David K Simon MD PhD

PubMed

• Automated Imaging Differentiation for Parkinsonism.
  David E Vaillancourt, Angelos Barmpoutis, Samuel S Wu, Jesse C DeSimone, Marissa Schauder
  JAMA Neurology. 2025-03-17
• Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies.
  Daoyuan Huang, Jingchao Wang, Li Chen, Weiwei Jiang, Hiroyuki Inuzuka
  Biomolecules. 2025-02-07
• Polygenic scores for disease risk are not associated with clinical outcomes in Parkinson's disease.
  Manuela Mx Tan, Hirotaka Iwaki, Sara Bandres-Ciga, Yuri Sosero, Maryam Shoai
  Medrxiv. 2025-02-03

Journal Articles

• Peripheral Biomarkers of Parkinson's Disease Progression and Pioglitazone effects  
  Simon DK, Simuni T, Elm J, Clark-Matott J, Graebner AK, Baker L, Dunlop SR, Emborg M, Kamp C, Morgan JC, Ross GW, Sharma S, Ravina B, on behalf of the NET-PD FS-Zone I..., J Parkinson’s Dis, 1/1/2015
• Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial  
  FS-ZONE Investigators (Simon DK), Lancet Neurology, 1/1/2015
• Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice  
  Dai Y, Clark J, Zheng K, Kujoth GC, Prolla TA, Simon DK, Neurotoxicology and Teratology, 1/1/2014
• Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation  
  Dai Y, Zheng K, Clark J, Swerdlow RH, Pulst SM, Sutton JP, Shinobu LA, Simon DK, Human Mol Genet, 1/1/2014
• No Sex Differences in Use of Dopaminergic Medication in Early Parkinson Disease in the US and Canada - Baseline Findings of a Multicenter Trial  
  Umeh CC, Perez A, Augustine EF, Dhall R, Dewey RB, Mari Z, Simon DK, Wills AA, Christine CW, Schneider JS, Suchowersky O, PLoS ONE, 1/1/2014
• Behavioral and metabolic deficits in heterozygous and homozygous POLG mutator mice  
  Dai Y, Kiselak T, Clark J, Clore E, Zheng K, Cheng A, Kujoth GC, Bilotti K, Cantuti-Castelvetri I, Prolla TA, Maratos-Flier T, Simon DK, Mitochondrion, 1/1/2013
• Somatic Mitochondrial DNA Mutations and Parkinsonism  
  Lin MT, Cantuti-Castelvetri I, Lees AJ, Beal MF, Simon DK, Ann Neurol, 1/1/2012
• Somatic mtDNA mutations in early Parkinson and incidental lewy body disease  
  Lin MT, Cantuti-Castelvetri I, Zheng K, Jackson KE, Tan YB, Arzberger T, Lees AJ, Betensky RA, Beal MF, Simon DK, Ann Neurol, 1/1/2012
• An inverse-Warburg effect and the origin of Alzheimer’s disease  
  Demetrius LA, Simon DK, Biogerontology, 1/1/2012
• Assessment of the interaction of UCHL1 and NAT2 genotypes with the risk and age at onset of Parkinson’s disease  
  Göbel A, Macklin EA, Winkler S, Klein C, Lohmann K, Simon DK, J Neurol, 1/1/2012
• Design Innovations and Baseline Findings in a Long-Term Parkinson’s Trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson’s  
  Elm JJ, The NINDS NET-PD Investigators (Simon DK), Movement Disorders, 1/1/2012
• The Utility of laser-generated visual-cueing in Parkinsonian patients with freezing of gait  
  Donovan S, Lim C, Rose P, Sudarsky LR, Tarsy D, Simon DK, Parkinsonism & Related Disorders, 1/1/2012
• Mitochondrial Dysfunction in Parkinson’s Disease  
  Simon DK, Chu CT, Swerdlow RH, Parkinsons Dis, 1/1/2011
• Do Somatic Mitochondrial DNA Mutations Contribute to Parkinson’s Disease?  
  Clark J, Dai Y, Simon DK, Parkinsons Dis, 1/1/2011
• Laser Light Cues for Gait Freezing in Parkinson’s Disease  
  Donovan S, Lim C, Diaz N, Browner N, Rose P, Sudarsky LR, Tarsy D, Fahn S, Simon DK, Parkinsonism & Related Disorders, 1/1/2011
• The c-237_236GA>TT THAP1 sequence variant does not increase risk for primary dystonia  
  Xiao J, Zhao Y, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello RC, Wszolek ZK, Uitti RJ, Van Gerpen JA, Simon DK, Tarsy D, Hedera P, Truong DD, ..., Movement Disord, 1/1/2011
• Narratives of medication induced hallucinations, delusions and compulsive behaviors in Parkinson’s disease  
  Friedman JH, Agarwal P, Alcalay R, Black KJ, Chou KL, Cote L, Dayalu P, Frank S, Hartlein J, Hauser RA, Lang AE, Marek K, Marsh L, Marshall F, Moskowitz C, Ravina B, R..., Int J Neurosci, 1/1/2011
• Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease  
  Clark J, Reddy S, Zheng K, Betensky RA, Simon DK, BMC Med Genet, 1/1/2011
• Mitochondrial DNA Haplogroups and Mutations in Pediatric Acquired Central Demyelination  
  Venkateswaran S, Zheng K, Sacchetti M, Gagne D, Arnold DL, Sadovnick AD, Scherer SW, Banwell B, Bar-Or A, Simon DK; on behalf of the Canadian Pediatric Demyelinating D..., Neurology, 1/1/2011
• Association of cumulative lead exposure with Parkinson's Disease  
  Weisskopf MG, Weuve J, Nie H, Saint-Hilaire M-H, Sudarsky L, Simon DK, Hersh B, Schwartz J, Wright RO, Hu H, Environmental Health Perspect, 1/1/2010
• Maternal Inheritance and Mitochondrial DNA Variants in Familial Parkinson Disease  
  Simon DK, Pankratz N, et al, for the Parkinson Study Group – PROGENI Investigators, BMC Medical Genetics, 1/1/2010
• MELAS Syndrome, Cardiomyopathy, Rhabdomyoloysis and autism associated with the A3260G Mitochondrial DNA Mutation  
  Connolly BS, Feigenbaum ASJ, Robinson BH, Dipchand DI, Simon, DK, Tarnopolsky MA, Biochem Biophys Res Commun, 1/1/2010
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  Clark J, Clore E, Zheng K, Sacchetti M, Masliah E, Simon DK, PLoS ONE, 1/1/2010
• Transcribe to Survive: Transcriptional Control of Antioxidant Defense Programs for Neuroprotection in Parkinson’s Disease  
  Clark J, Simon DK, Antioxidants & Redox Signaling, 1/1/2009
• Identification of a novel ataxia-associated mtDNA mutation (T9035C) and evaluation of its pathogenicity in transmitochondrial cybrids  
  Sikorska M, Sandhu JK, Simon DK, Pathiraja V, Sodja C, Li Y, Ribecco-Lutkiewicz M, Lanthier P, Borowy-Borowski H, Upton A, Raha S, Pulst S, Tarnopolsky MA, Muscle & Nerve, 1/1/2009
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Books/Book Chapters

• Encyclopedia of Movement Disorders 
  Chapter: Complex I Deficiency. 
  Simon DKEditors: Kompoliti K, and Verhagen Metman L.Academic Press, Oxford2010
• Encyclopedia of Movement Disorders 
  Chapter: Mitochondrial Encephalopathies 
  Simon DKEditors: Kompoliti K, and Verhagen Metman L.Academic Press, Oxford2010
• Textbook of Geriatrics and Gerontology, commional. 
  Chapter: Parkinson’s Disease 
  Simon DKEditors: Kyung-Hwan Cho.Medical Publishing Company, Seoul, Korea2010
• Encyclopedia of the Neurological Sciences 
  Chapter: Mitochondrial Encephalopathy, Lactic Acidosis and Stroke (MELAS) 
  Page 196 - 197Simon DKEditors: MJ Aminoff and RB Daroff.Academic Press, San Diego, CA2003
• Genetics of Movement Disorders 
  Chapter: Chapter 41: Mitochondrial Mutations in Parkinson's Disease and Dystonia 
  Page 473 - 490Simon DKEditors: S. Pulst.Academic Press2002
• Parkinson's Disease.: Diagnosis and Clinical Management 
  Chapter: Chapter 27: Pathogenesis: Oxidative Stress, Mitochondria Dysfunction and Excitotoxicity. 
  Simon DK, Beal MFEditors: SA Factor WJ Weiner.Demos Vermande, New York, NY2001
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Abstracts/Posters

• Multifocal Repetitive Transcranial Magnetic Stimulation Improves Motor and Mood Symptoms of Parkinson’s Disease Equally to a Sham Stimulation: Results of the MASTER-PD...
  Brys M, Biagioni M, Agarwal S, Dacpano G, Kumar P, Pirraglia L, Gray Z, Simon DK, Wu A, Fernandez H, Chen R, Wagle Shukla A, Lou JS, Di Rocco A, Pascual-Leone A, Movement Disorders Society Annual Meeting, San Diego, CA, 1/1/2015
• A Multi-Center, Double-Blind, Phase II Study of Pioglitazone in Early Parkinson’s Disease.
  NET-PD Investigators (Simon DK), Movement Disorders Society Annual Meeting, San Diego, CA, 1/1/2015
• Personality and Quality of Life Assessments Before and After Deep Brain Stimulation Surgery in Patients with Parkinson’s Disease.
  Newlon M, O’Connor M, Kapust L, Pierce C, Silver A, Simon DK, Tarsy D, Papavassiliou E, Alterman R, Shih LC, Movement Disorders Society Annual Meeting, San Diego, CA, 1/1/2015
• Biomarkers of pioglitazone effects in Parkinson’s Disease.
  Simon DK, Simuni T, Elm J, Clark J, Graebner A, Ravina B, on behalf of the NET-PD Investigators, Movement Disorders Society Annual Meeting, San Diego, CA, 1/1/2015
• Incidence of dyskinesia improvement following subthalamic DBS without medication reduction.
  Solis-Cohen L, Simon DK, Tarsy D, Alterman R, Shih LC, Movement Disorders Society Annual Meeting, San Diego, CA, 1/1/2015
• Dance exercise is an effective alternative to multimodal physical therapy to improve balance in Parkinson’s disease.
  Vanderhorst V, Harrier D, Snyder A, Shillue K, Oconnor M, Goodman N, Simon DK, Shih L, Tarsy D, Movement Disorders Society Annual Meeting, San Diego, CA, 1/1/2015
• Head Injury at Early Ages is Associated with Risk of Parkinson’s Disease
  Simon DK, American Academy of Neurology (AAN) annual meeting, Washington, DC, 1/1/2015
• Effect of endurance exercise on the brain of Polg mutator mice. (abstract 5804) Selected for presentation at Nanosymposium Session 392, Brain Wellness: Metabolism and ...
  Clark J, Saleem A, Wang R, Dai Y, Ma X, Safdar A, Tarnopolsky M, Simon DK, Society for neuroscience Annual Meeting, Washington, DC, 1/1/2014
• Effects of Coenzyme Q10 in PSP, A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study.
  Apetauerova D, Standaert D, Yacoubian T, Hamill R, Simon D, Scala S, Movement Disorders Society Annual Meeting, 1/1/2014
• PD Therapeutics Conference
  Simon D, Michael J Fox Foundation, 1/1/2012
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Lectures

• Clinical Trials and Slowing Progression of Parkinson’s Disease 
  Newton, MA - 1/6/2015
• ECG features and Autonomic Dysfunction in Parkinson’s Disease 
  Sanibel, FL - 1/1/2015
• Trial design for clinical studies of potential neuroprotective agents in Parkinson’s disease. 
  1/1/2015
• Clinical trial design for potential neuroprotective agents. 
  1/1/2015
• Medical Treatment of Parkinson’s Disease 
  1/1/2015
• Clinical Genetic Testing in Parkinson’s Disease 
  1/1/2015
• PD101. Parkinson’s Disease Overview. 
  1/1/2015
• Basic Science Breakthroughs. 
  1/1/2015
• Caffeine, creatine and genotype interactions with respect to progression of Parkinson’s Disease. 
  Sanibel, FL - 1/1/2015
• Biomarkers of PD Progression and Pioglitazone Effects 
  Sanibel, FL - 1/1/2015
• Genetics of PD and the Relevance of Genetic testing. 
  Brown University Medical School - 1/1/2015
• Tourette Syndrome and restless legs 
  BIDMC and Harvard medical School - 1/1/2015
• Diagnosis of Parkinson’s disease and early treatment. 
  BIDMC and Harvard medical School - 1/1/2015
• Slower is better: Slowing progression of Parkinson’s Disease 
  Beth Israel Deaconess Medical Center - 1/1/2015
• Movement Disorders Video Case Rounds 
  BIDMC and Harvard medical School - 1/1/2015
• Neuroprotection in Parkinson’s Disease 
  Nguyen Tri Phuong Hospital, Saigon, Vietnam - 1/14/2014
• Genetics, Mitochondrial Dysfunction and Neuroprotection in Parkinson’s Disease 
  1/1/2014
• Neuroprotection in Parkinson’s disease. 
  1/1/2014
• Neuroprotection in Parkinson’s disease: The present and the future. 
  Tufts Medical Center, Boston, MA - 1/1/2014
• Caffeine and progression of PD 
  St. Louis, MO - 1/1/2014
• Biomarkers of pioglitazone effects in PD 
  St. Louis, MO - 1/1/2014
• The Brain 
  1/1/2013
• Neuroprotection and Clinical Trial Design in Parkinson’s disease 
  1/1/2013
• Mitochondrial Dysfunction and Neuroprotection in Parkinson’s Disease 
  University of Pittsburgh School of Medicine, Pittsburgh, PA - 1/1/2012
• The Causes of Parkinson’s disease. 
  1/1/2012
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Other

• Dystonia. 
  Simon DK, Tarsy D, Shih LC, BMJ Point of Care
  www.pointofcare.bmj.com
  1/1/2014
• Pioglitazone and neuroprotective therapies for Parkinson’s disease (Interview). 
  Simon D, Healthday
  1/1/2014
• Mitochondrial Disorders (Interviewed as an expert) 
  Simon D, Yahoo Sports
  1/1/2008
• Parkinson's Disease 
  Simon D, Channel 56, 10pm local news
  Boston, MA - 1/1/2005
• Development of Topographic Order in the Mammalian Retinocollicular Projection (Ph.D. Thesis) 
  Simon D
  1/1/1990
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