DavidWDawsonMDPhD

PubMed

• Successful novel use of dupilumab for gastrointestinal involvement of idiopathic hypereosinophilic syndrome: case report and review of the literature.
  Clare Moffatt, Christopher Soriano, David W Dawson, Guy A Weiss
  Clinical Journal of Gastroenterology. 2024-12-01
• Oncogenic pathway signatures predict the risk of progression and recurrence in well-differentiated pancreatic neuroendocrine tumors.
  Michael A Mederos, Colin M Court, Benjamin J Dipardo, Joseph R Pisegna, David W Dawson
  Journal of Surgical Oncology. 2024-10-01
• 1 citations
  Promoter Methylation Leads to Hepatocyte Nuclear Factor 4A Loss and Pancreatic Cancer Aggressiveness.
  Maria Hatziapostolou, Marina Koutsioumpa, Abed M Zaitoun, Christos Polytarchou, Mouad Edderkaoui
  Gastro Hep Advances. 2024-01-01

Journal Articles

• A Prognostic Scoring System for the Prediction of Metastatic Recurrence Following Curative Resection of Pancreatic Neuroendocrine Tumors  
  Paul A Toste, Shonan Sho, Colin M Court, Joseph R Pisegna, Oscar J Hines, Howard A Reber, David W Dawson, Michael Lewis, James S Tomlinson, Timothy R Donahue, Journal of gastrointestinal surgery
• Epigenetic regulation affects N-myc downstream regulated gene-1 expression indirectly in pancreatic cancer cells.  
  Angst E, Dawson DW, Nguyen A, Park J, Go VLW, Reber HA, Hines OJ, Eibl G, Pancreas. 39:675-9. PMID: 20173668
• Quercetin aglycone is bioavailable in murine pancreas and pancreatic xenografts.  
  Zhang L, Angst E, Park JL, Moro A, Dawson DW, Reber HA, Eibl G, Hines OJ, Go VL and Lu QY, J. Agric. Food Chem. 58:7252-7. PMID: 20499918
• Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors.  
  Pham H, Chen M, Li A, King J, Angst E, Dawson DW, Park J, Reber HA, Hines OJ and Eibl G, Pancreas. 39:332-9. PMID: 19820419
• N-myc Downstream Regulated Gene-1 Expression Correlates with Reduced Pancreatic Cancer Growth and Increased Apoptosis in Vitro and in Vivo.  
  Angst E, Dawson DW, Stroka D, Gloor B, Park J, Candinas D, Reber HA, Hines OJ and Eibl G, Surgery. 149(5):614-24. PMID: 21236457
• Overexpression of CXCL5 Is Associated with Poor Survival of Patients with Pancreatic Cancer.  
  Li A, King J, Moro A, Sugi MD, Dawson DW, Kaplan J, Li G, Lu X, Strieter RM, Burdick M, Go VL, Reber HA, Eibl G and Hines OJ, Am. J. Pathol. 178(3):1340-9. PMID: 21356384
• Cyclooxygenase-2 confers growth advantage to syngeneic pancreatic cancer cells.  
  Takahashi H, Li A, Dawson DW, Hines OJ, Reber HA and Eibl G, Pancreas. 40(3):453-9. PMID: 21343834
• SSTR5 P335L monoclonal antibody differentiates pancreatic neuroendocrine neuroplasms with different SSTR5 genotypes.  
  . Zhou G, Gingras MC, Liu SH, Sanchez R, Edwards D, Dawson D, Christensen K, Paganelli G, Gibbs R, Fisher W and Brunicardi FC, Surgery. 150(6):1136-42. PMID: 22136833
• Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma.  
  Biechele TL, Kulikauskas RM, Toroni RA, Lucero OM, Swift RD, James RG, Robin NC, Dawson DW, Moon RT and Chien AJ, Sci. Signal. 10;5(206):ra3. PMID: 22234612
• Wilms tumor gene on the X chromosome (WTX) inhibits the degradation of NRF2 through competitive binding to KEAP1.  
  Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, Tang X, Zheng N, Major MB and Moon RT, J. Biol. Chem. 287: 6539-50. PMID: 22215675
• Chronic GLP-1 receptor activation by Exendin-4 induces expansion of Pancreatic Duct Glands in Rats and accelerates formation of Dysplastic Lesions and Chronic Pancreat...  
  Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM and Butler PC, Diabetes. 61(5):1250-62. PMID: 22266668
• Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer.  
  Donahue TR*, Tran LM, Hill R, Li Y, Kovochich A, Calvopina JH, Patel SG, Wu N, Hindoyan A, Farrell JJ, Li X, Dawson DW* and Wu H*, Clin. Cancer Res. 18:1352-63. PMID:22261810 *Co-corresponding authors
• Sleeping Beauty Mutagenesis Reveals Cooperating Mutations and Pathways in Pancreatic Adenocarcinoma.  
  Mann KM, Ward JM, Yew CCK, Kovochich A, Dawson DW, Black MA, Brett BT, Sheetz TE, Dupuy AJ, APGI, Chang DK, Biankin AV, Waddell N, Kassahn KS, Grimmond SM, Rust AG, Ad..., Proc. Natl. Acad. Sci. USA. 109:5934-41. PMID:22421440
• Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell. J. Gastroenterol. Hepatol.  
  Pandol S, Gukovskaya A, Edderkoui M, Dawson D, Eibl G and Lugea A, Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell. J. Ga
• HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma.  
  Kovochich AN, Arensman MD, Lay AR, Rao NP, Donahue T, Li X, French SW and Dawson DW, Cancer. 119:529-39. PMID: 22914903
• PDX-1 Is a Therapeutic Target for Pancreatic Cancer, Insulinoma and Islet Neoplasia Using a Novel RNA Interference Platform.  
  Liu SH, Rao DD, Nemunaitis J, Senzer N, Zhou G, Dawson D, Gingras MC, Wang Z, Gibbs R, Norman M, Templeton NS, Demayo FJ, O'Malley B, Sanchez R, Fisher WE and Brunicar..., PLoS One. 2012;7(8):e40452. PMID: 22905092
• Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5.  
  Zhou G, Liu SH, Shahi KM, Wang H, Duan X, Lin X, Feng XH, Li M, Fisher WE, Demayo FJ, Dawson D and Brunicardi FC, Mol. Endocrinol. 26(7):1225-34. PMID: 22669743
• Diagnosis of dysplasia in upper gastro-intestinal tract through digital microscopy.  
  Gui D, Cortina G, Naini B, Hart S, Gerney G, Dawson D and Dry S, J. Pathol. Inform. 3:27. PMID: 23024886
• SAMe treatment prevents the ethanol-induced epigenetic alterations of genes in the Toll-like receptor pathway.  
  Khachatoorian R, Dawson D, Maloney EM, Wang Jj, French BA, French SW and French SW, Exp. Mol. Pathol. 94(1):243-246. PMID: 23047067
• WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma.  
  Arensman MD, Kovochich AN, Kulikauskas RM, Lay AR, Yang PT, Li X, Donahue T, Major MB, Moon RT, Chien AJ and Dawson DW, Oncogene. Epub. PMID: 23416978
• Loss of acinar cell IKKα results in accumulation of p62 aggregates that trigger spontaneous pancreatitis. J. Clin. Invest.  
  Li N, Wu X, Holzer RG, Lee J-H, Park E-J, Gukovskaya AS, Gukovsky I, Moscat J, Deerinck T, Dawson D, VandenBerg S and Karin M, J. Clin. Invest. In press
• Delayed progression of pancreatic intraepithelial neoplasia in a conditional KrasG12D mouse model by a selective COX-2 inhibitor.  
  Funahashi H, Satake M, Dawson D, Huynh N-A, Reber H, Hines OJ and Eibl G, Cancer Res. 67:7068-71. PMID:17652141
• Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat.  
  Dawson DW, Volpert OV, Pearce SFA, Schneider AJ, Silverstein RL, Henkin J, and Bouck NP, Mol. Pharmacol. 55: 332-338. PMID: 9927626
• Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.  
  Dawson DW, Volpert, OV, Gillis, P, Crawford, SE, Xu H-J, Benedict W, and Bouck, NP, Science 285: 245-248. PMID: 10398599
• Virilization in bilateral macronodular adrenal hyperplasia controlled by luteinizing hormone. J. Clin. Endocrinol.  
  MO, Dawson DW, Li X, Lei Z, Shintaku P, Rao CV and VanHerle AJ, Metab. 88:73-77. PMID: 12519832
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Books/Book Chapters

• Thrombospondin as an inhibitor of angiogenesis. 
  Chapter: Antiangiogenic Agents in Cancer 
  Page 185 - 203Dawson DW and Bouck NEditors: B. Teicher.Humana, Totowa

Abstracts/Posters

• Chromatin, Chromosomes and Cancer Epigenetics
  Dawson, D.W., Wu, Y-Z., Smith, L., Plass, C. Teitell, M. Bioinformatics and Genome-wide assessment of mammalian CmC, AACR Special Conference, Waikailoa Village, HI
• Global methylation profiling in TCL1 transgenic mice reveals novel targets of DNA hypermethylation in mature B cell lymphomas.
  Dawson, D.W., Hong, J.S., Shen, R.R., French, S.W., Troke, J., Wu, Y-Z., Chen, S-S., Gui, D., Regelson, M., Marahrens, Y, Morse III, H.C., Said, J., Plass, C. and M.A...., AACR Annual Meeting, Anaheim, CA
• Global DNA methylation changes in pancreatic cancer.
  Nguyen, A.M., Pellegrini, M. and Dawson, D, UCLA Stein-Oppenheimer Endowment Awards Reception and Poster Presentation, Los Angeles, CA
• Global histone modification analysis predicts clinical prognosis in resectable pancreatic adenocarcinoma.
  Garcia, M., Dawson, N., Tze, S., Seligson, D., Winters, K., Farrell, J., Kurdistani, S. and Dawson, D.W, AACR Annual Meeting, San Diego, CA
• HOXB7 overexpression promotes pancreatic adenocarcinoma growth and invasion.
  Nguyen, A.M., Yang, N. and Dawson, D.W, AACR Annual Meeting, Denver, CO
• Loss of 15-hydroxyprostaglandin dehydrogenase contributes to increased prostaglandin E2 in pancreatic tumors.
  Pham, H., Li, A., Chen, M., King, J., Angst, E., Park, J., Dawson, D.W., Reber, H.A., Hines, O.J. and Eibl, G, AACR Annual Meeting, Denver, CO
• Epigenetic regulation affects N-myc downstream regulated gene-1 expression in pancreatic cancer cells.
  Angst, E., Dawson, D.W., Nguyen, A., Park, J., Reber, H.A., Hines, O.J. and Eibl, G, AACR Annual Meeting, Denver, CO
• Global Patterns of Histone Modifications Predict Clinical Outcome and Drug Response in Cancer Patients.
  Kurdistani, S.K., Seligson, D.B., Dawson, D. and Tahamtanzadeh, K, Tucson Symposium: Driving Pathology and Oncology Forward to Improve Patient Care
• Pancreatic cyst fluid miRNA 21 and 221 predict invasive cancer.
  Donahue, T.R., Tran, L., Wu, X., Wong, J., Tomlinson, J.S., Hines, O.J., Reber, H.A., Dawson, D.W. Wu, H. and Farrell, J.J, The Pancreas Club 45thAnnual Meeting, Northwestern University, Chicago, IL
• GLP-1 Receptor Activation by Exenatide Induces Expansion of Pancreatic Duct Glands.
  Gier, B., Matveyenko, A.V., Dawson, D.W., Dry, S.M. and Butler, P.C, Vol. 32 (03_MeetingAbstracts): P1-485. ENDO 2011 Annual Meeting, Boston
• Notch1 upregulation of PDX-1 synergistically contributes to the development of islet cell neoplasia.
  Liu, S-H., Zhou, G., Stehling, K.M., Nemunaitis, J., Dawson, D., Fisher, W. and Brunicardi, F.C, Academic Surgical Congress, Las Vegas, NV
• Survival following resection of well-differentiated pancreatic neuroendocrine tumors: examining the new 2010 WHO classification.
  Moriya, T., Donahue, T.R., Hines, O.J., Farrell, J.J., Reber, H.A., and Dawson, D.W, Annual Pancreas Club Meeting, San Diego, CA
• HOXB7 modulates tumor cell invasion and is a predictor of poor clinical outcome in pancreatic cancer.
  Arensman, M., Kovochich, A.N., Donahue, T., French, S.W., and Dawson, D.W, /PANCAN Special Conference: Pancreatic Cancer: Progress and Challenges, Lake Tahoe, NV
• Wnt7B mediates high levels of autocrine Wnt/β-catenin signaling in pancreatic adenocarcinoma.
  Arensman, M.D., Kovochich, A.N., Kulikauskas, R.M., Lay, A.R., Chien, A.J. and Dawson, D.W, AACR/PANCAN Special Conference: Pancreatic Cancer: Progress and Challenges, Lake Tahoe, NV
• Integrative MicroRNA Profiling of the Human Pancreatic Cancer Microenvironment Identifies Stromal miR-21 as a Metastatic Regulator Predictive 9of Poor Survival.
  Wei, C., Xu, X., Li, L., Hill, R., Wu, H., Dawson, D. and Donahue, T, AACR/PANCAN Special Conference: Pancreatic Cancer: Progress and Challenges, Lake Tahoe, NV
• A diet high in fats and calories leads to obesity and metabolic disturbances and accelerates pancreatic cancer development in the conditional KrasG12D mouse model.
  Moro, A., Lugea, A., Dawson, D.W., Pandol, S., Gukovskaya, A., Rozengurt, E., Go, V.L.W., Hines, O.J. and Eibl, G, AACR/PANCAN Special Conference: Pancreatic Cancer: Progress and Challenges, AACR/PANCAN Special Conference: Pancreatic Cancer: Progress and Challenges
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Lectures

• Cystic Neoplasms of the Pancreas. 
  International Academy of Pathology-Thailand 50th Annual Meeting. Bangkok, Thailand.
• Exploring Wnt Signaling in Pancreatic Cancer. 
  Pancreatic Cancer Action Network National Headquarters
• Wnt Signaling in Pancreatic Cancer. 
  Los Angeles County-Harbor Medical Center Department of Pathology Grand Rounds. Torrance, CA
• Pancreatic Cancer Research. 
  American Cancer Society Cancer Action Network Research
• Autocrine Wnt signaling in pancreatic cancer. 
  UCSF Pancreas Cancer Annual Retreat. San Francisco, CA
• Recent Research in Pancreatic Cancer. 
  Pancreatic Cancer Action Network: Pancreatic Cancer Symposium-Bay Area. Westin San Francisco Airport
• Cystic Neoplasms of the Pancreas. 
  Telepathology between UCLA Medical Center and the Second Affiliated Hospital of Zhejiang University
• Global histone modification status in pancreatic cancer. 
  Reagan Medical Center, Los Angeles, CA
• Pancreatic Cancer? Look Again! 
  Los Angeles Society of Pathologists Fall Slide Seminar. Los Angeles, CA
• Basic and Translational Research Career Paths in Pancreatic Cancer. 
  Peer-to-Peer Round Table Session at AACR Annual Meeting, Washington, D.C.
• Tissue Microarrays in Pancreatic Cancer Research. 
  6th Annual Agi Hirshberg Symposium on Pancreatic Cancer, Los Angeles, CA
• Wnt Signaling in Pancreatic Cancer Progenitor Cells. 
  Pancreatic Cancer Action Network Annual Grantee Research Session. Century City, CA
• Understanding the Concept of Pancreatic Cancer Stem Cells. 
  Pancreatic Cancer Action Network National Headquarters, El Segundo, CA
• Post-translational Histone Modifications in Pancreatic Cancer. 
  Pancreatic Cancer Research Team Annual Meeting, Orlando, FL
• Histopathology of Genetically-Engineered Mouse Models of Pancreatic Cancer. 
  5th Annual Agi Hirshberg Symposium on Pancreatic Cancer, Los Angeles, CA
• Canonical Wnt Signaling in Pancreatic Adenocarcinoma. 
  UCLA Jonsson Comprehensive Cancer Center Roundtable Symposium, Los Angeles, CA
• Stem Cells in Pancreatic Cancer Research. 
  Pancreatic Cancer Action Network Symposium, Phoenix, AZ
• Canonical Wnt Signaling in Pancreatic Cancer. 
  UCLA IMED/ICMIC Group Meeting
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