David A.FoxMD

PubMed

• 22 citations
  Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial.
  Dinesh Khanna, Dinesh Khanna, Cristina Padilla, Lam C Tsoi, Vivek Nagaraja
  JCI Insight. 2022-09-08
• 106 citations
  Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis
  Takashi Maehara, Naoki Kaneko, Cory A. Perugino, Hamid Mattoo, Jesper Kers
  The Journal of Clinical Investigation. 2020-05-01
• 93 citations
  Advances in the medical treatment of rheumatoid arthritis.
  J. Michelle Kahlenberg, David A. Fox
  Hand Clinics. 2011-02-01

Journal Articles

• The incidence of upper extremity surgery for rheumatoid arthritis among medicare beneficiaries  
  Waljee J, Zhong L, Kim HM, Baser O, Yuce H, Fox DA, Chung KC, J Bone Joint Surg Am, 1/1/2015
• Expression and function of aminopeptidase N/CD13 produced by fibroblast-like synoviocytes in rheumatoid arthritis  
  Morgan R, Endres J, Behbahani-Nejad N, Phillips K, Friday SC, Lanigan T, Urquhart A, Chung KC, and Fox DA, Arthritis Rheum, 1/1/2015
• Variation in rheumatoid hand and wrist surgery in the United States: a population – based cohort study  
  Zhong L, Chung K, Baser O, Fox D, Yuce H, Waljee J, J Rheumatol, 1/1/2015
• New therapeutic targets and treatments for immunologic disorders Current and future approaches to the treatment of immunological diseases: new targets and new therapeu...  
  Fox DA, Trans Res, 1/1/2015
• Human B cell-derived lymphoblastoid cell lines constitutively produce Fas ligand and secrete MHCII+FasL+ killer exosomes  
  Klinker MW, Lizzio V, Reed TJ, Fox DA, Lundy SK, Front Immunol, 1/1/2014
• IF-17A, F and AF in inflammation: a study in collagen induced arthritis and rheumatoid arthritis  
  Sarkar S, Justa S, Brucks M, Shivali J, Brucks M, Endres J, Fox DA, Zhou X, Alnaimat F, Whitaker B, Wheeler JC, Jones BH, Bommireddy SR, Clin Exp Immunol, 1/1/2014
• Targeting the myofibroblast genetic switch: inhibitors of MRTF/SRF-regulated gene transcription prevent fibrosis in a murine model of skin injury  
  Haak A, Tsou P-S, Amin M, Ruth J, Campbell P, Fox D, Khanna D, Larsen S, Neubig R, J Pharm Exp Ther, 1/1/2014
• cell subsets and their role in the pathogenesis of rheumatic disease  
  Gizinski AM, Fox DA, Current Opinion in Rheumatology, 1/1/2014
• The roles of IFN-gamma versus IL-17 in human Th17 cell pathogenic functions in rheumatoid arthritis  
  Kato H, Endres J, Fox DA, Mod Rheumatol, 1/1/2013
• Interleukin-5 supports the growth of Fas ligand-expressing regulatory B cells that induce antigen-specific apoptosis of CD4+ T cells  
  Klinker M, Reed T, Fox D, Lundy S, PLOS One, 1/1/2013
• The effect of swan neck and boutonniere deformities on the outcome of silicone metacarpophalangeal joint arthroplasty in rheumatoid arthritis (SARA) Study Group  
  Chetta M, Burns PB, Kim HM, Burke FD, Wilgis EFS, Fox DA, Chung KC, Plast. Reconstr. Surg., 1/1/2013
• Voriconazole-induced periostitis causing arthralgias mimicking a flare of granulomatosis with polyangitis  
  Gladue HS and Fox DA, J Clin Rheumatol, 1/1/2013
• Special Report: Blue Ribbon Panel on Academic Rheumatology Publishes Final Report  
  Fox DA and Holers VM, The Rheumatologist, 1/1/2013
• Blue Ribbon Panel Report on Academic Rheumatology  
  Fox DA, Holers VM et al, American College of Rheumatology, 1/1/2013
• Metacarpophalangeal implant surgery: time for a randomized clinical trial?  
  Kim HM, Burns PB, Fox DA, Chung KC, Burke FD, Wilgis EF, Arthritis Care & Research, 1/1/2013
• Regulation of Th17 Maturatino by Interleukin 4  
  Cooney LA and Fox DA, Critical Reviews in Immunology, 1/1/2013
• Noxa in rheumatic diseases: present understanding and future impact  
  Cottier KE, Fogle EM, Fox DA, Ahmed S, Rheumatology, 1/1/2013
• Long-term follow-up for rheumatoid arthritis patients in a multi-center outcomes study of silicone metacarpo-phalangeal joint arthroplasty  
  Chung KE, Burns PB, Kim HM, Burke FD, Wilgis EFS, Fox DA, Arthritis Care & Research, 1/1/2012
• Tregs cells to the rescue  
  Fox DA, Arthritis Rheum, 1/1/2012
• Kinase inhibition – a new approach to the treatment of rheumatoid arthritis  
  Fox DA, N Engl J Med, 1/1/2012
• Reflecting on early arthritis  
  Kovacs D, Torralba KD, Fox DA, Solomon DH, Panush RS, J Rheumatol., 1/1/2012
• Properties of the International Classification for Functioning, Disability and Health in assessing hand outcomes in patients with rheumatoid arthritis  
  Chung KC, Burns PB, Reichert HA, Fox DA, Burke FD, Wilgis EFS, Regan M, Kim HM, J Rehab Med, 1/1/2011
• Sensitivity and resistance to regulation by IL-4 during Th17 maturation  
  Cooney LA, Towery K, Endres J, Fox DA, J. Immunol., 1/1/2011
• Deciphering the role of Th17 cells in human disease  
  Wilke CM, Bishop K, Fox D and Zou W, Trends Immunol, 1/1/2011
• Advances in the medical treatment of rheumatoid arthritis  
  Kahlenberg M, Fox DA, Hand Clinics of North America, 1/1/2011
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Books/Book Chapters

• Rheumatology 
  Chapter: Emerging therapeutic targets: GM-CSF, IL-17and IL-23 
  Page 518 - 521Gizinski AM, Fox DAEditors: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, and Weisman MH.Elsevier Press, Philadelphia, PAEdition 6th,2015
• ACP Medicine: Allergy & Immunology 
  Chapter: Introduction to clinical immunology: overview of the immune response, autoimmne conditions, and immunosuppressive therapeutics 
  Page 1 - 15Lundy SK, Fox DA, Gizinski AEditors: Nabel EG.Decker Publishing, Hamilton, ON2012
• Rheumatic Disease Clinics of North America 
  Chapter: New Insights into Rheumatoid Arthritis 
  Editors: Fox, DA (Guest Editor),.W.B. Saunders, Elsevier Press, Philadelphia, PA2010
• Rheumatology 
  Chapter: Emerging therapeutic targets: IL15, IL17, IL18, IL23 
  Page 599 - 603Gizinski AM, Fox DAEditors: Hochberg MC.Elsevier Mosby, Philadelphia, PA2010
• The ACR at 75: A Diamond Jubilee 
  Chapter: The relationship between the ACR and the EULAR 
  Smolen JS, Dougado M, Fox, DA, Breedveld FCEditors: Pisetsky DS.Wiley-Blackwell2009
• Making and Using Antibodies: A Practical Handbook 
  Chapter: Quantitative Production of Monoclonal Antibodies 
  Page 95 - 123Fox DA and Smith EEditors: Howard GC, Kaser MR.CRC Press, Boca Raton, FL2006
• The Year in Rheumatic Disorders Volume 5 
  Chapter: Pathogenesis 
  Fox DAEditors: H Luthra, HA Capell, R Madhok.Clinical Publishing, Oxford, England2006
• Rheumatology Educational Initiative, A CME Textbook 
  Chapter: Pathogenesis of rheumatoid arthritis 
  Page 1 - 48Fox DAEditors: Schiff MH.2004
• Leukocyte Typing VII 
  Chapter: Effector function of resting T cells: activation of synovial fibroblasts 
  Page 716 - 718Yamamura Y, Gupta R, Morita Y, He X, Chung K, Freiberg A, and Fox DAOxford University Press2002
• Leukocyte Typing VII 
  Chapter: Functional effects of new T cell panel antibodies and other workshop reagents on interactions between T lymphocytes and synovial fibroblasts 
  Page 699 - 702Fox DA, Morita Y, Gupta R, Pai R, Endres J, and Horesji VOxford University Press2002
• Leukocyte Typing VII 
  Chapter: Human keratinocytes and synovial fibroblasts express a novel CD6 ligand 
  Page 707 - 710Singer NG, Joo YS, Sarkar S, Morita Y, Anderson CA, Endres J, and Fox DAOxford University Press2002
• Encyclopedia of Molecular Medicine 
  Chapter: CD98 (4F2 Antigen) 
  Fox DA2002
• Arthritis and Allied Conditions 
  Chapter: Etiology and pathogenesis of rheumatoid arthritis 
  Page 1085 - 1102Fox DAEditors: Koopman WJ.Edition 14th,2001
• Rheumatoid Arthritis: The New Frontiers in Pathogenesis and Treatment 
  Chapter: The role of T lymphocytes in rheumatoid arthritis 
  Page 89 - 100Fox DAEditors: Wollheim F, Firestein G, Panayi G.Oxford University Press2000
• Molecular Rheumatology 
  Chapter: Cytotoxic drugs 
  Page 451 - 464Fox DA, McCune WJEditors: Tsokos GC, Kammer G.Humana Press2000
• Lupus: Molecular and Cellular Pathogenesis 
  Chapter: Immunosuppressive agents - Biologic effects in vivo and in vitro 
  Page 612 - 641McCune WJ, Fox DAEditors: Tsokos GC, Kammer G.Humana Press1999
• Cells in Arthritis (Progress in Inflammation Research) 
  Chapter: T cell receptor rearrangements 
  Page 19 - 53Fox DA, Singer NGEditors: Miossec P, van den Berg WB, Firestein GS.Birkhauser Publishing Ltd.1998
• Leukocyte Typing VI: White Cell Differentiation Antigens 
  Chapter: EC/18/776 Neurothelin/Basigin/M6/EMMPRIN Workshop Panel Report 
  Page 760 - 763Stockinger H, Ebel T, Hansmann C, Koch C, Majdic O, Prager E, Patel DD, Fox DA, Horejsi V, Sagawa K, Shen DEditors: Kishimoto T, Kikutani H, von dem Borne AEGK, Goyert SM, Mason DY, Miyasaka M, Moretta L, Okumura K, Shaw S, Springer TA, Sugamura K, Zola H.Garland Publishing Inc.1997
• Leukocyte Typing VI: White Cell Differentiation Antigens 
  Chapter: Non-lineage antigens and dendritic cells functional studies: Characterization of synoviocytes as immunocompetent cells 
  Page 604 - 608Singer NS, He X, Diaz L, Freiberg A, Ames T, Fox DAEditors: Kishimoto T, Kikutani H, von dem Borne AEGK, Goyert SM, Mason DY, Miyasaka M, Moretta L, Okumura K, Shaw S, Springer TA, Sugamura K, Zola H.Garland Publishing Inc.1997
• Leukocyte Typing VI: White Cell Differentiation Antigens 
  Chapter: CD98 Workshop panel Report 
  Page 531 - 534Diaz LA, Antony PA, Endres J, Fox DAEditors: Kishimoto T, Kikutani H, von dem Borne AEGK, Goyert SM, Mason DY, Miyasaka M, Moretta L, Okumura K, Shaw S, Springer TA, Sugamura K, Zola H.Garland Publishing Inc.1997
• Leukocyte Typing V 
  Chapter: Classification and functional properties of normal T cell subsets 
  Page 437 - 443Fox DA, Sanders J, Diaz LA JrEditors: Schlossman S, Boumsell L, Gilks W, Harlan J, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R Springer T, Tedder T, Todd R.Oxford University Press1995
• Leukocyte Typing V 
  Chapter: Anti-CD6 monoclonal antibodies inhibit the antigen-specific and autoreactive responses of cloned human T lymphocytes 
  Page 419 - 422Singer NS, Bott CM, Lialios F, Richardson BC, Fox DAEditors: Schlossman S, Boumsell L, Gilks W, Harlan J, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R Springer T, Tedder T, Todd R.Oxford University Press1995
• Leukocyte Typing V 
  Chapter: Evidence that CD60 is distinct from other sialylated T cell surface antigens 
  Page 399 - 341Fox DA, Li LL, Shimizu Y, Kozarsky KFEditors: Schlossman S, Boumsell L, Gilks W, Harlan J, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R Springer T, Tedder T, Todd R.Oxford University Press1995
• Leukocyte Typing V 
  Chapter: Epitopes and functional responses defined by workshop anti-CD2 antibodies 
  Page 346 - 347Bowden G, Diaz LA Jr., Li LL, Fox DAEditors: Schlossman S, Boumsell L, Gilks W, Harlan J, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R Springer T, Tedder T, Todd R.Oxford University Press1995
• Leukocyte Typing V 
  Chapter: T-Cell Signaling: Workshop Report 
  Page 295 - 301Rudd CE, Altin JG, Cinek T, Crumpton MJ, Fox DA, Horejsi V, Krissanen GW, Levine BL, June CH, Osman N, Print C, Schraven B, Skubitz KM, Thompson LF, Bismuth GEditors: Schlossman S, Boumsell L, Gilks W, Harlan J, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R Springer T, Tedder T, Todd R.Oxford University Press1995
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Abstracts/Posters

• Evidence for Citrullination of the Nuclear Transciption Factor Inhibitor of DNA Binding 1 (Id1) in Rheumatoid Arthritis
  Ohara RA, Edhayan G, Ha CM, Amin MA, Arbab AS, Campbell PL, Fox DA and Ruth JH, Arthritis Rheum, 1/1/2014
• Correlates of Body Image Dissatisfaction in Patients with Limited and Diffuse Systemic Sclerosis
  Fox RS, Mills SD, Gholizadeh Si, Merz EL, Roesch SC, Clements PJ, Kafaja S, Khanna D, Furst DE and Malcarne VL, Arthritis Rheum, 1/1/2014
• Reliability and Validity of the Arthritis Helplessness Index in Systemic Sclerosis
  Gholizadeh S, Mills SD, Fox RS, Clements PJ, Kafaja S, Malcarne VL, Furst DE and Khanna D, Arthritis Rheum, 1/1/2014
• Inflammatory Properties of Inhibitor of DNA Binding 1 As a Unique Fibroblast Derived Nuclear Protein
  Edhayan G, Ha CM, Ohara RA, Isozaki T, Amin MA, Arbab A, Tsou P-S, Campbell PL, Schiopu E, Khanna D, Moran R, Friday SC, Fox DA and Ruth J, Arthritis Rheum, 1/1/2014
• Activation of the Thromboxane A2 Receptor By 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma
  Tsou P-S Tsou, Zakhem G, Balogh B, Amin MA, Campbell P, Edhayan G, Ohara RA, Schiopu E, Khanna D, Koch AE and Fox DA, Arthritis Rheum, 1/1/2014
• Lipoic acid plays a crucial role in scleroderma dermal fibroblasts
  Tsou P-S, Balough B, Pinney AJ, Zakhem G, Kendzicky A, Schiopu E, Khanna D, Fox DA, Koch AE, Arthritis Rheum, 1/1/2013
• Elevated 8-isoprostane in scleroderma: implications of its role in inhibiting vascular endothelial growth factor-induced angiogenesis
  Tsou P-S, Zakhem G, Balough B, Amin MA, Campbell P, Edhayan G, Ohara R, Schiopu E, Khanna D, Koch AE, Fox DA, Arthritis Rheum, 1/1/2013
• Citrullination of ENA-78/CXCL5 changes its receptor affinity from CXCR2 To CXCR1 and induces monocyte migration
  Yoshia K, Koch AE, Ohara RA, Campbell PL, Amin MA, Fox DA, Ruth JH, Arthritis Rheum, 1/1/2013
• A unique role for galectin-9 in angiogenesis and inflammatory arthritis
  Obrien M, Shu Q, Tsou P-S, Stinson W, Ruth JH, Isozaki T, Koch AE, Fox DA, Amin MA, Arthritis Rheum, 1/1/2013
• Inhibitor of DNA binding 1 mediates angiogenesis in rheumatoid arthritis by recruitment of endothelial progenitor cells
  Koch AE, Amin MA, Arbab AS, Edhayan G, Ha CM, Tsou P-S, Friday SC, Fox DA, Ruth JH, Arthritis Rheum, 1/1/2013
• Novel selective inhibitors of nuclear export attenuate inflammation and prevent bone mineral density loss in multiple preclinical models of rheumatoid arthritis
  Hamuza M, Landesman Y, Klebanov B, Kauffman M, Shacham S, Endres J, Fox DA, McCauley D, Arthritis Rheum, 1/1/2013
• Functions Of Aminopeptidase N/CD13 In Vitro On Rheumatoid Arthritis Synovial Cells
  Morgan R, Behbahani-Nejad N, Endres J, Fox DA, Arthritis Rheum, 1/1/2013
• Interpretation of patient reported outcomes measurement information system (PROMIS) by rheumatologists
  Nagaraja V, Fox DA, Francis S, Singer O, Khanna P, Laing T, Marks R, Monrad SU, Ognenovski VM, Phillips KI, Khanna D, Arthritis Rheum, 1/1/2013
• Modulating myofibroblast transition of human scleroderma fibroblasts through inhibition of Rho guanine nucleotidase-regulated gene transcription
  Haak A, Tsou P-S, Khanna D, Fox DA, Larsen SD, Neubig RR, Arthritis Rheum, 1/1/2013
• The DEK autoantigen regulates formation of neutrophil extracellular traps and zymosan induced arthritis
  Mor-Vaknin N, Saha AK, Legendre M, Gonzalez-Hernandez MJ, Amin MA, Rabquer BJ, Jorns JM, Kaplan MJ, Adams BS, Fox DA, Koch AE and Markovitz D, Arthritis Rheum, 1/1/2012
• Role of phospholipase D1 (PLD1) in the expression of proinflammatory genes in rheumatoid arthritis synovial fibroblasts (RASF)
  Friday SC, and Fox DA, Arthritis Rheum, 1/1/2012
• IL-5-induced FasL+ regulatory B cells are inhibited by IL-4 and cyclosporine
  Klinker MW, Alzua BR, Reed TJ, Fox DA and Lundy SK, Arthritis Rheum, 1/1/2012
• Aminopeptidase N/CD13 Localization and chemotaxis in rheumatoid arthritis in vivo and in vitro
  Morgan R, Behbahani-Nejad N, Endres J, Fox DA, Arthritis Rheum, 1/1/2011
• Defining pathogenicity of human Th17 cells in rheumatoid arthritis
  Kato H, Endres J, Fox DA, Arthritis Rheum, 1/1/2011
• Stratification of rheumatoid arthritis patients into disease subtypes with clinical implications
  Dennis G, Holweg C, Kackney J, Blibert H, Lin WY, Diehl L, Endres J, Fox DA, Townsend M, Martin F, Arthritis Rheum, 1/1/2010
• Role for IL-23 in Differentiation of Human Th17 Cells
  Kato H, Cooney L, Endres J, Fox DA, Arthritis Rheum, 1/1/2010
• Functional Expression of CD13/Aminopeptidase N by RA synovial cells in vitro and in vivo
  Morgan R, Endres J, Fox DA, Arthritis Rheum, 1/1/2010
• A genetic mechanism for the determination of the severity of rheumatoid arthritis: a polymorphism in the IL-4 receptor controls the ability of IL-4 to regulate Th17 cells
  Fox DA, Wallis SK, Tesmer L, Endres J, Lee J, Riu M, Somers E, Annals of the Rheumatic Diseases, 1/1/2009
• Role of renin-angiotensin system activation in the development of vascular damages in rat adjuvant-induced arthrits: effect of angiotensin receptor blockers
  Morita Y, Sajuta T, Satoh M, Fox DA, Kashihara N, Annals of the Rheumatic Diseases, 1/1/2009
• Gene expression signatures in synovial tissue define distinct molecular subtypes of rheumatoid arthritis
  Endres J, Fox, DA, Arthritis Rheum, 1/1/2009
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Other

• Knee Pain or Swelling: Acute or Chronic (Update) 
  Kiningham RB, Desmond JS, Fox DA, Haftel HM, Wojtys EM, McQuillan MA, Office of Clinical Affairs, University of Michigan Health System
  Ann Arbor, MI - 1/1/2002
• Michigan Arthritis Action Plan. A Strategic Plan to Reduce the Burden of Arthritis in Michigan 
  Fox DA, Glazier M, and members of the MAAP Steering Committee, Michigan Department of Community Health
  1/1/2001
• The immune system and your arthritis (pamphlet for patients) 
  O’Dell J, Fox DA, Robbins L, Arthritis Foundation
  1/1/2000
• Acute and Chronic Knee Pain and/or Swelling 
  Kiningham, RB, Desmond JS, Fox DA, Haftel HM, Wojtys EM, McQuillan MA, Office of Clinical Affairs, University of Michigan Health System
  Ann Arbor, MI - 1/1/1997
• (Reviewer, BF Haynes) Protein reviews on the web. Guide on CD98. 
  Diaz L, Fox DA, PROW CD Index
  1/1/1997
• (Reviewer, DA Fox) Protein reviews on the web. Guide on CD60 
  de Haas M, PROW CD Index
  1/1/1997
• Arthritis: A look to the future. A public health plan for arthritis programming in Michigan 
  Indenbaum S, Alderson M, Doyle TH, Fernandez-Madrid F, Fox DA, Hill G, Laing TJ, Leisen JC, Mayes M, Rosenthal J, Vert L, Winkel M, Kuehnel S, Izenson S, Arthritis Plan Committee, Chronic Disease Advisory Committee, Michigan Department of Public Health
  1/1/1993
• Rheumatoid Arthritis (pamphlet for patients) 
  Fox DA, Arthritis Foundation
  1/1/1993
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