David S Knopman MD

PubMed

• Eligibility for donanemab trial in a population-based study of cognitive aging.
  Katherine E Jones, Jeremiah A Aakre, Anna M Castillo, Vijay K Ramanan, Walter K Kremers
  The Journal of Prevention of Alzheimer's Disease. 2025-04-01
• High resolution autoradiography of [F]MK-6240 and [F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibril...
  Sujala Ghatamaneni, Courtney Hruska, Ian Shin, Tyler Bruinsma, Nancy Scott
  Acta Neuropathologica. 2025-03-14
• Relation of Alzheimer's disease-related TDP-43 proteinopathy to metrics from diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NOD...
  Anna Lavrova, Nha Trang Thu Pham, Robert I Reid, Bradley F Boeve, David S Knopman
  Neurobiology of Aging. 2025-03-08

Journal Articles

• Association of Initial Β-amyloid Levels with Subsequent Flortaucipir Positron Emission Tomography Changes in Persons Without Cognitive Impairment  
  David S Knopman, Bradley F Boeve, Ronald C Petersen, Clifford R Jack, JAMA Neurology
• Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated with MAPT, GRN, and C9orf72 Pathogenic Variants  
  Nupur Ghoshal, Neill R Graff-Radford, David S Knopman, Zbigniew K Wszolek, Joel H Kramer, Bradley F Boeve, Howard J Rosen, JAMA Network Open
• Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia  
  Mary M Machulda, Ronald C Petersen, David S Knopman, Yonas E Geda, Val J Lowe, Journal of the American Geriatrics Society
• Association of Apolipoprotein E ε4 with Transactive Response DNA-Binding Protein 43  
  Bradley F Boeve, Dennis W Dickson, David S Knopman, Joseph E Parisi, Ronald C Petersen, Keith A Josephs, JAMA
• Association of Cerebrospinal Fluid Neurofilament Light Protein with Risk of Mild Cognitive Impairment Among Individuals Without Cognitive Impairment  
  Ronald C Petersen, David S Knopman, JAMA
• Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery—2018  
  D S Knopman, M Berger, E S Oh, G Crosby, S T DeKosky, R G Eckenhoff, Canadian Anaesthetists’ Society Journal
• Association of Hospitalization, Critical Illness, and Infection with Brain Structure in Older Adults  
  Rebecca F Gottesman, David S Knopman, Journal of the American Geriatrics Society
• The Association of Multimorbidity with Preclinical AD Stages and SNAP in Cognitively Unimpaired Persons  
  Ronald C Petersen, Yonas E Geda, David S Knopman, Mary M Machulda, Val J Lowe, The Journals of Gerontology
• Regional Cortical Perfusion on Arterial Spin Labeling MRI in Dementia with Lewy Bodies: Associations with Clinical Severity, Glucose Metabolism and Tau PET  
  David T Jones, Tanis J Ferman, David S Knopman, Ronald C Petersen, Rodolfo Savica, Clifford R Jack, Val J Lowe, Bradley F Boeve, ScienceDirect
• 18F-FDG PET-CT Pattern in Idiopathic Normal Pressure Hydrocephalus  
  Hugo Botha, Bradley F Boeve, Val Lowe, David S Knopman, Ronald C Petersen, David T Jones, ScienceDirect
• Disrupted Functional Connectivity in Primary Progressive Apraxia of Speech  
  Mary M Machulda, Keith A Josephs, Rene L Utianski, Joseph R Duffy, David S Knopman, David T Jones, Ronald C Petersen, Edythe A Strand, ScienceDirect
• Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting  
  Mary M Machulda, David S Knopman, Yonas E Geda, Val J Lowe, Ronald C Petersen, JAMA
• Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up  
  Gottesman RF, Rawlings AM, Sharrett AR, Albert M, Alonso A, Bandeen-Roche K, Coker LH, Coresh J, Couper DJ, Griswold ME, Heiss G, Knopman DS, Patel MD, Penman AD, Powe..., Am J Epidemiol, 4/1/2014
• Vitamin D and cognitive function and dementia risk in a biracial cohort: The ARIC Brain MRI Study  
  Schneider ALC, Lutsey PL, Alonso A, Gottesman RF, Sharrett AR, Carson KA, Gross M, Post WS, Knopman DS, Mosley TH, Michos ED, Eur J Neurol, 1/1/2014
• Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: A population-based study  
  Geda YE, Roberts RO, Mielke MM, Knopman DS, Christianson TJH, Pankratz VS, Boeve BF, Sochor O, Tangalos EG, Petersen RC, Rocca WA, Am J Psychiatry, 1/1/2014
• Incidence of dementia among participants and nonparticipants in a longitudinal study of cognitive aging  
  Knopman DS, Roberts RO, Pankratz VS, Cha RH, Rocca WA, Mielke MM, Boeve BF, Tangalos EG, Ivnik RJ, Geda YE, Petersen RCKnopman DS, Roberts RO, Pankratz VS, Cha RH, Roc..., Am J Epidemiol, 1/1/2014
• Message from the editors to our reviewers  
  Gross RA, Knopman DS, Amato AA, Cascino GD, Ciccarelli O, Corboy JR, Elkind MSV, Mink JW, Ransohoff RM, Uitti RJ, Worrall BB, Neurology, 1/1/2014
• Reply: Considering the frontomedian cortex in revised criteria for behavioural variant frontotemporal dementia  
  Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Grossman M, Miller BL, Brain, 1/1/2012
• Transforming cerebrospinal fluid A beta 42 measures into calculated Pittsburgh compound B units of brain A beta amyloid  
  Weigand SD, Vemuri P, Wiste HJ, Senjem ML, Pankratz VS, Aisen PS, Weiner MW, Petersen RC, Shaw LM, Trojanowski JQ, Knopman DS, Jack CR Jr, Alzheimer's Dement, 1/1/2011
• Impact of vascular risk factors on brain structure  
  Knopman DS, Roberts R, Advances in Alzheimer's Disease, 1/1/2011
• Looking forward  
  Baskin PK, Knopman DS, Gross RA, Neurology, 7/1/2010
• Off-label medication use in frontotemporal dementia  
  Hu B, Ross L, Neuhaus J, Knopman D, Kramer J, Boeve B, Caselli RJ, Graff-Radford N, Mendez MF, Miller BL, Boxer AL, American Journal Of Alzheimers Disease And Other Dementias, 3/1/2010
• Association between mediterranean diet and late-life cognition  
  Knopman DS, JAMA, 12/1/2009
• Response to Letter from Dr William Hazzard  
  Knopman DS, J Am Geriatr Soc, 7/1/2009
• Mayo's older Americans normative studies: Visual form discrimination and copy trial of the Rey-Osterrieth Complex Figure": Corrigendum  
  Machulda MM, Ivnik RJ, Smith GE, Ferman TJ, Boeve BF, Knopman D, Petersen RC, Tangalos EG, J Clin Exp Neuropsychol, 1/1/2008
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Books/Book Chapters

• Goldman's Cecil medicine. 
  Chapter: Regional cerebral dysfunction: higher mental functions. 
  Page 2270 - 2274Knopman DSEditors: Goldman L; Schafer AI.Elsevier/Saunders, Philadelphia, PAEdition 24th,2012
• Goldman's Cecil medicine. 
  Chapter: Alzheimer's disease and other dementias. 
  Page 2274 - 2283Knopman DSEditors: Goldman L; Schafer AI.Elsevier/Saunders, Philadelphia, PAEdition 24th,2012
• Neurodegeneration: the molecular pathology of dementia and movement disorders. 
  Chapter: Clinical aspects of Alzheimer's disease. 
  Page 37 - 50Knopman DEdition 2nd,2011
• Cecil medicine. 
  Chapter: Alzheimer's disease and other dementias. 
  Page 2667 - 2676Knopman DSEditors: Goldman L, Ausiello D.Saunders Elsevier, Philadelphia, PAEdition 23rd,2008
• Cecil medicine. 
  Chapter: Regional cerebral dysfunction: higher mental functions. 
  Page 2662 - 2667Knopman DSEditors: Goldman L, Ausiello D.Saunders Elsevier, Philadelphia, PAEdition 23rd,2008
• ACP medicine: a publication of the American College of Physicians. 
  Chapter: Alzheimer disease and other major dementing illnesses. 
  Page 2218 - 2227Knopman DSWebMD, New York2006
• Principles and practice of geriatric psychiatry. 
  Chapter: Alzheimer's disease. 
  Page 283 - 300Knopman DEditors: Agronin ME, Maletta GJ.Lippincott Williams & Wilkins, Philadelphia, PA2006
• Principles of gender-specific medicine. Volume 2 
  Chapter: The principle syndromes of dementia. 
  Page 1216 - 1233Knopman D2004
• Vascular cognitive impairment: preventable dementia. 
  Chapter: Prevalence and incidence patterns of vascular dementia. 
  Page 21 - 32Rocca WA, Knopman DSEditors: Bowler JV, Hachinski V.Oxford University Press, Oxford2003
• Clinical neuropsychology. 
  Chapter: Neuropsychology of dementia. 
  Page 574 - 616Knopman D, Selnes OEditors: Heilman KM, Valenstein E.Oxford University Press, OxfordEdition 4th,2003
• Clinical neurology of the older adult. 
  Chapter: Diagnostic evaluation and treatment of dementia. 
  Page 259 - 272Knopman DSEditors: Sirven JI, Malamut BL.Lippincott Williams & Wilkins, Philadelphia, PA2002
• Evidence-based dementia practice. 
  Chapter: Diagnostic tools. 
  Page 237 - 238Knopman DEditors: Qizilbash N.Blackwell Science2002
• Evidence-based dementia practice. 
  Chapter: Clinical picture. 
  Page 234 - 237Knopman DEditors: Qizilbash N.Blackwell Science, Osney Mead2002
• Drug discovery and development for Alzheimer's disease 2000. 
  Chapter: Telephonic screening of mental status: a feasibility study in managed care clinic. 
  Page 17 - 23Knopman D, Vonsternberg T, Haefemeyer JEditors: Fillit HM, O'Connell AW.Springer Pub. Co., New York2002
• Evidence-based dementia practice. 
  Chapter: Diagnostic considerations. 
  Page 229 - 234Knopman DEditors: Qizilbash N.Blackwell Science, Osney Mead2002
• Evidence-based dementia practice. 
  Chapter: Alzheimer's disease. 
  Page 228 - 259Knopman D, Ritchie K, Polge C, Alafuzoff I, Soininen KEditors: Qizilbash N.Blackwell Science, Osney Mead2002
• Evidence-based dementia practice. 
  Chapter: Preamble. 
  Knopman DEditors: Qizilbash N.Blackwell Science, Osney Mead2002
• Early diagnosis of Alzheimer's Disease. 
  Chapter: Implications of early diagnosis for the development of therapeutics for AD. 
  Page 297 - 316Knopman DSEditors: Scinto LFM, Daffner K.Humana Press, Totowa NJ2000
• Neurobase (a CR-ROM-based textbook of Neurology) 
  Chapter: Frontal Lobe Dementia. 
  Knopman DSEditors: Gilman S, Goldstein G, Waxman SG.Arbor Publishing1999
• Neurobase (a CR-ROM-based textbook of Neurology) 
  Chapter: Memory Disorders. 
  Knopman DSEditors: Gilman S, Goldstein G, Waxman SG.Arbor Publishing1999
• Clinical Examination of the Nervous system. 
  Chapter: Mental Status Examination. 
  Knopman DSEditors: S Gilman.McGraw-Hill1999
• Pick's Disease and Pick Complex. 
  Chapter: Dementia lacking distinctive histology. 
  Knopman DSEditors: Kertesz A, Munoz DG.J Wiley & Sons Inc., New York1998
• Geriatric Neurology. Continuum Volume 2 
  Knopman DS, Knoefel JAmerican Academy of Neurology1996
• Handbook of Dementing Illness 
  Chapter: The non-Alzheimer Degenerative Dementias. 
  Page 265 - 291Knopman DSEditors: JC Morris.Marcel Dekker, New York1994
• Handbook of Neuropsychology 
  Chapter: The non-Alzheimer degenerative dementias. 
  Page 295 - 313Knopman DSEditors: Boller F, Grafman J.Elsevier, New York1993
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Abstracts/Posters

• Tdp-43 influences cognition, memory loss and hippocampal atrophy in Alzheimer's disease.
  Josephs K, Whitwell J, Weigand S, Murray M, Tosakulwong N, Liesinger A, Petrucelli L, Knopman D, Boeve B, Ivnik R, Smith G, Jack C, Parisi J, Petersen R, Dickson D, J Neuropathol Exp Neurol, 6/1/2014
• Antemortem characterization of a kindred carrying the non-coding GGGGCC hexanucleotide repeat expansion in C9ORF72.
  Adeli A, Boeve B, DeJesus-Hernandez M, Baker M, Rutherford N, Knopman D, Ivnik R, Fields J, Petersen R, Rademakers R, Neurology, 4/1/2012
• Characterization of the neuropsychiatric features associated with mutations in C9ORF72'MAPT and PGRN.
  Adeli A, Geda Y, Boeve B, Graff-Radford N, DeJesus-Hernandez M, Knopman D, Josephs K, Pedraza O, Rush B, Fields J, Rutherford N, Baker M, Smith G, Ivnik R, Pankratz V,..., Neurology, 4/1/2012
• A kindred with familial frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72.
  Boeve B, Daube J, DeJesus-Hernandez M, Parisi J, Dickson D, Josephs K, Baker M, Kuntz K, Johnson K, Knopman D, Ivnik R, Petersen R, Rademakers R, Neurology, 4/1/2012
• Characterization of frontotemporal dementia +/- amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72.
  Boeve B, Graff-Radford N, Boylan K, DeJesus-Hernandez M, Knopman D, Josephs K, Pedraza O, Vemuri P, Rush B, Fields J, Ferman T, Baker M, Rutherford N, Jones D, Lowe V,..., Neurology, 4/1/2012
• Risk factors for dementia with Lewy bodies.
  Boot B, Orr C, Ferman T, Roberts R, Pankratz V, Dickson D, Ahlskog J, Knopman D, Petersen R, Boeve B, Neurology, 4/1/2012
• Normal pressure hydrocephalus and pulse pressure (nph): the aric study.
  Graff-Radford N, Knopman D, Penman A, Coker L, Mosely T, Neurology, 4/1/2012
• Cingulate hypoperfusion is a common feature of the familial fronto-temporal dementias.
  Jones D, Boeve B, Knopman D, Petersen R, Jack C, Rademakers R, Lowe V, Neurology, 4/1/2012
• Risk of dementia in persons who refused to participate in a longitudinal study of cognitive aging.
  Knopman D, Roberts R, Pankratz V, Geda Y, Mielke M, Cha R, Boeve B, Tangalos E, Rocca W, Petersen R, Neurology, 4/1/2012
• RBD is associated with reduced Alzheimer's pathology in dementia with Lewy bodies.
  Murray M, Ferman T, Vemuri P, Dugger B, Jack C, Boeve B, Knopman D, Petersen R, Parisi J, Dickson D, Kantarci K, Neurology, 4/1/2012
• Cognitive endophenotype associated with the C9ORF72 GGGGCC Expansion in FTD/ALS.
  Pedraza O, Boeve B, DeJesus-Hernandez M, Rush B, Lucas J, Fields J, Machulda M, Graff-Radford N, Knopman D, Josephs K, Rutherford N, Baker M, Ferman T, Smith G, Ivnik ..., Neurology, 4/1/2012
• Does progression and mortality in mild cognitive impairment vary in men and women? The Mayo Clinic study of aging.
  Roberts R, Geda Y, Knopman D, Cha R, Pankratz V, Mielke M, Boeve B, Tangalos E, Ivnik R, Rocca W, Petersen R, Neurology, 4/1/2012
• Clinical characteristics of parkinsonism in frontotemporal dementia syndromes associated with mutations in MAPT, PGRN, C9ORF72.
  Savica R, Graff-Radford N, DeJesus-Hernandez M, Knopman D, Adeli A, Boot B, Kuntz K, Petersen R, Rutherford N, Baker M, Rademakers R, Boeve B, Neurology, 4/1/2012
• Neuroanatomical signature of C9ORF72: a comparison to MAPT, progranulin and sporadic FTD.
  Whitwell J, Weigand S, Boeve B, Senjem M, DeJesus-Hernandez M, Baker M, Knopman D, Wszolek Z, Parisi J, Dickson D, Petersen R, Rademakers R, Jack C, Josephs K, Neurology, 4/1/2012
• Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with GGGGCC repeat expansion in C9ORF72.
  Boeve B, Graff-Radford N, Boylan K, DeJesus-Hernandez M, Knopman D, Josephs K, Pedraza O, Vemuri P, Rush B, Fields J, Ferman T, Baker M, Rutherford N, Jones D, Lowe V,..., Dement Geriatr Cogn Disord, 1/1/2012
• The longitudinal associations between macronutrients and the risk of mild cognitive impairment.
  Roberts LA, Geda YE, Cha RH, Pankratz VS, Knopman DS, Petersen RC, Roberts RO, Am J Epidemiol, 6/1/2011
• High burden of comorbidity increases risk of cognitive impairment: the Mayo Clinic study of aging.
  Roberts RO, Geda YE, Knopman DS, Cha RH, Boeve BF, Rocca WA, Petersen RC, Am J Epidemiol, 6/1/2011
• Neuropathologic findings in 32 nondemented elderly subjects.
  Jentoft M, Parisi J, Dickson D, Johnson K, Boeve B, Knopman D, Petersen R, J Neuropathol Exp Neurol, 6/1/2011
• Pilot study of cyclic alternating pattern (cap) nrem sleep microarchitecture in patients with clinically diagnosed Lewy body dementia and Alzheimer disease.
  Pao W, St Louis EK, Ferman T, Lin S, Knopman DS, Petersen RC, Boeve BF, Sleep, 1/1/2011
• Neuropathological findings in non-amnestic mild cognitive impairment.
  Molano J, Parisi J, Dickson D, Johnson K, Boeve B, Knopman D, Petersen R, J Neuropathol Exp Neurol, 5/1/2009
• Quality of life in the oldest-old.
  Lapid MI, Rummans T, Boeve B, McCormick J, Pankratz V, Smith G, Ferman T, Ivnik R, Tangalos E, Knopman D, Petersen R, J Am Geriatr Soc, 4/1/2008
• Neuropathological correlates of antemortem H-1 MR Spectroscopy in Alzheimer disease.
  Kantarci K, Knopman D, Dickson D, Parisi J, Whitwell J, Weigand S, Josephs K, Boeve B, Petersen R, Jack C, Neurology, 3/1/2008
• Hippocampal atrophy, cortical infarctions and decreased NAA/Cr have additive effects on the risk of progression to dementia in MCI.
  Kantarci K, Weigand S, Shiung M, Whitwell J, Negash S, Knopman D, Boeve B, O'Brien P, Petersen RC, Jack C, Neurology, 3/1/2008
• Antemortem MRI based structural abnormality index (STAND)-scores correlate with postmortem Braak stages.
  Vemuri P, Whitwell J, Kantarci K, Josephs K, Parisi J, Knopman D, Boeve B, Petersen R, Dickson D, Jack C, Neurology, 3/1/2008
• A voxel-based morphometry study correlating MRI with neurofibrillary tangle pathology at autopsy.
  Whitwell J, Josephs K, Kantarci K, Przybelski S, Weigand S, Senjem M, Parisi J, Knopman D, Boeve B, Petersen R, Dickson D, Jack C, Neurology, 3/1/2008
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Lectures

• Alzheimers Disease 
  Curitiba, Brazil - 4/1/2004
• Symptoms of Dementia 
  University of Colorado - 3/1/2004
• 7th International Conference on Alzheimer's Disease 
  7/1/2000
• Dementia 
  St. Louis, MO - 10/1/1999
• Symposium on Neurodegenerative Disorders 
  Curitiba, Brazil - 8/1/1999
• Symposium on Alzheimer's Disease 
  Glasgow, United Kingdom - 7/1/1998
• 5th International Conference on Alzheimer's Disease 
  Osaka, Japan - 7/1/1996
• 2nd International Conference on Frontal Lobe Dementias 
  Lund, Sweden - 9/1/1993
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