DavidEThalerMDPhD, FAHA

PubMed

• 17 citations
  Association of Atrial Septal Aneurysm and Shunt Size With Stroke Recurrence and Benefit From Patent Foramen Ovale Closure.
  Jean-Louis Mas, Jeffrey L Saver, Scott E Kasner, Jason Nelson, John D Carroll
  JAMA Neurology. 2022-11-01
• Treatment Effects in Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale-Reply.
  David M Kent, Jeffrey L Saver, David E Thaler
  JAMA. 2022-04-12
• 110 citations
  Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke.
  David M Kent, Jeffrey L Saver, Scott E Kasner, Jason Nelson, John D Carroll
  JAMA. 2021-12-14

Journal Articles

• Patient Selection for PFO Closure Based on the RoPE Study  
  Thaler DE, Cardiac Interventions Today, 1/1/2014
• Recurrent stroke predictors differ in medically treated patients with pathogenic vs other PFOs  
  Thaler DE, Ruthazer R, Weimar C. et. al., Neurology, 1/1/2014
• Association of Ischemic Stroke, Hormone Therapy, and Right to Left Shunt in Postmenopausal Women  
  NC, Liebeskind DS, Gevorgyan R, Truong T, Cua B, Tseng C, Dodick DW, Demaerschalk BM, Thaler DE, Tobis JM, Catheterization and Cardiovascular Interventions, 1/1/2014
• Do We Know, or Do We Believe?  
  Thaler DE and C. Kimmelstiel, Cath Cardiovasc Interv, 1/1/2013
• Response to letter regarding article, “Critique of Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale: The Hole Truth?”  
  Thaler DE and Wahl A, Stroke, 1/1/2013
• Closure of patent foramen ovale versus medical therapy after cryptogenic stroke  
  Carroll JD, Saver JL, Thaler DE, Smalling RW, Berry S, MacDonald LA, Marks DS, Tirschwell DL for the RESPECT Investigators, NEJM, 1/1/2013
• Management strategies for asymptomatic carotid stenosis: A systematic review and meta-analysis  
  Raman G, Moorthy D, Hadar N, Dahabreh IJ, O’Donnell TF, Thaler DE, Feldmann E, Lau J, Kitsios GD, Ann Internal Med, 1/1/2013
• Bilateral subperiosteal hemorrhage of the orbit  
  Dibner MS, Carmody J, Strominger M, Kapadia M, and Thaler DE, Neurology, 1/1/2012
• Critique of Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale: The Hole Truth?  
  Thaler DE, Wahl A, Stroke, 1/1/2012
• The Risk of Paradoxical Embolism (RoPE) Study: Initial description of the completed database  
  Thaler DE, Di Angelantonio E, Di Tullio MR, Donovan JS, Elkind MSV, Griffith J, Homma S, Jaigobin C, Mas JL, Mattle HP, Michel P, Mono ML, Nedeltchev K, Papetti F, Rut..., International Journal of Stroke, 1/1/2012
• Recurrent stroke on imaging and presumed paradoxical embolism: a cross-sectional analysis  
  Kitsios GD, Lasker A, Singh J, Thaler DE, Neurology, 1/1/2012
• Stroke due to late device thrombosis following successful percutaneous patent foramen ovale closure  
  Korabathina R, Thaler DE, Kimmelstiel, Catheterization and Cardiovascular Interventions, 1/1/2012
• The Risk of Paradoxical Embolism (RoPE) Study: Developing risk models for application to ongoing randomized trials of percutaneous patent foramen ovale closure for cry...  
  Kent DM, Thaler DE, Trials, 1/1/2011
• Rethinking trial strategies for stroke and patent foramen ovale  
  Thaler DE, Kent DM, Curr Opinion Neurol, 1/1/2010
• Patent Foramen Ovale in Cryptogenic Stroke: Incidental or Pathogenic? A Systematic Review and Bayesian Approach  
  Alsheikh-Ali AA, Thaler DE, Kent DM, Stroke, 1/1/2009
• Patent foramen ovale and MRI: can imaging the brain tell us about the heart?  
  Thaler DE and DM Kent, Eur J Neurol, 1/1/2009
• Patent foramen ovale and cryptogenic stroke (letter to the editor)  
  Kent DM, Thaler DE, Trikalinos, NEJM, 1/1/2008
• Stroke prevention – Insights from incoherence  
  Kent DM and Thaler DE, NEJM, 1/1/2008
• Cryptogenic stroke and patent foramen ovale  
  Thaler DE, Saver JL, Curr Opinion Cardiol, 1/1/2008
• A Review of Stroke DRG Mortality Rate as a Quality of Care Measure  
  Hwang SW, Salem D, Thaler D, Heilman CB, AAANS Bulletin, 1/1/2007
• Is patent foramen ovale closure effective in reducing migraine symptoms? A controlled study  
  Kimmelstiel C, Gange C, Thaler D, Catheter Cardiovasc Interv, 1/1/2007
• Data that may shed some light on: “arguments insisting on randomized trials for PFO closure  
  Carrol J, Onorato E, Saver J, Smalling R, Thaler D, Tobis J, Catheter Cardiovasc Interv, 1/1/2007
• Coma, Evoked Potentials, Blood Tests, and Crystal Balls  
  Thaler DE, Journal Watch: Neurology, 1/1/2006
• Risk factors for untreated hypertension in hemorrhagic stroke  
  Thaler DE, Journal Watch: Neurology, 1/1/2004
• Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke  
  Sanchez-Moreno C, Dashe JF, Scott T, Thaler D, Folstein MF, Martin A, Stroke, 1/1/2004
• Join now to see all

Books/Book Chapters

• Imaging Cerebrovascular Disease 
  Chapter: Cerebral infarction during its subacute stage 
  Thaler DE, Sloan MA, Babikian VLEditors: Babikian VL, Wechsler LR, Higashida RT.Butterworth-Heinemann, Philadelphia, PA2003
• Oxford Handbook of Clinical Medicine: American Edition 
  Thaler D, Longmore M, and Hope ROxford University Press1999

Abstracts/Posters

• Anticoagulation versus Antiplatelet Therapy in Patients with Cryptogenic Stroke and Patent Foramen Ovale: An Adjusted Individual Patient Data and RoPE Score-Stratified...
  Kent DM, Dahabreh IJ, Ruthazer R, Furlan A, Weimar C, Serena J, Meier B, Mattle HP, Di Angelantonio E, Paciaroni M, Schuchlenz H, Homma S, Jaigobin C, Lutz JS, Thaler DE, European Stroke Conference, Nice, France, 1/1/2014
• Predictors Differ in Patients With ‘Probable Pathogenic’ Versus Other PFOs
  Thaler DE, Ruthazer R, Angelantonio ED, Di Tullio MR, Donovan JS, Elkind MS, Griffith J, Homma S, Jaigobin C, Mas JL, Mattel HP, Michel P, Mono ML, Nedeltchev K, Papet..., International Stroke Conference, Honolulu, HI, 1/1/2013
• An Analysis of ‘High Risk’ Features on Transesophageal Echocardiography in the Risk of Paradoxical Embolism Database
  Wessler B, Thaler DE, Di Tullio MR, Ruthazer R, Weimar C, Mas JL, Serena J, Angelantonio ED, Donovan JS, Elkind MS, Griffith J, Jaigobin C, Mattle HP, Michel P, Mono M..., International Stroke Conference, Honolulu, HI, 1/1/2013
• Late Adverse Events of Patent Foramen Ovale Closure: A Systematic Review
  Nelson S, Green A, Rhodes J, Thaler DE, International Stroke Conference, Honolulu, HI, 1/1/2013
• Cryptogenic Stroke and Patent Foramen Ovale: Posterior Circulation Strokes Are More Common In Men Than In Women
  Thaler DE, Ruthazer R, Angelantonio ED, Di Tullio MR, Donovan JS, Elkind MS, Griffith J, Homma S, Jaigobin C, Mas JL, Mattle HP, Michel P, Mono ML, Nedeltchev K, Papet..., International Stroke Conference, Honolulu, HI, 1/1/2013
• Qualifying and Outcome Strokes in the RESPECT PFO Trial: Additional Evidence of Treatment Effect
  Saver JL, Thaler D, Smalling R, Carroll JD, Berry S, MacDonald L, Marks D, Tirschwell D, Book D, Goldstein L, International Stroke Conference, Honolulu, HI, 1/1/2013
• Late Adverse Events of Patent Foramen Ovale Closure: A Systematic Review
  Nelson S, Green A, Rhodes J, Thaler DE, Annual Meeting of the American Academy of Neurology, San Diego, CA, 1/1/2013
• Further Analysis of Confirmed Endpoint Recurrent Strokes in Patent Foramen Ovale Patients in the RESPECT Trial
  Thaler DE, JL Saver, Smalling R, Carroll JD, EuroPCR Annual Meeting, Paris, France, 1/1/2013
• Dissection in the Veterans Administration (DIVA): Re-examining spinal manipulation and cervical artery dissection
  Thaler DE, Cai X, Razmara A, Paulus JK, Switkoski K, Goryachev SD, D’Avolio L, Fariborz PJ, Feldmann E, Annals of Neurology, Annual Meeting of the American Neurological Association, Boston, MA, 1/1/2012
• Warfarin use in patients with cryptogenic stroke and patent foramen ovale is guided by radiological and echocardiographic features and not by conventional vascular ris...
  Thaler DE, Di Tullio MR, Elkind MSV, Homma S, Jaigobin C, Mas JL, Mattle HP, Michel P, Mono ML, Nedeltchev K, Papetti F, Ruthazer R, Serena J, Weimar C, Kent DM, European Stroke Conference, Lisbon, 1/1/2012
• Hormone Replacement Therapy and Right-to-Left Intracardiac Shunts are More Prevalent in Post-menopausal Women with Cryptogenic Stroke
  Truong T, Gevorgyan R, Greep N, Tseng C-H, Liebeskind D, Demaerschalk B, Dodick D, Thaler DE, Tobis J, JACC, American College of Cardiology’s Scientific Sessions, Chicago, IL, 1/1/2012
• An Index to Identify Cryptogenic Stroke Patients whose Stroke is likely Attributable to Patent Foramen Ovale
  Kent DM; Ruthazer R, Weimar C, Serena J, Mas J-L; Homma S, Michel P, Elkind MS, Nedeltchev K, Mono M-L, Mattle H, DiTullio M, Thaler DE, International Stroke Conference, New Orleans, LA, 1/1/2012
• Superficial and Large Infarcts on Neuroimaging in Patients with Cryptogenic Stroke are Associated with the Presence or Absence of Patent Foramen Ovale
  Thaler DE, Ruthazer R, Weimar C, Serena J, Mas J-L, Homma S, Michel P, Elkind MS, Nedeltchev K, Mono M-L, Mattle H, DiTullio M, Kent DM, Stroke, International Stroke Conference, New Orleans, LA, 1/1/2012
• Stroke Study Using Evoked Potentials (SSEP): Feasibility and Proof of Principle
  Kornbluth JA, Feldmann E, Bergethon P, Alhumayyd Z, Clervil P, Clark-Coller M, Thaler DE, American Academy of Neurology Annual Meeting, Honolulu, HI, 1/1/2011
• The Risk of Paradoxical Embolism (RoPE) Study: Initial description of the complete database
  Thaler DE, Kent DK for the RoPE Investigators, European Stroke Conference, Hamburg, Germany, 1/1/2011
• Radiological Findings in Patients with Cryptogenic Stroke and Patent Foramen Ovale
  Thaler DE, Lasker A, Singh J, Kitsios GD, American Academy of Neurology Annual Meeting, Honolulu, HI, 1/1/2011
• Factors Supportive of a Diagnosis of Paradoxical Embolism in Patients with Cryptogenic Stroke and Patent Foramen Ovale Are Not Associated with Radiological Markers of ...
  Kitsios GD , Singh J, Lasker A, Thaler DE, American Academy of Neurology Annual Meeting, Honolulu, HI, 1/1/2011
• Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment Trial
  Thaler DE, Carroll J, Saver JL; Smalling R, Van Dorn B, International Stroke Conference, Los Angeles, CA, 1/1/2011
• The definition of cryptogenic stroke and the investigations needed to diagnose it are not consistent across studies
  Bonow RH, Thaler DE, Kent DM, European Stroke Conference, Barcelona, Spain, 1/1/2010
• Risk Profile of Subjects Enrolled in the Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment (RESPECT) Tr...
  Thaler DE, Book DS, Carroll JD, Goldstein LB, Lutsep HL, Saver JL, Smalling RW, Tirschwell DL, Van Dorn BM, and the RESPECT Trial Investigators, American Academy of Neurology Annual Meeting, Toronto, 1/1/2010
• Antiplatelet vs Anticoagulant Therapy Recommended as Best Medical Care in the Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current St...
  Tirschwell DL, Book DS, Carroll JD, Lutsep HL, Pettigrew LC, Saver JL, Smalling RW, Thaler DE, Van Dorn BM, Goldstein LB, and The RESPECT Trial Investigators, International Stroke Conference, San Antonio, TX, 1/1/2010
• Randomized evaluation of recurrent stroke comparing PFO closure to established current standard of care treatment (RESPECT) trial
  Thaler DE, Saver JL, Carroll JD, Smalling RW, Lyle CT, Veltum-Dockter K, International Stroke Conference, San Francisco, CA, 1/1/2007
• The clinical features of retinal ischemia in the Tufts-New England Medical Center patent foramen ovale (PFO) Database
  Thaler DE, Neurology, 58th Annual Meeting of the American Academy of Neurology, San Diego, CA, 1/1/2006
• Reduction in Migraine Symptoms Following PFO Closure: A Controlled Study
  Kimmelstiel CD, Gange C, Lyle C, Thaler DE, Stroke, 31st International Stroke Conference, Kissimmee, FL, 1/1/2006
• Thaler DE, O’Toole M, 28th International Stroke Conference, Phoenix, AZ, 1/1/2003
• Join now to see all

Lectures

• PFOs should be closed in patients with cryptogenic stroke 
  Copenhagen, Denmark - 1/1/2014
• PFO and Stroke: Let me show you the RoPE 
  Massachusetts General Hospital Stroke Service, Boston, MA - 1/1/2014
• Spinal Manipulation therapy and arterial dissection 
  Boston, MA - 1/1/2014
• PFO and Stroke: Finally Some Data 
  1/1/2014
• How to identify the patient with PFO stroke 
  La Jolla, CA - 1/1/2014
• Patent Foramen Ovale and Stroke: Finally some evidence 
  Tufts Medical Center, Boston, MA - 1/1/2014
• Practical Management of PFOs 
  Harvard Medical School, Dept of Continuing Education, Boston, MA, 2013, 2014 - 1/1/2014
• Closing PFOs for Strokes … Finally we have some data?!? 
  New Paultz, NY - 1/1/2013
• Patent Foramen Ovale and Stroke: Finally some data 
  Multiple locations, 2013 - 1/1/2013
• The PFO: News from Trials and RESPECT: A deep dive into the data 
  Milan, Italy - 1/1/2013
• Update on PFO, Trials and tribulations 
  San Francisco, CA - 1/1/2013
• Patent Foramen Ovale and Stroke, Finally some data 
  Beth Israel Deaconess Medical Center, Needham, MA - 1/1/2013
• How to attribute a stroke to a PFO: facts and models 
  Zurich, Switzerland - 1/1/2013
• PFO closure would benefit from a CHADS-Like score to select the patients who will benefit 
  San Francisco, CA - 1/1/2013
• The Case of Ms LL: Spinal manipulation therapy and vertebral artery dissection 
  Yale-New Haven Hospital, New Haven, CT - 1/1/2012
• Cryptogenic stroke vs PFO Stroke? Neurology perspectives, Late breaking clinical trials – RESPECT, PC Trial 
  Miami, FL - 1/1/2012
• Risk of Paradoxical Embolism (RoPE) Study 
  Frankfurt, Germany - 1/1/2012
• Patent Foramen Ovale: Epidemiology, Evidence, and Trial Design 
  Lawrence Memorial Hospital, Medford, MA, 2012 ; Melrose-Wakefield, Medford, MA, 2012 - 1/1/2012
• Vertebral Dissection following Chiropractic Manipulation - What is the Risk? 
  Boston Medical Center (Boston University), Boston, MA - 1/1/2012
• PFO Closure for Stroke Prevention: Meta-Analysis Evidence from Non-Randomized Trials 
  San Francisco, CA - 1/1/2011
• Stroke in the Young – A Case-Based Approach 
  Milton Hospital, Milton, MA - 1/1/2011
• Plenary Session XVII, PFO Closure for Stroke Prevention and Migraine Treatment 
  San Francisco, CA - 1/1/2011
• Left Atrial Appendage Closure: Indications, Devices, and Techniques 
  San Francisco, CA - 1/1/2011
• PFO and Stroke: Case Closed 
  Yale University, New Haven, CT - 1/1/2011
• Overview of PFO/Stroke Studies, PFO Propensity and Recurrence Risk and How Does a Neurologist Determine that a PFO Caused a Stroke? 
  Boston, MA - 1/1/2011
• Join now to see all

Other

• Supplementary Motor Cortex and the Control of Action 
  Thaler D
  1/1/1988
• Differing Predictors for Recurrent Stroke Among Treated Patients With Possible Incidental PFO 
  Thaler DE, PracticeUpdate website
  http://www.practiceupdate.com/journalscan/11250
  1/12/2014