DavidJLangerMD

Neurosurgery • New York, NY

Cerebrovascular Neurosurgery, Interventional Neuroradiology

Chairman of Neurosurgery Lenox Hill Hospital Vice President Neurosurgery Western Region Northwell Health

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Office
425 W 59th St
Ste 4e
New York, NY 10019
Phone+1 212-636-3204

Fax+1 212-636-3201

Summary

David Langer, MD, is the chair of neurosurgery at Lenox Hill Hospital and Vice President of neurosurgery for Northwell Health's Western Region. He is Professor of Neurosurgery and Radiology at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. Internationally recognized as an expert in cerebral revascularization and cerebral aneurysms, his work focuses on diseases of the brain vessels. Dr. Langer's work has been featured in numerous peer-reviewed publications and he has spoken nationally and internationally on vascular disorders such as aneurysms and arteriovenous malformations (AVMs) of the brain. He is one of the few cerebral bypass surgeons in the country. He also maintains an active practice in spinal disease and benign brain tumors including acoustic neuromas and meningiomas.

A third generation physician, Dr. Langer attended the University of Pennsylvania for undergraduate and medical school. He stayed on at Penn and completed his neurosurgical residency under the direction of Eugene Flamm, MD. Dr. Langer also completed a mid-career fellowship at the University at Buffalo in cerebrovascular disease treatment including aneurysms, AVMs, and carotid disease.

Dr. Langer established the Moyamoya Center of the Neuroscience Institute at Northwell Health and developed a project focused on the use of social networking technology and video to enhance the patient experience and improve the medical record which has become Playback Health- a Snapchat and Instagram for healthcare.

In 2013 Dr. Langer was recruited as director of neurosurgery at Lenox Hill and subsequently went on to help establish the first Department of Neurosurgery at Lenox Hill Hospital. He is currently Chairman of this new department. His goal is to further expand this program by creating an environment emphasizing collaboration, communication and world-class clinical care.

Operating In 3D

Neurosurgeons at Lenox Hill Hospital are revolutionizing operative neurosurgery with cutting-edge, 3D and 4K technology utilizing an innovative video exoscope.

Lenox Hill Hospital Department of Neurosurgery Overview

The neurosurgery experts at Lenox Hill Hospital, in New York City, are recognized leaders in the treatment of brain, spine and nervous system disorders.

Dr. Langer Receives Innovation Award

In 2015, Dr. Langer received the Northwell Health System's President's Award for innovation.

Creating the Lenox Bypass

Anew type of intracranial (occurring within the skull) bypass developed and performed by our expert surgeons for the treatment of brain aneurysms.

Education & Training

University at Buffalo School of MedicineFellowship, Endovascular Surgical Neuroradiology, 2009 - 2010
Mount Sinai Beth Israel HospitalFellowship, Neurology and Neurosurgery, 1998 - 1999
University of Pennsylvania Health SystemResidency, Neurological Surgery, 1992 - 1998
University of Pennsylvania Health SystemInternship, Surgery, 1991 - 1992
Perelman School of Medicine at the University of PennsylvaniaClass of 1991
University of PennsylvaniaBachelor, Arts cum laude (Biology), 1985 - 1985

Certifications & Licensure

NY State Medical License 1998 - 2026
PA State Medical License 1991 - 2014
American Board of Neurological Surgery Neurological Surgery

Awards, Honors, & Recognition

The Sally Harrington Goldwater Memorial Visiting Professor Award Barrow Neurological Foundation, 2018
New York Magazine: Top Doctors Castle Connolly, 2014-2018
Top Doctors: New York Metro Area Castle Connolly, 2010-2018
President's Award Northwell Health, 2015
Newsday - Top Doctors on Long Island Castle Connolly, 2011-2013
AANS/Upjohn Cerebrovascular Resident Research Award 1995
Morris Ginsberg Memorial Prize 1991
I.S. Ravdin Memorial Prize 1991
George Householder Memorial Award 1991
Four Schools Physician Scientist Award 1989
Super Doctor SuperDoctors.com
Whos Who in Medicine and Healthcare Marquis Whos Who
Fellow (FAANS) American Association of Neurological Surgeons
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Clinical Trials

Paclitaxel, Cisplatin, and Filgrastim Combined With Radiation Therapy in Treating Patients With Locally Recurrent Head and Neck Cancer Start of enrollment: 2000 Mar 01
Completed
Phase 2
Ischemia Driven Enoxaparin Therapy in ACS Presenting as Low Risk (IDEAL) Start of enrollment: 2007 Aug 01
Terminated
Phase 4
Super-Selective Intraarterial Cerebral Infusion Of Temozolomide (Temodar) For Treatment Of Newly Diagnosed GBM And AA Start of enrollment: 2010 Aug 01
Completed
Phase 1
Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA Start of enrollment: 2010 Oct 01
Recruiting
Phase 1, Phase 2
Repeated Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed GBM Start of enrollment: 2013 Feb 01
Completed
Phase 1, Phase 2
Super-Selective Intraarterial Infusion of Cetuximab (Erbitux) With or Without Radiation Therapy for the Treatment of Unresectable Recurrent Squamous Cell Carcinoma of the Head and Neck Start of enrollment: 2015 May 01
Terminated
Phase 1
Super-selective Intra-arterial Cerebral Infusion of Trastuzumab for the Treatment of Cerebral Metastases of HER2/Neu Positive Breast Cancer Start of enrollment: 2015 Aug 01
Terminated
Phase 1
An Electronic Multimedia Discharge Application Start of enrollment: 2016 Aug 01
Terminated
Not Applicable
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA Start of enrollment: 2016 May 01
Recruiting
Phase 2
Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma Start of enrollment: 2016 Jun 01
Recruiting
Phase 1, Phase 2
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM Start of enrollment: 2017 Jun 13
Recruiting
Phase 1, Phase 2
Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM Start of enrollment: 2018 Jul 27
Active, not recruiting
Not Applicable
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Publications & Presentations

PubMed

Efficacy and safety of anticoagulant and antiplatelet therapies in the medical management of carotid free-floating thrombus: A systematic review.
Raphael Camerotte, Marina Vilardo, Filipe Virgilio Ribeiro, Jhon E Bocanegra-Becerra, Ocilio Ribeiro Gonçalves
Interventional Neuroradiology. 2024-12-10
The impact of cerebrovascular steno-occlusive disease subtype on surgical and clinical outcomes after direct STA-MCA bypass surgery.
Danielle Golub, Joshua D McBriar, Shyle H Mehta, Harshal A Shah, Justin Turpin
Journal of Neurosurgery. 2024-12-06
Analysis of Current Evidence in the Endovascular Treatment of Intracranial Aneurysms: A Systematic Review and Proposal for a Reporting Guideline to Enhance Reproducibi...
Marcio Yuri Ferreira, Sávio Batista, Raphael Camerotte, Marina Vilardo, Bernardo Vieira Nogueira
Operative Neurosurgery. 2024-11-25

Journal Articles

Diagnosis and Treatment of Occult Subclavian Steal in the Setting of Right Middle Cerebral Ischemia: A Clinical Role for Quantitative MRA?
D. J. Langer, D. Lefton, L. Ostengren,, C. Brockington , J. Song , Y. Niimi , P. Bhargava , A. Berenstein, Neurosurgery
Embolization of Vein of Galen Malformations: Quantification of Shunt Reduction with MR Non-invasive Optimal Vessel Analysis (NOVA).
D. J. Langer, J. K. Song, Y. Niimi, M. Chwajol, D.R. Lefton, J.L. Brisman, M. J. Kupersmith, and A. Berenstein, J. Neurosurgery Pediatrics
In Vivo Protein Expression from mRNA Delivered into Adult Rat Brain.
K. Kariko, J.M. Keller, V.A. Harris, D.J. Langer, F.S. Welsh, J. Neurosci Methods
Phosphate-enhanced transfection of cationic lipid-complexed mRNA and plasmid DNA.
K.Kariko, A. Kuo, E.S. Barnathan, D.J. Langer, Biochimica et Biophysica Acta
Thermal Preconditioning Before Rat Arterial Balloon Injury: Limitation of Injury and Sustained Reduction of Intimal Thickening.
D.G. Neschis, S.D. Safford , P.N. Raghunath, D.J. Langer, M.L. David, A.K. Hanna, J.E. Tomaszewski, K. Kariko, E.S. Barnathan, M.A. Golden, Arterioscler Thromb Vasc Biol
Adenovirus Vector-Mediated Gene Transfer into Human Epileptogenic Brain Slices: Prospects for Gene Therapy in Epilepsy.
O'Connor W.M. , Davidson B.L., Kaplitt M.G., Abbey M.V., During M.J., Leone P., Langer D, O'Connor M.J., Freese A, Experimental Neurology
Regulation of the endothelial cell urokinase type plasminogen activator receptor:evidence for cAMP dependent and protein kinase C dependent pathways.
Langer D.J., Kuo A., Kariko K., Ahuja M., Klugherz B., Ivanics K.M., Hoxie J.A., Williams W.V., Liang B.T., Cines D.B., Barnathan E.S, Circulation Research
Direct Gene Transfer into Human Epileptogenic Hippocampal Tissue with an Adeno-associated Virus Vector: Implications for a gene therapy approach to epilepsy.
A. Freese, M. G. Kaplitt, W.M. O'Connor, D.J. Langer, P. Leone, M.J. O'Connor, M.J. During, Epilepsia
Regulation of the Urokinase Receptor on Human Endothelial Cells-Evidence for cAMP Dependent and Independent Pathways.
D.J. Langer, A. Kuo, K. Kariko, D.B. Cines, E.S. Barnathan, Clinical Research
Laser Light Scattering Determination of Size and Particle Composition of Delta Endotoxin Crystals from B. thuringiensis.
D.B. Sattelle, D.J. Langer, C.A. Haniff, D.J. Ellar, Royal Society of Chemistry Dynamic Properties of Biomolecular Assemblies
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Books/Book Chapters

Parasurgical Management of Aneurysmal Subarachnoid Hemorrhage.
Chapter: Neurologic and Neurosurgical Emergencies
Page 205 - 241Langer D.J., Zager E., Flamm E.SEditors: Cruz, J.W.B. Saunders, Philadelphia
Surgical Treatment of Anterior Circulation Aneurysms.
Chapter: Neurobase
Langer D.J. and Flamm E.SEditors: Stein S.
Clinical Presentation of Cerebral Aneurysms and Subarachnoid Hemorrhage.
Chapter: Management of Cerebral Aneurysms
Schwartz LF and Langer DJEditors: LeRoux PD, Winn HR.W.B. Saunders, Philadelphia
The State of the Art in Cerebrovascular Bypasses: Side to Side in situ PICA-PICA Bypass, o Intracranial Bypass Using Elana Technique, Cerebral Revascularization: Techniques in Extracranial-to-Intra...
Page 113 - 118Korja M, Kivipelto L, Sen C and Langer DElsevier Saunders
Extracranial To Intracranial Bypass Using Elana Technique, Cerebral Revascularization: Techniques in Extracranial-to-Intracranial Bypass Surgery.
Page 145 - 153Chakraborty S., Van Doormaal T, Kivipelto L and Langer DElsevier Saunders
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Abstracts/Posters

Outcome Analysis for Repeat Cervical Surgery in the “Failed Neck”.
Patient, D.J. Langer, R. Weil, P.M. Marcotte, CNS
High Level of Protein Expression Achieved by mRNA Transfection In Cultured Neurons Rat Brain.
K. Karikó*, E. S. Barnathan, V. M.-Y. Lee, Y. Rangel, D. J. Langer, and F. A. Welsh., Society for Neuroscience Abstract
Adenoviral Penton Protein Improves Transfection Efficiency of mRNA and Plasmid DNA in Primary Neuroglial Cells.
D.J. Langer, K.J. Fisher, R.W. Malone, J.A. Hecker, E.S. Barnathan, F.A. Welsh, M.A. Dichter, and K. Kariko, Society for Neuroscience Abstract
Gene transfer into Human Hippocampal Tissue Using an Adeno-Associated Virus Vector: Prospects for Gene Therapy in Focal Epilepsy.
A. Freese, M.J. O'Connor, D.J. Langer, M. G. Kaplitt, W.M. O'Connor, M.J. During, CNS
Feasibility Studies of mRNA Transfection for Intermediate Duration, Perioperative Modulation of CNS Responses Accessible via Cerebrospinal Fluid.
J.G, Hecker, D.J. Langer, B.E. Marshall, E.S Barnathan, K. Kariko, AUA
Cerebral Arteriovenous Malformations: Risk of Hemorrhage Based on Angiographic and Clinical Criteria.
D.J. Langer, T.M. Lasner, R.W. Hurst, J.T. King, E.L. Zager, E.S. Flamm, AANS
Charybdotoxin (CTX) Selectively Blocks Calcium Mediated Potassium Conductance that Contributes to the Action Potential Recorded Optically from Nerve Terminals of the ...
A.L. Obaid, D.J. Langer, B.M. Salzberg, Society for Neuroscience Abstract
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Lectures

Operative Visualization- The Next Generation
Mount Sinai Digital Neuro Symposium, New York, NY. - 12/7/2018
Operating microscope in Neurosurgery
University of Kansas Health System, Invited Lecturer, Kansas City, MO. - 11/2018
Presentation on the Orbeye Exoscope
CNS Annual Meeting, Houston, TX. - 10/2018
Management of Spinal AVM
CNS Annual Meeting, Houston, TX - 10/2018
5th Annual EANS Vascular Section Meeting
Nice, France - 9/2018
Moderator, Bypass for Ischemia
Cerebrovascular and Skull Base Symposium at Brigham Women’s Hospital, Boston, MA. - 9/2018
Moderator Parent and Branch Vessel Occlusion during Aneurysm Surgery
Cerebrovascular and Skull Base Symposium at Brigham Women’s Hospital, Boston, MA. - 9/2018
Panel Discussant Intraoperative Complication Management.
Cerebrovascular and Skull Base Symposium at Brigham Women’s Hospital, Boston, MA. - 9/2018
Next Generation of Operative Innovation
Hatzolah of Williamsburg, Brooklyn, NY - 7/2018
The Olympus Orbeye and the Future of the Operating Microscope
Northwell Neuroscience Institute Annual Symposium - 6/2018
Lenox Hill Neurosurgery III – Lessons of Success and Failure in Neurovascular Treatment.
New York, NY - 6/1/2018
Leadership in Neurosurgery
Leadership in Healthcare Course, Rosemont, IL. - 5/2018
Future of Cerebral Revascularization
Grand Rounds, Barrow Neurological Institute, Phoenix, AZ. - 5/2018
Cerebral Bypass and the Next Generation
Israeli Neurovascular Conference, Tel Aviv, Israel - 5/2018
Cerebral Revascularization for Skull Base Tumors: How I do it
The Lenox Hill Skull Base Course, Lenox Hill Hospital, New York, NY - 3/15/2018
Operating Exoscope in Neurosurgery
Jackson Hole, WY. - 3/2018
LINNC Seminar- US Edition, Moderator AVM and Aneurysm Session, Neurosurgery at Jackson Hole
Jackson Hole, WY. - 3/2018
Operating Exoscope in Neurosurgery
Steamboat Springs, CO. - 2/2018
Use of internal maxillary artery for bypass
North American Skull Base Annual Conference, Coronado, CA. - 2/2018
Vascular Neurosurgery and patient satisfaction
National Undergraduate and Foundation Surgery Conference, London, UK. - 1/2018
CNS Leadership in Healthcare Course
Chicago, IL. - 5/19/2017
Bypass surgery after Pipeline and COSS
University of Arizona Neuroscience Grand Rounds, Tucson, AZ - 2017
Bypass surgery after COSS and Flow, Diversion
Montreal Neurological Institue Grand Rounds, Montreal, CA - 2017
Complex open vascular surgery cases
AANS/CNS Joint Cerebrovascular Section Annual Meeting, Houston, TX - 2017
Bypass surgery after COSS and Pipeline
2017 Inaugural Winter Neurosurgical Forum, Steamboat Springs, CO - 2017
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Other

Transportable Imaging- Combining OsiriX for Mac with the iPad for PACS retrieval.
D.J. Langer, Philadelphia Magazine
Philadelphia Magazine

Authored Content

Internal Maxillary Artery to Middle Cerebral Artery Cranial Bypass; The New “Work Horse” for Cerebral Flow ReplacementApril 2018
Internal Maxillary Artery to Middle Cerebral Artery Cranial Bypass; The New “Work Horse” for Cerebral Flow ReplacementApril 2018

Press Mentions

Lenox Hill Hospital First in Manhattan to Use Brain Mapping TechnologyMay 16th, 2023
Spinal Cord Stimulator Helps Paralysis Patient Walk AgainFebruary 22nd, 2023
'i'm a Neurosurgeon Who Can't Move. Now What?'June 15th, 2022
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