DanielCLinkMD

PubMed

• 30 citations
  Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells
  Darja Karpova, Michael P. Rettig, Julie Ritchey, Daniel Cancilla, Stephanie Christ
  The Journal of Clinical Investigation. 2019-07-01
• 99 citations
  The diversity of mutations and clinical outcomes for ELANE-associated neutropenia.
  Vahagn Makaryan, Cornelia Zeidler, Audrey Anna Bolyard, Julia Skokowa, Elin Rodger
  Current Opinion in Hematology. 2015-01-01
• 123 citations
  Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia.
  Jun Xia, Audrey Anna Bolyard, Elin Rodger, Steve Stein, Andrew A. Aprikyan
  British Journal of Haematology. 2009-11-01

Journal Articles

• Age-realted mtuations associated with clonal hematopoietic expansion and malignancies  
  Xie M. Lu C, Wang J. McLellan MD, Johnson KF, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MK, Mardis ER, Di..., Nat Med, 10/1/2014
• Regulation of hematopoietic stem cells by bone marrow stromal cells  
  Anthony BA, and Link DC, Trends in immunology, 1/1/2014
• Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing  
  Hughes AEO, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliot K, Hath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, DiPersio JF, ..., Plos Genetics, 1/1/2014
• Megakaryocytes in the hematopoietic stem cell niche  
  Day RB and Link DC, Nat Med, 1/1/2014
• Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer  
  Panni RA, Sanford DE, Belt BA, Mitchem JB, Worley LA, Goetz BD, Mukherjee P, Wang-Gilliam A, Link DC, Deardo DG, Goedegebuure SP, Linehan DC, Cancer Immunol Immunother, 1/1/2014
• Caspase 9 is required for normal hematpoietic development and protection from alkylator-induced DNA damage in mice  
  Lu EP, McLellan M, Ding L, Fulton R. Mardis ER, Wilson RK, Miller C, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, and Graubert TA, Blood, 1/1/2014
• Inherited bone marrow failure syndromes in adolescents and young adults  
  Wilson DB, Link DC, Mason PJ, Bessler M, Annals of Internal Medicine, 1/1/2014
• Regulation of hematopoietic stem cell activity by inflammation  
  Schuettpelz L and Link DC, Frontiers in Immunology, 7/1/2013
• Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia  
  Link DC, NEJM, 1/1/2013
• CXCL12 production by early mesenchymal progenitors is required for hematopoietic stem cell maintenance  
  Greenbaum A, Hsu MS, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC, Nature, 1/1/2013
• SNAREing a new cause of neutropenia  
  Link DC, Blood Commentary, 1/1/2013
• Clonal architecture of secondary acute myeloid leukemia  
  Walter MJ, Shen D, Ding L, Shao J, Koboldt DC, Chen K, Larson DE, McLellan MD, Dooling D, Abbott R, Fulton R, Magrini V, Schmidet H, Kalicki-Veizer J, O’Laughlin M, Fa..., NEJM, 1/1/2012
• Molecular Genetics of AML  
  Link DC, Best Practice & Research Clinical Haematology, 1/1/2012
• N-cadherin in osteolineage cell is not required for maintenance of hematopoietic stem cells  
  Greenbaum AM, Revollo LD, Woloszynek JR, Civitelli R, and Link DC, Blood, 1/1/2012
• Kruppel like factor 7 suppresses hematopoietic stem and progenitor cell function  
  Schuettpelz L, Gopalan PK, Romine M, Fiuste F, and Link DC, Blood, 1/1/2012
• The origin and evolution of mutations in acute myeloid leukemia  
  Welch, J.S., Ley, T.J., Link, D.C. (co-first author), Miller, C.A., Larson, D.E., Koboldt, D.C., Wartman, L.D., Lamprecht, T.L., Liu, F., Xia, J., et al, Cell, 1/1/2012
• Regulation of neutrophil trafficking from the bone marrow  
  Day RB and Link DC, Cellular and Molecular Life Sciences, 1/1/2012
• Enhancing growth factor performance (Invited Commentary)  
  Yen-Michael S. Hsu and Link DC, Nat Med, 1/1/2012
• Clonal evolution in relapsed acute myeloid leukaemia revealed by whole genome sequencing  
  Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, Dooling D..., Nature, 1/1/2012
• Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice  
  Christopher JM, Rao M, Liu F, Woloszynek JR, and Link DC, JEM, 1/1/2011
• Genomics of AML: Clinical Applications of Next Generation Sequencing  
  Blood, American Society of Hematology Education Program, 1/1/2011
• CXCR2 is the TPO of the iceberg (Inside Blood Commentary)  
  Greenbaum AM and Link DC, Blood, 1/1/2011
• Dual functions of cell-autonomous ADAM10 activity in granulopoiesis  
  Yoda M, Kimura T, Tohmonda T, Uchikawa S, Koba T, Takito J, Morioka H, Matsumoto M, Link DC, Chiba K, Okada Y, Toyama Y, Horiuch K, Blood, 1/1/2011
• Alterations in the bone marrow microenvironment contribute to oxidate stess and DNA damage in hematopoietic stem/progenitors carrying a Csf3r truncation mutation  
  Kunter G, Woloszynek JR, and Link DC, Experimental Hematology, 1/1/2011
• Niche competition and cancer metastasis to bone (Invited Commentary)  
  Schuettpelz LG and Link DC, JCI, 1/1/2011
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Books/Book Chapters

• Cellular complexity of the bone marrow hematopoietic stem cell niche. 
  Calvi LM, and Link DC2014
• American Society of Hematology Self-Assessment Program (SAP) 
  Chapter: Myeloid disorders. 
  Link DC and Wun TEditors: Kahn MJ and Gregory S.American Society of Hematology PublishersEdition 3rd,2007
• Current topics in developmental biology. 
  Chapter: Mechanisms of disordered granulopoiesis in congenital neutropenia. 
  Grenda DS and Link DCEditors: Gerald P. Schatten.Elsevier Inc. Publishers2006
• Clinical applications of cytokines and growth factors. 
  Chapter: Mechanisms of growth factor mobilization of hematopoietic progenitors. 
  Link DCEditors: Wingard J.R., Demetri, G..Kluwer Academic Publishers, Norwell, MA2000
• Nathan and Oski’s Hematology of Infancy and Childhood 
  Chapter: Inherited bone marrow failure syndromes 
  Bessler M, Mason PJ, Link DC, and Wilson DBEditors: Orkin SH, Nathan DG, Ginsburg D, Look AT, and Fisher DE.Edition 7th,
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Abstracts/Posters

• TGF-_ Signaling Contributes to Myelofibrosis and Clonal Dominance of Myeloproliferative Neoplasms
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• CXCR4 Inhibition with BL-8040 in Combination with Nelarabine in Patients with Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia / Lymphoblastic Lymphoma
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• CXCR4 Blockade By BL-8040 in T Cell Acute Lymphoblastic Leukemia Decreases Mitochondrial Mass and Induces Non-Apoptotic Cell Death
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Canonical Signaling By TGF Family Members in Mesenchymal Stromal Cells Is Dispensable for Hematopoietic Niche Maintenance Under Basal and Stress Conditions
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Severe Chronic Neutropenia in the Large Granular Lymphocyte Syndrome: Outcomes in Response to Granulocyte Colony Stimulating Factor (G-CSF) and Immunosuppressive Thera...
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Heterozygous Mutations of Clpb As a Newly Identified and Frequent Cause of Severe Congenital Neutropenia
  Daniel C. Link, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Lectures

• New concepts in stem cell activity regulation. Invited Speaker 
  Denver, CO - 1/1/2013
• Chemokine Regulation of Neutrophil Trafficking. Invited Speaker 
  New Orleans, LA - 1/1/2013
• Genomics of AML (Invited Speaker) 
  San Francisco, CA - 1/1/2012
• AML in the Genomics Age, Education Session (Chair and Speaker) 
  San Diego, CA - 1/1/2011
• Hematology-Oncology Grand Rounds. Invited Speaker 
  Northwestern University - 1/1/2009
• Regulation of Normal and Malignant Hematopoietic Stem cells. 
  1/1/2008
• Apoptosis Seminar Series. Invited Speaker 
  Houston, TX - 1/1/2008
• Plenary Scientific Session. Introducer 
  San Francisco, CA - 1/1/2008
• Neutrophils and Monocytes. Moderator 
  San Francisco, CA - 1/1/2008
• Effect of SBDS mutations on Hematopoiesis. Invited Speaker 
  Boston, MA - 1/1/2007
• Frontiers in Medicine Seminar Series. Invited Speaker 
  Washington University - 1/1/2007
• Cancer Center Seminar Series. Invited Speaker 
  St. Louis University - 1/1/2007
• Herman B Wells Seminar Series. Invited Speaker 
  Indianapolis, IN - 1/1/2007
• Monocytes and Granulocytes. Moderator 
  Atlanta, GA - 1/1/2007
• Molecular Pathogenesis of Severe Congenital Neutropenia 
  Orlando, FL - 1/1/2006
• Regulation of Myelopoiesis Session. Invited Speaker 
  New London, CT - 6/1/2005
• Hematopoiesis: Microenvironment, cell adhesion, and mesenchymal stem cells. Moderator 
  San Francisco, CA - 1/1/2005
• Symposium on Regulation of Hematopoiesis. Invited Speaker 
  Seattle, WA - 1/1/2003
• Workshop on Myeloid Development IInvited speaker) 
  Philadelphia, PA - 1/1/2002
• Signaling and In Vivo Hematopoiesis. Moderator 
  Philadelphia, PA - 1/1/2002
• Molecular Structure of hematopoietic growth receptors. Moderator 
  Miami, FL - 1/1/1998
• Preclinical models of hematopoietic progenitor mobilization. 
  1/1/1997
• Cytokine regulation of granulopoiesis: Lessons from G-CSF receptor deficient mice. 
  1/1/1996
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