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Office
5132 Rockville Pike
Rm 4E
Bethesda, MD 20892Phone+1 301-496-5093Fax+1 301-594-1290
Education & Training
- Boston University Medical CenterResidency, Internal Medicine, 1984 - 1987
- Harvard Medical SchoolClass of 1984
Certifications & Licensure
- MD State Medical License 1989 - 2026
- American Board of Internal Medicine Internal Medicine
Awards, Honors, & Recognition
- Elected Member The American Society for Clinical Investigation, 2003
Clinical Trials
- Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives Start of enrollment: 1996 Mar 18
- Screening for Hematology Branch Protocols Start of enrollment: 1996 Dec 31
- A Pilot Study of the Thrombopoietin-Receptor Agonist Eltrombopag in Refractory Aplastic Anemia Patients Start of enrollment: 2009 May 29
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Publications & Presentations
PubMed
- SARS-CoV-2 pseudovirus dysregulates hematopoiesis and induces inflammaging of hematopoietic stem and progenitor cells.Dong-Hoon Chae, Hyun Sung Park, Kyoung-Myeon Kim, Aaron Yu, Jae Han Park
Experimental & Molecular Medicine. 2025-03-01 - 1 citationsBCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate.Selami Demirci, Jing Zeng, Rahul Palchaudhuri, Chuanfeng Wu, Diana M Abraham
Cell Stem Cell. 2025-02-06 - In vivo tracking of ex-vivo-generatedZr-oxine-labeled plasma cells by PET in a non-human primate model.David J Young, Abigail J Edwards, Kevin G Quiroz Caceda, Ella Liberzon, Johana Barrientos
Molecular Therapy. 2025-02-05
Abstracts/Posters
- An All Antibody Approach for Conditioning Bone Marrow for Hematopoietic Stem Cell Transplantation with Anti-cKIT and Anti-CD47 in Non-Human PrimatesCynthia E. Dunbar, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Lectures
- Eltrombopag Improves Hematopoiesis in Patients with Low to Intermediate-2 Risk Myelodysplastic Syndrome(MDS)2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
- Modeling Human Paroxysmal Nocturnal Hemoglobinuria Via CRISPR/Cas9 HSPC Gene Editing in Non-Human Primate2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Press Mentions
- With Chemo, Blinatumomab Boosts DFS in Pediatric B-ALLDecember 8th, 2024
- Bispecific Combo New Standard for Pediatric Acute Lymphoblastic Leukemia, Experts SayDecember 7th, 2024
- ASH 2024: What Blood Cancer Advances Could Change Practice?December 2nd, 2024
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Grant Support
- Retroviral Mediated Gene Transfer Into Primate Hematopoietic CellsNational Heart, Lung, And Blood Institute2010–2011
- Gene Transfer And Ex Vivo Manipulation Of Hematopoietic CellsNational Heart, Lung, And Blood Institute1998–2008
- Gene Transfer And Ex Vivo Manipulation Of HematopoieticNational Heart, Lung, And Blood Institute2001–2006
- Gene Transfer To Hematopoietic Progenitor, Stem, And Stromal CellsNational Heart, Lung, And Blood Institute1995–1997
- Gene Transfer To Human Hematopoietic Progenitor, Stem, And Stromal CellsNational Heart, Lung, And Blood Institute1994
- Preclinical And Clinical Gene Transfer To Human Hematopoietic Stem CellsNational Heart, Lung, And Blood Institute1992–1993
- Investigation of underlying mechanisms and novel therapies for human acquired and congenital disorders of hematopoiesisNATIONAL HEART, LUNG, AND BLOOD INSTITUTEPresent
- Investigation of underlying mechanisms and novel therapies for human acquired and congenital disorders of hematopoiesisNATIONAL HEART, LUNG, AND BLOOD INSTITUTEPresent
- Macaque models for preclinical development of iPSCsNATIONAL HEART, LUNG, AND BLOOD INSTITUTEPresent
- Optimization of genetic modification of HSCs in the NHP model and creation of relevant preclinical models of human disease and therapiesNATIONAL HEART, LUNG, AND BLOOD INSTITUTEPresent
- Clonal and imaging analyses of in vivo hematopoiesis, immune cell ontogeny and adoptive cell therapiesNATIONAL HEART, LUNG, AND BLOOD INSTITUTEPresent
- Optimization of genetic modification of HSCs in the NHP model and creation of relevant preclinical models of human disease and therapiesNATIONAL HEART, LUNG, AND BLOOD INSTITUTEPresent
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