DavidJTweardyMD

PubMed

• 4 citations
  Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis.
  Prema Robinson, Kelsey Montoya, Emily Magness, Emma Rodriguez, Viviana Villalobos
  Cancers. 2023-05-30
• 4 citations
  Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers.
  Moses M Kasembeli, Efiyenia Kaparos, Uddalak Bharadwaj, Ahmad Allaw, Alain Khouri
  Blood. 2023-03-23
• 21 citations
  Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease.
  Jingjing Jiao, Jessica I Sanchez, Omar A Saldarriaga, Luisa M Solis, David J Tweardy
  JHEP Reports. 2023-02-01

Journal Articles

• Adult Intracranial Tuberculoma Case Series from Houston, Texas: a report of 13 consecutive patients  
  Kelly JD, Teeter LD, Graviss EA and Tweardy DJ, Scand J Infect Dis, 10/1/2011
• IL-6-Mediated Activation of Stat3 alpha Prevents Trauma/Hemorrhagic Shock-Induced Liver Inflammation  
  Moran A, Thacker SA, Arikan AA, Mastrangelo MA, Wu Y, Yu B and Tweardy DJ, PLoS ONE, 6/29/2011
• Stat5: From Breast Development to Cancer Prognosis, Prediction, and Progression  
  Tweardy DJ and Chang JC, J Clin Oncol, 6/1/2011
• Stat3 Signaling in Acute Myeloid Leukemia: Ligand-dependent and –Independent Activation, and Induction of Apoptosis by a Novel Small Molecule Stat3 Inhibition  
  Redell MS, MJ Ruiz, TA Alonzo, RB Gerbing and DJ Tweardy, Blood, 3/9/2011
• Leukemic transformation by the APL fusion protein PRKAR1A-RARa critically depends on recruitment of RXRa  
  Qiu J, X Lu, BB Zeisig, Z Ma, X Cai, S Chen, H Gronemeyer, DJ Tweardy, CW Eric So, S Dong, Blood, 1/1/2010
• Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis  
  Garza A, Tweardy DJ, Weinstock J, Viswanathan B, Robinson P, J Biomed Biotechnol, 1/1/2010
• “Personalizing” academic medicine: opportunities and challenges in implementing genomic profiling  
  Tweardy DJ and Belmont JW, Transl Res, 12/1/2009
• Chemical probes that competitively and selectively inhibit Stat3 activation  
  Xuejun X, MM Kasembeli, X Jiang, BJ Tweardy and DJ Tweardy, PLoS ONE, 3/10/2009
• Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6 mediated activation of Stat3  
  Moran A, AI Tsimeltzon, MA Mastrangelo, W Yong, B Yu, SA Hilsenbeck, V Poli, and DJ Tweardy, Clinical and Tranlational Science, 1/1/2009
• SH2 domain binding to phosphopeptide ligands: potential for drug targeting  
  Kasembeli MM, X Xu and DJ Tweardy, Front Biosci, 1/1/2009
• Substance P is required for the pathogenesis of EMCV infection in mice  
  Robinson P, Garza A, Moore J, Eckols TK, Parti S, Balaji V, Vallejo J, Tweardy DJ, Int J Clin Exp Med, 1/1/2009
• Acute bacterial pneumonia is associated with the occurrence of acute coronary syndromes  
  Corrales-Medina VF, Serpa J, Rueda AM, Giordano TP, Bozkurt B, Madjid M, Tweardy DJ, Musher DM, Medicine (Baltimore), 5/1/2008
• Substance P receptor antagonism for treatment of cryptosporidiosis in immunosuppressed mice  
  Robinson P, Martin Jr P, Garza A, D' Souza M, Mastrangelo M, Tweardy DJ, J Parasitol, 3/11/2008
• Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3  
  Alten JA, Moran A, Tsimelzon AI, Mastrangelo MA, Hilsenbeck SG, Poli V, Tweardy DJ, PLoS ONE, 2/13/2008
• Prevention of trauma/hemorrhagic shock-mediated liver apoptosis and inflammation by exogenous IL-6-mediated activation of Stat3  
  Moran M, A Arikan-Akan, MA Mastrangelo, Y Wu, B Yu, DJ Tweardy, Int J Clin Exp Med, 1/1/2008
• Substance P receptor antagonist reverses intestinal pathophysiological alterations occurring in a novel ex-vivo model of Cryptosporidium parvum infection of intestinal...  
  Garza A, Lackner A, Aye P, D'Souza M, Martin P Jr, Borda J, Tweardy DJ, Weinstock J, Griffiths J, Robinson P, J Med Primatol, 1/1/2008
• STAT3 isoforms, alpha and beta , demonstrate distinct intracellular dynamics with prolonged nuclear retention of STAT3beta mapping to its unique C-terminal end  
  Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy DJ, J Biol Chem, 9/12/2007
• Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis  
  Hernandez J, Lackner A, Aye P, Mukherjee K, Tweardy DJ, Mastrangelo MA, Weinstock J, Griffiths J, D'Souza M, Dixit S, Robinson P, Infect Immun, 1/1/2007
• Aberrant Chromatin Remodeling by Retinoic Acid Receptor alpha Fusion Proteins Assessed at the Single-Cell Level  
  Qiu J, Huang Y, Chen G, Chen Z, Tweardy DJ, Dong S, Mol Biol Cell, 1/1/2007
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  Redell MS, Tsimelzon A, Hilsenbeck SG, Tweardy DJ, J Leukoc Biol, 1/1/2007
• Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci  
  Shelburne SA 3rd, Greenberg SB, Aslam S and Tweardy DJ, J Infect, 7/7/2006
• IL-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock  
  Arikan AA, B Yu, MA Mastrangelo and DJ Tweardy, Crit Care Med, 1/1/2006
• Decreased intranuclear mobility of acute myeloid leukemia 1-containing fusion proteins is accompanied by reduced mobility and sequestration of core binding factor beta  
  Qiu J, J Wong, DJ Tweardy and S Dong, Oncogene, 1/1/2006
• Suppression of head and neck tumor growth by targeting Stat3 with G-quartet oligonucleotides: a novel strategy for cancer therapy  
  Jing N, Zhu Q, Li Y, Yuan P, Mao L and DJ Tweardy, Mol Cancer Ther, 1/1/2006
• Unique structural determinants for signal transducer and activator of transcription (STAT)3 recruitment and activation by the granulocyte colony-stimulating factor rec...  
  Shao H, X Xu, N Jing and DJ Tweardy, J Immunol, 1/1/2006
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Books/Book Chapters

• The Cytokine Handbook (4th Edition) 
  Chapter: Granulocyte colony-stimulating factor 
  Page 525 - 546White SM and DJ TweardyEditors: A Thompson and M Lotze.Academic Press, LondonEdition 4th ,2003
• Proceedings of the Fourth International Congress on the Immunological Consequences of Trauma, Sepsis and Shock 
  Chapter: G-CSF and IL-6 are produced in the lung in hemorrhagic shock where they contribute to the recruitment and activation of neutrophils 
  Page 595 - 599Hierholzer C, JC Kalff, L Omert, TR Billiar, and DJ TweardyEditors: Eugene Faist.Monduzzi Editore, Bologna, Italy1996
• Molecular Biology of Haematopoiesis 
  Chapter: G-CSF receptor signaling involves SRC-related and non-SRC related tyrosine kinases with evidence of a three-component complex 
  Page 607 - 619Tweardy DJ, AL Burkhardt, J Bolen, RL Geahlen and SJ CoreyIntercept Ltd, Andover, Hampshire1994
• Hematopoiesis. UCLA Symposia on Molecular and Cellular Biology 
  Chapter: Monoclonal antibodies to an IL-3-receptor protein 
  Page 133 - 143Morel PA, K Townsend, M Gross, JM Chiller, and DJ TweardyEditors: SC Clark and DW Golde.Alan R. Liss, Inc., New York1990
• Phenotypic and Functional Aspects of Hematopoiesis 
  Chapter: Granulopoiesis: In search of growth and differentiation of regulatory genes 
  Rovera G, DJ Tweardy, D Santoli, B Kreider, M Valtieri, I Gemperlein, and F MavilioEditors: Grignani F, MF Martelli, and KY Mason.Raven Press, NY1988
• Identification of stimulatory and suppressor growth factors 
  Chapter: Proliferation and differentiation of human myelogenous leukemia and preleukemia cells in culture 
  Page 104 - 110Rovera G, DJ Tweardy, D Santoli, S Altmann, M Valtieri, and B Lange1987
• Immune Regulation by Characterized Peptides. UCLA Symposia on Molecular and Cellular Biology, New Series 
  Chapter: T leukemia-derived suppressor lymphokine (TLSL): Biology and biochemistry 
  Page 485 - 494Tweardy DJ, D Santoli, B Dietzschold, MJ Wheelock, SW Altmann, and G RoveraEditors: G. Goldstein, JF Bach, and H Wigzell.Alan R. Liss, Inc., NY1986
• Current Controversies in Therapeutics 
  Chapter: Lithium maintenance therapy of manic depressive disorders 
  Tweardy DJ, YMM Bishop, AP Donner, GL Klerman, OL Peterson, P Reich, LM Lister-Rosenoer, VM Rosenoer, and BA RosnerEditors: VM Rosenoer.SP Medical Scientific Books, New York, NY1980
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Lectures

• Drugging STAT proteins to treat inflammation and cancer 
  Internal Medicine and Cancer Survivorship Grand Rounds, UT M.D. Anderson Cancer Center, Houston, TX - 11/16/2012
• Drugging STAT proteins to treat cancer and inflammatory disorders 
  Verna and Marrs McLean Department of Biochemistry and Molecular Biology Research Seminar, Baylor Col - 4/26/2012
• Contributions of Abnormal Proteostasis to Cellular Dysfunction 
  Plenary Symposium Presentation, 34th Annual Conference on Shock, Norfolk, VA - 6/12/2011
• Modulating the damage response to treat disease 
  Department of Medicine Grand Rounds, Baylor College of Medicine, Houston, TX - 9/30/2010
• Modulating Stat3 activity to treat disease 
  Department of Medicine Grand Rounds, UT M.D. Anderson Cancer Center, Houston, TX - 8/20/2010
• Chemical probes that competitively and selectively inhibit Stat3 activation 
  Invited Speaker: Novartis Institute for Biomedical Research, Cambridge, MA - 9/18/2009
• Chemical probes that target cancer stem cells 
  Invited Speaker: Department of Cancer Biology Seminar Series, MD Anderson Cancer Center, Houston, TX - 9/8/2009
• Controlling Inflammation and Apoptosis to Reduce Susceptibility to Acute Bacterial Infections 
  Invited Speaker: Novartis Institute for Biomedical Research, Cambridge, MA - 8/18/2009
• Update on Sepsis 
  Grand Rounds, St. Luke’s Episcopal Hospital, Houston, TX - 2/9/2009
• Translating Science into Personalized Health Care: the View from Baylor College of Medicine 
  Invited Speaker: Ohio State’s Inaugural Personalized Health Care National Conference, Columbus, OH - 10/16/2008
• Harnessing the protein-folding machinery to modulate programmed cell death (apoptosis) and treat disease 
  Invited Speaker: Grand Challenges for Collaborative Nanomedicine: Bridging Basic and Clinical Resear - 5/8/2008
• Interplay of Inflammation, Apoptosis and Infection 
  Grand Rounds, UT M.D. Anderson Cancer Center, Houston, TX - 4/25/2008
• Stat3 and TRiC interactions in apoptosis control 
  Invited Speaker: 2008 Center for Protein Folding Machinery 3rd Annual Retreat, University of Califor - 4/5/2008
• Signal transducer and activator of transcription (STAT) 3 in apoptosis control 
  Invited Speaker: Baylor College of Medicine Center for Protein Folding Machinery - 4/1/2008
• Update on West Nile Virus 
  Lecturer, Current Clinical Issues in Primary Care, Pri-Med Southwest, Houston TX - 3/6/2008
• Structure-Assisted Targeting of Signal Transducer and Activator of Transcription (STAT) 3 for Cancer Treatment and Chemical Genetics 
  Invited Speaker: University of Houston, Department of Biology and Biochemistry - 4/26/2006
• Sepsis: Recent insights into pathogenesis and new approaches to treatment and prevention 
  Invited Speaker: Creighton University School of Medicine, Department of Medicine Grand Rounds - 3/29/2006
• Enhancing or eliminating signals for cell survival to treat disease 
  Invited Speaker: American Clinical and Climatological Association, Santa Barbara, CA, 2005; Invited - 11/7/2005
• Sepsis: Recent insight into its pathogenesis and new approaches to therapy 
  Invited Speaker: Medical College of Wisconsin, Department of Medicine Grand Rounds - 5/7/2004
• Cytokine-directed therapies in acute inflammation: IL-6 administration in resuscitated hemorrhagic shock 
  Invited Speaker: Biology of Inflammation Grand Rounds - 3/3/2004
• Targeting Stat3 interactions for cancer therapy 
  Invited Speaker: MD Anderson Cancer Center, Bioimmunotherapy Lecture Series - 5/6/2003
• Structural requirements for design of peptidomimetics targeting Stat3 activation by the EGFR 
  Proceedings of the American Association for Cancer Research - 1/1/2003
• Inhibition of Stat3 activity by G-quartet oligodeoxynucleotides 
  Proceedings of the American Association for Cancer Research - 1/1/2003
• Stat3 in Cell Growth and Differentiation 
  Invited Speaker, Department of Pathology, University of Texas at Houston, 1999; Invited Speaker: MD - 3/10/2001
• G-CSF: From bench to bedside and back 
  Invited Speaker: Roswell Park Cancer Institute, Buffalo, NY, Medical Grand Rounds - 5/12/2000
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