DarrellLewisMD

Child Neurology • Durham, NC

Professor, Pediatrics, Duke University School of Medicine

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Office
2100 Erwin Rd
Durham, NC 27705
Phone+1 919-620-4467

Summary

I am a Pediatric Neurologist with special interest in Epilepsy. Although I am in partial retirement, I continue to act as Principal Investigator of the Imaging Core of the FEBSTAT project, a multicenter, NINDS funded longitudinal study entitled, “Consequences of Prolonged Febrile Seizures in Childhood” (PI Dr Shlomo Shinnar). This project was based to a large part on the widely cited preliminary study I conducted at Duke about 20 years ago (Vanlandingham, KE, Heinz, JE, Cavazos, JE, and Lewis, DV. MRI evidence of hippocampal injury following prolonged, focal febrile convulsions. Ann Neurol, 43:413-426, 1998). The goal of FEBSTAT is to determine the long term effects of infantile febrile status epilepticus on development and brain growth with special emphasis on the development of temporal lobe epilepsy. FEBSTAT is now in its 12th year and is providing valuable information on febrile status and its consequences (Publications listed under Publications and Presentations with “FEBSTAT Study” in title).

Education & Training

Duke University HospitalResidency, Pediatrics, 1975 - 1977
Johns Hopkins UniversityResidency, Pediatrics, 1969 - 1972
University of Minnesota Medical SchoolClass of 1969
University of MinnesotaB.A., 1965

Certifications & Licensure

NC State Medical License 2010 - 2025
American Board of Psychiatry and Neurology Neurology with Special Qualification in Child Neurology

Awards, Honors, & Recognition

Alpha Omega Alpha Medical Honor Society University of Minnesota
James Moor Honorary Society University of Minnesota

Publications & Presentations

PubMed

170 citations
Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT study
Darrell V. Lewis, Shlomo Shinnar, Dale C. Hesdorffer, Emilia Bagiella, Jacqueline A. Bello
Annals of Neurology. 2014-02-01
79 citations
Neuronal migration disorders: positron emission tomography correlations.
Namsoo Lee, Rodney A. Radtke, Linda Gray, Peter C. Burger, Thomas J. Montine
Annals of Neurology. 1994-03-01
84 citations
Hippocampal MRI Signal Hyperintensity After Febrile Status Epilepticus Is Predictive of Subsequent Mesial Temporal Sclerosis
James M. Provenzale, Daniel P. Barboriak, Kevan E. VanLandingham, James R. MacFall, David M. DeLong
AJR. American Journal of Roentgenology. 2008-04-01

Journal Articles

Hippocampal Malrotation (HIMAL) is Associated with Prolonged Febrile Seizures: Results of the FEBSTAT Study
Chan S, Bello JA, Shinnar S, Hesdorffer DC, Lewis DV, et al, AJR, 1/1/2015
Risk Factors for Febrile Status Epilepticus: A Case Control Study
Hesdorffer, DC, Shinnar, S, Lewis, DV, et al, J Pediatr, 1/1/2013
MR Imaging abnormalities following Febrile Status Epilepticus in Children: Results of the FEBSTAT Study
Shinnar S, Bello JA, Chan S, Hesdorffer DC, Lewis DV, MacFall J, Pellock, JM, Nordli DR, Frank ML, Moshe SL, Gomes W, Shinnar R, Sun S and the FEBSTAT Study Team, Neurology, 1/1/2012
GFAP mutations, age at onset, and clinical subtypes in Alexander disease
Prust M, Wang J, Morizono H, Messing A, Brenner M, Gordon E, Hartka T, Sokohl A, Schiffmann R, Gordish-Dressman H, Albin R, Amartino H, Brockman K, Dinopoulos A, Dotti..., Neurology, 1/1/2011
The effect of vagus nerve stimulation on body mass index in children
Kansagra S, Ataya N, Lewis D, Gallentine W, and Mikati M, Epilepsy and Behavior, 1/1/2010
A Comparison of Automated Segmentation and Manual Tracing for Quantification of Hippocampal and Amygdala Volumes
Morey RA, Petty CM, Xu Y, Hayes JP, Wagner HR, Lewis DV, Labar KS, Styner M, and McCarthy G, Neuroimage, 1/1/2009
Extra hippocampal involvement in human Herpesvirus 6 encephalitis depicted at MR imaging
Provenzale, Vanlandingham, Lewis, White et al, Radiology, 1/1/2008
Phenomenology of Prolonged Febrile Seizures: Results of the FEBSTAT study
Shinnar S, Hesdorffer DC, Nordli DR Jr, Pellock, JM, O'Dell C, Lewis, DV, Frank LM, Moshe SL, Epstein, LG, Marmarou A, Bagiella E and the FEBSTAT study team, Neurology, 1/1/2008
Hippocampal MR Imaging Signal Hyperintensity following Febrile Status Epilepticus Is Predictive of Subsequent Mesial Temporal Sclerosis
Provenzale, JM, Barboriak,DP, Vanlandingham, K, MacFall J, Delong D and Lewis DV, American Journal of Roentgenology, 1/1/2008
Effects of Gamma Hydroxybutyric Acid on Inhibition and Excitation in Rat Neocortex
Li, Q, Kuhn, CM, Wilson, WA and Lewis, DV, Neuroscience, 1/1/2007
Parry-Romberg syndrome with fatal brain stem involvement
Sathornsumette, S, Schanberg, L, Rabinovich, E, Lewis, D, and Weisleder, P, J. Pediatr, 1/1/2005
Dietary prenatal choline supplementation enhances excitatory function and morphology of hippocampal CA1 pyramidal cells
Li, Q, Guo-Ross, S, Lewis, DV, Turner, D, White, AM, Wilson, WA, and Swartzwelder, HS, Journal of Neurophysiology, 1/1/2004
Do Prolonged Febrile Seizures Produce Medial Temporal Sclerosis? Hypotheses, MRI Evidence and Unanswered Questions
Lewis, DV, Barboriak D,MacFall, JR, Provenzale, JM, Mitchell, TV,and VanLandingham, KD, Prog in Brain Res, 1/1/2002
NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: A potential mechanism of neurotoxicity
Li, Q, Clark, S, Lewis, DV, and Wilson, WA, J Neurosci, 1/1/2002
Clinical and molecular characterization of Alexander disease patients
Gorospe, JR, Naidu, S, Johnson, A, Ayuste, O, Puri, V, Raymond, G, Jenkins, S, Pedersen,R, Lewis, D, Knowles, P, Fernandez, R, and Hoffman, E, Neurology, 1/1/2002
Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy
Verma, A, Lewis, D, Vanlandingham, KE, Husain, AM, Friedman, AH, Thompson, E, and Radtke, RA, Epil Res, 1/1/2001
Human herpesvirus 6 limbic encephalitis after stem cell transplant
Wainwright, MS, Martin, PL, Morse, RP, Lacaze, M, Provenzale, JM, Coleman, RE, Morgan, MA, Hulette, C, Kurtzberg, J, Bushnell, C, Epstein, L, and Lewis, DV, Annals of Neurology, 1/1/2001
Seizure outcome after temporal lobectomy for temporal lobe epilepsy: A Kaplan-Meier survival analysis
Foldvary, N, Nashold, B, Mascha, E, Thompson, EA, Lee, N, McNamara, JO, Lewis, DV, Luther, JS, Friedman, AH, and Radtke, RA, Neurology, 1/1/2000
Early diffusion weighted MR abnormalities in status epilepticus
Kassem-Moussa, H, Provenzale, JM, Petrella, JR, and Lewis, DV, Amer. J. Roent, 1/1/2000
Three children with a syndrome of obesity and overgrowth, atypical psychosis, and seizures: A problem in neuro-psychopharmacology
Jobe A, Lewis DV, Wainwright M, DeLong GR, Journal of Child Neurology, 1/1/2000
GABAB receptor mediated currents in interneurons of the dentate hilus border
Mott, DD, Li, Q, Okazaki, MM, Turner, DA, Li, Q, and Lewis, DV., J. Neurophysiol, 1/1/1999
Febrile convulsions and mesial temporal sclerosis
Lewis, DV, Current Opinion in Neurology, 1/1/1999
Effect of antiepileptic drug therapy on California achievement test scores
Tennison M Kankirawatana, P, Bowman, MR, Greenwood, R Lewis, D, and Burchinal, M, J. Epilepsy, 1/1/1998
MRI evidence of hippocampal injury following prolonged, focal febrile convulsions
Vanlandingham, KE, Heinz, JE, Cavazos, JE, and Lewis, DV, Ann Neurol, 1/1/1998
Involvement of cAMP dependent protien kinase in mu opioid modulation of NMDA receptor dependent synaptic currents
Xie, CW and Lewis, DV, J. Neurophysiol, 1/1/1997
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Books/Book Chapters

Epilepsy, A Comprehensive Textbook
Chapter: Febrile Status Epilepticus
Page 731 - 736Lewis, DV and Shinnar, SEditors: Engel and Pedley.2008
Febrile Seizures
Chapter: Do prolonged febrile seizures injure the hippocampus: Human MRI studies
Page 103 - 121Mitchell, TV and Lewis, DVEditors: TZ Baram and S Shinnar.2002
International Review of Neurobiology
Chapter: Pharmacology and Function of Central GABAB Receptors
Page 97 - 210Mott, DD and Lewis, DVEditors: R.J. Bradley and R.A. Harris.Academic Press1994
Presynaptic Receptors in the CNS: Physiology and Pharmacology
Chapter: The role of GABAB receptors in stimulus dependent disinhibition and the induction of long term potentiation
Page 160 - 179Lewis, DV, Mott, DD, Swartzwelder, HS and Xie, CWEditors: T.V. Dunwiddie and D.M. Lovinger.Springer-Verlag1993
The Dentate Gyrus and Its Role in Seizures
Chapter: GABAB Receptors Mediate Disinhibition and Facilitate Long Term Potentiation in the Dentate Gyrus
Page 119 - 134Mott, DD and Lewis, DVEditors: C. Ribak, C. M. Gall and I. Mody.Epilepsy Research Supplement1992
Kindling 4
Chapter: Spontaneous electrographic seizures in the hippocampal slice: An in vitro model for the study of the transition from interictal to ictal activity
Page 11 - 19Lewis DV and Wilson WAEditors: J. Wada.Plenum Press, New York, NY1990
The NMDA Receptor
Chapter: The NMDA receptor in epilepsy
Page 166 - 176Wilson, WA, Stasheff, S, Swartzwelder, S, Clark, S, Anderson, AA, and Lewis, DVEditors: JC Watkins and GL Collingridge.Oxford University Press, Oxford, England1989
Basic Mechanisms of the Epilepsies Molecular and Cellular Approaches
Chapter: Membrane currents underlying bursting pacemaker activity and spike frequency adaptation in invertebrates
Lewis DV, Huguenard JP, Anderson WN, Wilson WAEditors: Delgato_x001E_Esqueta, AV, Ward AA, Woodbury DM.Raven Press, New York, NY1986
Physiology and Pharmacology of Epileptogenic Phenomena
Chapter: Enhancement of spike frequency adaptation by anticonvulsants
Page 259 - 267Wilson WA, Zbicz KL, Lewis DVEditors: Klee MR, Lux HD, Speckman EJ.Raven Press, New York, NY1982
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