DavidGMutchMD

PubMed

• A toolkit for a modern gynecologic oncology tissue bank.
  Olivia Graham, Jeimmy Rodriguez, Rachel Abbott, Elena Lomonosova, Bisiayo Fashemi
  Gynecologic Oncology. 2024-10-01
• Prophylactic antibiotics for excision of premalignant vulvar lesions: A pilot randomized controlled trial.
  Mary M Mullen, Whitney R Grither, Hannah Millimet, David G Mutch, Andrea R Hagemann
  Gynecologic Oncology Reports. 2024-10-01
• 1 citations
  Phase I and Randomized Phase II Study of Ruxolitinib With Frontline Neoadjuvant Therapy in Advanced Ovarian Cancer: An NRG Oncology Group Study.
  Charles N Landen, Ronald J Buckanovich, Michael W Sill, Robert S Mannel, Joan L Walker
  Journal of Clinical Oncology. 2024-07-20

Journal Articles

• Therapeutic Inhibition of the Receptor Tyrosine Kinase AXL Improves Sensitivity to Platinum and Taxane in Ovarian Cancer  
  Ian S Hagemann, Premal H Thaker, Carolyn K McCourt, Katherine C Fuh, David G Mutch, Andrea R Hagemann, Matthew A Powell, Clinical Cancer Research
• Endometrial Carcinoma Recurrence According to Race and Ethnicity: An NRG Oncology/Gynecologic Oncology Group 210 Study  
  M L Pearl, D S Miller, W T Creasman, P H Thaker, J F Boggess, S R Guntupalli, D G Mutch, J L Walker, O B Ioffe, D E Cohn, L S Downs, International Journal of Cancer
• Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer  
  Ian S Hagemann, Carolyn K McCourt, Matthew A Powell, Premal H Thaker, David G Mutch, Katherine C Fuh, Andrea R Hagemann, Clinical Cancer Research
• Role of computed axial tomography of the chest in staging patients with nonmetastatic gestational trophoblastic disease.  
  Mutch, D.G., Soper, J.T., Baker, M.E., Bandy, L.C., Cox, E.B., Clarke-Pearson, D.L., and Hammond, and C.B, Obstet. Gynecol; 68:348-352
• Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal anti¬body.  
  Budwit, D.A., Cox, E.B., Soper, J.T., Mutch, D.G., McCarty, K.S., Sr., Creasman, W.T., and McCarty, K.S., and Jr, Cancer Res; 46:5419-5425
• Long-term effects on bladder function following radical hysterectomy with and without postoperative radiation.  
  Bandy, L.C., Clarke-Pearson, D.L., Soper, J.T., Mutch, D.G., MacMillan, J., and Creasman, and W.T, Gynecol. Oncol; 26:160-168
• Histologic composition of endometrial carcinoma analyzed for steroid receptor content.  
  Soper, J.T., Cox, E.B., Budwit, D.A., Mutch, D.G., Creasman, W.T., McCarty, K.S., Sr., amd McCarty, K.S., and Jr, Am. J. Obstet. Gynecol; 157:26-27
• Endometrial adenocarcinoma receptor content: Association of clinicopathologic features with standard biochemical determination.  
  Mutch, D.G., Budwit, D.A., Cox, E.B., Soper, J.T., Creasman, W.T., McCarty, K.S., Sr., and McCarty, K.S., and Jr, Am. J. Obstet. Gynecol; 157:924-931
• Small cell undifferentiated carcinoma of the cervix: A clinicopathologic, ultrastructural and immunocytochemical study of 15 cases.  
  Gersell, D.J., Mazoujian, G., Mutch, D.G., and Rudloff, and M.A, Am. J. Pathol; 12(9):684-698
• Renal metastases in gestational trophoblastic disease: A report of eight cases.  
  Soper, J.T., Mutch, D.G., Chin, N.O., Clarke-Pearson, D.L., Hammond, C.B, Obstet. Gynecol; 72:796- 798
• Endometrial cancer: Histologic correlates of immunohisto¬chemical localization of progesterone receptor and estrogen receptor.  
  Segreti, E.M.; Novotny, D.B.; Soper, J.T.; Mutch, D.G.; Creasman, W.T. and McCarty, K.S, Obstet. Gynecol; 73:780-785
• An in vitro analysis of the anticancer potential of tumor necrosis factor (TNF) in combination with cisplatin.  
  Mutch, D.G., Kao, M.S., Powell, C.B. and Collins, J.L, Gyn. Onc; 34:328
• Dexamethasone used as an antiemetic in chemotherapy protocols inhibits Natural Cytotoxic (NC) activity.  
  Powell, C.B.; Mutch, D.G.; Kao, M.S.; Kao, J.W.; Perry, D.L.; Westphale, E. and Collins, J.L, Cancer; 65:80
• Estrogen and progesterone receptor content of endome¬trial carcinomas: Comparison of total tissue versus cancer component analy¬sis.  
  Soper, J.T., Segreti, E.M., Novotny, D.B., Mutch, D.G., Creasman, W.T. and McCarty Jr., K.S, Gyn Onc; 36:363-368
• Ex¬pression of a resistance mechanism in ovarian and cervical carcinoma cells prevents their lysis by Interferon gamma.  
  Massad, L.S., Mutch, D.G., Powell, C.B., Kao, M.S. and Collins, J.L, Can Res; 50:4923-4928
• Recurrent gestational trophoblastic neoplasm (GTN): Experience of the Southeastern Regional Trophoblastic Disease Center (SRTDC).  
  Mutch, D.G., Soper, J.T., Babcock, C.J., Creasman, W.T., and Hammond, C.B, Cancer; 66:978-982
• Common expression of a tumor necrosis factor resistance mechanism among gynecological malignancies.  
  Powell, C.B., Mutch, D.G., Kao, M.S., Massad, L.S. and Collins, J.L, Cancer Immunol Immunotherapy; 32:131-136
• Prolif¬erative and antiproliferative effects of interferon gamma and tumor necrosis factor-? on cell lines derived from cervical and ovarian malignancies.  
  Mutch, D.G., Massad, L.S., Powell, C.B., Kao, M.S. and Collins, J.L, Am J OB GYN; 163:1920-1924
• Inhibi¬tion of protein synthesis increases the lytic effects of tumor necrosis factor alpha and interferon gamma in cell lines derived from gynecologic malignan¬cies.  
  Massad, L.S., Mutch, D.G., Powell, C.B., Kao, M.S. and Collins, J.L, Cancer Immunol Immunotherapy; 33:183-188
• Resistance to lysis by TNF? in malignant gynecologic cell lines is associated with the expression of protein(s) that prevent the activation of phospholipase A2 by TNF?  
  Mutch, D.G., Powell, C.B., Kao, M.S. and Collins, J.L, Cancer Res; 52:866-872.
• Populations with high rates of atypical cervical cytology: Occurrence and clinical significance.  
  Pearlstone, A.C., Grigsby, P.W. and Mutch, D.G, Obstetrics and Gynecology; 80:191-195
• The effects of cy¬closporin-A on the lysis of ovarian cancer cells by cisplatin or adriamycin.  
  Mutch, D.G., Herzog, T.J., Chen, C.H. and Collins J.L, Gynecol Oncol; 47:28-33
• Effects of radiation on TNF? mediated cytolysis of cell lines derived from cervical carcinomas.  
  Herzog, T.J., Nelson, K.P., Mutch, D.G., Kao, M.S. and Collins J.L, Gyn Oncol; 47:196-202
• Divergent effects of taxol on TNF?-mediated cytolysis of ovarian carcinoma cells.  
  Williams S., Mutch, D.G., Kao, M.S., and Collins, J.L, Am J OB GYN; 167:1870-1876
• The use of speculoscopy in the evaluation of women with atypical papinicolaou smears: Improved cost effectiveness by selective colposcopy.  
  Massad L. S., Lonky N. M., Mutch, D.G., Mann, W.J., Blanco, J.S., Vasilev, S.A., and Finan M.A, J Reprod Med; 38(3): 163-169
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Books/Book Chapters

• Conn's Current Therapy. 
  Chapter: Carcinoma of the uterine cervix 
  Mutch, D.GEditors: Rakel, R.W.B. Saunders Company
• Clinical Gynecologic Oncology. 
  DiSaia PJ, Creasman WT, Mannel RS, McMeekin DS, Mutch DGEditors: DiSaia PJ, Creasman WT, Mannel RS, McMeekin DS, Mutch DG (eds).ElsevierEdition 8th,
• Clinical Gynecologic Oncology. 
  Chapter: Molecular and Clinical Genetics of Gynecologic cancers 
  Mutch DGEditors: Mutch DG, Mannel R, McMeekin S.ElsevierEdition 8th,
• Principles and Practice of Gynecologic Oncology. 
  Chapter: Management of Late Effects of Treatment 
  Mutch DGEditors: Hoskins WJ, Perez, CA, Young RC, Barakat R, Markman M., Randall M.E.Lippincott Williams and WilkinsEdition 4th,
• Gynecologic Cancer: Controversies in Management. 
  Chapter: Molecular Genetics of Endometrial Cancers 
  Mutch D.GEditors: Gershenson, D.M., McGuire, W.P., Gore, M., Quinn, M.A., Thomas, G.Elsevier
• Principles and Practice of Gynecologic Oncology. 
  Chapter: Management of Late Effects of Treatment 
  Mutch D.GEditors: Hoskins W.J., Perez, C.A., Young R.C., Barakat R., Markman M., Randall M.E.Lippincott Williams and WilkinsEdition 4th,
• Danforth’s Obstetrics and Gynecology. 
  Chapter: Uterine cancer 
  Mutch, D.GLippincott, Williams and Wilkins
• Glass’ Office Gynecology. 
  Chapter: Abnormal cytology and Human Papillomavirus 
  Buttin, B.M., Herzog, T.J., Mutch, D.GEditors: Curtis, M., Clarke-Pearson, D., Hopkins M.Lippincott, Williams and WilkinsEdition Sixt,
• Clinical Obstetrics and Gynecology. 
  Chapter: Gynecologic surgery and oncology updates 
  Mutch, D.GEditors: Mutch D.G.Lippincott, Wiliams and Wilkins
• Conn's Current Therapy. 
  Chapter: Neoplasms of the vulva 
  Easley, K.O. and Mutch, D.GEditors: Rakel, R.W.B. Saunders Company
• Gynecology and Obstetrics. 
  Chapter: Gestational trophoblastic neoplasms 
  Hammond, C.B., Lewis, J.L., and Mutch, D.GEditors: Sciarra.Harper and Row, Publishers, Inc
• Handbook of Obstetrics and Gynecology. 
  Chapter: Complications of gynecologic surgery 
  Mutch, D.G. and Herzog, TEditors: Gast, M.J. and Jacobs, A.J.
• Clinical Obstetrics and Gynecology. 
  Chapter: Biology of epithelial ovarian cancer 
  Mutch, D.G. and Williams, SEditors: Soper, J. T., and Varner, M. W.. B. Lippincott Co
• Textbook of Gynecology. 
  Chapter: Fallopian tube neoplasms 
  Mutch, D.G. and Massad, L.SEditors: Copeland, L.W.B Saunders Co
• Gynecology and Obstetrics: An Integrated Approach. 
  Chapter: Gestational trophoblastic disease 
  Massad, L.S., Mutch, D.GEditors: Moore, T., Reiter, C, Rebar, R.W., Baker V.V.Churchill Livingstone, New York
• Practical Gynecology: a Lange Clinical Manual. 
  Chapter: Benign diseases of the vulva 
  Massad, L.S. and Mutch, D.GEditors: Gast, M.J. and Jacobs, A.J.
• Ovarian Cancer 2. 
  Chapter: TNF_ Mediated Lysis in Gynaecological Malig¬nancies 
  Mutch, D.G. and Collins, J.LEditors: Sharp, F., Mason, W.P, and Creasman, W.Chapman and Hall Medical
• Manual of Emergency and Outpa¬tient Techniques. 
  Chapter: Obstetrics and Gynecology 
  Mutch, D.GEditors: Sicard, G. and Klippel, A.Little, Brown and Co
• Malignant Trophoblastic Disease. 
  Chapter: The role of surgery in gesta¬tional trophoblastic disease 
  Soper, J.T., Mutch, D.G., and Hammond, C.BEditors: Buchsbaum, H. and Szulman, R.Springer-Verlag
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Abstracts/Posters

• Abstracts presented for the 41st Annual Meeting of the Society of Gynecologic Oncologists.
  Mutch DG and Herzog TJ, Gynecologic Oncology 116:3 S1-S198
• Glandular-stromal relationships in estrogen receptor expression in human endometrial lesions as demonstrated by anti-estrogen receptor monoclonal antibody.
  McCarty, K., Jr., Budwit, D., Soper, J., Miller, L., Cox, W., Mutch, D., Creasman, W., and McCarty, K., Sr, Presentation: International Academy of Pathology, International Academy of Pathology, Canadian-American Division
• Endometrial adenocarcinoma estrogen receptor content: Association of clinicopathologic features with immunohistochem¬ical analysis compared with standard biochemical d...
  Mutch, D.G., Budwit, D.A., Cox, E.B., Soper, J.T., Creasman, W.T., McCarty, K.S., Sr., and McCarty, K.S., Jr, Presentation: Society of Gynecologic Oncologists Annual Meeting
• Endometrial carcinoma: Immunohistochemical distribution of proges¬terone and estrogen.
  Segreti, E., Budwit, D., Soper, J., Mutch, D., Greene, G., Konrath, J., and McCarty, K, Presentation: International Academy of Pathology, Canadian-American Division
• Recurrent gestational trophoblastic neoplasm (GTN): Experience of the South¬eastern Regional Trophoblastic Disease Center (SRTDC).
  Mutch, D.G.,Soper, J.T., Babcock, C.J., Creasman, W.T. and Hammond, C.B, Presentation: Society of Gynecologic Oncologists Annual Meeting
• An in vitro analysis of the anticancer potential of tumor necrosis factor (TNF) in combination with cisplatin.
  Mutch, D.G., Kao, M.S., Powell, C.B., and Collins, J.L, Presented at the Society of Gynecologic Oncologists Annual Meeting
• Dexamethasone used as an antiemetic in chemotherapy protocols inhibits Natural Cytotoxic (NC) cell Activity.
  Powell, C.B.; Mutch, D.G.; Kao, M.S.; Kao, J.; Perry, D.L.; Westphale. E. and Collins, J.L, Presented at the Society for Gyneco¬logic Investigation Annual Meeting
• Expression of a protein synthesis dependent resistance mechanism by ovarian and cervical cancer cells prevents their lysis by tumor necrosis factor (TNF?).
  Powell, C.B., Mutch, D.G., Kao, M.S. and Collins, J.L, Presented at the Society of Gynecologic Oncologists Annual Meeting
• Reduced natural cytotoxic (NC) cell activity in patients receiving Cisplatin based chemotherapy.
  Powell, C.B., Mutch, D.G., Kao, M.S., and Collins, J.L, Presented at the Society of Gynecologic Investigation Annual Meeting
• Combination antican¬cer therapies involving radiation and hyperthermia for the treatment of gynecologic malignancies.
  Mutch, D.G., Powell, C.B., Kao, M.S. and Collins, J.L, Presented at the Annual Meeting of the Society of Gynecologic Investigation
• The effects of interferon and tumor necrosis factor on the in vitro growth of cell lines of gynecologic malignancies.
  Massad, L.S., Mutch, D.G., Powell, C.B., Kao, M.S. and Collins, J.L, Presented at the Annual Meeting of the Society of Gynecologic Investigation
• Protein synthesis dependent resistance to lysis by interferon gamma.
  Massad, L.S., Mutch, D.G., Powell, C.B., Kao, M.S. and Collins, J.L, Presented at the Annual Meeting of the Society of Gynecologic Investigation
• Malignant gynecolog¬ic cell lines are resistant to TNA_ because they express protein(s) that prevent tha activation of the TNF_ lytic mechanism.
  Mutch, D.G., Powell, C.B., Kao, M.S. and Collins, J.L, Presented at the Annual Meeting of the Society of Gynecologic Oncologists
• Reversal of resist¬ance to lysis by TNFß in the presence of inhibitors of protein synthesis: Compari¬son with TNF?.
  Mutch, D.G., Powell, C.B., Kao, M.S. and Collins, J.L, Presented at the Annual Meeting of the Society of Gynecologic Oncologists
• Combining tumor necrosis alpha and interferon gamma enhances theur in vitro lytic effects on cell lines dervied from cervical and ovarian malignancies.
  Massad, L.S., Mutch, D.G., Kao, M.S. and Collins, J.L, Presented at the Annual Meeting of the Society for Gynecologic Investigation
• Increased sensitivity to adriamycin and reversal of resistance to cisplatin by cyclosporin A or emetine in cervical carcinoma cell lines.
  Mutch, D.G., Herzog, T.J., Chen, C-A, Kao, M.S. and Collins, J.L, Presented at the Annual Meeting of the Society of Gynecologic Oncologists
• The lysis of cervical carcinoma cells is synergistically increased by the combination of tumor necrosis factor alpha (TNF?) and radiation.
  Herzog, T.J., Mutch, D.G., Nelson, P.K., Kao, M.S. and Collins, J.L, Presented at the Annual Meeting of the Society of Gynecologic Oncologists
• Tumor necrosis factor alpha (TNF) mediates lysis through two distinct biochemical path¬ways.
  Powell, C.B., Mutch, D.G., Herzog, T.J., Kao, M.S. and Collins, J.L, Presented at the Annual Meeting of the Society of Gynecologic Oncologists
• Divergent effects of taxol on TNF-mediated cytolysis of ovarian carcinoma cells.
  Williams, S., Mutch, D.G., Kao, M.S. and Collins J.L, Presented at the Annual Meeting of the Society of Gynecologic Oncologists
• Cyclosporin enhancement of cisplatin chemotherapy in patients with refractory gynecologic cancer.
  Manetta, A., Berman, M., Boyle, J., DiSaia, P.S., Lentz, S., Liao, S.Y., Mutch, D.G. and Slater, L, Presented at the Annual Meeting of the Society of Gynecologic Oncologists
• Tumor necrosis factor alpha (TNF) mediates lysis through two distinct biochemical path¬ways.
  Powell, C.B., Mutch, D.G., Herzog, T.J., Kao, M.S. and Collins, J.L, Presented at the Annual Meeting of the Society for Gynecologic Investiga-tion
• Divergent effects of taxol on TNF_-mediated cytolysis of ovarian carcinoma cells.
  Williams, S., Mutch, D.G., Kao, M.S. and Collins J.L, Presented at the Annual Meeting of the Society for Gynecologic Investigation
• The use of speculoscopy in the evaluation of women with atypical papanicolaou smears: Improved cost effectiveness by selective colposco¬py.
  Massad, L.S., Mann, W.J., Nelson, A.L., Vasilev, S.A., Blanco, J.S., Finan, M.A. and Mutch, D.G, Presented at the Biennial Meeting of the American Society for Colposcopy and Cervical Pathology
• Speculoscopy improves screening for cervical intraepithelial neoplasia (CIN): Results of a prospective multi-center study.
  Blanco, J.S., Mutch, D.G., Massad, L.S., Finan, M.A., Nelson, A.L. and Mann, W.J, Presented at the Biennial Meet¬ing of the American Society for Colposcopy and Cervical Pathology
• Cell lines derived from endome¬trial cancers are resistant to lysis by taxol.
  Massad, L.S., Williams, S and Mutch, D.G, Presented at the Annual Meeting of the Society of Gynecologic Oncologists
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Lectures

• Effects of Growth Factors, Cytokines and Immunoproteins. 
  Third Biennial International Forum on Ovarian Cancer, Charleston, South Carolina
• Current Issues and Controversies in Obstetrics and Gynecology. 
  Sloane Symposium Lecture, Columbia University
• Obligation of commitment to lifelong learning. 
  Sanford School of Medicine – University of South Dakota, Sioux Falls, South Dakota
• The importance of the tripartite mission for all: Patient care, research and teaching. 
  Sanford School of Medicine – University of South Dakota, Sioux Falls, South Dakota
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Other

• Treatment Strategies and Prognosis of Endometrial Cancer, Cancer of the Uterine Endometrium - Advances and Controversies. 
  Garg, G. and Mutch. DG, J. Salvador Saldivar (Ed.), ISBN: 978-953-51-0142-0, InTech
  http://www.intechopen.com/articles/show/title/treatment-strategies-and-prognosis-in-endometrial-canc