DavidJangMD

Summary

• Description of Research Expertise
  "Abnormal Mitochondrial Bioenergetic and Motility Signatures in Acute Care Illness in a Translational Approach from Bench to Bedside."
  
  We are interested in studying the interaction of mitochondrial bioenergetics and dynamics in the area of acute care that includes sepsis and acute toxicological poisoning. We are currently taking a translational approach studying the mitochondria at a cell-based level all the way to the clinical setting actively enrolling patients with these acute medical conditions with the goal to develop better prognostic measures with the potential for mitochondrial-directed therapy.
  
  We have both the latest model of the O2k-FluoRespirometer (O2k-Series H) and Seahorse XFe24 to study mitochondrial respiration in both intact and permeabilized cells. In addition we also study mitochondrial dynamics examining both mitochondrial motility and fusion/fission events with microscopy while also examining other mitochondrial functions such as membrane potential and ROS. Combining these elements we aim to better understand the complex interactions of both bioenergetics and motility in issues of acute care to better improve patient care and outcomes.
  
  Our other area of interest includes research objectives relevant to the Office of Naval Research (ONR) where we leverage our expertise in this area to study cellular dysfunction in response to decompression injuries from the cell to clinical in a translational fashion. Our research in this area is also to study more effective treatments directed at the mitochondrial-level to improve function which will result in better safety and performance in naval personnel.