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David Scadden, MD, Hematology, Boston, MA

DavidTScaddenMD

Hematology • Boston, MA

Hematologic Oncology

Gerald and Darlene Jordan Professor of Medicine; Professor of Stem Cell and Regenerative Biology, Harvard University. Chair, Center for Regenerative Medicine, Massachusetts General Hospital. Co-director, Harvard Stem Cell Institute.

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  • Office

    185 Cambridge Street
    Boston, MA 02114
    Phone+1 617-726-5615
    Fax+1 617-726-4691

Summary

  • I am a physician-scientist with board certification in Hematology and Medical Oncology. I focus on hematopoiesis and the hematopoietic stem cell niche in blood disorders. My laboratory is split between the Massachusetts General Hospital and Harvard Department of Stem Cell and Regenerative Biology both within the Harvard Stem Cell Institute. I focus on translating hematopoietic biology to therapy and have co-founded the public companies Fate Therapeutics and Magenta Therapeutics. I am a director for Magenta, Editas and Agios.

Education & Training

  • Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer Institute
    Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 1983 - 1987
  • Brigham and Women's Hospital
    Brigham and Women's HospitalResidency, Internal Medicine, 1980 - 1983
  • Case Western Reserve University School of Medicine
    Case Western Reserve University School of MedicineClass of 1980

Certifications & Licensure

  • MA State Medical License
    MA State Medical License 1982 - 2025
  • American Board of Internal Medicine Internal Medicine
  • American Board of Internal Medicine Hematology
  • American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

  • Honorary Doctorate Case Western Reserve University, 2019
  • Donal Metcalf Award International Society for Experimental Hematology, 2019
  • Visiting scholar Cambridge University, Pembroke College, UK, 2019
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Clinical Trials

Publications & Presentations

PubMed

Abstracts/Posters

  • A Specific Mesenchymal Stem and Progenitor Cell (MSPC) Subpopulation with a Multi-Potent Gene Signature Is Transcriptionally Altered in the Setting of Myelodysplastic ...
    David T. Scadden, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
  • Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress
    David T. Scadden, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
  • Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting
    David T. Scadden, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
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Lectures

  • Deciphering Clonal Evolution and Dissemination of Multiple Myeloma Cells In Vivo 
    2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Other

Press Mentions

  • Will We All Soon Live in Cancerland?
    Will We All Soon Live in Cancerland?December 17th, 2021
  • Changing the Identity of Cancer Cells to Eliminate Them
    Changing the Identity of Cancer Cells to Eliminate ThemDecember 1st, 2021
  • Off-the-Shelf Stem Cell Company Forms, Gains $72M
    Off-the-Shelf Stem Cell Company Forms, Gains $72MSeptember 24th, 2021
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Grant Support

  • Mechanisms Of Hematopoiesis In AIDSNational Heart, Lung, And Blood Institute1996–2012
  • Building The Hematopoietic Stem Cell NicheNational Institute Of Biomedical Imaging And Bioengineering2011
  • Stromal Regulation Of Bone MetastasisNational Cancer Institute2011
  • Stem Cell Engagement Of The NicheNational Heart, Lung, And Blood Institute2010–2011
  • Microenvironmental Control Of Progenitors In Organ Dysfunction And RepairNational Heart, Lung, And Blood Institute2009–2011
  • Harvard Stem Cell Institute Training Program For Pre- And Post-Doctoral FellowsNational Heart, Lung, And Blood Institute2008–2011
  • Enhancement Of Stem Cell Engraftment And Immune Recovery Following HematopoieticNational Cancer Institute2010
  • Center For Regenerative Medicine (CRM) Support For New Faculty MemberNational Heart, Lung, And Blood Institute2009–2010
  • Dynamic Interactions Between Stem Cells And Their Niche.National Institute Of Diabetes And Digestive And Kidney Diseases2007–2010
  • Targeted Manipulation Of Stem Cells For AIDS TherapyNational Heart, Lung, And Blood Institute2001–2010
  • Stem Cell Engagement Of The NicheNational Heart, Lung, And Blood Institute2009
  • Mesenchyme Organizers Of Organ Development, Maintenance And RepairNational Heart, Lung, And Blood Institute2009
  • Enhancement Of Stem Cell Engraftment And Immune Recovery Following HematopoieticNational Cancer Institute2006–2009
  • Specialized Center For Cell Based TherapyNational Heart, Lung, And Blood Institute2005
  • Oral Immune Responses In Human And Simian Herpesvirus InfectionNational Institute Of Dental &Craniofacial Research2003–2005
  • Boston AIDS Malignancy ConsortiumNational Cancer Institute1999–2004
  • Functional Isolation Of Human Hematopoietic Stem CellsNational Institute Of Diabetes And Digestive And Kidney Diseases1995–2004
  • Oral Immune Responses In Human And Simian Herpesvirus InfectionNational Institute Of Dental &Craniofacial Research2001–2002
  • T Cell Neogenesis After Stem Cell TransplantationNational Institute Of Allergy And Infectious Diseases2000–2002
  • Core--DevelopmentalNational Institute Of Allergy And Infectious Diseases2000–2002
  • COL-3 In HIV Associated Kaposi'S SarcomaNational Center For Research Resources2000–2002
  • Hematopoietic Cell TrackingNational Cancer Institute2000–2002
  • Kaposi'S Sarcoma Herpesvirus As Target For Immunotherapy In Multiple MyelomaNational Cancer Institute1998–2002
  • Boston AIDS Oncology Training ProgramNational Cancer Institute1998–2001
  • Immunobiology Of HHV8 In Kaposis SarcomaNational Cancer Institute1996–2000
  • Comparative Biology Of Hematopoietic Stem CellsNational Heart, Lung, And Blood Institute1995–1999
  • Boston AIDS Malignancies ConsortiumNational Cancer Institute1995–1998
  • Mechanisms Of Hematopoiesis In AIDSNational Heart, Lung, And Blood Institute1994–1995
  • Immunoconjugate Therapy For Relapsed AIDS LymphomaNational Cancer Institute1994
  • Adoptive Immunotherapy For AIDS LymphomaNational Cancer Institute1994
  • Immunoconjugate Therapy For Relapsed AIDS LymphomaNational Cancer Institute1993
  • Biological Approaches To AIDS LymphomaNational Cancer Institute1993
  • Adoptive Immunotherapy For AIDS LymphomaNational Cancer Institute1993
  • Mechanisms Of Hematopoiesis In AIDSNational Heart, Lung, And Blood Institute1991–1993
  • Biological Approaches To AIDS LymphomaNational Cancer Institute1991–1992
  • Leukemia In AKR Mouse: Studies On Retroviral ReceptorNational Cancer Institute1989–1990
  • Leukemia In The AKR Mouse: Studies On The Retroviral RENational Cancer Institute1988
  • Leukemia In AKR Mouse: Studies On Retroviral ReceptorNational Cancer Institute1988

Professional Memberships

Dr. David Scadden, Dr. David Scadden, MD, Dr. D Scadden, Dr. David T Scadden