DavidMichaelAsmuthMD

PubMed

• Women are from venus: implications for diversified sex-based preexposure prophylaxis approaches
  Giulia Marchetti, David M. Asmuth
  AIDS. 2021-08-01
• 37 citations
  Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96...
  Onyema Ogbuagu, Peter Ruane, Daniel Podzamczer, Laura C Salazar, Keith Henry
  The Lancet. HIV. 2021-07-01
• 3 citations
  Potential use of serum-derived bovine immunoglobulin/protein isolate for the management of COVID-19.
  Netanya S. Utay, David M. Asmuth, Shahin Gharakhanian, Moises Contreras, Christopher D. Warner
  Drug Development Research. 2021-06-10

Journal Articles

• IL-7 administration drives T-cell cycle entry and expansion in HIV-1 infection.  
  Sereti I, Dunham RM, Spritzler J, Aga E, Proschan M, Medvik K, Battaglia CA, Landay A, Pahwa S, Fischl MA, Asmuth DM, Tenorio AR, Altman JD, Fox L, Moir S, Malaspina A..., Blood
• Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy.  
  Zhou L, Kitch DW, Evans SR, Hauer P, Raman S, Ebenezer GJ, Gerschenson M, Marra CM, Valcour V, Diaz-Arrastia R, Goodkin K, Millar L, Shriver S, Asmuth DM, Clifford DB,..., Neurology
• Evidence for Calpain mediated Androgen Receptor Cleavage as a Mechanism for Androgen Independence and Potential Therapeutic Target in Prostate Tumors.  
  Libertini SJ, Tepper CG, Rodriguez V, Asmuth DM, Kung H-J, Mudryj M, Cancer Res
• Pegylated Interferon-?2a Treatment of Chronic SIV-Infected Macaques.  
  Asmuth DM, Abel K, George MD, Dandekar S, Pollard RB, Miller CJ, J Med Primatol
• Nine color flow cytometry for accurate measurement of T-cell subsets and cytokine responses. Part I: Panel Design by an Empiric Approach.  
  McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon D, Ottinger J, Oxford C, Evans TG, Asmuth DM., Cytometry
• Nine color flow cytometry for accurate measurement of T-cell subsets and cytokine responses. Part II: Panel Performance across different instrument platforms.  
  McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon D, Ottinger J, Li J, Beckett L, Evans TG, Asmuth DM, Cytometry
• Low sensitivity of T-cell based detection of tuberculosis among HIV co-infected Tanzanian in-patients.  
  Seshadri C, Uiso LO, Ostermann J, Diefenthal H, Shao HJ, Chu HY, Asmuth DM, Thielman NM, Bartlett JA, Crump JA, East Afr Med J
• Incomplete Reconstitution of T-cell Subsets on Combination Antiretroviral Therapy in ACTG 384.  
  Robbins GK, Spritzler JG, Chan ES, Asmuth DM, Gandhi RT, Rodriguez BA, Skowron G, Skolnik PR, Shafer RW, Pollard RB, Clin Infect Dis
• Replication Capacity in Relation to Immunologic and Virologic Outcomes in HIV-1 infected, Treatment-Naïve Subjects.  
  Skowron G, Spritzler J, Weidler J, Robbins GK, Johnson VA, Chan ES, Asmuth DM, Gandhi RT, Lie Y, Bates M, Pollard RB, for the NIH/NIAID ACTG 384 protocol team and Mon..., J Acquir Immune Defic Syndr
• Quantitative 3D Video Microscopy of HIV Transfer Across T cell Virological Synapses.  
  Hübner W, McNerney GP, Dale BM, Chen P, Gordon R, Chuang FYS, Li X-D, Asmuth DM, Huser T, and Chen BK, Science
• UC Davis Clinical and Translational Science Center: Coming of Age.  
  Asmuth D, Wun T, Mullen N, Garcia E, Whitney E, Gillis M, Anderson K, Tarantal A, Kenyon N, Curry FR, Berglund L, Clin Translational Sci
• Effect of Baseline- and Treatment-related Factors on Immunologic Recovery after Initiation of Antiretroviral Therapy in HIV-1+ Subjects: Results from ACTG 384.  
  Gandhi RT, Spritzler J, Chan E, Asmuth DM, Rodriguez B, Merigan TC, Hirsch MS, Shafer RW, Robbins GK, Pollard RB, J AIDS
• Comparative Cell-Mediated Immunogenicity of DNA/DNA, DNA/Ad5, or Ad5/Ad5 HIV-1 Clade B gag Vaccine Prime-Boost Regimens.  
  Asmuth DM, Brown EL, DiNubile MJ, Sun X, del Rio C, Harro C, Keefer MC, Kublin JG, Dubey SA, Kierstead LS, Casimiro DR, Shiver JW, Robertson MN, Quirk EK, Mehrotra DV, J Infect Dis
• Impact of Highly Active Antiretroviral Therapy on Hepatitis C Virus Protease Quasispecies Diversity in HIV Co-Infected Patients.  
  Winters MA, Chary A, Eison R, Asmuth D, Holodniy M, J Med Virol
• Safety, Tolerability and Mechanisms of Antiretroviral Activity of Peginterferon alfa-2a in HIV-1-Mono-infected Subjects: A Phase II Clinical Trial.  
  Asmuth DM, Murphy RL, Rosencranz SL, Lertora JJ, Kottilil S, Cramer Y, Chan ES, Schooley RT, Rinaldo CR, Thielman N, Li X-D, Wahl SM, Shore J, Janik J, Lempicki RA, Si..., J Infect Dis
• HIV-1 viruses detected during episodic blips following interleukin-7 administration are similar to the viruses present before and after interleukin-7 therapy.  
  Imamichi H, Degray G, Asmuth DM, Fischl MA, Landay AL, Lederman MM, Sereti I, AIDS
• Molecular Characterization of Stool Microbiota in HIV-Infect Subjects by Panbacterial and Order-Level 16S Ribosomal DNA (rDNA) Quantification and Correlations with Imm...  
  Ellis CL, Ma Z-M, Mann SK, Li C-S, Wu J, Knight TH, Yotter T, Hayes TL, Maniar AH, Troia-Cancio PV, Overman HA, Torok NJ, Albanese A, Rutledge JC, Miller CJ, Pollard R..., J Acquir Immune Defic Syndr
• Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with Pegylated interferon-alpha 2a.  
  Hubbard JJ, Greenwell-Wild T, Yang J, Lempicki RA, Wahl SM, Asmuth DM, Murphy RL, Pollard RB, Kottilil S, J Infect Dis
• Quantitation of Hepatitis C Virus RNA in Peripheral Blood Mononuclear Cells from HCV-Monoinfected and HIV/HCV-Coinfected Patients.  
  Aarthi C, Winters MA, Eison R, Knight TH, Asmuth DM, Holodniy M, J Med Virol
• Interferon-Alpha administration enhances CD8+ T cell activation in HIV infection.  
  Manion M, Rodriguez B, Medvik K, Hardy G, Harding CV, Schooley RT, Pollard R, Asmuth D, Murphy R, Barker E, Brady KE, Landay A, Funderburg N, Sieg SF, Lederman MM, PLoS ONE
• Multifunctional HIVgag Specific CD8+ T-cell Responses in Rectal Mucosa and PBMC During Chronic HIV-1 Infection.  
  22. Critchfield JW, Lemongello D, Walker DH, Garcia JC, Asmuth DM, Pollard RB, Shacklett BL, J Virol
• Entrapment of recent thymic emigrants and naïve CD4 T cells in lymphoid tissues from HIV infected patients: Association with HIV cellular viral load.  
  Nokta MA, Li X-D, McVey Z, Al-Harthi L, Pou A, Nichols J, Asmuth D, Landay A, Pollard RB, AIDS
• Clinical features of Microsporidiosis in patients with AIDS.  
  Asmuth DM, DeGirolami PC, Federman M, Ezratty CR, Pleskow DK, Desai G, Wanke CA, Clin Infect Dis
• Diagnosis of intestinal Microsporidiosis by microscopic examination of stool and duodenal aspirate with Weber's modified trichrome and uvitex 2B stains  
  DeGirolami PC, Ezratty CR, Desai G, McCullough A, Asmuth DM, Wanke CA, Federman M, J Clin Micro
• Effects of Clostridium perfringens recombinant and crude phospholipase C and ? toxins on rabbit hemodynamic parameters.  
  Asmuth DM, Olsen RD, Bryant AE, Tweten RK, Tso JY, Hackett SP, Zollman T, Stevens DL, J Infect Dis
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Books/Book Chapters

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  Chapter: Microsporidia and diarrhea in AIDS patients 
  Page 179 - 183Asmuth DM
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  Chapter: Microsporidia and diarrhea in AIDS patients 
  Asmuth DM
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  Chapter: Nevirapine 
  Page 303 - 343Asmuth DM, Pollard RBEditors: Skowron G, Ogden R.Humana Press, Inc., Totowa, NJ
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  Chapter: Lessons from maraviroc clinical trials 
  Page 649 - 651Troia-Cancio P, Asmuth DMEditors: e.g. Tangney J.e.g. Doximity Press, e.g. San MateoEdition e.g.,
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  Chapter: Nevirapine in Reverse Transcriptase Inhibitors in AIDS Therapy 
  Page 303 - 343Asmuth DM, Pollard RBEditors: Skowron G, Ogden R.e.g. Doximity Press, Totowa, NJEdition e.g.,
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Abstracts/Posters

• Effect of Antiretroviral Therapy Initiation on Mucosal T-cells in HIV Infection.
  Hayes TL, Critchfield JW, Knight TH, Yotter T, Young DH, Pollard RB, Asmuth DM, and Shacklett BL, Keystone: HIV Vaccines (X5), Banff, Alberta
• Association between Pre-therapy Replication Capacity (RC) and Pre-therapy/On-therapy Immunologic and Virologic Parameters in Antiretroviral-Naïve Subjects in ACTG 384.
  Skowron G, Chan E, Weidler J, Robbins G, Johnson V, Spritzler J, Asmuth D, Gandhi R, Lie Y, Bates M, Pollard R for the AIDS Clinical Trials Group 384 protocol team and..., In Abstracts for the 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Pr, Sydney, Australia
• A phase II open-label pilot trial of the antiretroviral activity, safety, and tolerability of pegylated interferon-?-2a (40KD)(PegIFN) in HIV-1 infected subjects.
  Asmuth D, Chan E, Cai T, Murphy R, Schooley R, Thielman N, Rinaldo C, Li X-D, Schreiber M, Shore J, Janik J, Lertora J, Simpson Y, Pollard R for the ACTG 5192 Team, Abstracts for the 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Preve, Sydney, Australia
• Baseline CD4 Cell Count and Immune Reconstitution During Combination Antiretroviral Therapy in ACTG 384.
  Robbins GK, Spritzler J, Chan ES, Asmuth DM, Gandhi RT, Rodriguez BA, Skowron G, Skolnik PR, Shafer RW, Pollard RB and the ACTG 384 Team, Abstracts for the 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Preve, Sydney, Australia
• CD4+ Cell Restoration after 48 Weeks in the Maraviroc (MVC) Treatment-Experienced (TE) Trials MOTIVATE 1 and 2.
  Asmuth D, Goodrich J, Cooper D, Haubrich R, Rajicic N, Valdez H, Hirschel B, Mayer H., In Abstracts for the XVII International AIDS Conference, August 3-8, 2008, Mexico City, Mexico, Mexico City, Mexico
• Pharmacokinetic and Pharmacodynamic Parameters in HIV-1 Subjects Receiving Pegylated Interferon-alpha-2a Therapy: AIDS Clinical Trials Group Study 5192.
  Asmuth D, Rosenkranz S, Cramer Y, Lertora J, Rinaldo C, Murphy R, Schooley R, Thielman N, Li X-D, Pollard R. and ACTG 5192, Abstracts for the 16th Conference on Retroviruses and Opportunistic Infections, Montreal, Canada
• Induction of the Interferon Response Pathway Is Associated with Suppression of HIV-1 Viral Load after Receiving Interferon-alpha in Hepatitis B/C Virus Seronegative Su...
  Asmuth D, Lempicki R, Kottilil S, Lertora J, Rinaldo C, Wahl S, Schooley R, Li X-D, Murphy R, Pollard R. and ACTG 5192, In Abstracts for the 16th Conference on Retroviruses and Opportunistic Infections, Montreal, Canada
• Quantitative 3-D Video Microscopy of HIV Transfer across Virological Synapses.
  Chen B, Hubner W, Del Portillo A, McNerney G, Chen P, Dale B, Chuang F, Li X-D, Asmuth D, Huser T, In Abstracts for the 16th Conference on Retroviruses and Opportunistic Infections, Montreal, Canada
• Impact of antiretroviral therapy on hepatitis C virus protease gene quasipecies diversity in co-infected patients.
  Winters M, Chary A, Eison R, Asmuth D, Holodniy M, Abstracts for the 5th International AIDS Society Conference on HIV Pathogenesis, Treatment and Preve, Cape Town, South Africa
• Antiviral Activity, Safety and Pharmacokinetics of IDX184, a Liver-Targeted Nucleotide HCV Polymerase Inhibitor, in Patients with Chronic Hepatitis C – LB18.
  Lalezari J, Asmuth D, Casiro A, Vargas HE, Patrick GD, Liu W, Pietropaolo K, Zhou X-J, Sullivan-Bolyai J, Mayers DL, Abstracts for the 60th Annual American Association for the Study of Liver Disease Conference, Boston, MA
• Early ART Compared to Deferred ART during Acute Opportunistic Infection Leads to a Reduction in the Systemic Inflammatory Response Resulting in Improved Immunologic Ou...
  Sanchez A, Komarow L, Andersen J, Zolopa A, Grant P, Asmuth D, Pollard R, Devaraj S, Sattler F., In Abstracts for the 17th Conference on Retroviruses and Opportunistic Infections, San Francisco, CA, USA
• CD4+ T-cell depletion in gut-associated lymphoid tissue and CD8+ T-cell hyperactivation in peripheral blood are linked to greater gut-proportion of Enterobacteriales a...
  Ellis CL, Li CS, Hartman AL, Knight T, Overman HA, Mann SK, Ma M, Miller CJ, Yotter T, Melcher GP, Siddiqui J, Troia-Cancio PV, Albanese A, Li XD, Pollard RB, Eisen JA..., In Abstracts for Digestive Disease Weekly 2010 Conference, New Orleans, LA
• Systemic Immune Activation and Duodenal CD4+ T-cell Depletion are Associated with Increased Proportions of Gut Enterobacteriales and Bacteroidales by 16S rDNA Sequence...
  Ellis CL, Mann S, Ma Z-M, Li C-S, Wu J, Knight TH, Overman H, Maniar A, Byun R, DeFreitas D, Li X-D, Torok N, Albanese A, Eisen JA, Rutledge JC, Miller CJ, Pollard RB,..., International AIDS Society – Workshop ”Towards a Cure”: HIV Reservoirs and Strategies to Control The, University of Vienna, Vienna, Austria
• Systemic Immune Activation and Duodenal CD4+ T-cell Depletion are Associated with Increased Proportions of Gut Enterobacteriales and Bacteroidales by 16S rDNA Sequence...
  Ellis CL, Mann S, Ma Z-M, Li C-S, Wu J, Knight TH, Overman H, Maniar A, Byun R, DeFreitas D, Li X-D, Torok N, Albanese A, Eisen JA, Rutledge JC, Miller CJ, Pollard RB,..., bstracts for 28th International AIDS Conference, Vienna, Austria
• Interferon-alpha administration enhances CD8+ T-cell activation in HIV+ persons. In Abstracts for 28th International AIDS Conference.
  Manion M, Rodriguez B, Medvik K, Funderburg, Asmuth D, Landay A, Sieg S, Lederman M., Abstracts for 28th International AIDS Conference., Vienna, Austria
• Impact of Intestinal Fibrosis and Baseline Duodenal Tissue TGF-beta Expression on Immune Reconstitution Following Initiation of Antiretroviral Therapy.
  Asmuth DM, Wu J, Mann S, Ma Z-M, Li C-S, Li X-D, Knight TH, Godinez I, Troia-Cancio P, Maniar A, Flynn N, Chen X, Saroufeem R, Ellis CL, Pinchuk I, Torok N, Baumler AJ..., Abstracts for 28th International AIDS Conference, Vienna, Austria
• Functional Profile of HIV-specific T Cells in Rectal Mucosa.
  Critchfield J, Lemongello D, Young D, Morris M, Schreiber M, Autret B, Garcia J, Asmuth D, Pollard R, Shacklett B., In Abstracts for the 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, CA
• Effect of Antiretroviral Therapy Initiation on Mucosal T-cells in HIV Infection.
  Hayes TL, Critchfield JW, Knight TH, Yotter T, Young DH, Pollard RB, Asmuth DM, and Shacklett BL, In Abstracts for the AIDS Vaccine Conference, Atlanta, GA
• Shifts in Proportions of Higher-taxa Bacterial Orders Measured by 16S rDNA PCR in the Stools of HIV Patients Following Antiretroviral Therapy (ART) and Correlations wi...
  Ellis CL, Li C-S, Ma Z-M, Overman HA, Knight TH, Yotter T, Albanese A, Miller CJ, Rutledge JC, Asmuth DM, In Abstracts for the 18th Conference on Retroviruses and Opportunistic Infections, Boston, MA
• Gastrointestinal-Associated Lymphoid Tissue (GALT) Immune Reconstitution Following Antiretroviral Therapy in Naive Subjects: Results of a Pilot Randomized Clinical Tri...
  Asmuth DM, Ma Z-M, Mann S, Li C-S, Chun T-W, Knight TH, Maniar A, Li X-D, Miller CJ, Pollard RB, In Abstracts for the 18th Conference on Retroviruses and Opportunistic Infections, Boston, MA
• Immunologic Predictors of Immune Reconstitution Inflammatory Syndrome (IRIS) in AIDS Clinical Trials Group (ACTG) A5164.
  Grant P, Komarow L, Lederman M, Pahwa S, Zolopa A, Andersen J, Asmuth D, Pollard R, Richterman A, Sereti I, In Abstracts for the 18th Conference on Retroviruses and Opportunistic Infections, Boston, MA
• Exploring immunopathogenic viral-disruption of bacterial community structure and ecosystem diversity within complex human gut biospheres: specific taxa proportions and...
  Ellis CL, Li C-S, Ma Z-M, Overman HA, Mann SK, Knight TH, Yotter T, Latimore DA, Melcher G, Miller CJ, Rutledge JC, Asmuth DM, Abstracts Book of the Keystone Symposia on Molecular & Cellular Biology – “Microbial Communities as, Breckenridge, CO
• TLR4 Mediated Activation of the CD90+ Mesenchymal Stromal Cells: Role in HIV Associated Intestinal Fibrosis.
  Pinchuk I, Ma Z-M, Mann S, Vargas G, Powell D, Wu J, Li C-S, Knight TH, Latimore D, Miller CJ, Pollard RB, Asmuth DM, Abstracts of the 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy
• The effect of HIV-infection and highly-active anti-retroviral therapy on the human gut microbiome investigated by phylogenetic-targeted 454 pyrosequencing: A meta-geno...
  Ellis C, Li C-S, Mann S, Ma Z-M, Overman H, Maniar A, Yotter T, Tsuchida E, Knight TH, Rutledge JC, Miller CJ, Pollard RB, Asmuth DM, Abstracts of the 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy
• A phase II, randomized, double-blind, multicenter, immunogenicity study of Vacc-4x versus placebo in patients infected with HIV-1 who have maintained an adequate respo...
  Rockstroh JK, Pantaleo G, Pollard R, Van Lunzen J, Asmuth D, Peters B, Lazzarin A, Podzamczer D, Ellefsen-Lovoie, Baksaas, Sommerhelt MA, Wendel-Hansen V, Sorensen B, ..., abstracts of the 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy
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