Crystal S Denlinger MD

Oncology•Plymouth Meeting, PA

Gastrointestinal Cancer, Hematologic Oncology

Senior Vice President, Chief Scientific Officer, National Comprehensive Cancer Network

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3025 Chemical RdSuite 100Plymouth Meeting, PA 19462
Phone+1 267-622-6654

Summary

Provides oversight to NCCN’s Oncology Research Program and select Compendia products. Participates in NCCN policy and global initiatives. Practicing clinician with part-time voluntary faculty appointment at Fox Chase Cancer Center.

Education & Training

Temple University Hospital-Fox Chase Cancer CenterFellowship, Hematology and Medical Oncology, 2004 - 2007
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalResidency, Internal Medicine, 2001 - 2004
Rutgers New Jersey Medical SchoolClass of 2001

Certifications & Licensure

PA State Medical License 2004 - 2026
NY State Medical License 2002 - 2004
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Fellow American College of Physicians

Clinical Trials

Phase I Safety Study of the Drug MM-121 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment Start of enrollment: 2008 Jul 01
Completed
Phase 1
Chemoembolization With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery Start of enrollment: 2009 Oct 28
Completed
Phase 3
Bevacizumab and Combination Chemotherapy Before Surgery in Treating Patients With Locally Advanced Esophageal or Stomach Cancer Start of enrollment: 2011 Apr 27
Completed
Phase 2
Combination Chemotherapy and Cetuximab or Bevacizumab in Treating Patients With Metastatic Colorectal Cancer Start of enrollment: 2010 Mar 01
Terminated
Not Applicable
Safety Study of MM-121 in Combination With Multiple Anticancer Therapies in Patients With Advanced Solid Tumors Start of enrollment: 2011 Oct 01
Completed
Phase 1
Adherence to Survivorship Care Guidelines in Health Care Providers for Non-Small Cell Lung Cancer and Colorectal Cancer Survivor Care Start of enrollment: 2013 Jan 01
Completed
Not Applicable
SGI-110 in the Treatment of Advanced Hepatocellular Carcinoma (HCC)
COMPLETED
PHASE2
A Study of MM-111 and Paclitaxel With Trastuzumab in Patients HER2 Positive Carcinomas of the Distal Esophagus, Gastroesophageal (GE) Junction and Stomach Start of enrollment: 2013 Jan 01
Terminated
Phase 2
Dose Escalation Study of OMP-54F28 in Combination With Sorafenib in Patients With Hepatocellular Cancer Start of enrollment: 2014 Jan 01
Completed
Phase 1
A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer Start of enrollment: 2016 May 19
ACTIVE_NOT_RECRUITING
PHASE2
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Publications & Presentations

PubMed

QIM25-225: Do Oncology Patients Want to Know Both Generic and Brand Drug Names?
Laura Hanisch, Erin Vidic, Tanya Fischer, Tim Rinehart, Patrick K Delaney
Journal of the National Comprehensive Cancer Network. 2025-03-28
Neratinib Alone or in Combination with Immune Checkpoint Inhibitors with or without Mammalian Target of Rapamycin Inhibitors in Patients with Fibrolamellar Carcinoma.
Ghassan K Abou-Alfa, Tim Meyer, Richard Kinh Gian Do, Sarina A Piha-Paul, Joseph S Light
Liver Cancer. 2025-03-01
Trastuzumab Plus Pertuzumab Versus Cetuximab Plus Irinotecan in Patients WithWild-Type, HER2-Positive, Metastatic Colorectal Cancer (S1613): A Randomized Phase II Trial.
Kanwal Pratap Singh Raghav, Katherine A Guthrie, Benjamin Tan Jr, Crystal S Denlinger, Marwan Fakih
Journal of Clinical Oncology. 2025-01-06

Journal Articles

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors
David S Hong, Marwan G Fakih, Gregory A Durm, Geoffrey I Shapiro, Gerald S Falchook, Adrian Sacher, Crystal S Denlinger, John C Krauss, Andrew L Coveler, Suresh S Rama..., The New England Journal of Medicine

Lectures

Impact of Health Disparities on Cancer Survivorship
ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/25/2020

Authored Content

Cardiovascular Toxicity in Cancer Survivors: Current Guidelines and Future DirectionsJune 2018

Press Mentions

NCCN Announces Expanded Practice Guidelines for Breast Cancer with Hereditary RisksDecember 13th, 2024
NCCN Awards Grants to Improve Care for Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaDecember 4th, 2024
NCCN Guidelines Expanded to Meet Growing Understanding of Hereditary RiskNovember 24th, 2024
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Grant Support

NCCN Foundation Young Investigator AwardNCCN Foundation2012–2014

Committees

Chair, NCCN Survivorship Guidelines Panel 2012 - Present
Member, Chemotherapy subcommittee, NCCN Esophagogastric Cancers Guidelines Panel 2009 - Present
Member, NCI Esophagogastric Task Force 2012 - 2013