DavidRoyGiusMDMD, PhD

PubMed

• 324 citations
  Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
  Vinodkumar B. Pillai, Sadhana Samant, Nagalingam R. Sundaresan, H. Raghuraman, Gene Kim
  Nature Communications. 2015-04-14
• 11 citations
  Systemic application of honokiol prevents cisplatin ototoxicity without compromising its antitumor effect
  Xiaodong Tan, Yingjie Zhou, Aditi Agarwal, Michelle Lim, Yingyue Xu
  American Journal of Cancer Research. 2020-12-01
• 625 citations
  SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
  Hyun-Seok Kim, Krish Patel, Kristi Muldoon-Jacobs, Kheem S. Bisht, Nukhet Aykin-Burns
  Cancer Cell. 2010-01-19

Journal Articles

• ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA  
  Zhang H, Li X, Daddacha W, Pan Y, Madden WZ, Park S-H, Duong DM, Xie M, Yu1 B, Warren MD, Liu EA, Deng X, Seyfried NT, Yu DS, Cell Reports, 1/1/2016
• G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes  
  Wang XX, Edelstein MH, Gafter U, Qiu L, Luo Y, Dobrinskikh E, Lucia S, Adorini L, D'Agati VD, Levi J, Rosenberg A, Kopp JB, Saleem MA, Levi M, J Am Soc Nephrology, 1/30/2015
• Honokiol is an activator of SIRT3 that protects the heart from pressure overload mediated cardiac hypertrophy in mice  
  Pillai VB, Samant S, Sundaresan NR, Raghuraman H, Kim G, Bonner M, Arbiser J, Gupta MP, Nature Communications, 1/1/2015
• Makes Caterpillars Floppy (MCFVv)-like domain of Vibrio vulnificus induces mitochondrial-mediated apoptosis  
  Agarwal S, Zhu Y, Satchell K, Infection and Immunity, 1/1/2015
• Vibrio vulnificus MARTX toxin effector domain with Ras and Rap1 switch I specific processing activity  
  Antic I, Biancucci M, Zhu Y, Satchell KJF, Nature Communications, 1/1/2015
• CDK1 enhances SIRT3 activity in mitochondria causing tumor adaptive resistance to radiation  
  Rui Liu R, Fan M, Eldridge A, Candas D, Zhang T-Q, Zou J, Jin C, Zhang X, Perks J, Sun L-Q, Vaughan Hai C, Lu JJ, Molecular Cancer Therapeutics, 1/1/2015
• SIRT3 is crucial for maintaining skeletal muscle insulin action and protects against severe insulin resistance in high fat fed mice  
  Lantier L, Williams AS, Williams IM, Yang KK, Bracy DP, Goelzer M, James FD, Wasserman DH, Diabetes, 1/1/2015
• Antioxidant inhibition of steady-state reactive oxygen species and cell growth in Neuroblastoma  
  Zhu Y, Paul P, Lee S, Craig BT, Rellinger EJ, Qiao J, Chung DH, Surgery, 1/1/2015
• Wee1 Murine Deficiency Induces Hyper-activation of APC/C and Results in Genomic Instability and Breast Carcinogenesis  
  Vassilopoulos A, Tominaga Y, Kim Y-S, Tahusen T, Li B, Yu H, Deng C-X, Oncogene, 1/1/2015
• Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.  
  Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS,..., Science 342:1243417., 2/1/2014
• SIRT2 directs the replication stress response through CDK9 deacetylation.  
  Zhang H, Park SH, Pantazides BG, Karpiuk O, Warren MD, Hardy CW, Duong DM, Park SJ, Kim HS, Vassilopoulos A, Seyfried NT, Johnsen SA, Gius D, Yu DS., Proc Natl Acad Sci U S A. 2013, 110:13546-13551.
• SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.  
  Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X, Li C, Veenstra TD, Li B, Yu H, Ji J, Wang XW, Park SH, Cha YI, Gius D, Deng CX., Cancer Cell 2011, 20:487-499.
• Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.  
  Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, Kim HS, Flynn CR, Hill S, Hayes McDonald W, Olivier AK, Spitz DR, Gius D., Molecular Cell. 2010, 40:893-904.
• Dietary restriction: standing up for sirtuins.  
  Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Verdin, E., Science. 2010, 329:1012-1013
• SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.  
  Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, A..., Cancer Cell. 2010, 17:41-52.
• Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA.  
  Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H., Nature. 2008, 451:202-206.
• Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.  
  Gius D, Cui H, Bradbury CM, Cook J, Smart DK, Zhao S, Young L, Brandenburg SA, Hu Y, Bisht KS, Ho AS, Mattson D, Sun L, Munson PJ, Chuang EY, Mitchell JB, Feinberg AP., Cancer Cell. 2004, 6:361-371.
• SIRT3 deacetylates and increase pyruvate dehydrogenase activity in cancer cells  
  Ozkan O, Park S-H, Song HA, Zhu Y, Wagner B.A, Vassilopoulos A, Buettner GR, Free Radic Biol Med, 1/1/2014
• Strategies of dose escalation in the treatment of locally advanced non-small cell lung cancer: image guidance and beyond  
  Chi A, Nguyen MP, Welsh JS, Tse W, Monga M, Oduntan O, Almubarak M, Rogers J, Remick SC, Frontiers in Oncology, 1/1/2014
• Cell-type restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing  
  Xu YX, Gao D, Lee J-H, Huang H, Tan H, Ahn J, Reinke LM, Peter ME, Feng Y, Siziopikou KP, Peng J, Xiao X, and Cheng C, Genes and Development, 1/1/2014
• SIRT3 Deacetylates ATP Synthase F1 Complex Proteins in Response to Nutrient and Exercise-Induced Stress in Muscle  
  Vassilopoulos A, Pennington JP, Andresson T, Rees D, Bosley AD, Fearnley IM, Ham A, Flynn CR, Jones K, Kim H-K, Deng C-X, Walker J, Antioxidant and Redox Signaling, 1/1/2014
• Decreased SIRT3 Expression is a Potential Molecular Biomarker Associated with Poor Outcome in Breast Cancer  
  Desouki MM, Doubinskaia I, Abdulkadir SA, Human Pathology, 1/1/2014
• SIRT3 and SIRT4 are Mitochondrial Tumor Suppressor Proteins that Connect Mitochondrial Metabolism and Carcinogenesis  
  Zhu Y, Yan Y, Principe DR, Zou X, Vassilopoulos A, Cancer & Metabolism, 1/1/2014
• Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis  
  Tao R, Vassilopoulos A, Parisiadou L, Yan Y, Antioxidant and Redox Signaling, 1/1/2014
• Superoxide Mediates Acute Liver Injury in Irradiated Mice Lacking Sirtuin 3  
  Coleman MC, Olivier AK, Jacobus JA, Mao G, Martin SM, Riley DP, Spitz DR, Antioxidants and Redox Signaling, 1/1/2014
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Books/Book Chapters

• Oxidative Stress in Applied Basic Research and Clinical Practice 
  Chapter: Oxidative Stress in Cancer Biology and Therapy 
  Douglas R. Spitz, Kenneth J. Dornfeld, Koyamangalath KrishnanSpringer2012
• Bethesda Handbook of Clinical Oncology 
  Chapter: Head and Neck Cancer 
  Page 3 - 31Conley BA, Forastierre A, Van Waes CEditors: J Abraham.Lippincott Williams and Wilkins, Philadelphia PAEdition 2nd,2005