CynthiaLSearsMD

PubMed

• The Evolution of Tuberculosis Community Transmission Science and its Ethical and Legal Constructs.
  Cynthia L Sears, Maunank Shah
  The Journal of Infectious Diseases. 2024-12-11
• 1 citations
  An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk.
  Kai Wang, Chun-Han Lo, Raaj S Mehta, Long H Nguyen, Yiqing Wang
  Gastroenterology. 2024-12-01
• Colorectal Cancer in Inflammatory Bowel Disease: A Review of the Role of Gut Microbiota and Bacterial Biofilms in Disease Pathogenesis.
  David A Muñiz Pedrogo, Cynthia L Sears, Joanna M P Melia
  Journal of Crohn's & Colitis. 2024-10-15

Journal Articles

• The Contributions of Physician-Scientists Within Divisions of Infectious Diseases  
  Cynthia Sears, MD, The Journal of Infectious Diseases
• High-speed, ultrahigh-resolution distal scanning OCT endoscopy at 800 nm for in vivo imaging of colon tumorigenesis on murine models  
  Mavadia-Shukla J, Fathi P, Liang W, Wu S, Sears CL, and Li X., Biomedical Optics Express., 1/1/2018
• A Blueprint to Advance Colorectal Cancer Immunotherapies  
  Le DT, Hubbard-Lucey VM, Morse MA, Heery CR, Dwyer A, Marsilje TH, Brodsky AN, Chan E, Deming DA, Diaz LA Jr, Fridman WH, Goldberg RM, Hamilton SR, Housseau F, Jaffee ..., Cancer Immunol Res., 1/1/2017
• High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia  
  Drewes JL, White JR, Dejea CM, Fathi P, Iyadorai T, Vadivelu J, Roslani AC, Wick EC, Mongodin EF, Loke MF, Thulasi K, Gan HM, Goh KL, Chong HY, Kumar T, Wanyiri JW, an..., NPJ Biofilms Microbiomes., 1/1/2017
• Clostridium difficile in Pediatric Inflammatory Bowel Disease  
  Hourigan SK, Sears CL, Oliva-Hemker M., Inflamm Bowel Dis., 1/1/2016
• Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis  
  Housseau F, Wu S, Wick EC, Fan H, Wu X, Llosa NJ, Smith KN, Tam A, Ganguly S, Wanyiri JW, Iyadorai T, Malik AA, Roslani AC, Vadivelu JS, Van Meerbeke S, Huso DL, Pardo..., Cancer Res, 1/1/2016
• Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus  
  Miller PE, Haberlen SA, Brown TT, Margolick JB, DiDonato JA, Hazen SL, Witt MD, Kingsley LA, Palella FJ Jr, Budoff M, Jacobson LP, Post WS, Sears CL., J Acquir Immune Defic Syndr., 1/1/2016
• Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system  
  Salzberg SL, Breitwieser FP, Kumar A, Hao H, Burger P, Rodriguez FJ, Lim M, Qui�ones-Hinojosa A, Gallia GL, Tornheim JA, Melia MT, Sears CL, Pardo CA, Neurol Neuroimmunol Neuroinflamm., 1/1/2016
• Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment  
  DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL., J Infect Dis, 1/1/2016
• Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-kappaB activation  
  Fu K, Sun X, Wier EM, Hodgson A, Liu Y, Sears CL, Wan F., eLife, 1/1/2016
• Do biofilms confer a pro-carcinogenic state?  
  Dejea CM, Sears CL, Gut Microbes, 1/1/2016
• Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy  
  Drewes JL, Housseau F, Sears CL, Br J Cancer., 1/1/2016
• The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints  
  Llosa NJ, Cruise M, Tam A, Wick EC, Hechenbleikner EM, Taube JM, Blosser L, Fan H, Wang H, Luber B, Zhang M, Papadopoulos N, Kinzler KW, Vogetlstein B, Sears CL, Ander..., Cancer Discovery., 1/1/2015
• The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients  
  Boleij A, Heckenbleikner EM, Goodwin AC, Badani R, Stein EM, Lazarev MG, Ellis B, Carroll KC, Albesiano E, Wick EC, Platz EE, Pardoll DM, Sears CL., Clin Infect Dis, 1/1/2015
• Metabolism links bacterial biofilms and colon carcinogenesis  
  Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, Uriboonthai W, Goetz L, Casero RA, Pardoll DM, Whi..., Cell Metab., 1/1/2015
• Fecal detection of enterotoxigenic Bacteroides fragilis  
  Chen LA, Van Meerbeke S, Albesiano E, Goodwin A, Wu S, Yu H, Carroll K, Sears C., Eur J Clin Microbiol Infet Dis., 1/1/2015
• Microbiome changes associated with sustained eradication of Clostridium difficile after single faecal microbiota transplantation in children with and without inflammat...  
  Hourigan SK, Chen LA, Grigoryan Z, Laroche G, Weidner M, Sears CL, Oliva-Hemker M, Aliment Pharmacol Ther., 1/1/2015
• Regulatory T cell response to enterotoxigenic Bacteroides fragilis colonization triggers IL-17-dependent colon carcinogenesis  
  Geis AL, Fan H, Wu X, Wu S, Huso DL, Wolfe JL, Sears CL, Pardoll DM, Housseau F, Cancer Discov., 1/1/2015
• The intestinal microbiome and health  
  Tuddenham S, Sears CL, Curr Opin Infect Dis, 1/1/2015
• Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia  
  McAllister F, Bailey JM, Alsina J, Nirschl CJ, Sharma R, Fan H, Rattigan Y, Roeser JC, Lankapalli RH, Zhang H, Jaffee EM, Drake CG, Housseau F, Maitra A, Kolls JK, Sea..., Cancer Cell., 1/1/2014
• Microbiota organization is a distinct feature of proximal colorectal cancers  
  Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rosetti, BJ, Peterson SN, Snesrud EC, Borisy GG, Lazarev M, Stein E, Vadivelu J, Roslani AC, Malik A, Wa..., Proc Natl Acad Sci USA., 1/1/2014
• Microbiota and immune responses in colon cancer: more to learn  
  McAllister F, Housseau F, Sears CL., Cancer J., 1/1/2014
• Microbes, Microbiota and Colon Cancer  
  Sears CL, Garrett WS., Cell Host Microbe., 1/1/2014
• Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis  
  Sears CL, Geis AL, Housseau F., J Clin Invest., 1/1/2014
• Bartlett: a transformative, visionary leader of Johns Hopkins Infectious Diseases  
  Auwaerter PG, Quinn TC, Sears CL, Thomas DL. John G., Clin Infect Dis, 1/1/2014
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Books/Book Chapters

• Sleisenger and Fordtran 
  Chapter: Infectious Enteritis and Proctocolitis 
  Haines CF and Sears CLElsevierEdition 10th,2014
• Principles and Practices of Infectious Diseases 
  Chapter: Prebiotics, Probiotics and Synbiotics 
  Rabizadeh S, Miller M, Sears CLEditors: Mandell GL, Douglas G, Bennett J.Elsevier Inc2009
• Encyclopedia of Public Health 
  Chapter: Infectious Diseases: Escherichia coli 
  Wanke CA, Sears CLEditors: Heggenhougen K.Elsevier Inc2008
• Sourcebook of Bacterial Protein Toxins 
  Chapter: The Toxins of Bacteroides fragilis. 
  Sears CLEditors: Alouf JE, Freer JH.Academic Press, NYEdition 3rd,2005
• Microbial Pathogenesis and the Intestinal Epithelial Cell 
  Chapter: Enteric Microbial Toxins and the Intestinal Epithelial Cytoskeleton. 
  Nataro JP, Sears CL, Fasano A, Block R.Editors: Hecht G.ASM Press2003
• Osler Handbook for House Officers 
  Chapter: Diarrhea 
  Ang GB, Donowitz M, Sears CLJohns Hopkins University2003
• Principles and Practice of Clinical Parasitology 
  Chapter: Cryptosporidium/Isospora. 
  Sears CL, Kirkpatrick B.Editors: Gillespie, Pearson RD.John Wiley and Sons, Susset, England2001
• Sourcebook of Bacterial Protein Toxins 
  Chapter: The Toxins of Bacteroides fragilis 
  Sears CLEditors: Alouf JE, Freer JH.Academic Press, NYEdition 2nd,1999
• Cecil Textbook of Medicine 
  Chapter: Cryptosporidium 
  Kirkpatrick B and Sears CL.Editors: Goldman L, Bennett JC.WB Saunders CoEdition 21st,1999
• Cecil Textbook of Medicine 
  Chapter: Giardia 
  Sears CLEditors: Goldman L, Bennett JC.WB Saunders CoEdition 21st,1999
• Sexually Transmitted Diseases 
  Chapter: Intestinal Protozoa: Giardia lamblia, Entamoeba histolytica and Cryptosporidium. 
  Guerrant RL, Sears CL, Ravdin JI.Editors: Holmes KK, Sparling PF, Mardh PA, Lemon SM, Stamm WE, Piot P, Wasserheit JN.McGraw-Hill Inc, New York, NYEdition 3rd,1999
• Infections of the Gastrointestinal Tract 
  Chapter: Bacterial Toxins. 
  Page 617.0 - 634.0Sears CL, Guerrant RL, Kaper JB.Editors: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL.Raven Press, New York, NY1995
• Principles and Practices of Infectious Diseases 
  Chapter: Isospora belli, Sarcocystis species, Balantidium coli, Blastocystis huminis, and Cyclospora 
  Page 2510. - 2513.Sears CLEditors: Mandell GL, Dolin R, Bennett JE.Churchill Livingstone Inc, New York, NY1995
• Medical and Environmental Aspects of Anaerobes 
  Chapter: Enterotoxin as a Virulence Factor in Bacteroides fragilis - associated Diarrheal Disease 
  Page 90.0 - 100.0Myers LL, Weikel CS.Editors: Duerden BI, Brazier JS, Seddon SV, Wade WG.Wrightson Biomedical Publishing Ltd, Great Britain1992
• Pathophysiology of Secretory Diarrhea 
  Chapter: Parasitic Causes of Diarrhea: An Overview. 
  Page 273.0 - 280.0Guerrant RL, Petri WA, Weikel CSEditors: Lebenthal E, Duffey M.Raven Press1990
• Principles and Practice of Infectious Diseases 
  Chapter: Other Protozoa; Including Cryptosporidium, Microsporidia, Sarcocystis, Isospora, and Balantidium coli. 
  Page 2122. - 2130.Soave R., Weikel CS.Editors: John Wiley and Sons Inc.New York, NY1989
• Advances in Research on Cholera and Related Diarrheas 
  Chapter: Pharmacologic Pathways Leading to Intestinal Secretion: Stimulation by Enterotoxins and by C-Kinase Activators. 
  Page 181.0 - 188.0Guerrant RL, Weikel CSEditors: S Kuwahara and Pierce NF.KTK Scientific Publishers, Tokyo, Japan1988
• Advances in Research on Cholera and Related Diarrheas 
  Chapter: Intestinal Secretion Stimulated by Protein Kinase C Activators. 
  Page 181.0 - 190.0Weikel CS, Sando JJ, Guerrant RL.Editors: Kuwahara S, Pierce NF.KTK Scientific Publishers, Tokyo1988
• Sexually Transmitted Diseases 
  Chapter: Intestinal Protozoa: Giardia lamblia, Entamoeba histolytica and Cryptosporidium 
  Guerrant RL, Weikel CS, Ravdin JI.Editors: Holmes KK, Mardh P-A, Sparling PF, Wiesner PJ.McGraw-Hill Book Co, New York, NYEdition 2nd,1988
• Medical Care of Refugees 
  Chapter: Dengue Fever and Rickettsial Diseases 
  Page 287.0 - 294.0Weikel CSEditors: TC Jones R Sandler.Oxford University Press1987
• Internal Medicine 
  Chapter: Norwalk-like Agents 
  Page 1620. - 1621.Weikel CS, Guerrant RLEditors: JH Stein.Little, Brown and Co1987
• Internal Medicine 
  Chapter: Rotaviruses 
  Page 1603. - 1605.Weikel CS, Guerrant RL.Editors: JH Stein.Little, Brown and Co1987
• Conn's Current Therapy 
  Chapter: Salmonellosis (other than Typhoid Fever) 
  Page 104.0 - 106.0Weikel CS, Guerrant RLEditors: RE Rakel.Little, Brown and Co1987
• Current Therapy in Infectious Disease-2 
  Chapter: Infectious Diarrhea - A Patient in the United States 
  Page 165.0 - 171.0Weikel CS, Guerrant RL.Editors: Kass EH, Platt R.BC Decker Inc, Philadelphia1986
• Advances in Research on Cholera and Related Diarrheas 
  Chapter: E. coli STb: A New Mechanism for Secretory Diarrhea? 
  Page 333.0 - 341.0Weikel CS, Long-Krug S, Guerrant RL.Editors: Kuwahara S and Pierce NF.KTK Scientific Publishers, Tokyo, Japan1986
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Lectures

• The Human Microbiome: Emerging Themes at the Horizon of the 21st Century 
  Bethesda, MD - 1/1/2017
• From Initiation to Outcomes 
  Tampa, TL - 1/1/2016
• Biofilms and Microbes in Colon Cancer 
  1/1/2015
• Fight CRC 
  1/1/2015
• Colon Cancer and Microbiota 
  1/1/2015
• Biofilms in Colon Cancer 
  Waterville Valley, New Hampshire - 1/1/2014
• Microbiota: Biofilms vs Composition in Colon Cancer: Will There Be a Victor? 
  Chicago, IL - 1/1/2014
• Bacterial Instigators of Colon Cancer 
  1/1/2014
• Colonic Commensals, B. fragilis and Colorectal Cancer 
  British Columbia, Canada - 1/1/2014
• Colon Cancer: A Community Conspires in Disease 
  Louisiana State University, SOM, New Orleans, LA - 1/1/2013
• Colon Cancer: How your microbiome may do you wrong 
  Vanderbilt University, SOM, Nashville, TN - 1/1/2013
• The Role of Inflammation during Carcinogenesis 
  Dublin, Ireland - 1/1/2012
• Probiotics, Intestinal Microbiota and the Host: Physiological and Clinical Implications 
  Carefree, AZ - 1/1/2011
• Your Flora: Your Destiny? 
  New York, NY, 2007; University of Virginia, Charlottesville, VA, 2007 - 1/1/2007
• Enterotoxigenic Bacteroides fragilis stimulate colonic hyperplasia and inflammation in mice 
  Petersburg, FL - 1/1/2006
• Intestinal Flora: New Lessons about Physiology, Immunity and Disease 
  1/1/2006
• Enterotoxigenic Bacteroides fragilis: Can this organism instigate chronic colonic disease 
  1/1/2004
• Toxigenic Bacteroides fragilis: A Rogue Among Commensals 
  New Orleans, LA - 1/1/2004
• Toxigenic Bacteroides fragilis: A Commensal Launches a Diverse Attack on the Gut 
  Prague, Czech Republic - 1/1/2004
• Mechanisms of Action of Bacterial Toxins 
  Salt Lake City, UT - 1/1/2001
• Toxin attack on epithelial tight junctions 
  Atlanta, GA - 1/1/2001
• Enterotoxigenic Bacteroides fragilis: A New View of Pathogenesis 
  Manchester, England - 1/1/2000
• Cryptosporidium parvum: miniscule but mighty 
  1/1/1999
• Pathogenesis of Enterotoxigenic Bacteroides fragilis 
  Rocky Mountain Laboratories, NIH/NIAID - 1/1/1999
• Enterotoxigenic Bacteroides fragilis 
  1/1/1998
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Other

• Drive out the �bad bugs� to prevent colon cancers 
  Sears CL, Microbiology
  TheScienceBreaker.org
  1/1/2018
• Microbiota dysbiosis in select human cancers: Evidence of association and causality. 
  Chen J, Domingue JC, Sears CL., Semin Immunol, on-line
  1/16/2017