation
Shah RJ, J.M. Diamond, E. Cant, J. Flesch, J.C. Lee, D.J. Lederer, V.N. Lama, J. Orens, A. Weinacker, D.S. Wilkes, D. Roe, S. Bhorade, K.M. Wille, L.B. Ware, S.M. Pa..., Am J Transplant, 1/1/2015
Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis
LEAD AUTHORS: Martinez, F.J., deAndrade, J., Anstrom K.J., King, T.E., Raghu G. COLLABORATORS: Martinez FJ, Raghu G, Schwarz M, Toews GB, Hunninghake G, Zibrak J, Deme..., N Engl J Med, 1/1/2014
An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome
Meyer KC, Raghu G, Verleden GM, Corris PA, Aurora P, Wilson KC, Brozek J, Glanville AR; ISHLT/ATS/ERS BOS Task Force Committee; ISHLT/ATS/ERS BOS Task Force Committee...., Eur Respir J, 1/1/2014
HMGB1-RAGE Axis Mediates Traumatic Brain Injury-induced Pulmonary Dysfunction in Lung Transplantation
Weber, D.J., M.S. Ripsch, A.J. Fisher, A.S.A. Gracon, M. Ripsch; A.J. Fisher; B.M. Cheon, P.H. Pandya, R. Vittal; M. Capitano; K. Youngsong; Y.M. Allete; K.M. Brown, ..., Science Translational Medicine, 1/1/2014
Lung Transplantation: Chronic Allograft Dysfunction and Establishing Immune Tolerance
Gracon, A.S., D.S. Wilkes, Human Immunology, 1/1/2014
Blockade of the Programmed Death-1 Pathway restores Sarcoidosis CD4+ T cells proliferative capacity
Braun, N.A., L.J. Celada, J.D. Herazo-Maya, S. Abraham, G. Shaginurova, C.M. Sevin., J. Grutters, D.A. Culver, R. Dworski, J. Sheller, P.P. Massion, V.V. Polosukhin..., American Journal of Respiratory and Critical Care Medicine, 1/1/2014
Elevated Plasma Angiopoietin-2-levels and Primary Graft Dysfunction after Lung Transplantation
Diamond, J.M., M.K. Porteous, E. Cantu, N. J Meyer, R. J. Shah; D. J. Lederer, S.M. Kawut; J.C Lee, S. Bellamy, S.M. Palmer, V. N. Lama, S. Bhorade, M. Crespo, E. Demi..., PlosOne, 1/1/2013
Allergic airway disease enhances inflammation during acute pulmonary vaccinia virus infection
Walline, C., S. Sehra, A. Fisher, L. Guindon, I. Kratzke, J. Montgomery, N.L. Glosson, H.L. Benson, D.S. Wilkes, R.R. Brutkiewicz, M.H. Kaplan, J.S. Blum, Plos One, 1/1/2013
Role of Complement Activation in Obliterative Bronchiolitis Post Lung Transplantation
Suzuki, H., M.E. Lasbury, L. Fan, R. Vittal, E.A. Mickler, H.L. Benson, R. Shilling, Q. Wu, D.J. Weber, S.R. Wagner, M. Lasaro, D. Devore, Y. Wang, G.E. Sandusky, K. L..., Journal of Immunology, 1/1/2013
Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosis
Kyra A. Oswald-Richter, K.A., B.W. Richmond, N.A. Braun, J. Isom, S. Abraham, T.R. Taylor, J.M. Drake, D.A. Culver, D.S. Wilkes, W.P. Drake, Journal of Immunology, 1/1/2013
Prednisone, Azathioprine, and N-acetylcysteine for Pulmonary Fibrosis
LEAD AUTHORS: Raghu G, Anstrom KJ, King TE Jr, Lasky JA, Martinez FJ. COLLABORATORS: Martinez FJ, Raghu G, Schwarz M, Toews GB, Hunninghake G, Zibrak J, Demersky A, V..., N Engl J Med, 1/1/2012
Donor Lung Derived Myeloid and Plasmacytoid Dendritic Cells Differentially Regulate T Cell Proliferation and Cytokine Production
Benson, H.L., H. Suzuki, J. Lott, A.J. Fisher, C. Walline, K.M. Heidler, R. Brutkiewicz, J.S. Blum, D.S. Wilkes, Respiratory Research, 1/1/2012
Endogenous MMP2 and MMP9 Regulate the Activation of CD4+ and CD8+ T Cells
Benson, H.L., S. Mobashery, M. Chang, F. Kheradmand, J.S. Hong, G.N. Smith, R. Shilling, D.S. Wilkes, American Journal of Respiratory Cell and Molecular Biology, 1/1/2011
Neutralizing IL-17 Prevents Obliterative Bronchiolitis in Murine Orthotopic Lung Transplantation
Fan, L., H.L. Benson, R. Vittal, E. A. Mickler, R. Presson, A.J. Fisher, O.W. Cummings, K.M. Heidler, M.R. Keller, W.J. Burlingham, D.S. Wilkes, Am J Transplant, 1/1/2011
Chronic Lung Allograft Rejection and Airway Microvasculature: Is HIF-1 the Missing Link?
Wilkes, D.S., Journal of Clinical Investigation, 1/1/2011
Diversifying Biomedical Training: A Synergistic Intervention Journal of Women and Minorities in Science and Engineering
Gibau, G.S.; Foertsch, J., Blum, J.S., Brutkiewicz, R., Queener, S. Roman, A., Rhodes, S. Sturek, M.,; Wilkes, D.S., Broxmeyer, H, J Women Minor Sci Eng, 1/1/2010
IL-17-dependent Autoimmunity to Collagen Type V in Atherosclerosis
Dart, M.L., E. Jankowska-Gan, D.A. Roenneburg, G. Huang, M.R. Keller, J.R. Torrealba, A. Rhoads, S. Marshall-Case, D.S. Wilkes, W.J. Burlingham, D.S. Greenspan, Circ Res, 1/1/2010
Type V Collagen-Induced Oral Tolerance Plus Low Dose Cyclosporine Prevents Rejection of MHC Class I and II Incompatible Lung Allografts
Yamada, Y., S. Yoshida, I. Petrache, H. Benson, D. Brand, I. Yoshino, Y. Sekine, D.S. Wilkes, J Immunol, 1/1/2009
Critical Role of Lysosomal Acid Lipase in T Cell Development and Function
Qu P, Du H, D.S. Wilkes, Yan C, American J Pathology, 1/1/2009
Immunobiology of Chronic Lung Allograft Dysfunction: New Insights from the Bench and Beyond
Shilling, R.S., D. S. Wilkes, Am J Transplant, 1/1/2009
A Breath of Fresh Air for Lung Transplant Recipients
Wilkes, D.S., Science Translational Medicine, 1/1/2009
Transfer of tolerance to collagen type V suppresses Th-17 lymphocyte mediated acute lung transplant rejection
Braun, R.K., M. Molitor-Dart, Z. Xiang, S.B. Fain, E Jankowska-Gan, C.M. Seroogy, W.J. Burlingham, D.S. Wilkes, D.D. Brand, J. Torrealba, R.B. Love, Transplantation, 1/1/2009
C4d Deposition and Cellular Infiltrates as Markers of Acute Rejection in Rat Models of Orthotopic Lung Transplantation
Murata, K., T. Iwata, S. Nakashima, K. Fox-Talbot, Z. Qian, D.S. Wilkes, W. M. Baldwin, Transplantation, 1/23/2008
Clinical Year in Review III: Interstitial Lung Disease, Occupational Lung Disease, Pulmonary Vascular Disease, Lung Transplantation
Wilkes, D.S., Proceedings of the American Thoracic Society, 1/1/2008
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Books/Book Chapters

Lung Transplantation
Chapter: Immunology of Lung Transplantation
Shilling, R.A., D.S. WilkesEditors: Wickii Vigneswaran and Edward Garrity.Informa Healthcare Publishers2010
Encyclopedia of Respiratory Medicine.
Chapter: CD11/CD18.
Page 338 - 342Wilkes, D.S. and T. Roberts-WebbEditors: Geoffrey J. Laurent and Steven D. Shapiro.Elsevier Ltd.2006
Immunobiology of Organ Transplantation.
Chapter: Dendritic Cells in Transplantation: Origin, Immune Activation, and Allograft Tolerance.
Swanson, K., D.S. WilkesEditors: D.S. Wilkes and W. Burlingham.Kluwer/Plenum Publishing Corporation2004
Immunobiology of Organ Transplantation.
Editors: Wilkes, D.S. and W. Burlingham.Kluwer/Plenum Publishing Corporation2004
Lung Macrophages and Dendritic Cells.
Chapter: Role of dendritic cells and alveolar macrophages in regulating pulmonary B cell function.
Page 335 - 372Weissler J.C. and D.S. WilkesEditors: Marcel-Dekker.1997
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Lectures

Autoimmunity post transplant: Is this simply an immune memory response?
Vail, CO - 1/1/2015
Emerging concepts in innate and adaptive immunity in airway fibrogenesis post lung transplantation.
Vail, CO - 1/1/2015
A Career in Academic Medicine – One Man’s Journey
1/1/2015
A career in Academic Medicine: One Man’s Journey.
Cleveland Clinic Foundation - 1/1/2014
Role of Complement Activation in BOS Post Lung Transplantation.
Cleveland Clinic Foundation - 1/1/2014
Immune Mechanisms Leading to Autoimmunity Following Organ Transplantation.
San Diego, CA - 1/1/2014
The Role of the Complement System in Pulmonary Dysfunction Among Traumatic Brain Injured Donors.
San Diego, CA - 1/1/2014
Role of Autoimmunity in the Pathogenesis of Chronic Lung Allograft Dysfunction.
San Francisco, CA - 1/1/2014
Autoimmunity to Type V Collagen: An Emerging Paradigm in Lung Disease.
Atlanta, GA - 1/1/2013
Role of Autoimmunity in the Pathogenesis of Idiopathic Pulmonary Fibrosis.
Cold Spring Harbor, NY - 1/1/2013
Professionalism in Medicine: Providing Comfort to our Patients
Indiana University School of Medicine - 1/1/2013
Randomized Phase 1 Trial of IW001 in Pulmonary Fibrosis.
La Jolla, CA - 1/1/2013
Art and Science of Lung Transplantation.
Indiana University Purdue University at Indianapolis - 1/1/2012
Careers in Academic Medicine
Indiana University School of Medicine - 1/1/2012
Careers in Academic Medicine: One Man’s Journey.
Northwestern University School of Medicine - 1/1/2012
Lung Transplantation: Are we there yet?
Northwestern University School of Medicine - 1/1/2012
Emerging Trends in BOS: Autoimmunity.
Prague, Czechoslovakia - 1/1/2012
Role of Autoimmunity in Lung Transplant Rejection
1/1/2012
Role of complement activation in the pathogenesis of obliterative bronchiolitis post lung transplantation.
Hartford, CT - 1/1/2011
Lung Transplantation: Are we there yet?
Indiana University School of Medicine - 1/1/2011
Potential Role of Complement Activation in Obliterative Bronchiolitis.
Pittsburg, PA - 1/1/2011
A Career in Science and Medicine – One Man’s Journey.
Temple University School of Medicine, Philadelphia, PA - 1/1/2011
Role of IL-17 in Obliterative Bronchiolitis.
Vail, CO - 1/1/2011
Update on Autoimmunity in Lung Transplantation
Vail, CO - 1/1/2011
The Future of Immune Modulation in the Clinical Setting.
1/1/2011
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Other

Lung Transplantation (interview for “Sound Medicine”)
Wilkes D, National Public Radio
1/1/2005
Videotape – NIH T35 Summer Research Program
D.S. Wilkes - Executive Producer
1/1/2000
Smoking & Pregnancy - Invited guest
Wilkes D, Channel 13 News
1/1/1995
Invited guest to discuss "Deep venous thrombosis and pulmonary emboli"
Wilkes D, Health News-Channel 13 News
1/1/1994
Tuberculosis
Wilkes D, Health Talk-Channel 16 TV Show
1/1/1994
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Press Mentions

Dr. David S. Wilkes Appointed to Syneos Health Board of DirectorsJune 16th, 2021
Melina R. Kibbe Named Dean of UVA School of MedicineJune 9th, 2021
U.Va. Names New Medical School DeanJune 9th, 2021
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Grant Support

IU Training Prog. In Molecular Physiology And Clinical Mechanisms Of Lung DiseaseNational Heart, Lung, And Blood Institute2009–2012
TH17 Autoimmunity To Type V Collagen In Heart And Lung TransplantNational Institute Of Allergy And Infectious Diseases2010–2011
IL-17A And Anti-Col (V) Humoral Immunity In Lung Allograft RejectionNational Institute Of Allergy And Infectious Diseases2010–2011
Administrative CoreNational Institute Of Allergy And Infectious Diseases2010–2011
Role Of Anti-Col (V) Immunity In Primary Graft DysfunctionNational Heart, Lung, And Blood Institute2010–2011
Type V Collagen Prevents Lung Allograft RejectionNational Heart, Lung, And Blood Institute2001–2011
MMPS In Alloimmune And Autoimmune Lung DiseaseNational Heart, Lung, And Blood Institute2005–2008
Immune Responses In Lung Allograft RejectionNational Heart, Lung, And Blood Institute1999–2006
Innovative Methods For Immune Tolerance In Lung Transpl*National Heart, Lung, And Blood Institute2001–2003
Short-Term Training For Minority StudentsNational Heart, Lung, And Blood Institute1999–2003
Accessory Cells In Lung Allograft RejectionNational Heart, Lung, And Blood Institute1997–2000
Accessory Cells And Lung Allograft RejectionNational Heart, Lung, And Blood Institute1996
Role Of Type V Collagen In Lung Allograft RejectionNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1995–1996
Regulation Of B Cells In Human LungNational Center For Research Resources1995