ConstantineGeorgeLyketsosMDMHS

Geriatric Psychiatry, Neuropsychiatry, Psychosomatic Medicine

Professor of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine; Elizabeth Plank Althouse Professor and Chair of Psychiatry, Johns Hopkins Bayview; Vice Chairman, Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medicine; Director, Memory and Alzheimer's Treatment Center

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Office
5300 Alpha Commons Drive
4th floor
Baltimore, MD 21224
Phone+1 410-550-6337

Summary

Dr. Constantine Lyketsos is a psychiatrist in Baltimore, MD and is affiliated with Johns Hopkins Bayview Medical Center and Johns Hopkins Hospital. He received his medical degree from Washington University School of Medicine in St. Louis and has been in practice schedule 1988. He speaks fluent Greek.

Education & Training

Johns Hopkins School of Public HealthM.H.S., Epi/ Clinical Epi, 1994
Johns Hopkins UniversityResidency, Psychiatry, 1988 - 1992
Washington University in St. Louis School of MedicineClass of 1988
Northwestern UniversityB.A., with Distinction, 1984

Certifications & Licensure

FL State Medical License 2021 - Present
MD State Medical License 1989 - 2026
VA State Medical License 2023 - 2026
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2001-2023
Fellow American College of Neuropsychopharmacology, 2004
Fellow American College of Psychiatrists, 2003
Top Doctors:Washington-Baltimore Castle Connolly, 2012
Fellow American College of Neuropsychopharmacology (ACNP), 2012
Distinguished Scientist Award American Association for Geriatric Psychiatry, 2012
Distinguished Physician Hellenic Medical Society of New York, 2009
William S. Proxmire Award for Extraordinary Leadership in the Fight Against Alzheimer's Disease 2006
Included in “Guide to America’s Top Psychiatrists” Consumers’ Research Council of America, 2004
Distinguished Fellow American Psychiatric Association, 2004
Dorfman Journal Paper Award for Best Paper in Psychosomatics 2003
Advising, Mentoring and Teaching Award Johns Hopkins Bloomberg School of Public Health, 2002
Research Award Academy of Psychosomatic Medicine, 2002
Bayer Education Fund Scholar Wake-Forest University, 2001
Fellow Academy of Psychosomatic Medicine, 1996
Dlin/Fisher Award (Excellence in Clinical Research) Academy of Psychosomatic Medicine, 1995
William Sorum Award American Psychiatric Association, 1993
Lilly Research Fellowship (Honorable Mention) American Psychiatric Association, 1992
Ginsburg Fellow Group for the Advancement of Psychiatry, 1991
Outstanding Resident Award National Institute of Mental Health, 1990
Merck Award Washington University School of Medicine, 1988
Medical Fund Prize in Surgery Washington University School of Medicine, 1988
Alpha Omega Alpha Washington University School of Medicine, 1988
University Service Award Northwestern University College of Arts and Sciences, 1984
Phi Beta Kappa Northwestern University College of Arts and Sciences, 1984
Departmental Honors in Psychology Northwestern University College of Arts and Sciences, 1984
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Clinical Trials

Escitalopram for Agitation in Alzheimer's Disease Start of enrollment: 2018 Jan 03
Active, not recruiting
Phase 3

Publications & Presentations

PubMed

Neuropsychiatric Symptoms Associated With Frontotemporal Atrophy in Older Adults Without Dementia.
Ioannis Liampas, Vasileios Siokas, Polyxeni Stamati, Panayiota Kyriakoulopoulou, Zisis Tsouris
International Journal of Geriatric Psychiatry. 2024-12-01
Preoperative Neurofilament Light Associated With Postoperative Delirium in Hip Fracture Repair Patients Without Dementia.
Mfon E Umoh, Haijuan Yan, Jeannie-Marie Leoutsakos, Alexandria Lewis, Edward R Marcantonio
Journal of the Academy of Consultation-Liaison Psychiatry. 2024-11-08
Motor signs and incident dementia with Lewy bodies in older adults with mild cognitive impairment.
Ioannis Liampas, Vasileios Siokas, Polyxeni Stamati, Elli Zoupa, Zisis Tsouris
Journal of the American Geriatrics Society. 2024-11-05

Journal Articles

Correlates of objective and subjective measures of caregiver burden among dementia caregivers: influence of unmet patient and caregiver dementia-related care needs
Hughes TB, Black BS, Albert M, Gitlin LN, Johnson DM, Lyketsos CG, Samus QM, Int Psychogeriatr, 11/1/2014
Medication development for agitation and aggression in Alzheimer disease: review and discussion of recent randomized clinical trial design
Soto M, Andrieu S, Nourhashemi F, Ousset PJ, Ballard C, Robert P, Vellas B, Lyketsos CG, Rosenberg PB, Int Psychogeriatr, 9/1/2014
Dementia caregivers' coping strategies and their relationship to health and well-being: the Cache County Study
Snyder CM, Fauth E, Wanzek J, Piercy KW, Norton MC, Corcoran C, Rabins PV, Lyketsos CG, Tschanz JT, Aging Ment Health, 8/1/2014
A Call to Restructure Psychiatry General and Subspecialty Training
Kirwin P, Conroy M, Lyketsos C, Greenwald B, Forester B, Devries C, Ahmed II, Wiechers I, Zdanys K, Steffens D, Reynolds CF 3rd, Acad Psychiatry, 5/9/2014
A multidimensional home-based care coordination intervention for elders with memory disorders: the Maximizing Independence at Home (MIND) Pilot Randomized Trial
Samus QM, Johnston D, Black BS, Hess E, Lyman C, Vavilikolanu A, Pollutra J, Leoutsakos J-M, Gitlin LN, Rabins PV, Lyketsos CG, Am J Geriatr Psychiatry, 4/1/2014
Systematic review of neuroimaging correlates of executive functioning: converging evidence from different clinical populations
Nowrangi MA, Lyketsos C, Rao V, Munro CA, J Neuropsychiatry Clin Neurosci, 4/1/2014
Management of neuropsychiatric symptoms of dementia in clinical settings: Recommendations from a multidisciplinary expert panel
Kales HC, Gitlin LN, Lyketsos C for the Detroit Expert Panel on the Assessment and Management of Neuropsychiatric Symptoms of Dementia, J Am Geriatr Soc, 3/17/2014
Unmet needs of community-residing persons with dementia and their informal caregivers: findings from the maximizing independence at home study
Black BS, Johnston D, Rabins PV, Morrison A, Lyketsos C, Samus QM, J Am Geriatr Soc, 12/1/2013
A review of neuroimaging findings of apathy in Alzheimer's disease
Theleritis C, Politis A, Siarkos K, Lyketsos CG, Int Psychogeriatr, 10/1/2013
A randomized controlled trial of a community-based dementia care coordination intervention: effects of MIND at Home on caregiver outcomes
Tanner J, Black B, Johnston D, Hess E, Leoutsakos J, Gitlin L, Rabins P, Lyketsos C, Samus Q, Am J Geriatr Psychiatry, 8/1/2013
Depression and incident Alzheimer's Disease: the impact of depression severity
Gracia-Garcia P, de-la-Camara C, SantabárbaraJ, Lopez-Anton R, Quintanilla MA, Ventura T, Marcos G, Campayo A, Saz P, Lyketsos C, Lobo A, Am J Geriatr Psychiatry, 6/1/2013
The Brazilian version of the Neuropsychiatric Inventory-Clinician rating scale (NPI-C): reliability and validity in dementia
Stella F, Forlenza OV, Laks J, de Andrade LP, Avendaño MA, Se EV, Cacao JD, Lyketsos CG, de Medeiros K, Int Psychogeriatr, 6/1/2013
Alzheimer's Disease Neuroimaging Initiative Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: The Cache County Deme...
Peterson D, Munger C, Crowley J, Corcoran C, Cruchaga C, Goate AM, Norton MC, Green RC, Munger RG, Breitner JC, Welsh-Bohmer KA, Lyketsos C, Tschanz J, Kauwe JS, Alzheimers Dement, 5/1/2013
Neuropsychiatric Syndromes Professional Interest Area of ISTAART Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future
Geda YE, Schneider LS, Gitlin LN, Miller DS, Smith GS, Bell J, Evans J, Lee M, Porsteinsson A, Lanctôt KL, Rosenberg PB, Sultzer DL, Francis PT, Brodaty H, Padala PP, ..., Alzheimers Dement, 4/3/2013
Cognition and amyloid load in Alzheimer’s imaged with florbetapir F 18 (AV-45) PET
Rosenberg PB, Wong DF, Edell S, Ross JS, Joshi AD, Brasic JR, Zhou Y, Raymont V, Kumar A, Ravert HT, Dannals RF, Pontecorvo MJ, Skovronsky DM, Lyketsos CG, Am J Geriatr Psychiatry, 3/1/2013
The Association of Neuropsychiatric Symptoms in MCI With Incident Dementia and Alzheimer Disease
Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG, Am J Geriatr Psychiatry., 2/1/2013
12-month Incidence, Prevalence, Persistence and Treatment of Mental Disorders among Individuals Recently Admitted to Assisted Living Facilities in Maryland
Samus QM, Onyike CU, Johnston D, Mayer L, McNabney M, Baker A, Brandt J, Rabins PV, Lyketsos CG, Rosenblatt A, International Psychogeriatrics, Int Psychogeriatr, 1/1/2013
Systematic Review of the Effectiveness of Pharmacologic Interventions to Improve Quality of Life and Well-being in People With Dementia
Cooper C, Mukadam N, Katona C, Lyketsos CG, Blazer D, Ames D, Rabins P, Brodaty H, de Mendonca Lima C, Livingston G, Am J Geriatr Psychiatry, 1/1/2013
A systematic review of treatment for Mild Cognitive Impairment
Cooper C, Li R, Lyketsos C, Livingston G, British Journal of Psychiatry, 1/1/2013
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
European Alzheimer's Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer's Disease; Alzheimer's Disease Genetic Consortium; Cohorts for Heart and Ag..., Nat Genet, 1/1/2013
Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer's disease
Trzepacz PT, Cummings J, Konechnik T, Forrester TD, Chang C, Dennehy EB, Willis BA, Shuler C, Tabas LB, Lyketsos C, Int Psychogeriatr, 12/1/2012
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
Whitcomb DC,… Lyketsos CG, …Devlin B, Nat Genet, 11/11/2012
Cognitive outcomes after sertraline treatment in patients with depression of Alzheimer’s disease
Munro CA, Longmire CF, Drye LT, Martin BK, Frangakis CE, Meinert CL, MintzerJE, Porsteinsson AP, Rabins PV, Rosenberg PB, Schneider LZ, Weintraub D, Lyketsos CG, for t..., Am J Geriatr Psychiatry, 10/1/2012
Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study
Peters ME, Rosenberg PB, Steinberg M, Norton MC, Welsh-Bohmer KA, Hayden KM, Breitner J, Tschanz JT, Lyketsos CG; the Cache County Investigators, Am J Geriatr Psychiatry, 9/12/2012
Atypical antipsychotic use in patients with dementia: managing safety concerns
Steinberg M, Lyketsos CG, Am J Psychiatry, 9/1/2012
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Books/Book Chapters

Gabbard’s Treatments of Psychiatric Disorders
Chapter: Chapter 64: Neurocognitive disorder due to Alzheimer’s disease.
Page 957 - 966Marano C, Rabins PV, Lyketsos CGAPPI Press2014
Designing and Delivering Dementia Services.
De Waal H, Lyketsos C, Ames D, O’Brien JWiley Blackwell, London2013
Systematic Psychiatric Evaluation.
Chisolm MC, Lyketsos CGJohns Hopkins University Press, Baltimore, MD2012
Handbook of Alzheimer’s Disease
Chapter: DTI analyses and clinical applications in Alzheimer’s Disease.
Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori SEditors: M. Smith, G. Perry, J. W. Ashford, A. Rosen, M. Adamson, O. Sabri, S. Black, G. B. Frisoni, C. R. Jack and M. W. Weiner.2011
Imaging the Alzheimer’s Disease Brain, Volume 2
Chapter: Chapter 7: DTI analyses and clinical applications in Alzheimer’s Disease.
Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori SEditors: M. Smith, G. Perry, J. W. Ashford, A. Rosen, M. Adamson, O. Sabri, S. Black, G. B. Frisoni, C. R. Jack and M. W. Weiner.2011
Principles and Practice of Geriatric Psychiatry
Chapter: Chapter 52: Pharmacologic therapies in Alzheimer’s disease.
Page 304 - 311Steinberg M, Lyketsos CGEditors: Abou Saleh, Katona, Kumar.Wiley BlackwellEdition 3rd,2011
Principles and Practice of Geriatric Psychiatry
Chapter: Chapter 44: Mouse models of Alzheimer’s disease.
Page 252 - 256Oh E, Lyketsos CG, Wong PEditors: Abou Saleh, Katona, Kumar.Wiley BlackwellEdition 3rd,2011
Principles and Practice of Geriatric Psychiatry
Chapter: Chapter 41: Clinical features of Alzheimer’s disease: cognitive and non-cognitive.
Page 226 - 231Salami O, Lyketsos CGEditors: Abou Saleh, Katona, Kumar.Wiley BlackwellEdition 3rd,2011
Dementia
Chapter: Chapter 8: Neuropsychiatric aspects of dementia.
Page 70 - 74Leroi I, Lyketsos CGEditors: Ames, Burns, and O’Brien.Hodder Arnold, London2010
Textbook of Geriatric Psychiatry
Chapter: Chapter 13: Dementia and Milder Cognitive Syndromes.
Page 243 - 260Lyketsos CGEditors: Blazer and Steffens.APPI2009
Treating dementia: do we have a pill for it?
Ballenger JF, Whitehouse PJ, Lyketsos CG, Rabins PV, Karlawish JHTJohns Hopkins University Press, Baltimore, MD2009
Psychiatric aspects of neurological diseases.
Editors: Lyketsos CG, Rabins PV, Lipsey J, Slavney PR.Oxford University Press, New York2008
Dementia
Chapter: Chapter 6: Neuropsychiatric aspects of dementia.
Page 55 - 63Leroi I, Lyketsos CGEditors: Burns, O’Brien, and Ames.Cambridge Press, Cambridge, MA2005
Comprehensive Textbook of Psychiatry
Chapter: Neuropsychiatric aspects of HIV infection and AIDS.
Page 426 - 451Treisman GJ, Angelino AF, Hutton HE, Hsu J, Lyketsos CGEditors: Sadock and Sadock.Lippincott, Williams, and Wilkins, Philadelphia, PAEdition 8th,2004
Textbook of Psychosomatic Medicine
Chapter: Aggression and violence.
Page 171 - 191Onyike CU, Lyketsos CGEditors: Levenson et al.American Psychiatric Press Inc., Washington, DC2004
Psychiatry in the Medically Ill.
Editors: Levenson J, Lyketsos CG, Trzepacz PT.Psychiatric Clinics of North America, Saunders, Philadelphia, PA2002
Research and Practice in Alzheimer’s disease (Volume 6)
Chapter: Sertraline for major depression in Alzheimer’s disease: the DIADS study.
Page 223 - 231Lyketsos CG, Rabins PVSerdi/Springer, Paris2002
En Tratado de Neurologia Clinica
Chapter: Trastornos de la conducta en la demencia.
Page 753 - 762Taragano F, Lyketsos CEditors: Federico Michelli et al.Medica Panamericana, Buenos Aires, Argentina2002
Geriatrics Review Syllabus
Chapter: Neuropsychiatric and behavioral disturbances in dementia (Chapter 18)
Page 125 - 131Lyketsos CGBlackwell PublishingEdition 5th,2002
Psychiatric Clinics of North America
Chapter: Psychiatric aspects of traumatic brain injury.
Page 43 - 69Rao V, Lyketsos CGEditors: Levenson, Lyketsos, Trzepacz.Saunders Publishing2002
Research and Practice in Alzheimer’s disease (Volume 5)
Chapter: Mental and Behavioral Disturbances in Dementia: Findings from the Cache County Study of Memory in Aging.
Page 144 - 150Lyketsos CG, Breitner JCSSerdi/Springer, Paris2001
Textbook of Geriatric Neuropsychiatry
Chapter: Neuropsychiatry in the Nursing Home.
Page 891 - 903Rovner B, Katz I, Lyketsos CGEditors: Coffey and Cummings.American Psychiatric Press Inc., Washington, DC2000
Textbook of Geriatric Neuropsychiatry
Chapter: Aggression.
Page 477 - 488Lyketsos CGEditors: Coffey and Cummings.American Psychiatric Press Inc., Washington, DC2000
Handbook of Psychiatric Measures.
Chapter: Behavioral measures for cognitive disorders.
Page 393 - 416Lyketsos CG, Steinberg MAmerican Psychiatric Association, Washington, DC2000
Research and Practice in Alzheimer’s disease (Volume 3)
Chapter: Aggression in patients with dementia.
Page 169 - 177Lyketsos CGSerdi/Springer, Paris2000
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Abstracts/Posters

Depression in HIV infection: recognition, assessment, and management.
Lyketsos CG, AIDS: Healthcare Professionals' Conference, Medical University of South Carolina, Charleston, SC, 2/4/1994
HIV, AIDS and Mania.
Lyketsos CG, The AIDS Dementia Conference, Institute of Pennsylvania Hospital, Philadelphia, PA, 1/26/1994
The Impact of HIV Infection on Psychiatric Services.
Lyketsos CG, Treisman GJ, Fishman M, 45th Institute on Hospital and Community Psychiatry, Baltimore, MD, 10/1/1993
Depression does not affect medical outcomes in HIV infection.
Lyketsos CG, 5th B. Frank Polk Symposium, Center for AIDS Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD, 4/1/1993
Dementia and secondary mood disorders in AIDS (Plenary Presentation).
Lyketsos CG, Lyketsos GC, Fishman M, Treisman GJ, Xth Southeastern European Neuropsychiatric Congress, Thessaloniki, Greece, 9/1/1992
Mood disorders in temporal lobe epilepsy (Plenary Presentation).
Lyketsos CG, 4th Annual Conference of the American Neuropsychiatric Association, Washington, DC, 5/1/1992
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Lectures

Dementia Care: background, evidence, and practice. Keynote Lecture
Towson, MD - 5/14/2014
Progress in treatment development for Alzheimer's disease: where are we in 2014? Plenary Lecture
Sani, Halkidiki, Greece - 4/26/2014
All things remembered. Plenary Lecture
West Palm Beach, FL - 1/23/2014
Agitation as a target for treatment development. Plenary Lecture
San Diego, CA - 11/15/2013
Neuropsychiatric Symptoms in Dementia: Where are we headed?
Boston University, Boston, MA - 11/6/2013
Dementia Care at Home: State of the Art in 2013.
Boston, Waltham - 11/6/2013
Treatment development for Alzheimer’s Disease: how are we doing?
Aiginition Hospital, University of Athens, Athens, Greece - 10/8/2013
Agitation definition in AD citalopram trials.
Boston, MA - 7/12/2013
Care for People with Alzheimer's and Related Dementia and their Families: State of the Art 2013. Keynote Lecture
Annapolis, MD - 4/9/2013
Care for People with Alzheimer's and Related Dementia and their Families: State of the Art 2012.
Baltimore, MD - 11/27/2012
Balancing care with cure in Alzheimer’s disease. Plenary Symposium
Baltimore, MD - 9/6/2012
Tackling overlap of neuropsychiatric symptoms in Alzheimer’s and other dementias: Toward a unified approach to evaluation and treatment. Chair and Speaker
Vancouver, British Columbia, Canada - 7/15/2012
Discussant: Session IV: Drug Repurposing and Combinatorial Therapy.
Washington, DC - 5/15/2012
Who are responders to treatment with ELND0005 treatment? Plenary Panel Presentation
Stockholm, Sweden - 5/12/2012
Using antipsychotics in patients with dementia. Invited Plenary
Sao Paulo, Brazil - 3/24/2012
Neuropsychiatric symptoms in dementia: where are we headed? Invited Plenary
Sao Paulo, Brazil - 3/23/2012
Managing the cure versus care conundrum in dementia. Distinguished Scientist Award Lecture
Washington, DC - 3/18/2012
Neuropsychiatric Syndromes in Dementia and MCI: Where are we heading? Invited Lecture
Montreal, Canada - 1/26/2012
Neuropsychiatric Syndromes in Dementia and MCI: Where are we heading? Plenary Presentation
Porte de Versailles, Paris, France - 7/18/2011
Depression and psychosis in dementia: therapeutic perspectives. Invited Lecture
New York, NY - 3/10/2011
Providing dementia care in the community on a large scale. Invited Lecture
Boston, MA - 10/15/2010
Current issues in the diagnosis and treatment of dementia. Keynote Address
Holy Cross Hospital, Silver Spring, MD - 10/2/2010
How to diagnose and treat “Mild Cognitive Impairment” AND “How to manage co-morbid depression in cognitively impaired patients” [In Greek]. Invited Workshop
Athens, Greece - 9/15/2010
Epidemiology of Neuropsychiatric Disorders in Dementia Keynote Presentation
Washington, DC - 4/29/2010
Executive Dysfunction. Plenary Presentation
Washington, DC - 4/29/2010
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Other

The Copper Ridge Institute Dementia Care Certification Course (electronic media).
Steele CD, Brandt J, Baker A, Vozella S, Hovanec L, Lyketsos CG, Lippincott Williams and Wilkins Press, Philadelphia
1/1/2004

Press Mentions

Eye Changes May Reveal Early Signs of Alzheimer’s DiseaseMarch 30th, 2023
Health Experts Want FDA Safety Review of Fast-Tracked Alzheimer's DrugFebruary 6th, 2023
FDA Approves Alzheimer’s Drug from Eisai, Biogen in Closely Watched DecisionJanuary 6th, 2023
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