Cornelia M Weyand MD

PubMed

• 1 citations
  Distinctive clinical features in biopsy-proven nerve large-arteriole vasculitis and microvasculitis.
  Pannathat Soontrapa, Marcus V Pinto, Kamal Shouman, Jay Mandrekar, JaNean K Engelstad
  Brain. 2025-03-06
• 3 citations
  Metabolic checkpoints in rheumatoid arthritis.
  Cornelia M Weyand, Jörg J Goronzy
  Seminars in Arthritis and Rheumatism. 2025-02-01
• Immune Aging in Rheumatoid Arthritis.
  Cornelia M Weyand, Jörg J Goronzy
  Arthritis & Rheumatology. 2025-01-12

Journal Articles

• Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells  
  Cornelia Weyand, MD, Frontiers in Immunology
• Epigenetics of T cell aging  
  Goronzy JJ, Hu B, Kim C, Jadhav RR, Weyand CM, J Leukoc Biol, 1/27/2018
• The immunoinhibitory PD-1/PD-L1 pathway in inflammatory blood vessel disease  
  Weyand CM, Berry GJ, Goronzy JJ, J Leukoc Biol, 1/1/2018
• Refractory giant cell arteritis complicated by vision loss from optic atrophy and maculopathy associated with pachymeningitis  
  Uribe JA, Aggarwal I, Witthayaweerasak J, Liao YJ, Berry GJ, Sab UK, Weyand CM, J. Neuroophthalmol, 1/1/2018
• Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation  
  Zeisbrich M, Yanes RE, Zhang H, Watanabe R, Li Y, Brosig l, Hong J, Wallis BB, Giacomini JC, Assimes TL Goronzy JJ, Weyand CM, Ann Rheum Dis, 1/1/2018
• Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: Roles of STAT3, interleukin 6 and hydrogen peroxide  
  Loperena R, Van Beusecum JP, Itani HA, Engel N, Laroumanie F, Ziao L, Elijovich F, Laffer CL, Gnecco JS, Noonan J, Maffia P, Jasiewicz-Honkisz B, Czesnikiewicz-Guzik M..., Cardiovasc Res, 1/1/2018
• Matrix metalloprotease-9 (MMP-9)-producing monocytes enable T cells to invade the vessel wall and cause vasculitis  
  Watanabe R, Maeda T, Zhang H, Berry GJ, Zeisbrich M, Brockett RD, Greenstein AE, Tian L, Goronzy J, Weyand CM, Circ Res, 1/1/2018
• A mitochondrial checkpoint in autoimmune disease  
  Weyand CM, Goronzy JJ, Cell Metab, 1/1/2018
• DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system  
  Li Y, Goronzy JJ, Weyand CM, Exp Gerontol, 1/1/2018
• Redox-sensitive signaling in inflammatory T cells and in autoimmune disease  
  Weyand CM, Shen Y, Goronzy JJ, Free Radic Biol Med, 1/1/2018
• T follicular helper cell development and functionality in immune ageing  
  Gustafson CE, Weyand CM, Goronzy JJ, Clin Sci (Lond), 1/1/2018
• Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis  
  Zhang H, Watanabe R, Berry GJ, Vaglio A, Liao YJ, Warrington KJ, Goronzy JJ, Weyand CM, Proc Natl Acad Sci USA, 1/1/2017
• Epigenomics of human CD8 T cell differentiation and aging  
  Moskowitz DM, Zhang DW, Hu B, Le Saux S, Yanes RE, Ye Z, Buenrostro JD, Weyand CM, Greenleaf WJ, Goronzy JJ, Sci Immunol, 1/1/2017
• PKC-epsilon and TLR4 synergistically regulate resist-mediated inflammation in human macrophages  
  Zuniga MC, Raghuraman G, Hitchner E, Weyand C, Robinson W, Zhou W, Atherosclerosis, 1/1/2017
• Clinical and pathological evolution of giant cell arteritis: A prospective study of follow-up temporal artery biopsies in 40 treated patients  
  Maleszewski JJ, Younge BR, Fritzlen JT, Hunder GG, Goronzy JJ, Warrington KJ, Weyand CM, Modern Pathol, 1/1/2017
• Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity  
  Watanabe R, Shirai T, Namkoong H, Zhang H, Berry GJ, Wallis BB, Schaefgen B, Harrison DG, Tremmel JA, Giacomini JC, Goronzy JJ, Weyand CM, J Clin Invest, 1/1/2017
• The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway  
  Wen Z, Shen Y, Berry G, Shahram F, Li Y, Watanabe R, Liao YJ, Goronzy JJ, Weyand CM, Sci Transl Med, 1/1/2017
• Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells  
  Shen Y, Wen Z, Li Y, Matteson EL, Hong J, Goronzy JJ, Weyand CM, Nat Immunol, 1/1/2017
• Pro-inflammatory and anti-inflammatory T cells in giant cell arteritis  
  Watanabe R, Hosgur E, Zhang H, Wen Z, Berry G, Goronzy JJ, Weyand CM, Joint Bone Spine, 1/1/2017
• Lymphocytes T pro-inflammatoires et anti-inflammatoires dans l'arterite a cellules geantes  
  Watanabe R, Hosgur E, Zhang H, Wen Z, Berry G, Goronzy JJ, Weyand CM, Revue du Rhumatisme, 1/1/2017
• The life cycle of a T cell after vaccination - where does immune aging strike?  
  Kim C, Fang F, Weyand CM, Goronzy JJ, Clin Exp Immunol, 1/1/2017
• Lymphocyte generation and population homeostasis throughout life  
  Yanes RE, Gustafson CE, Weyand CM, Goronzy JJ, Semin Hematol, 1/1/2017
• Immune checkpoint dysfunction in medium and large vessel vasculitis  
  Watanabe R, Zhang H, Berry G, Goronzy JJ, Weyand CM, Am J Physiol Heart Circ Physiol, 1/1/2017
• Metabolic signatures of T-cells and macrophages in rheumatoid arthritis  
  Weyand CM, Zeisbrich M, Goronzy JJ, Curr Opin Immunol, 1/1/2017
• Immune activation caused by vascular oxidation promotes fibrosis and hypertension  
  Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, R..., J Clin Invest, 1/1/2016
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Books/Book Chapters

• Clinical Immunology: Principles and Practice 
  Chapter: Immune deficiencies at the extremes of age. 
  Page 535 - 543Goronzy JJ, Gustafson CE, Weyand CMEditors: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Jr, Frew AJ, Weyand CM.ElsevierEdition 5th,2018
• Oxford Textbook of Vasculitis 
  Chapter: Giant cell arteritis and polymyalgia rheumatic. 
  Page 307 - 318Warrington KJ, Weyand CMEditors: Ball GV, Fessler BJ and Bridges SL.Oxford University PressEdition 3rd,2014
• Clinical Immunology: Principles and Practices 
  Chapter: Aging and the immune system. 
  Page 414 - 420Goronzy JJ, Weyand CMEditors: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Jr, Frew AJ, Weyand CM.ElsevierEdition 4th,2012
• Clinical Immunology: Principles and Practices 
  Chapter: Large-vessel vasculitides. 
  Page 716 - 727Weyand CM, Goronzy JJEditors: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Jr, Frew AJ, Weyand CM.ElsevierEdition 4th,2012
• Inflammatory Diseases of Blood Vessels 
  Chapter: Giant cell arteritis. 
  Page 263 - 275Weyand CM, Goronzy JJEditors: Hoffman GS, Weyand CM, Langford CA, Goronzy JJ.Blackwell Publishing Ltd.Edition 2nd,2012
• Inflammatory Diseases of Blood Vessels 
  Chapter: Dendritic cells and vascular inflammation. 
  Page 39 - 49Weyand CMEditors: Hoffman GS, Weyand CM, Langford CA, Goronzy JJ.Blackwell Publishing Ltd.2012
• Epigenetics of Aging 
  Chapter: DNA methylation, age-related immune defects and autoimmunity. 
  Page 327 - 345Goronzy JJ, Li G, Weyand CMEditors: Tollefsbol, TO.Springer2010
• Handbook on Immunosenescence: Basic Understanding and Clinical Applications 
  Chapter: Age, T-cell homeostasis, and T-cell diversity in humans. 
  Page 167 - 192Lamar DL, Weyand CM, Goronzy JJEditors: Fulop T, Franceschi C, Hirokawa K, Pawelec G.Springer2009
• Rheumatology 
  Chapter: Polymyalgia rheumatica and giant cell arteritis. 
  Page 1521 - 1531Weyand CM, Goronzy JJEditors: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH.Mosby/ElsevierEdition 4th,2008
• Clinical Immunology: Principles and Practice 
  Chapter: Large-vessel vasculitides. 
  Page 885 - 897Weyand CM, Goronzy JJEditors: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Jr, Frew AJ, Weyand CM.Mosby/ElsevierEdition 3rd,2008
• Primer on the Rheumatic Diseases 
  Chapter: Vasculitides. A. Giant cell arteritis, polymyalgia rheumatica, and Takayasu's arteritis. 
  Page 398 - 415Weyand CM, Goronzy JJEditors: Klippel JH, Stone JH, Crofford LJ, White PH.Springer Science+Business Media, LLCEdition 13th,2007
• The Autoimmune Diseases 
  Chapter: Large and medium vessel vasculitides. 
  Page 921 - 934Weyand CM, Goronzy JJEditors: Rose NR and Mackay IR.Elsevier Academic PressEdition 4th,2006
• Textbook of Rheumatoid Arthritis 
  Chapter: Immunosenescence and T-cell biology in rheumatoid arthritis. 
  Page 213 - 222Weyand CM, Goronzy JJEditors: St. Clair EW, Haynes BF, Pisetsky DS.Lippincott Williams & Wilkins2004
• Cecil Textbook of Medicine 
  Chapter: The innate and adaptive immune systems. 
  Page 208 - 217Goronzy JJ, Weyand CMEditors: Goldman L, Bennett JC, Ausiello A, Cecil RL.W. B. SaundersEdition 22nd,2003
• Inflammatory Diseases of Blood Vessels 
  Chapter: Giant cell arteritis: Pathogenesis. 
  Page 413 - 424Weyand CM, Goronzy JJEditors: Hoffman GS, Weyand CM.Marcel Dekker, Inc., New York, NY2002
• Inflammatory Diseases of Blood Vessels 
  Chapter: Vasculitis: A dialogue between the artery and the immune system. 
  Page 1 - 12Weyand CMEditors: Hoffman GS, Weyand CM.Marcel Dekker, Inc., New York, NY2002
• Curr Dir Autoimmun: Rheumatoid Arthritis 
  Chapter: Lymphoid microstructures in rheumatoid synovitis. 
  Page 168 - 187Weyand CM, Braun A, Takemura S, Goronzy JJEditors: Goronzy JJ, Weyand CM.Karger, Basel2001
• Primer on the Rheumatic Diseases 
  Chapter: Vasculitides: giant cell arteritis, polymyalgia rheumatica, and Takayasu's arteritis. 
  Page 397 - 405Weyand CM, Goronzy JJEditors: Klippel JH, Weyand CM, Stone JH, Crofford J.Arthritis Foundation, Atlanta, GAEdition 12th,2001
• Autoimmunity 
  Chapter: The role of T cells in rheumatoid arthritis. 
  Page 183 - 196Weyand CM, Bryl E, Goronzy JJEditors: Gorski A.Kluwer Academic Publishers, The Netherlands2001
• Curr Dir Autoimmun: Rheumatoid Arthritis 
  Chapter: T cell homeostasis and autoreactivity in rheumatoid arthritis. 
  Page 112 - 132Goronzy JJ, Weyand CMEditors: Goronzy JJ, Weyand CM.Karger, Basel2001
• Textbook of the Autoimmune Diseases 
  Chapter: Rheumatoid Arthritis. 
  Page 573 - 595Weyand CM, Goronzy JJEditors: Lahita RG, Chiorazzi N, Reeves WH.Lippincott Williams & Wilkins, Philadelphia, PA2000
• Molecular Rheumatology 
  Chapter: Vasculitis. 
  Page 385 - 399Goronzy JJ, Weyand CMEditors: Tsokos GC.Humana Press, Inc., Totowa, NJ2000
• Advances in Osteoarthritis 
  Chapter: Results of a phase II rheumatoid arthritis clinical trial using T-cell receptor peptides. 
  Page 153 - 162Brostoff SW, Carlo DJ, Diveley JP, Morgan EE, Nardo CJ, Richieri SP, Adamson TC, Fronek Z, Calabrese LH, Cash JM, Markenson JA, Bathon J, Matsumoto AK, Matteson EL, Ur...Editors: Tanaka S, Hamanishi C.Springer-Verlag, Tokyo, Japan1999
• Primer on the Rheumatic Diseases 
  Chapter: Rheumatoid arthritis: epidemiology, pathology, and pathogenesis. 
  Page 155 - 161Goronzy JJ, Weyand CMEditors: Klippel JH.Arthritis Foundation, Atlanta, GAEdition 11th,1997
• Mechanisms of Disordered Immune Regulation. In: Medical Immunology 
  Chapter: Clinical Immunology. 
  Page 444 - 455Weyand CM, Goronzy JJEditors: Stites DP, Terr AI, Parslow TG.Appleton & Lange, Stamford, CTEdition 9th,1997
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Abstracts/Posters

• Immune Aging as a Risk Factor for Inflammatory Disease.
  Weyand CM, Immune-Tissue Cell Interactions, Trinity College, Oxford, UK, 1/1/2017
• Metabolic activity sustains macrophage cytokine production in rheumatoid arthritis and coronary artery disease.
  Zeisbrich M, Brosig L, Wallis B, Roche N, Lin J, Goronzy JJ, Weyand CM, Arthritis Rheumatol, 1/1/2017
• Tissue-invasive T cells in rheumatoid arthritis.
  Shen Y, Li Y, Matteson E, Goodman S, Goronzy JJ, Weyand CM, Arthritis Rheumatol, 1/1/2017
• The microvascular niche instructs pathogenic T cells in medium and large vessel vasculitis.
  Wen Z, Shen Y, Berry G, Liao YJ, Goronzy JJ, Weyand CM, Arthritis Rheumatol, 1/1/2017
• Comparative analysis of the macrophage glycolytic machinery in giant cell arteritis (GCA) and in coronary artery disease (CAD).
  Watanabe R, Shirai T, Zhang H, Berry G, Goronzy JJ, Weyand CM, Arthritis Rheumatol, 1/1/2017
• Systems analysis of microRNAs reveals a novel link between CD8 T cell dysfunction and TGF-Beta signaling in immune aging.
  Gustafson CE, Cavanagh M, Hu B, Zhang D, Weyand CM, Goronzy JJ, J Immunol, 1/1/2016
• Age-related defects in the immune system of patients with GCA.
  Wen Z, Shimojima Y, Berry G, Hosgur E, Liao YJ, Forbess L, Weisman M, Goronzy JJ, Weyand CM, Arthritis Rheumatol, 1/1/2016
• PD-1-expressing T cells in GCA fail to promote immune tolerance functions.
  Watanabe R, Zhang H, Hosgur E, Berry G, Goronzy JJ, Weyand CM, Arthritis Rheumatol, 1/1/2016
• Switching from anabolic to catabolic metabolism - a novel immunomodulatory therapy in RA.
  Yang Z, Shen Y, Matteson E, Hosgur E, Hong J, Goronzy J, Weyand C, Arthritis Rheumatol, 1/1/2016
• Hyper-inflammatory macrophages in coronary artery disease and rheumatoid arthritis; a signature of CCL18, Kruppel-like factor 2 and 4 and oxidative stress response genes.
  Shirai T, Schaefgen B, Nazarewicz RR, Wallis BB, Assimes TL, Harrison DG, Goronzy JJ, Weyand CM, Arterioscler Thromb Vasc Biol, 1/1/2015
• Failure in nutrient sensing supports mTOR hyperactivity and proinflammatory functions in T cells from patients with rheumatoid arthritis.
  Yang Z, Matteson EL, Hong J, Goronzy J, Weyand CM, Arthritis Rheumatol, 1/1/2015
• Enhanced oxidant signaling in inflammatory macrophages in rheumatoid arthritis (RA) and in coronary artery disease (CAD).
  Shirai T, Schaefgen B, Wallis B, Matteson EL, Assimes TL, Harrison DG, Goronzy J, Weyand CM, Arthritis Rheumatol, 1/1/2015
• Telomere damage in rheumatoid arthritis.
  Li Y, Ju J, Bush TM, Genovese MC, Goronzy J, Weyand CM, Arthritis Rheumatol, 1/1/2015
• Second temporal artery biopsies in patients with temporal arteritis (TA).
  Fritzlen J, Younge B, Weyand CM, Hunder GG, Goronzy J, Warrington KJ, Maleszewski J, Arthritis Rheumatol, 1/1/2015
• Endothelial cells regulate proinflammatory T cell responses in large vessel vasculitis via NOTCH-NOTCH ligand interactions.
  Zhenke W, Zhang H, Liao J, Berry G, Forbess LJ, Weissman M, Goronzy J, Weyand CM, Arthritis Rheumatol, 1/1/2015
• Chronic Inflammation and Immune Aging - The Role of DNA Damage.
  Weyand CM, The Yin and Yang of Inflammation: The Role of Inflammation in Health & Disease, Trudeau Institute, 1/4/2014
• Richness and clonality of the human naive T cell receptor repertoire in healthy aging.
  Qi Q, Liu Y, Cheng Y, Glanville J, Zhang D, Lee J-Y, Olshen R, Weyand C, Boyd S, Goronzy J, Age & Immunity, Summer Frontiers, Nijmegen, The Netherlands, 1/1/2014
• Suppressed glycolytic activity in T cells in rheumatoid arthritis (RA).
  Stobernack T, Yang Z, Fuji H, Goronzy J, Weyand C, Age & Immunity, Summer Frontiers, Nijmegen, The Netherlands, 1/1/2014
• Immune Aging and Autoimmune Disease - A story of energy resources, oxygen radicals and telomeric ends.
  Weyand CM, Age & Immunity, Summer Frontiers, Nijmegen, The Netherlands, 1/1/2014
• Depletion of reactive oxygen species biases T cells to proinflammatory cytokine production in rheumatoid arthritis.
  Yang Z, Matteson EL, Goronzy JJ, Weyand CM, Arthritis Rheumatol, 1/1/2014
• Distinct profiles of proinflammatory macrophages in rheumatoid arthritis and coronary artery disease.
  Shirai T, Matteson EL, Harrison DG, Wallis BB, Assimes TL, Goronzy JJ, Weyand CM, Arthritis Rheumatol, 1/1/2014
• Unopposed Immune Stimulation in Giant Cell Arteritis (GCA): A Consequence of a Reprogrammed STAT1 Signalling Pathway.
  Mohan SV, Liao YJ, Yang B, Hartmann B, Grossniklaus HE, Weisman MH, Goronzy JJ, Weyand CM, North American Neuro-Ophthalmology Society 39th Annual Meeting, Snowbird, UT, 1/9/2013
• The STAT1 signaling pathway in giant cell arteritis.
  Hartmann B, Liao J, Weisman MN, Warrington KJ, Goronzy JJ, Weyand CM, Arthritis Rheum, 1/1/2013
• Deficiency of the protein kinase ataxia telangiectasia mutated accelerates T cell aging in rheumatoid arthritis.
  Yang Z, Fujii H, Matteson E, Goronzy J, Weyand C, Arthritis Rheum, 1/1/2013
• JAK/STAT-signaling in giant cell arteritis.
  Hartmann B, Mohan SV, Goronzy JJ, Weyand CM, Circulation, 1/1/2013
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Lectures

• "Inflammation - Friend or Foe?" 
  1/28/2018
• "The metabolic signature of pro-inflammatory T cells." 
  London, England - 1/28/2018
• "Giant Cell Arteritis 2018" 
  Sonoma, CA - 1/25/2018
• "Bio-energetic strategies of pro-inflammatory T cells." 
  Sitges, Spain - 1/25/2018
• "Macrophage Phenotypic Modulation in Coronary Artery Disease" 
  San Diego, CA - 1/22/2018
• "Immunmetabolismus bei chronischer Entzundung" 
  Mannheim, Germany - 1/21/2018
• "The Role of Aging T Cells and Rheumatoid Arthritis" 
  Chicago, IL - 1/21/2018
• "Metabolic rewiring of inflammatory T cells." 
  Vancouver, BC, Canada - 1/20/2018
• "Immunometabolism in Rheumatoid Arthritis" 
  Chihuahua, Mexico - 1/17/2018
• "The Immunopathogenesis of GCA" 
  Rochester, MN - 1/16/2018
• "Fan the Flame, Feed the Fire" 
  University of Pennsylvania, Philadelphia, PA - 1/16/2018
• "Feeding Inflammation" 
  New York, NY - 1/15/2018
• "Rheumatoid Arthritisi: How Inflammtory Cells fuel Their Bad Habits" 
  Marina Del Rey, CA - 1/14/2018
• "Bioenergetics and Genome Instability in T Cell Aging" 
  Rockville, MD - 1/14/2018
• "Metabolic regulation of immune responses in inflammatory disease." 
  1/7/2018
• "Metabolic Strategies of Pro-inflammatory T Cells in Rheumatoid Arthritis." 
  Atlanta, GA - 1/4/2018
• "Rheumatoid Arthritis - Understanding the energy needs of inflammatory cells." 
  Shanghai, China - 1/4/2018
• "Succeeding in Academic Research: A Personal Journey" 
  Glasgow, Scotland - 1/30/2017
• "Metabolic Signatures and Maladaptive T-cell Aging in Rheumatoid Arthritis" 
  Bethesda, MD - 1/28/2017
• "Metabolic and telomeric control of pro-inflammatory T cells." 
  Stanford, CA - 1/28/2017
• "T-Cell Immunity in Large Vessel Vasculitis" 
  Palermo, Italy - 1/27/2017
• "Immunometabolism in Inflammatory Disease" 
  Nashville, TN - 1/24/2017
• "Immunometabolic Signatures in Autoimmunity" 
  Woolloongabba, Queensland, Australia - 1/20/2017
• "Aortitis and Large Vessel Vasculitis" 
  1/18/2017
• "Metabolic Repression of T cells in Rheumatoid Arthritis" 
  Irvine, CA - 1/16/2017
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Other

• "Healthy Aging - Polymyalgia Rheumatica and Giant Cell Arteritis" 
  Weyand C, SiriusXM Radio Show
  1/22/2016
• Rheumatoid arthritis: autoimmunity as a consequence of premature aging. 
  Weyand CM, Goronzy JJ, Karger Gazette
  1/1/2002
• Cellular immune responses to Borrelia burgdorferi in Lyme disease. 
  Goronzy JJ, Weyand CM, Clin Immunol Newsletter
  1/1/1991
• Coronary artery disease in rheumatoid arthritis: Diagnostic and therapeutic implications 
  Weyand CM, Connolly HM, Schur PH
  http://www.uptodate.com/contents/coronary-artery-disease-in-rheumatoid-arthritis-diagnostic-and-ther
  UpToDate, Wolters Kluwer Health - 2012-08-20
• Coronary artery disease in rheumatoid arthritis: Epidemiology, pathogenesis, and risk factors 
  Weyand CM, Schur PH
  http://www.uptodate.com/contents/coronary-artery-disease-in-rheumatoid-arthritis-epidemiology-pathog
  UpToDate, Wolters Kluwer Health - 2012-10-01
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