DanielSanghoonShinMDPhD

PubMed

• Enhanced CTLA-4 blockade anti-tumor immunity with APG-157 combination in a murine head and neck cancer.
  Daniel Sanghoon Shin, Daniel Sanghoon Shin, Saroj Basak, Mysore S Veena, Begoña Comin-Anduix
  Cancer Medicine. 2024-05-01
• Gigaxonin Suppresses Epithelial-to-Mesenchymal Transition of Human Cancer Through Downregulation of Snail.
  Mysore S Veena, Jungmo J Gahng, Mustafa Alani, Albert Y Ko, Saroj K Basak
  Cancer Research Communications. 2024-03-08
• 5 citations
  CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes.
  Sameeha Jilani, Justin D Saco, Edurne Mugarza, Aleida Pujol-Morcillo, Jeffrey Chokry
  Nature Communications. 2024-02-09

Journal Articles

• Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer  
  Mysore S Veena, Santanu Raychaudhuri, Saroj K Basak, Natarajan Venkatesan, Parameet Kumar, Roopa Biswas, Rita Chakrabarti, Jing Lu, Trent Su, Marcus Gallagher-Jones, M..., Journal of Biological Chemistry, 12/11/2020
• Conserved interferon-γ signaling drives clinical response to immune checkpoint blockade therapy in melanoma  
  Catherine S Grasso, Jennifer Tsoi, Mykola Onyshchenko, Gabriel Abril-Rodriguez, Petra Ross-Macdonald, Megan Wind-Rotolo, Ameya Champhekar, Egmidio Medina, Davis Y Torr..., Cancer Cell, 10/12/2020
• A randomized, phase 1, placebo‐controlled trial of APG‐157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor‐associated m...  
  Saroj K Basak, Alakesh Bera, Alexander J Yoon, Marco Morselli, Chan Jeong, Anela Tosevska, Tien S Dong, Michael Eklund, Eric Russ, Hassan Nasser, Venu Lagishetty, Rong..., Cancer, 4/15/2020
• Clinical features and outcomes of immune checkpoint inhibitor–associated AKI: a multicenter study  
  Frank B Cortazar, Zoe A Kibbelaar, Ilya G Glezerman, Ala Abudayyeh, Omar Mamlouk, Shveta S Motwani, Naoka Murakami, Sandra M Herrmann, Sandhya Manohar, Anushree C Shir..., Journal of the American Society of Nephrology: JASN, 1/2/2020
• Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis  
  Nicolaos Jay Palaskas, Jacob David Garcia, Roksana Shirazi, Daniel Sanghoon Shin, Cristina Puig-Saus, Daniel Braas, Antoni Ribas, Thomas Glen Graeber, Cell discovery, 11/26/2019
• Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation  
  Srinivas Aluri, Rongbao Zhao, Kai Lin, Daniel Sanghoon Shin, Andras Fiser, I David Goldman, Journal of Biological Chemistry, 5/2019
• Genetic mechanisms of immune evasion in colorectal cancer  
  Catherine S Grasso, Marios Giannakis, Daniel K Wells, Tsuyoshi Hamada, Xinmeng Jasmine Mu, Michael Quist, Jonathan A Nowak, Reiko Nishihara, Zhi Rong Qian, Kentaro Ina..., Cancer Discovery, 6/1/2018
• Interferon receptor signaling pathways regulating PD-L1 and PD-L2 expression  
  Angel Garcia-Diaz, Daniel Sanghoon Shin, Blanca Homet Moreno, Justin Saco, Helena Escuin-Ordinas, Gabriel Abril Rodriguez, Jesse M Zaretsky, Lu Sun, Willy Hugo, Xiaoya..., Cell Reports, 5/9/2017
• Mutations associated with acquired resistance to PD-1 blockade in melanoma  
  Jesse M Zaretsky, Angel Garcia-Diaz, Daniel S Shin, Helena Escuin-Ordinas, Willy Hugo, Siwen Hu-Lieskovan, Davis Y Torrejon, Gabriel Abril-Rodriguez, Salemiz Sandoval,..., NEJM, 9/2016
• The evolution of checkpoint blockade as a cancer therapy: what's here, what's next?  
  Daniel Sanghoon Shin, Antoni Ribas, Current Opinion in Immunology, 2015
• Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method  
  Daniel Sanghoon Shin, Rongbao Zhao, Andras Fiser, I David Goldman, American Journal of Physiology-Cell Physiology, 6/15/2013
• Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)  
  Rongbao Zhao, Daniel Sanghoon Shin, Andras Fiser, I David Goldman, American Journal of Physiology-Cell Physiology, 9/15/2012
• A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding  
  Daniel Sanghoon Shin, Rongbao Zhao, Enghui H Yap, Andras Fiser, I David Goldman, American Journal of Physiology-Cell Physiology, 5/1/2012
• Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method  
  Rongbao Zhao, Ersin Selcuk Unal, Daniel Sanghoon Shin, I David Goldman, Biochemistry, 4/6/2010
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Abstracts/Posters

• Impact of a pathologist-driven molecular testing protocol on veterans with non-small cell lung cancer
  Rui Li, M Carmen Frias Kletecka, Daniel Sanghoon Shin, ASCO Annual Meeting 2023, abstract_ePoster, 5/31/2023
• Enhanced tumor control with a combination of APG-157 and immune checkpoint inhibitors for head and neck cancer
  Daniel Sanghoon Shin, Saroj K Basak, Mysore S Veena, Begoña Comin-Anduix, Arjun Bhattachrya, Tien Dong, Luis Z Avila, Marilene Wang, Eri Srivatsan, ASCO Annual Meeting 2022, Chicago, IL, 6/2/2022
• Phenotypic characteristics of T cells co-expressing SOX2, OCT3/4, and NANOG
  9. Michael Cerniglia, Helena Escuin-Ordinas,,Caroline Porter, Maria Aleshin, Gardenia Cheung-Lau, ZoranGalic, Inbal, Daniel Sanghoon Shin, Oritz Rosenblatt-Rosen, Anto..., Cancer Research, 2021
• Inverse relationship between Giant Axonal Neuropathy gene expression and EMT in human tumors
  8. Mysore S. Veena, Daniel Sanghoon Shin, Chan Jeong, Jenna R. Chatoff, Natarajan Venkatesan, Saroj K. Basak, David Gray, Sharon P. Wilczysnki3 Steven J. Gray, Donald ..., Cancer Research, 2020
• Immunoediting in untreated mismatch repair deficient colorectal cancer
  6. Catherine Grasso, Marios Giannakis, Daniel Wells, David Wheeler, Eve Shinbrot, Syed Zaidi, Jeroen Huyghe, Milan Geybels, Stephen Salipante, Gabriel Abril-Rodriguez,..., Molecular Cancer Therapeutics, 1/2018
• Loss of adaptive PD-L1 expression is associated with upregulation of PBRM1 chromatin regulator in melanoma
  7. Daniel Sanghoon Shin, Chen Cheng, Nhat Truong, Mykola Onyshchenko, Gabriel Abril-Rodriguez, Catherine Grasso, Begonya Comin-Anduix, Sk Kurdistani, Antoni Ribas, J Clin Oncol, 2018
• Interrogating resistance mechanisms to PD-1 blockade therapy with CRISPR
  4. Davis Yuri Torrejon, Jesse Meir Zaretsky, Daniel Sanghoon Shin, Mykola Onyshchenko, Gabriel Abril-Rodriguez, Agustin Vega-Crespo, Cristina Puig-Saus, Gardenia Cheun..., Journal of Clinical Oncology, 2017
• Abstract NG04: Mechanisms of resistance to anti-PD-1 immunotherapy through interferon pathway mutations
  5. Jesse Zaretsky, Angel Garcia-Diaz, Daniel S Shin, Helena Escuin-Ordinas, Willy Hugo, Siwen Hu-Lieskovan, Zeynep Eroglu, Davis Y Torrejon, Paul C Tumeh, Roger S Lo, ..., Cancer Research, 2017
• 2015 SITC abstract: Innate resistance of PD-1 blockade through loss of function mutations in JAK resulting in inability to express PD-L1 upon interferon exposure
  3. Daniel Sanghoon Shin, Angel Garcia-Diaz, Jesse Zaretsky, Helena Escuin-Ordinas, Siwen Hu-Lieskovan, Nicolaos J Palaskas, Willy Hugo, Marie Sara Komenan, Bartosz Chm..., Journal for Immunotherapy of Cancer, 11/2015
• 2015 SMR Congress abstract: JAK2, STAT1 and 3 and IRF1 are the key signaling molecules from the interferon receptor to regulate PD-L1 and PD-L2 expression
  2. Angel Garcia, Daniel Sanghoon Shin, Blanca Homet Moreno, Helena Escuin-Ordinas, Justin Saco, Siwen Hu-Lieskovan, Lidia Robert, Jesse Zaretsky, Beata Berent-Maoz, Gi..., Pigment Cell & Melanoma Research, 10/2015
• Abstract 5013: Toward better selection of PD-1 blockade responders through direct markers of adaptive immune resistance
  1. Daniel Sanghoon Shin, Angel Garcia-Diaz, Helena Escuin-Ordinas, Nicolaos J. Palaskas, Sara M. Komenan, Thomas G. Graeber, Begonya Comin-Anduix, Antoni Ribas, Cancer Research, 8/2015
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