DarrellWuMD

PubMed

• Commentary: Unraveling the mysteries of atherogenesis: An elusive goal.
  Darrell Wu, Shuab Omer
  The Journal of Thoracic and Cardiovascular Surgery. 2021-05-01
• Commentary: Of mice and Marfan.
  Darrell Wu, Shuab Omer
  The Journal of Thoracic and Cardiovascular Surgery. 2020-05-01
• 62 citations
  Targeting the NLRP3 inflammasome with inhibitor MCC950 prevents aortic aneurysms and dissections in mice
  Pingping Ren, Darrell Wu, Richard Appel, Lin Zhang, Chen Zhang
  Journal of the American Heart Association. 2020-04-09

Journal Articles

• Postoperative Chylothorax After Thoracoabdominal Aortic Aneurysm Repair  
  Wu D, Chesnokova AE, Akvan S, Price MD, Sugarbaker DJ, Coselli JS, LeMaire SA, Semin Thorac Cardiovasc Surg, 1/8/2018
• Unplanned Readmissions After Open Thoracoabdominal Aortic Aneurysm Repair  
  Wu D, Price MD, Amarasekara HS, Green SY, Woodside SJ, Tullos A, Zhang Q, Coselli JS, LeMaire SA, Ann Thorc Surg, 1/1/2018
• NLRP3 (Nucloetide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflamamsome Degrades Contractile Proteins: Implications for Aortic...  
  Wu D, Ren P, Zheng Y, Xu G, Zhang L, Xie W, Lloyd E, Zhang S, Curci J, Milewicz D, Shen Y, LeMaire SA, Arterioscler Thromb Vasc Biol, 1/1/2017
• Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice  
  Ren P, Hughes M, Krishnamoorthy S, Zou S, Zhng L, Wu D, Zhang C, Curci JA, Coselli JS, Milewicz DM, LeMaire SA, Shen YH, Sci Rep, 1/1/2017
• Hepatopancreatobiliary Laboratory Values after Thoracoabdominal Aortic Aneurysm Repair  
  Wu D, Coselli JS, Johnson ML, LeMaire SA, Aorta, 1/1/2014
• D-dimer levels remain elevated in acute aortic dissection ten days after onset  
  Albini, PA, Barshes N, Wu D, Shen YH, Russel L, Albini P, Haas D, Allison P, LeMaire SA, J Surg Res, 1/1/2014
• Inflammatory cell infiltrates after thoracic aortic dissection  
  WuD, Choi JC, Sameri A, Minard CG, Coselli JS, Shen YH, LeMaire SA, Aorta, 1/1/2013
• Altered expression of matrix metalloproteinase levels in chronic descending thoracic aortic dissection  
  Fung X, Wu D, Choi JC, Zhang X, Russell L, Coselli JS, Shen YH, LeMaire SA, J Surg Res
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Books/Book Chapters

• Thoraco-abdominal Aortic Aneurysm Repair 
  Chapter: Definitions and classifications. 
  Wu D, LeMaire SA, Coselli JSEditors: Chiesa R, Zangrillo A, Alfieri O, Melissano G, Coselli JS.2011

Abstracts/Posters

• Redo Sternotomy in 235 Aortic Root Patients.
  Wu D, PRice, MS, Green S, DelaCruz KI, Preventza O, LeMaire SA, Coselli JS, Association for Academic Thoracic Surgery, 1/1/2018
• Postoperative Chylothorax After Thoracoabdominal Aortic Aneurysm Repair.
  Wu D, Chesnokova AE, Akvan S, Price MD, Sugarbaker DJ, Coselli JS, LeMaire SA, Aortic Symposium, Association for Academic Thoracic Surgery, 1/1/2016
• NLRPS Inflammasome Cascade and STING/IRF3 Pathway Induce Vascular Smooth Muscle Cell Phenotypic Switch in Aortic Aneurysms and Dissection.
  Zheng Y, Hughes M, Wu D, Krishnamurthy S, Zhang L, Coselli JS, Shen YH, LeMaire SA, National Student Research Forum, University of Texas Medical Branch in Galveston, 1/1/2015
• NLRP3 Inflammasome Induces Smooth Muscle Cell Dedifferentiation Leading to Thoracic Aortic Biomechanical Failure.
  Wu D, Zheng Y, Hughes M, Zhang L, Coselli JS, Shen HY, LeMaire SA, Walter Lillehei Surgical Forum, American Association for Thoracic Surgery, Toronto, CA, 1/26/2014
• ADAMTS-4 deficiency attenuates aortic aneurysm and dissection formation in mice.
  LeMaire SA, Ren P, Zou S, Krishnamoorthy S, Zhang L, Hou X, Lu X, Wu D, Choi JC, Coselli JS, Shen YH, Aortic Symposium, American Association for Thoracic Surgery, New York, NY, 1/24/2014
• Glyburide prevents aortic aneurysm and dissection in a mouse model.
  Wu D, Zheng Y, Choi JC, Zhang L, Coselli JS, Shen HY, LeMaire SA, American College of Surgeons South Texas Chapter, Austin, TX, 1/21/2014
• Stress-induced activation of TGFBeta signaling during acute ascending aortic stress.
  Choi JC, Wu D, Zheng Y, Zhang L, Coselli JS, Shen YH, LeMaire SA, American College of Surgeons South Texas Chapter, Austin, TX, 1/21/2014
• Blockade of the NLRP3 inflammasome cascade prevents thoracic aortic aneurysm and dissection Formation.
  Wu D, Zheng Y, Choi JC, Zhang L, Coselli JS, Shen YH, LeMaire SA, J Surg Res, 1/1/2014
• NLRP3 Inflammasome Degrades Contractile Proteins Leading to Thoracic Aortic Biomechanical Failure in a Murine Model.
  Zheng Y, Wu D, Hughes M, Zhang L, Coselli JS, LeMaire SA, GenTAC Thoracic Aortic Disease Summit, 1/1/2014
• Stress-induced activation of TGFBeta signaling during acute ascending aortic stress.
  Choi JC, Wu D, Zheng Y, Zhang L, Coselli JS, Shen YH, LeMaire SA, 2nd Annual Baylor College of Medicine Cardiovascular Institute Symposium, 1/1/2014
• Blockade of the NLRP3 inflammasome cascade prevents thoracic aortic aneurysm and dissection Formation.
  Wu D, Zheng Y, Choi JC, Zhang L, Coselli JS, Shen YH, LeMaire, SA, 2nd Annual Baylor College of Medicine Cardiovascular Institute Symposium, 1/1/2014
• Crosstalk between the NLRP3 inflammasome complex and TGF signaling.
  Choi JC, Wu D, Zhang L, Cosell JS, Shen YH, LeMaire SA, Michael E. DeBakey Department of Surgery Research Day, 1/5/2013
• NLRP3 inflammasome cascade activates MMP-9 and induces smooth muscle cell contractile dysfunction and ECM destruction in thoracic aortic disease.
  Wu D, Xu G, Ren P, Zhang L, Coselli JS, Shen HY, LeMaire SA, Michael E. DeBakey Department of Surgery Research Day, 1/5/2013
• NLRP3 inflammasome activates matrix metalloproteinase-9: potential role in smooth muscle cell dysfunction in thoracic aortic disease.
  Wu D, Choi JC, Coselli JS, Shen YH, LeMaire SA, J Surg Res, 8th Academic Surgical Congress, New Orleans, LA, 1/5/2013
• Inflammatory infiltrate in thoracic aortic dissection.
  Choi JC, Wu D, Sameri A, Albini P, Nguyen MT, Russel L, Palmero L, Coselli JS, Shen YH, LeMaire SA, J Surg Res, 8th Academic Surgical Congress, New Orleans, LA, 1/5/2013
• AKT2 deficient aortas exhibit reduced residual strain.
  Wu D, Choi JC, Coselli JS, Shen YH, LeMaire SA, J Surg Res, 8th Academic Surgical Congress, New Orleans, LA, 1/5/2013
• Advanced aortic atherosclerosis is associated with increased medial degeneration in sporadic ascending aortic aneurysms.
  Albini PT, Segura AM, Minard CG, Liu G, Wu D, Nguyen MT, Palmero L, Zhang L, Song J, Coselli JS, Milewicz D, Shen YH, LeMaire SA, 1st Annual Michael E. DeBakey Department of Surgery Research Day, Baylor College of Medicine, 1/5/2013
• Crosstalk between the NLRP3 inflammasome complex and TGF signaling.
  Choi JC, Wu D, Zhang L, Cosell JS, Shen YH, LeMaire SA, 1st Annual Michael E. DeBakey Department of Surgery Research Day, Baylor College of Medicine, 1/5/2013
• NLRP3 inflammasome cascade activated MMP-9, and induces smooth muscle cell contractile dysfunction and ECM destruction in thoracic aortic disease.
  Wu D, Xu G, Ren P, Zhang L, Coselli JS, Shen YH, LeMaire SA, 1st Annual Baylor College of Medicine Cardiovascular Institute Symposium, 1/1/2013
• Inflammatory cell infiltrates after Thoracic Aortic Dissection.
  Choi JC, Wu D, Sameri A, Nguyen MT, Minard CG, Coselli JS Shen YH, LeMaire SA, 1st Annual Baylor College of Medicine Cardiovascular Institute Symposium, 1/1/2013
• Advanced aortic atherosclerosis is associated with increased medial degeneration in sporadic ascending aortic aneurysms.
  Albini PT, Wu D, Segura AM, Minard CG, Liu G, Nguyen MT, Palmero L, Zhang L, Song J, Coselli JS, Milewicz D, Shen YH, LeMaire SA, 1st Annual Baylor College of Medicine Cardiovascular Institute Symposium, 1/1/2013
• Atherosclerosis in sporadic ascending aortic aneurysm.
  Albini PT, Wu D, Xu G, Xie W, Ren P, Zhang L, Palmero L, Coselli JS, Shen HY, LeMaire SA, J Surg Res, 1/1/2012
• NLRP3 inflammasome is upregulated in thoracic aortic aneurysms and dissections.
  Wu D, Albini P, Xu G, Xie W, Ren P, Zhang L, Palmero L, Coselli JS, Shen YH, LeMaire SA, J Surg Res, 1/1/2012
• AKT2 deficient mice are susceptible to developing aortic aneurysms and dissection.
  LeMaire SA, Zhang L, Nguyen MT, Ren P, Wu D, Coselli JS, Shen YH, GenTAC Thoracic Aortic Disease Summit, 1/1/2012
• Amplification of the NLRP3 inflammasome cascade in thoracic aortic aneurysms and dissections: a potential mechanism for matrix metalloprotinease-9 activation.
  Wu D, Albini P, Xu G, Xie W, Ren P, Zhang L, Palmero L, Coselli JS, Shen YH, LeMaire SA, GenTAC Thoracic Aortic Disease Summit, 1/1/2012
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Lectures

• Unplanned Readmissions After Open Thoracoabdominal Aortic Aneurysm Repair. 
  1/1/2017
• Postoperative chylothorax following thoracoabdominal aortic aneurysm repair. 
  1/1/2015
• Glyburide prevents aortic aneurysm and dissection in a mouse model. 
  Austin, TX - 1/21/2014
• Blockade of the NLRP3 inflammasome cascade prevents thoracic aortic aneurysm and dissection Formation. 
  San Diego, CA, 2014 - 1/3/2014
• NLRP3 inflammasome activates matrix metalloproteinase-9 leading to smooth muscle cell contractile dysfunction and extracellular matrix destruction. 
  Houston, TX - 1/14/2013
• Amplification of the NLRP3 inflammasome cascade in thoracic aortic aneurysms and dissections. 
  1/6/2012
• NLRP3 inflammasome is upregulated in thoracic aortic aneurysms and dissections. 
  Las Vegas, NV - 1/5/2012
• NLRP3 inflammasome activates matrix metalloproteinase-9: potential role in smooth muscle cell dysfunction in thoracic aortic disease. 
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Other

• AKT2 deficient aortas exhibit reduced residual strain. 
  Wu D, 8th Academic Surgical Congress
  New Orleans, LA - 1/5/2013