DavidLeitenbergMD

PubMed

• 62 citations
  Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes.
  Terrence L. Geiger, Phuong L. Nguyen, David Leitenberg, Richard A. Flavell
  Blood. 2001-10-15
• 106 citations
  The Potency of TCR Signaling Differentially Regulates NFATc/p Activity and Early IL-4 Transcription in Naive CD4+ T Cells
  Jennifer L. Brogdon, David Leitenberg, Kim Bottomly
  Journal of Immunology. 2002-04-15
• 14 citations
  Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer.
  Stephanie Gomez, Olivia L Cox, Reddick R Walker 3rd, Uzma Rentia, Melissa Hadley
  Journal for Immunotherapy of Cancer. 2022-11-01

Journal Articles

• Major Histocompatibility Complex Class II Deficiency due to a Novel Mutation in RFXANK in a Child of Mexican Descent  
  Clarridge, K., D. Leitenberg, B. Loechelt, C. Picard, M. Keller, J Clinical Immunol, 1/1/2016
• HLA Class I Depleted hESC as a Source of Hypoimmunogenic Cells for Tissue Engineering Applications  
  Karabekian Z, Ding H, Stybayeva G, Ivanova I, Muselimyan N, Haque A, Toma I, Posnack NG, Revzin A, Leitenberg D, Laflamme MA, Sarvazyan N, Tissue Eng, 1/1/2015
• Ganglioside-treated dendritic cells inhibit T cell effector function by promoting regulatory T cell activity  
  Falahati, R., E. Mari, A. Jales, E.J. Stemy, W. Shen, C. Southammokasone, D. Herzog, S. Ladisch, D. Leitenberg, Immunology, 1/1/2011
• Selective Regulation of TCR Signaling Pathways in Primary Thymocytes by the CD45 tyrosine phosphatase  
  Falahati, R., and D. Leitenberg, J Immunol, 1/1/2008
• CD45-associated protein regulates the response to low-potency T cell stimulation and promotes CD45 association with CD3/TCR and lck  
  Leitenberg, D., Falahati, R., Lu, D., and Takeda, A, Immunology, 1/1/2007
• Changes in the role of the CD45 Protein Tyrosine Phosphatase in Regulating of Lck Tyrosine Phosphorylation During Thymic Development  
  Falahati, R., and D. Leitenberg, J Immunol, 1/1/2007
• CD4-dependent regulation of Activation-induced cell death promotes selection of Th2 effector cells  
  Tatari-Calderone, Z, Brogdon, J.L., Tinsley, K., Ramezani, A., and D. Leitenberg, J Immunol, 1/1/2005
• The modulation of CD4 T helper cell differentiation by tumor ganglioside  
  Shen, W., R. Falahati, R. Stark, D. Leitenberg, and S. Ladisch, J Immunol, 1/1/2005
• The Potency of TCR Signaling Differentially Regulates NFATc/p Activity and Early IL-4 Transcription in Naive CD4(+) T Cells  
  Brogdon, J., D. Leitenberg, and K. Bottomly, J Immunol, 1/1/2002
• Integrated src kinase activity enhances signal transduction through single chain chimeric receptors in T lymphocytes  
  Geiger, T.L., P. Nguyen, D. Leitenberg, and R.A. Flavell, Blood, 1/1/2001
• Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation  
  Leitenberg, D., F. Balamuth, and K. Bottomly, Seminars in Immunology, 1/1/2001
• Deficiency of small GTPase Rac2 GTPase affects T cell activation  
  Yu, H., D. Leitenberg, B. Li, D.A. Williams, and R.A. Flavell, J Exp Med, 1/1/2001
• CD45 modulates galectin-1 induced T cell death: regulation by expression of core 2 O-glycans  
  Nguyen, J.T., D.P. Evans, M. Galvan, K.E. Pace, D. Leitenberg, T.N. Bui, and L.G. Baum, J Immunol, 1/1/2001
• Combinatorial effect of TCR ligation and CD45 isoform expression on the regulation of small GTPases ras and rap1  
  Czyzyk, J., D. Leitenberg, T. Taylor, K. Bottomly, Mol Cell Biol, 1/1/2000
• Specific biochemical association of CD45 with the T cell receptor: regulation by CD45 isoform and during T cell activation  
  Leitenberg, D., Y. Boutin, D. Lu, and K. Bottomly, Immunity, 1/1/1999
• The T cell receptor zeta chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes  
  Geiger, T.L., D. Leitenberg, and R.A. Flavell, J Immunol, 1/1/1999
• Regulation of naive T cell differentiation by varying the potency of TCR signal transduction  
  Leitenberg, D. and K. Bottomly, Seminars in Immunology, 1/1/1999
• CD4 regulation of T cell receptor signaling and T cell differentiation following stimulation with peptides of different affinities for the T cell receptor  
  Leitenberg, D., Y. Boutin, S. Constant, and K. Bottomly, J Immunol, 1/1/1998
• Epstein Barr virus suspension cell assay using in situ hybridization and flow cytometry  
  Crouch, J., D. Leitenberg, B.R. Smith, and J.G. Howe, Cytometry, 1/1/1997
• Distinct biochemical signals characterize agonist and altered peptide ligand-induced diferentiation of naive CD4 T cells into Th1 and Th2 subsets  
  Boutin, Y., D. Leitenberg, X. Tao, and K. Bottomly, J Immunol, 1/1/1997
• Deficient expression of p56lck in Th2 cells leads to partial TcR signaling and a dysregulation in lymphokine mRNA levels  
  Al-Ramadi, B.K., T. Nakamura, D. Leitenberg, and A.L.M. Bothwell, J Immunol, 1/1/1996
• The extracellular domain of CD45 controls association with the CD4/T cell receptor complex and the response to antigen-specific stimulation  
  Leitenberg D, T. Novak, D. Farber, B.R. Smith and K. Bottomly, J Exp Med, 1/1/1996
• Lymphocyte adhesion-dependent calcium signalling in human endothelial cells  
  Pfau S, D. Leitenberg, H Rinder, BR Smith, R Pardi, and JR Bender, J Cell Biol, 1/1/1995
• B-Cell precursor bone marrow reconstitution after bone marrow transplantation  
  Leitenberg D, JM Rappeport, BR Smith, Am J Clin Path, 1/1/1994
• Neutrophil but not monocyte activation inhibition of P-selectin mediated platelet adhesion  
  Rinder HM, JC Tracey, CS Rinder, D Leitenberg, and BR Smith, Thrombosis and Haemostasis, 1/1/1994
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Books/Book Chapters

• T cell dependent and independent B cell activation. 
  Chapter: T cell control of memory development. 
  Page 205 - 230Braley-Mullen H, D Leitenberg, and TL FeldbushEditors: EC Snow.1991

Lectures

• Tumor Immunology for PhD and MS level students 
  Multiple Locations, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019 - 1/1/2019
• Clinical Flow Cytometry 
  Georgetown University, 2018, 2019 - 1/1/2019
• Hypersensitivity Responses 
  Georgetown University, 2018, 2019 - 1/1/2019
• Immunodeficiency diagnosis 
  Georgetown University, 2018, 2019 - 1/1/2019
• Introduction to the Immune System 
  Multiple Locations, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 20 - 1/1/2018
• Tuning T cell activation: Role of the CD45 protein tyrosine phosphatase 
  Yale University, New Haven, CT, 2002, 2014 - 1/1/2014
• CD45 Regulation of T lymphocyte Activation 
  Bethesda, MD - 1/1/2012
• CD45 regulation of thymocyte development 
  Bethesda, MD, 2005; George Washington University, Washington, DC, 2008 - 1/1/2008
• CD45 regulation of T cell activation and development 
  University of Maryland School of Medicine, Baltimore, MD - 1/1/2007
• Effects of GD1a gangliosides on T cell Differentiation 
  Frederick, MD - 1/1/2006
• CD45 regulation of T lymphocyte activation and development 
  Georgetown University, Washington, DC - 1/1/2004
• CD4 Regulation of T lymphocyte effector function 
  Rockville, MD - 1/1/2003
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