DavidLKeefeMD

PubMed

• Mapping of long interspersed element-1 (L1) insertions by TIPseq provides information about sub chromosomal genetic variation in human embryos.
  Fabiana B Kohlrausch, Fang Wang, Wilson McKerrow, Mark Grivainis, David Fenyo
  Journal of Assisted Reproduction and Genetics. 2024-09-01
• Cell-Free DNA Analysis of Fetal Aneuploidies in Early Pregnancy Loss.
  William H Kutteh, Charles E Miller, John K Park, Victoria Corey, Mauro Chavez
  Journal of Clinical Medicine. 2024-07-23
• 1 citations
  Telomere dynamics and reproduction.
  LeRoy G Robinson Jr, Keri Kalmbach, Olivia Sumerfield, Wafa Nomani, Fang Wang
  Fertility and Sterility. 2024-01-01

Journal Articles

• Management and counseling of the male with advanced paternal age  
  Jennings, M O; Owens, R C; Keefe, D; Kim, E D, Fertility & Sterility, 1/1/2017
• Pregnancy Outcomes After Fertility Preservation in Transgender Men  
  Maxwell, Susan; Noyes, Nicole; Keefe, David; Berkeley, Alan S; Goldman, Kara N, Obstetrics & Gynecology, 1/1/2017
• Telomeres, Reproductive Aging, and Genomic Instability during early development  
  Keefe D, Reproductive Science, 1/1/2016
• Inflammatory biomarkers and telomere length in women with polycystic ovary syndrome  
  Pedroso DC, Miranda-Furtado CL, Kogure GS, Meola J, Okuka M, Silva C, Calado RT, Ferriani RA, Keefe DL, Dos Reis RM, Fertil Steril, 1/1/2015
• Oocyte competency is the key to embryo potential  
  Keefe D, Kumar M, Kalmbach K, Fertil Steril, 1/1/2015
• Impact of the ENRICH (Educating Nurses about Reproductive Issues in Cancer Healthcare) Web- Based Training Program  
  Bowman M, Sehovic I, Kelvin J, Gwede C, Meade C, Reinecke J, Reich R, Quinn G, Vadaparampil S, and the ENRICH Training Group* ENRICH Training Group: Boyington DD, Bra..., Journal of the American Psychological Oncology Society, 1/1/2015
• Individual and workplace changes: results of nurse reproductive health training program follow-up survey  
  Sehvovic I, Bowman M, Kelvin J, Gwede C, Meade C, Reinecke J, Reich R, Quinn G, Vadaparampil, and the ENRICH Training Group*: Boyington DD, Brannigan R, Christie J, Cl..., Journal of the American Psychological Oncology Society, 1/1/2015
• Telomere length variability is related to symptoms and cognition in schizophrenia  
  Vaez-Azizi LM, Rudy E, Dracxler R, Rothman K, Perrin M, Walsh-Messinger J, Antonius D, Goetz RR, Goetz DM, Keefe DL, Malaspina D, Schizophr Res, 1/1/2015
• Increased DNA damage and repair deficiency in granulosa cells are associated with ovarian aging in rhesus monkey  
  Zhang D, Zhang X, Zeng M, Yuan J, Liu M, Yin Y, Wu X, Keefe DL, Liu L, J Assist Reprod Genet, 1/1/2015
• Telomores and Female Reproductive Aging  
  Kalmbach KH, Antunes DM, Kohlrausch F, Keefe DL, Semin Reprod Med, 1/1/2015
• A single cell assay for telomere DNA content shows increasing telomere length heterogeneity, as well as increasing mean telomere length in spermatozoa with advancing age  
  Keefe D, Antunes D, Kalmbach K, Wang F, Dracxler R, Seth-Smith M, Buldo-Licciardi J, Kohlrausch F, Kramer Y, Journal of Asst Reprod and Gen, 1/1/2015
• Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing  
  Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A, Liu L, Dev Cell, 1/14/2014
• Telomere length, family history, and paternal age in schizophrenia  
  Malaspina, D, Dacxler R, Walsh-Messinger J, Harlap S, Goetz R, Keefe D, Perrin MC, Mol Genet Genomic Med, 1/1/2014
• In every end there is a beginning-telomeres in male reproduction  
  Keefe, DL, Fertil Steril, 1/1/2014
• Robust Measurement of telomere length in single cells  
  Fang W, Pan X, Kalmbach K, Seth-Smith M, Ye X, Antunes D, Yin Y, Liu L, Keefe DL, Weissman SM, Proc Natl Acad Sci, 1/21/2013
• Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke  
  Huang J, Okuka M, Lu W, Tsibris JC, McLean MP, Keefe DL, Liu L, Reprod Toxicol., 1/1/2013
• Resveratrol protects against age-associated infertility in mice  
  Liu M, Yin Y, Ye X, Zeng M, Zhao Q, Keefe DL, Liu L, Hum Reprod, 1/1/2013
• Breastfeeding status and maternal cardiovascular variables across the postpartum  
  Groer MW, Jevitt CM, Sahebzamani F, Beckstead JW, Keefe DL, J Womens Health (Larchmt)., 1/1/2013
• Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC)  
  Jinmiao Liu, Mengyuan Liu, Xiaoying Ye, Kai Liu, Junjiu Huang, Lingling Wang, Guangzhen Ji, Na Liu, Xiangdong Tang, Jay M. Baltz, David L. Keefe and Lin Liu, Hum Reprod, 1/1/2012
• Association of telomere length with authentic pluripotency of ES/iPS cells  
  Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L, Cell Res, 1/1/2011
• Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary  
  Liu Z, Hu Z, Pan X, Li M, Togun TA, Tuck D, Pelizzola M, Huang J, Ye X, Yin Y, Liu M, Li C, Chen Z, Wang F, Zhou L, Chen L, Keefe DL, Liu L, Hum Mol Genet, 1/1/2011
• Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro  
  Huang J, Okuka M, McLean M, Keefe DL, Liu L, Free Radic Biol Med., 1/15/2010
• Functional mapping of drug response with pharmacodynamic-pharmacokinetic principles  
  Ahn K, Luo J, Berg A, Keefe D, Wu R, Trends Pharmacol Sci, 1/1/2010
• Decisions and ethical issues among BRCA carriers and the use of preimplantation genetic diagnosis  
  Quinn GP, Vadaparampil ST, Bower B, Friedman S, Keefe, DL, Minerva Med, 1/1/2009
• Telomeres and reproductive aging  
  Keefe DL, Liu L, Reprod Fertil Dev, 1/1/2009
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Books/Book Chapters

• General Gynecology. The Requisites in Obstetrics and Gynecology 
  Chapter: Chapter 2: Reproductive Physiology 
  Keefe DL, Wright KPEditors: Sokol AI and Sokol ER.Mosby Elsevier, Philadelphia PA2007
• General Gynecology. The Requisites in Obstetrics and Gynecology 
  Chapter: Chapter 1: Embryology 
  Keefe DL, Wright KPEditors: Sokol AI and Sokol ER.Mosby Elsevier, Philadelphia PA2007
• Assisted Reproductive Technology 
  Chapter: New technologies in assisted reproductive technology 
  Keefe DLEditors: M. Cedars.Mosby2004
• Reproductive Endocrinology 
  Chapter: The role of prostanoids and oxygen radicals in reproduction 
  Arici A, Behrman H, Keefe DLEditors: S Yen, R Jaffee, R Barbieri.W. B. SaundersEdition 4th,1999
• Principles of Oocyte and Embryo Donation 
  Chapter: Synchronization of donors and recipients 
  Prapas Y, Wheeler CW, Keefe DLEditors: M. Sauer.Springer-Verlag1998
• Primary Care Medicine 
  Chapter: Menopause 
  Keefe DLEditors: J Noble.MosbyEdition 2nd,1996
• Pharmacology of Contraceptive Steroids 
  Chapter: Neuropsychiatric effects of sex steroids 
  Keefe DLEditors: J Goldzieher, K Fotherby.Raven Press, New York1994
• Modern Management of Premenstrual Syndrome 
  Chapter: Brain neurochemistry and mood 
  Keefe DL, Naftolin FEditors: S Smith and I Schiff.Norton1992
• Achievements in Gynecology 
  Chapter: The apparent paradox of sexual differentiation of the brain 
  Naftolin F, Keefe DL, Palumbo A, Garcia-Segura LMEditors: S Mancuso.Karger Contrib Gynecol Obstet, Basel1991
• New Biology of Steroid Hormones 
  Chapter: Estrogen effects on the organization of the rat brain: astrocytes within the hypothalamic arcuate nucleus contain estrogen-sensitive peroxidase activity and may mediate synaptic plasticity in the rat 
  Keefe DL, Michelson D, Naftolin FEditors: RB Hochberg, F Naftolin.Raven Press, New York1991
• Local Systems in Reproduction 
  Chapter: Neuron-glial interactions in the estrogen-sensitive zone of reaction of the rat hypothalamus 
  Keefe DL, Moore C, Stein M, Naftolin FEditors: R Magness, F Naftolin.Raven Press, New York
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Abstracts/Posters

• DNA Damage and Telomere Shortening in Embryonic Stem Cells Induced by Cigarette Smoke
  Huang J, Okuka M, Weisi L, Tsibris J, Mclean M, Keefe DL, Liu L, 44th SSR Annual Meeting, Portland, OR, 1/31/2011
• Frozen hope: fertility preservation for women with cancer
  Quinn GP, Vadaparampil ST, Jacobsen PB, Knapp C, Keefe DL, Bell GE; Moffitt Fertility Preservation Group, J Midwifery Women’s Health., 1/1/2010
• High Risk Men's Perceptions of PGD for Hereditary Breast and Ovarian Cancer (HBOC)
  Quinn GP, Vadaparampil ST, Wilson T, Plosker S, Malo T, Keefe DL, Fertility and Sterility, 1/1/2009
• National survey of physicians practice patterns: fertility preservation and cancer patients
  Quinn G, Vadaparampil ST, Jacobsen P, Lee J, Lancaster J, Bepler G, Keefe DL, Albrecht TL, J Clin Oncol, 2009 ASCO Annual Meeting Proceedings Plenary, Late-Breaking, and Clinical Review Abstracts, 1/1/2009
• Mice derived from embryonic stem cells injected into 4- or 8-cell embryos by Piezo Micromanipulation
  Huang J, Deng K, We H, Liu Z, Liu Y, Chen Z, Cao S, Ye X, Keefe D, Liu L, 41st Annual Meeting of SSR, Kona, HI, 1/30/2008
• Patient – provider communication issues concerning fertility preservation with newly diagnosed cancer patients
  Vadaparampil ST, Quinn GP, Lancaster J, Jacobsen P, Keefe D, Albrecht TL, ASCO Annual Meeting, Chicago, Il, 1/30/2008
• Patient - Provider communication issues concerning fertility preservation with newly diagnosed cancer patients (2008)
  Vadaparampil ST, Quinn GP, Lancaster JM, Bepler G, Jacobsen PB, Keefe DL, Albrecht TL, Journal of Clinical Oncology, 1/1/2008
• Gene Expression Profiles in the Testis of Telomerase deficient mice
  Czerwiec E, Liu L, Blasco M, Keefe DL, Society for the Study of Reproduction, 1/1/2004
• Short telomeres in eggs are associated with decreased outcomes following IVF-Toward a telomere theory of reproductive aging in women
  Keefe DL, Franco S, Liu L, Trimarchi J, Cho B, Weitzen S, Agarwal S, Blasco M, American Society for Reproductive Medicine General Program Prize Paper Session, 1/1/2003
• Short telomeres in spare eggs of women undergoing IVF portend poor prognosis
  Keefe DL, Liu L, Franco S, Agarwal S, Blasco M, Cold Spring Harbor Meeting on Telomeres and Telomerase, 1/1/2003
• Effects of arsenite on meiotic progression, preimplantation development and apoptosis
  Navarro P, Liu L, Keefe DL, Society for the Study of Reproduction, Baltimore, MD, 1/1/2002
• Rigorous thermal control during ICSI stabilizes the meiotic spindle and improves fertilization pregnancy rates
  Keefe DL, Wang WH, Oldenbourg R, Pezzuolo N, Focht D, Hackett RJ, Meng L, European Society of Human Reproduction and Embryology 16th Annual Meeting, 1/1/2000
• Aneuploidy but not maternal imprinting associated developmental arrest and apoptosis in mouse preimplantation embryos
  Keefe DL, Liu L, Society for the Study of Reproduction, 33rd Annual Meeting, 1/1/2000
• Spindle observation and its relationship with fertilization after ICSI in living human oocytes
  Wang WH, Hackett RJ, Meng L, Keefe DL, American Society for Reproductive Medicine, 55th Annual Meeting, 1/1/1999
• In vitro maturation of reconstructed oocytes following heterologous germinal vesicle transfer-A model to study nuclear cytoplasmic interactions
  Gao SR, Wang WH, Meng L, Keefe DL, American Society for Reproductive Medicine, 55th Annual Meeting, 1/1/1999
• On the feasibility of rescuing the oxidation-induced zygotic death through nuclear transfer
  Liu L, Keefe DL, American Society for Reproductive Medicine, 55th Annual Meeting, 1/1/1999
• Potassium efflux occurs early during apoptosis in preimplantation mouse embryos
  Trimarchi JR, Liu L, Smith PJS, Keefe DL, American Society for Reproductive Medicine, 55th Annual Meeting, 1/1/1999
• Nuclear-cytoplasmic interactions determine apoptosis in preimplantation mouse embryos
  Keefe DL, Liu L, Trimarchi JR, American Society for Reproductive Medicine, 55th Annual Meeting, 1/1/1999
• Nurses’ role in maintaining temperature stability of oocyte collection media during aspiration for in vitro fertilization (IVF)
  Pearson SJ, Siegel MB, Hackett RJ, Meng L, Keefe DL, American Society for Reproductive Medicine, 54th Annual Meeting, 1/1/1998
• Influence of oolemma flexibility on outcome after intracytoplasmic sperm injection (ICSI)
  Zhao QY, Hackett RJ, Alexander K, Meng L, Keefe DL, American Society for Reproductive Medicine, 54th Annual Meeting, 1/1/1998
• Patient satisfaction with the use of Crinone 8% in women undergoing assisted reproductive technology (ART)
  Wolf A, Batzer FR, Gutmann JN, English ME, Corson SL, Kelly M, Gocial B, Wood EG, Keefe DL, et al., American Society for Reproductive Medicine, 54th Annual Meeting, 1/1/1998
• Non-invasive determination of calcium and oxygen fluxes in developing mouse embryos
  Porterfield DM, Kommineni K, Keefe DL, Smith PJS, Annual Meeting of Professional Research Scientists, Experimental Biology 98, San Francisco, CA, 1/1/1998
• Non-destructive imaging of spindles in metaphase II oocytes with a new digital polarization microscope demonstrates exquisite temperature sensitivity
  Keefe DL, Kommineni K, Oldenbourg R, American Society for Reproductive Medicine, 53rd Annual Meeting, 1/1/1997
• Oocyte transmembrane calcium currents provide a non-invasive assay for determination of fertilization
  Keefe DL, Pepperell JR, Kommineni K, 10th World Congress on In Vitro Fertilization, 1/1/1997
• The organization of zona pellucida filaments changes during in vitro culture of preimplantation mouse embryos
  Pellegrini C, Oldenbourg R, Keefe DL, 10th World Congress on In Vitro Fertilization, 1/1/1997
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Lectures

• Biomarkers in Reproductive Medicine 
  Honolulu, HI - 1/18/2014
• Genomic Instability During Early Embryo Development 
  Greenwood Village, CO - 1/13/2014
• What Causes Reproductive Aging 
  State University of New York at Stony Brook, NY - 1/1/2014
• Epigenetic Causes of Oocyte Disfunction 
  Porto Alegre, BR - 1/1/2014
• Obesity and Infertility 
  New Orleans, LA - 1/1/2013
• Surgical Management of Severe Endometriosis 
  New York, NY - 1/1/2013
• Telomeres and Reproductive Aging 
  Orlando, FL - 1/1/2013
• Frontiers in Reproductive Aging 
  New Orleans, LA - 1/1/2013
• Update on Reproductive Aging 
  Taipei, Taiwan - 1/1/2012
• Genomic Instability During Preimplantation Embryo Development 
  New York Medical College, Valhalla, NY - 1/1/2011
• Telomere Dynamics During Early Development 
  Taormina, Italy - 1/1/2011
• Advances in Reproductive Biology 
  Orlando, FL - 1/16/2009
• Fertility and Adoption Options 
  Orlando, FL - 1/15/2009
• A good ending makes a good beginning: the telomere theory of reproductive aging 
  Tampa, FL - 1/14/2009
• Fertility preservation for cancer patients 
  Baptist Hospital, Pensacola, FL - 1/31/2008
• Managing Change in Clinical Practice 
  Sturbridge, MA - 1/30/2008
• Ovarian Aging 
  San Diego, CA - 1/26/2008
• Fertility after breast cancer: exploring your options 
  Jacksonville, FL - 1/23/2008
• Fertility Issues 
  Tampa, FL - 1/16/2008
• New frontiers in reproductive technology 
  Las Vegas, NV - 1/14/2008
• Hypothalamic and pituitary causes of reproductive dysfunction 
  Tampa, FL - 1/9/2008
• Options for Fertility Preservation 
  Clearwater, FL - 1/7/2008
• Frontiers in Reproduction 
  Marine Biological Institute, Woods Hole, MA - 1/7/2008
• A good ending is a good beginning: the telomere theory of reproductive aging 
  Center for Reproductive Sciences, Northwestern University, Chicago, IL - 1/5/2008
• Advances in Reproductive Medicine: Egg Freezing 
  Orlando, FL - 1/4/2008
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