David Gozal MD MBA, DSc(Hon)

PubMed

• Circulating exosomes in pediatric obstructive sleep apnea with or without neurocognitive deficits and their effects on a 3D-blood-brain barrier spheroid model.
  Trupti Joshi, Yen On Chan, Zhuanhong Qiao, Leila Kheirandish-Gozal, David Gozal
  Experimental Neurology. 2025-05-01
• Impact of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial.
  Siraj Omar Wali, Ghadah Batawi, Omar Kanbr, Nadeem Shafique Butt, Murad A Yasawy
  Sleep & Breathing = Schlaf & Atmung. 2025-04-01
• Circulating Exosomal MicroRNAs and Subclinical Atherosclerosis in Obstructive Sleep Apnea.
  David Sanz-Rubio, Inmaculada Martín-Burriel, Jorge Rodríguez, Marta Marín-Oto, Abdelnaby Khalyfa
  Archivos De Bronconeumologia. 2025-04-01

Journal Articles

• Sleep-Disordered Breathing, Circulating Exosomes, and Insulin Sensitivity in Adipocytes  
  David Gozal, MD, Nature
• Acetylsalicylic Acid Prevents Intermittent Hypoxia-Induced Vascular Remodeling in a Murine Model of Sleep Apnea  
  David Gozal, MD, Frontiers in Neurology
• Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice  
  Zhang SX, Khalyfa A, Wang Y, Carreras A, Hakim F, Neel BA, Brady M, Qiao Z, Hirotsu C, Gozal D, International Journal of Obesity, 1/1/2014
• Chronic fragmented sleep promotes obesity in mice  
  Wang Y, Carreras A, Lee SH, Hakim F, Zhang SXL, Nair D, Ye H, Gozal D, Obesity, 1/1/2014
• Substance P and neurokinin 1 receptors as potential therapeutic targets in children with OSA  
  Gozal D, Kim J, Bhattacharjee R, Goldman JL, Kheirandish-Gozal L, Chest, 1/1/2014
• Vitamin D levels and pediatric obstructive sleep apnea  
  Kheirandish-Gozal L, Peris E, Gozal D, Sleep Medicine, 1/1/2014
• Fragmented sleep accelerates tumor growth and progression through recruitment of tumor-associated macrophages and TLR4 signaling  
  Hakim F, Wang Y, Zhang SX, Zheng J, Yolcu E, Carreras A, Khalyfa A, Shirwan H, Almendros I, Gozal D, Cancer Res, 1/1/2014
• Contextualized urinary biomarker analysis facilitates diagnosis of pediatric obstructive sleep apnea  
  Becker L, Kheirandish-Gozal L, Peris E, Schoenfelt KQ, Gozal D, Sleep Medicine, 1/1/2014
• Intermittent hypoxia-induced changes in tumor-associated macrophages and tumor malignancy in murine sleep apnea model  
  Almendros I, Wang Y, Becker L, Lennon F, Zheng J, Coats B, Schoenfelt KS, Carreras A, Hakim F, Zhang SX, Farre R, Gozal D, Am J. Resp Crit Care Med, 1/1/2014
• The promise of translational and personalized approaches for paediatric obstructive sleep apnoea: An “Omics” perspective  
  Tan H, Kheirandish-Gozal L, Gozal D, Thorax, 1/1/2014
• Nitric oxide production by monocytes in children with OSA and endothelial dysfunction  
  Kheirandish-Gozal L, Wang Y, Duggan RC, Harshan Vardhan S, Tan HL, Molero Ramirez H, Khalyfa A, Bhattacharjee R, Bandla HP, Gozal D, Clin Sci (Lond), 1/1/2014
• Sleep apnea awakes cancer: a unifying immunological hypothesis  
  Gozal D, Almendros I, Hakim F, OncoImmunol, 1/1/2014
• Estimating child sleep from parent report of time in bed: Development and evaluation of adjustment approaches  
  Nelson TD, Lundhal A, Molfese DL, Waford R, Roman A, Gozal D, Molfese VJ, Rue A, Ferguson M, J. Pediatr. Psychol, 1/1/2014
• Sleep disordered breathing in children with craniosynostosis  
  Alsaadi MM, Iqbal SM, Elgamal EA, Salih MA, Gozal D, Sleep & Breath, 1/1/2013
• TREM 1 and Pentraxin 3 plasma levels and their association with obstructive sleep apnea, obesity, and endothelial function in children  
  Kim J, Gozal D, Bhattacharjee R, Kheirandish-Gozal L, Sleep, 1/1/2013
• Circulating adropin levels in pediatric OSA: Potential relevance to endothelial function  
  Gozal D, Kheirandish-Gozal L, Bhattacharjee R, Molero Ramirez H, Tan HL, Bandla HPR, J Pediatr, 1/1/2013
• C-Reactive Protein and obstructive sleep apnea syndrome in children  
  Gozal D, Kheirandish-Gozal L, Bhattacharjee R, Kim J, Frontiers in Bioscience, 1/1/2012
• Algorithm for the diagnosis and management of pediatric OSA: A proposal  
  Kaditis AG, Kheirandish-Gozal L, Gozal D, Sleep Medicine, 1/1/2012
• A mediation model linking body weight, cognition, and sleep disordered breathing  
  Spruyt K, Gozal D, Am J. Resp Crit Care Med, 1/1/2012
• Pathological consequences of intermittent hypoxia in the central nervous system  
  Zhang SXL, Wang Y, Gozal D, Comprehensive Physiol, 1/1/2012
• Sympathetic and catecholaminergic alterations in pediatric sleep disorders  
  Hakim F, Gozal D, Kheirandish-Gozal L, Front Neurol, 1/1/2012
• Response to letter on “Adenotonsillectomy outcomes in treatment of obstructive sleep apnea in children: A multicenter retrospective study”  
  Bhattacharjee R, Gozal D, Am. J. Respir. Crit. Care Med, 1/1/2012
• Obstructive sleep apnea in poorly controlled asthmatic children: effect of adenotonsillectomy  
  Kheirandish-Gozal L, Dayyat EA, Eid NS, Morton RL, Gozal D, Pediatr. Pulmonol, 9/1/2011
• Pediatric sleep questionnaires as diagnostic or epidemiological tools: a review of currently available instruments  
  Spruyt K, Gozal D, Sleep Med Rev, 1/1/2011
• Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea  
  Bhushan B, Khalyfa A, Spruyt K, Kheirandish-Gozal L, Sans Capdevila O, Bhattacharjee R, Kim J, Keating B, Hakonarson H, Gozal D, Sleep Medicine, 1/1/2011
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Books/Book Chapters

• Sleep: A Comprehensive Handbook. 
  Chapter: Sleep and breathing during early post natal life. 
  Page 511 - 516Goldbart AD, Tauman R, Gozal DEditors: Lee-Chiong T. Wiley-Liss.Hoboken, New Jersey
• Clinical guide to pediatric sleep medicine. 
  Chapter: Metabolic Consequences of Sleep Disorders. 
  Gozal DEditors: Kheirandish-Gozal L, Gozal D.Humana Press
• Clinical guide to pediatric sleep medicine. 
  Chapter: Lymphadenoid Tissues in the Upper Airway. 
  Kim J, Gozal DEditors: Kheirandish-Gozal L, Gozal D.Humana Press
• Best of Sleep Medicine 2011. 
  Chapter: What factors predict successful outcomes following adenotonsillectomy for obstructive sleep apnea in children? 
  Bhattacharjee R, Kheirandish-Gozal L, Gozal DEditors: Lee-Chiong T.
• Sleep Epidemiology: From Aetiology to Public Health. 
  Chapter: Sleep in children: The Evolving Challenge of Catching Enough and Quality Zzz’s. 
  Spruyt K, Gozal DEditors: Capuccio FP, Miller MA, Lockley SW.Oxford University Press
• Emedicine from WebMD. 
  Chapter: Congenital Central Hypoventilation Syndrome. 
  Chin T, Ischander MM, Gozal Dhttp://www.emedicine.com/ped/topic1645.htm
• Rudolph’s Pediatrics. 
  Chapter: Disorders of Breathing During Sleep. 
  Gozal D, Kheirandish-Gozal LEditors: Rudolph AM, Rudolph C, First L, Lister G, Gershon AA.Edition 22,
• Casebook of Sleep Medicine. A Learning Companion to the International Classification of Sleep Disorders. 
  Chapter: Insomnia Due to Medical Condition. 
  Crabtree VM, Krishna J, Gozal DEditors: Winkleman JW, Henderson II JH, Kotagal S, Lee-chiong TL, Lichstein KL, Murray BJ, Schenck CH..American Academy of Sleep MedicineEdition 2,
• Encyclopedia of Neuroscience. 
  Chapter: Respiratory network responses to hypoxia. 
  Simakajornboon N, Gozal DEditors: Binder MD, Hirokawa N, Windhorst U, Hirsch MC, Springer Verlag.
• Handbook of Clinical Neurology: Sleep Disorders. 
  Chapter: Sleep-associated respiratory disorders and their psycho-behavioral consequences in children. 
  Montgomery-Downs HE, Gozal DEditors: P. Montagna and S. Chokroverty., Elsevier.Handb Clin Neurol
• Genetic Basis for Respiratory Control Disorders. 
  Chapter: Respiratory control disorders: from genes to patients and back. 
  Gozal DEditors: Gaultier C.Springer Verlag
• The Urinary Proteome. 
  Chapter: Urinary proteins for the diagnosis of obstructive sleep apnea syndrome. 
  Snow A, Gozal D, Valdes Jr R, Jortani SEditors: Ray A.Methods in Mol Biol
• Sleep Apnea: Pathogenesis,Diagnosis and Treatment. 
  Chapter: Intermittent Hypoxia and Neurocognitive Function. 
  Gozal D, Kheirandish-Gozal L, Row BWEditors: Pack AI.Lung Biology in Health and Disease, Marcel Dekker, Inc., New YorkEdition 2,
• Sleep and Breathing in Children - A Developmental Approach. 
  Chapter: Metabolic Aspects of Sleep Apnea in Children. 
  Tauman R, Gozal DEditors: Loughlin GM, Marcus CL, Carrol JL, Donnelly, D.Lung Biology in Health and Disease, Marcel Dekker, Inc., New YorkEdition 2,
• Sleep and Breathing in Children - A Developmental Approach. 
  Chapter: Maturation and Plasticity of Central Components in Cardiovascular and Respiratory Control. 
  Gozal D, Harper RMEditors: Loughlin GM, Marcus CL, Carrol JL, Donnelly, D.Lung Biology in Health and Disease, Marcel Dekker, Inc., New YorkEdition 2,
• Nelson Textbook of Pediatrics. 
  Chapter: Respiratory manifestations of neuromuscular diseases. 
  Gozal D, Kheirandish LWB Saunders, Philadelphia
• Ventral Brainstem Mechanisms and Control Functions. 
  Chapter: Functional assessment of the ventral medullary surface by optical imaging. 
  Page 67 - 79Gozal D, Rector DM, Harper RMEditors: Trouth CO, Millis RM, Kiwull-Schöne H, Schläfke ME, Lung Biology in Health and Disease, Marcel...
• D. Molfese and V. Molfese Handbook of Developmental Neuropsychology. 
  Chapter: Sleep-disordered breathing. 
  Crabtree, VM, Gozal DLawrence Erlbaum Associates
• Clinician’s Guide to Pediatric Sleep Disorders. 
  Chapter: Neurobehavioral morbidity in children with sleep-disordered breathing. 
  Gozal D, Kheirandish-Gozal LEditors: Richardson MA, Friedman NR.Informa Healthcare
• Kendig’s Disorders of the Respiratory Tract in Children. 
  Chapter: Disorders of Breathing During Sleep. 
  Page 1046 - 1070Gozal D, Kheirandish LEditors: Chernick V, Boat T, Wilmott R, Bush A.Elsevier Ltd.
• Encyclopedia of Respiratory Medicine. 
  Chapter: Inherited Myopathies 
  Page 98 - 103Gozal D, Godbart ADEditors: Geoffrey J. Laurent and Steven D. Shapiro.Elsevier Ltd
• Pharmacology and Pathophysiology of the Control of Breathing. 
  Chapter: Congenital central hypoventilation syndrome: should we rename it congenital autonomopathy? 
  Gozal DEditors: Ward D, Dahan A, Teppema L.Lung Biology in Health and Disease, Marcel Dekker, Inc., New York
• Nelson Textbook of Pediatrics. 
  Chapter: Respiratory manifestations of neuromuscular diseases. 
  Gozal DWB Saunders, PhiladelphiaEdition 17,
• Animal Models of Sleep Related Breathing Disorders. 
  Chapter: Gene and protein expression and regulation in the CNS. 
  Page 109 - 179Kubin L, Czycyk-Krzeska MF, Gozal DEditors: Carley D, Radulovacki M.Lung Biology in Health and Disease, Marcel Dekker, Inc., New York
• Pediatric Sleep Medicine: Principles & Practice. 
  Chapter: Consequences of obstructive sleep apnea in children. 
  O'Brien LM, Gozal DEditors: Sheldon, Dahl, Kryger, and Ferber, W.B. Saunders.
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Abstracts/Posters

• Year Book of Critical Care Medicine.
  Gozal D, Ziser A, Shupak A, Melamed Y, Accidental carbon monoxide poisoning in children: Emphasis on hyperbaric oxygen treatment
• Mosby Year Book of Pulmonary Disease.
  Gozal D, Colin AA, Jaffe M, Hochberg Z, Water, electrolyte and endocrine homeostasis on infants with bronchiolitis

Lectures

• Advances in Kids Medicine 
  The University of Chicago, Center for Continuing Medical Education, Lemont, Illinois - 11/2/2011