DavidBSykesMDPhD
Hematology • Boston, MAClotting Disorder, Myeloproliferative Disorder Hematology-Oncology
Mass General Hospital Division of Hematology
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Office
55 Fruit St
Boston, MA 02114Phone+1 617-724-4000Fax+1 617-724-6801
Education & Training
Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 2007 - 2011
Massachusetts General HospitalResidency, Internal Medicine, 2004 - 2007
University of California San Diego School of MedicineClass of 2004
Certifications & Licensure
MA State Medical License 2006 - 2025- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Hematology
- American Board of Internal Medicine Medical Oncology
Publications & Presentations
PubMed
- 128 citationsThe novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.Sven Christian, Claudia Merz, Laura Evans, Stefan Gradl, Henrik Seidel
Leukemia. 2019-04-02 - 306 citationsInhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid LeukemiaDavid B. Sykes, Youmna Kfoury, Francois Mercier, Mathias Wawer, Jason M. Law
Cell. 2016-09-22 - 80 citationsInduction of a Timed Metabolic Collapse to Overcome Cancer ChemoresistanceNick van Gastel, Jessica B. Spinelli, Azeem Sharda, Amir Schajnovitz, Ninib Baryawno
Cell Metabolism. 2020-08-06
Abstracts/Posters
- Functionally Distinct Subsets of Monocytes in Mouse and Human BloodDavid B Sykes, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
- What Links Neutropenia to Immature Cardiolipin in Patients with Barth Syndrome (tafazzin-deficiency)?David B Sykes, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to StressDavid B Sykes, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Press Mentions
Telangiectasias: When Is It TEMPI Time?October 19th, 2022- Case Records of the Massachusetts General HospitalMarch 29th, 2022
- Case Records for the MGHMarch 28th, 2022
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Professional Memberships
- Member
Other Languages
- French
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