DavidBernardMiklosMDPhD

Hematologic Oncology

Associate Professor of Medicine & Associate Chief - Blood & Marrow Transplantation, Clinical Director - Cancer Cell Therapy Program, Stanford University Medical Center

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Office
300 Pasteur Dr
Stanford, CA 94305
Phone+1 650-723-4000

Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 1998 - 2001
Yale School of MedicineClass of 1995

Certifications & Licensure

CA State Medical License 2004 - 2026
MA State Medical License 2001 - 2006
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012

Clinical Trials

Bone Marrow Grafting for Leukemia and Lymphoma Start of enrollment: 1988 Mar 01
Enrolling by invitation
Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD Start of enrollment: 2005 Jun 01
Completed
Phase 2
A Phase 2 Trial of Rituximab and Corticosteroid Therapy for Newly Diagnosed Chronic Graft Versus Host Disease Start of enrollment: 2006 Aug 01
Completed
Not Applicable
Autologous Followed by Non-myeloablative Allogeneic Transplantation for Non-Hodgkin's Lymphoma Start of enrollment: 2007 Jan 01
Terminated
Phase 2
Phase 1-2 of a CpG-Activated Whole Cell Vaccine Followed by Autologous Immunotransplant for MCL Start of enrollment: 2009 Aug 01
Completed
Phase 2
A Pilot Study of Imatinib Mesylate in Steroid Refractory Chronic Graft Versus Host Disease Start of enrollment: 2008 Sep 01
Completed
Phase 1
Ph II of Non-myeloablative Allogeneic Transplantation Using TLI & ATG In Patients w/ Cutaneous T Cell Lymphoma Start of enrollment: 2009 May 01
Completed
Phase 2
Phase 1 Nilotinib in Steroid Dependent/Refractory Chronic Graft Versus Host Disease Start of enrollment: 2010 Aug 01
Completed
Phase 1
Post T-plant Infusion of Allogeneic Cytokine Induced Killer (CIK) Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorders Start of enrollment: 2011 Mar 01
Completed
Phase 2
Phase 1-2 MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell Start of enrollment: 2011 Dec 01
Completed
Phase 1, Phase 2
CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells With or Without NKTR-255 in Adults With Recurrent or Refractory B Cell Malignancies Start of enrollment: 2017 Sep 01
Active, not recruiting
Phase 1
Dose-escalation Study of Safety of PBCAR20A in Subjects With r/r NHL or r/r CLL/SLL Start of enrollment: 2020 Mar 24
Completed
Phase 1, Phase 2
A Phase 1 Study of ADI-001 in B Cell Malignancies Start of enrollment: 2021 Mar 04
Recruiting
Phase 1
Roles: Contact
Long-term Follow-up Study of Allogeneic Gamma Delta (γδ) CAR T Cells Start of enrollment: 2022 Feb 14
Enrolling by invitation
A Study of bbT369 in Relapsed and/or Refractory B Cell Non-Hodgkin's Lymphoma (NHL) Start of enrollment: 2022 Jan 24
Recruiting
Phase 1, Phase 2
Roles: Contact
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Publications & Presentations

PubMed

1 citations
Tocilizumab Prophylaxis Following Axicabtagene Ciloleucel in Relapsed or Refractory Large B-Cell Lymphoma.
Frederick L Locke, Sattva S Neelapu, Nancy L Bartlett, Lazaros J Lekakis, Caron A Jacobson
Transplantation and Cellular Therapy. 2024-11-01
1 citations
Five-Year Follow-Up of Standard-of-Care Axicabtagene Ciloleucel for Large B-Cell Lymphoma: Results From the US Lymphoma CAR T Consortium.
Michael D Jain, Jay Y Spiegel, Loretta J Nastoupil, John Tamaresis, Armin Ghobadi
Journal of Clinical Oncology. 2024-10-20
3 citations
A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia.
Hrishikesh Srinagesh, Clayton Jackson, Parveen Shiraz, Nikeshan Jeyakumar, Mark Hamilton
Blood. 2024-10-17

Abstracts/Posters

Detectable Circulating Tumor DNA 28 Days after the CD19 CAR T-Cell Therapy, Axicabtagene Ciloleucel, Is Associated with Poor Outcomes in Patients with Diffuse Large B-...
David B Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Circulating DNA for Molecular Response Prediction, Characterization of Resistance Mechanisms and Quantification of CAR T-Cells during Axicabtagene Ciloleucel Therapy
David B Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Characteristics and Outcomes of Patients Who Did Not Develop CRS after Axicabtagene Ciloleucel for Relapsed/Refractory Large B-Cell Lymphoma: Results from the US Lymph...
David B Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
CD19-Loss with Preservation of Other B Cell Lineage Features in Patients with Large B Cell Lymphoma Who Relapsed Post_Axi-Cel
David B. Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Experience with Axicabtagene Ciloleucel (Axi-cel) in Patients with Secondary CNS Involvement: Results from the US Lymphoma CAR T Consortium
David B Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
ZUMA-11: A Phase 1/2 Multicenter Study of Axicabtagene Ciloleucel (Axi-Cel) + Utomilumab Patients with Refractory Large B Cell Lymphoma
David B. Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Characteristics and Outcomes of Patients Who Did Not Develop CRS after Axicabtagene Ciloleucel for Relapsed/Refractory Large B-Cell Lymphoma: Results from the US Lymph...
David B Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
A Comparison of Two-Year Outcomes in ZUMA-1 (Axicabtagene Ciloleucel) and SCHOLAR-1 in Patients with Refractory Large B Cell Lymphoma
David B. Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Improved Outcomes for Relapsed/Refractory Classic Hodgkin Lymphoma Following Autologous Stem Cell Transplantation in the Era of Novel Agents
David B Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Ibrutinib for Chronic Pulmonary Graft-Versus-Host-Disease after Progression on Prior Therapy
David B. Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Phase I Trial Using CD19/CD22 Bispecific CAR T Cells in Pediatric and Adult Acute Lymphoblastic Leukemia (ALL)
David B Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
KTE-X19, an Anti-CD19 Chimeric Antigen Receptor (CAR) T Cell Therapy, in Patients (Pts) With Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL): Results of the Phase...
David B. Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Identification of Two CAR T-Cell Populations Associated with Complete Response or Progressive Disease in Adult Lymphoma Patients Treated with Axi-Cel
David B Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Immune Reconstitution and Long-Term Outcomes Following Allo-HCT with TLI-ATG and Post-Transplant Rituximab
David B Miklos, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

Axicabtagene Ciloleucel (Axi-cel) CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma: Real World ExperienceClinically Re...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Advancing Care for Patients With GvHD: Making Sense of Recent Approvals and Late-Stage Compounds
60th American Society of Hematology Annual Meeting - 11/30/2018

Press Mentions

CAR T-cell Therapy Moves into the Fast LaneDecember 20th, 2024
Nektar Announces Publication in Blood of Phase 1 Data for Novel IL-15 Agonist NKTR-255 in Combination with Autologous CD19-22 CAR-T Cell Therapy in Patients with B-cell Acute Lymphoblastic LeukemiaOctober 17th, 2024
Blood Test Predicts Chances of Lymphoma Relapse After TherapyAugust 6th, 2021
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Grant Support

Biology And Treatment Of Cutaneous SclerosisNational Cancer Institute2011
Allogeneic B Cell ResponsesNational Cancer Institute2007–2011
Biology And Treatment Of Cutaneous SclerosisNational Institute Of Allergy And Infectious Diseases2009–2010
Microarray Analysis Of H-Y Antibodies In Human TransplantationNational Heart, Lung, And Blood Institute2007–2008
Identification Of Minor Histocompatibility AntigensNational Heart, Lung, And Blood Institute2005–2006
Identification Of Minor Histocompatibility AntigensNational Heart, Lung, And Blood Institute2002–2004