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David Holtzman, MD, Neurology, Saint Louis, MO

DavidMHoltzmanMD

Neurology • Saint Louis, MO

Dementia & Geriatrics

Andrew B. and Gretchen P. Jones Professor of Neurology Charlotte and Paul Hagemann Professor of Neurology Chairman, Department of Neurology Professor, Molecular Biology and Pharmacology Neurologist-in-Chief, Barnes-Jewish Hospital

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  • Office

    4921 Parkview Pl
    # Dv
    Saint Louis, MO 63110
    Phone+1 314-362-1408
    Fax+1 314-286-1985

Education & Training

  • University of California (San Francisco)
    University of California (San Francisco)Residency, Neurology, 1989 - 1990
  • University of California (San Francisco)
    University of California (San Francisco)Residency, Neurology, 1986 - 1989
  • University of California (San Francisco)
    University of California (San Francisco)Internship, Internal Medicine, 1985 - 1986
  • Northwestern University The Feinberg School of Medicine
    Northwestern University The Feinberg School of MedicineClass of 1985

Certifications & Licensure

  • CA State Medical License
    CA State Medical License 1986 - Present
  • MO State Medical License
    MO State Medical License 1995 - 2026
  • American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

  • CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012
  • Elected Member Institute of Medicine, 2008
  • Elected Member The American Society for Clinical Investigation, 2004

Publications & Presentations

PubMed

Journal Articles

  • Interplay Between Innate Immunity and Alzheimer Disease: APOE and TREM2 in the Spotlight  
    David Holtzman, MD, Nature
  • Trisomy of Human Chromosome 21 Enhances Amyloid-Β Deposition Independently of an Extra Copy of APP  
    David Holtzman, MD, Brain
  • Lack of BACE1 S-palmitoylation Reduces Amyloid Burden and Mitigates Memory Deficits in Transgenic Mouse Models of Alzheimer’s Disease  
    David Holtzman, MD, Proceedings of the National Academy of Sciences
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Press Mentions

  • Alzheimer's Panel Validated in University of Pittsburgh Study
    Alzheimer's Panel Validated in University of Pittsburgh StudyNovember 4th, 2024
  • Multiple Sclerosis Appears to Protect Against Alzheimer’s
    Multiple Sclerosis Appears to Protect Against Alzheimer’sAugust 23rd, 2024
  • Multiple Sclerosis Appears to Protect Against Alzheimer's Disease
    Multiple Sclerosis Appears to Protect Against Alzheimer's DiseaseAugust 23rd, 2024
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Grant Support

  • Antecedent Biomakers Of AD In CSF And PlasmaNational Institute On Aging2009–2012
  • Proteomic Analysis Of Human Cerebrospinal FluidNational Center For Research Resources2009–2011
  • Washington University Center For Translational NeuroscienceNational Institute Of Neurological Disorders And Stroke2006–2011
  • Effect Of APOE On CNS Neurons: Role Of LRPNational Institute On Aging2004–2011
  • Nervous System Development And InjuryNational Institute Of Neurological Disorders And Stroke2004–2011
  • LC-MS/MS Analysis Of CSF And Antecedent Biomarkers Of ADNational Institute On Aging2009–2010
  • Pathogenesis Of Caa-Induced Neurovascular DysfunctionNational Institute Of Neurological Disorders And Stroke2006–2010
  • Effects Of Polyphenols On Neonatal HI Brain InjuryNational Institute Of Neurological Disorders And Stroke2008
  • Novel Biomarkers To Predict Alzheimer DiseaseNational Institute On Aging2004–2008
  • Healthy Aging And Senile DementiaNational Center For Research Resources2006–2007
  • Functional Analysis Of Astrocyte-Derived APOE3 And APOE4National Center For Research Resources2005
  • Cns/Plasma Abeta Clearance Of Anti-Abeta AntibodyNational Institute On Aging2001–2003
  • APOE Effect On CNS Neurons--Role Of LRPNational Institute On Aging1996–2003
  • Caspase Dependent And Independent InjuryNational Institute Of Neurological Disorders And Stroke2002
  • Core--Transgenic Mouse Facility And Morphometric CenterNational Institute On Aging2000–2002
  • CNS Apolipoprotein J--Role In A Beta DepositionNational Institute On Aging2000–2002
  • Core--StereologyNational Institute Of Neurological Disorders And Stroke2000–2002
  • Functional Analysis Of Astrocyte Derived APOE3 And APOE4National Center For Research Resources2000–2002
  • Mechanisms Of Neonatal Ischemic Brain InjuryNational Institute Of Neurological Disorders And Stroke1997–2001
  • Creatine Kinase And Brain EnergeticsNational Institute Of Neurological Disorders And Stroke1997–1999
  • Creatine Kinase &Mouse Brain EnergeticsNational Center For Research Resources1997
  • Creatine Kinase And Brain EnergeticsNational Institute Of Neurological Disorders And Stroke1993–1996
  • Trisomy 16 And Ngf--Effects On CNS Gene ExpressionNational Institute On Aging1989–1993
  • Cellular Energy Metabolism In Mature And Developing BrainNational Center For Research Resources1989–1993
  • Maturation Of Brain Energetics By NMR SpectroscopyNational Institute Of Neurological Disorders And Stroke1986–1987

Dr. David Holtzman, Dr. David Holtzman, MD, Dr. D Holtzman, Dr. David M Holtzman