Constantine George Lyketsos MD MHS

PubMed

• Escitalopram for agitation in Alzheimer's dementia: a randomized controlled phase 3 trial.
  Tarek K Rajji, Sheriza N Baksh, David M Shade, Zahinoor Ismail, Amer M Burhan
  Nature Medicine. 2025-03-25
• Cohen-mansfield agitation inventory total score as a measure of agitation and aggression in Alzheimer's disease: A factor analysis.
  Suzanne B Hendrix, Mary Sano, Constantine Lyketsos, Paul B Rosenberg, Anton P Porsteinsson
  International Psychogeriatrics. 2025-03-18
• Rates and Predictors of Performance Validity Test Failure in Adults Treated for Post-COVID-19 Condition: a Brief Report.
  Phoebe A Clark, Samantha Horn, Natalie Wang, Constantine G Lyketsos, Ann M Parker
  Archives of Clinical Neuropsychology. 2025-01-02

Journal Articles

• Correlates of objective and subjective measures of caregiver burden among dementia caregivers: influence of unmet patient and caregiver dementia-related care needs  
  Hughes TB, Black BS, Albert M, Gitlin LN, Johnson DM, Lyketsos CG, Samus QM, Int Psychogeriatr, 11/1/2014
• Medication development for agitation and aggression in Alzheimer disease: review and discussion of recent randomized clinical trial design  
  Soto M, Andrieu S, Nourhashemi F, Ousset PJ, Ballard C, Robert P, Vellas B, Lyketsos CG, Rosenberg PB, Int Psychogeriatr, 9/1/2014
• Dementia caregivers' coping strategies and their relationship to health and well-being: the Cache County Study  
  Snyder CM, Fauth E, Wanzek J, Piercy KW, Norton MC, Corcoran C, Rabins PV, Lyketsos CG, Tschanz JT, Aging Ment Health, 8/1/2014
• A Call to Restructure Psychiatry General and Subspecialty Training  
  Kirwin P, Conroy M, Lyketsos C, Greenwald B, Forester B, Devries C, Ahmed II, Wiechers I, Zdanys K, Steffens D, Reynolds CF 3rd, Acad Psychiatry, 5/9/2014
• A multidimensional home-based care coordination intervention for elders with memory disorders: the Maximizing Independence at Home (MIND) Pilot Randomized Trial  
  Samus QM, Johnston D, Black BS, Hess E, Lyman C, Vavilikolanu A, Pollutra J, Leoutsakos J-M, Gitlin LN, Rabins PV, Lyketsos CG, Am J Geriatr Psychiatry, 4/1/2014
• Systematic review of neuroimaging correlates of executive functioning: converging evidence from different clinical populations  
  Nowrangi MA, Lyketsos C, Rao V, Munro CA, J Neuropsychiatry Clin Neurosci, 4/1/2014
• Management of neuropsychiatric symptoms of dementia in clinical settings: Recommendations from a multidisciplinary expert panel  
  Kales HC, Gitlin LN, Lyketsos C for the Detroit Expert Panel on the Assessment and Management of Neuropsychiatric Symptoms of Dementia, J Am Geriatr Soc, 3/17/2014
• Unmet needs of community-residing persons with dementia and their informal caregivers: findings from the maximizing independence at home study  
  Black BS, Johnston D, Rabins PV, Morrison A, Lyketsos C, Samus QM, J Am Geriatr Soc, 12/1/2013
• A review of neuroimaging findings of apathy in Alzheimer's disease  
  Theleritis C, Politis A, Siarkos K, Lyketsos CG, Int Psychogeriatr, 10/1/2013
• A randomized controlled trial of a community-based dementia care coordination intervention: effects of MIND at Home on caregiver outcomes  
  Tanner J, Black B, Johnston D, Hess E, Leoutsakos J, Gitlin L, Rabins P, Lyketsos C, Samus Q, Am J Geriatr Psychiatry, 8/1/2013
• Depression and incident Alzheimer's Disease: the impact of depression severity  
  Gracia-Garcia P, de-la-Camara C, SantabárbaraJ, Lopez-Anton R, Quintanilla MA, Ventura T, Marcos G, Campayo A, Saz P, Lyketsos C, Lobo A, Am J Geriatr Psychiatry, 6/1/2013
• The Brazilian version of the Neuropsychiatric Inventory-Clinician rating scale (NPI-C): reliability and validity in dementia  
  Stella F, Forlenza OV, Laks J, de Andrade LP, Avendaño MA, Se EV, Cacao JD, Lyketsos CG, de Medeiros K, Int Psychogeriatr, 6/1/2013
• Alzheimer's Disease Neuroimaging Initiative Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: The Cache County Deme...  
  Peterson D, Munger C, Crowley J, Corcoran C, Cruchaga C, Goate AM, Norton MC, Green RC, Munger RG, Breitner JC, Welsh-Bohmer KA, Lyketsos C, Tschanz J, Kauwe JS, Alzheimers Dement, 5/1/2013
• Neuropsychiatric Syndromes Professional Interest Area of ISTAART Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future  
  Geda YE, Schneider LS, Gitlin LN, Miller DS, Smith GS, Bell J, Evans J, Lee M, Porsteinsson A, Lanctôt KL, Rosenberg PB, Sultzer DL, Francis PT, Brodaty H, Padala PP, ..., Alzheimers Dement, 4/3/2013
• Cognition and amyloid load in Alzheimer’s imaged with florbetapir F 18 (AV-45) PET  
  Rosenberg PB, Wong DF, Edell S, Ross JS, Joshi AD, Brasic JR, Zhou Y, Raymont V, Kumar A, Ravert HT, Dannals RF, Pontecorvo MJ, Skovronsky DM, Lyketsos CG, Am J Geriatr Psychiatry, 3/1/2013
• The Association of Neuropsychiatric Symptoms in MCI With Incident Dementia and Alzheimer Disease  
  Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG, Am J Geriatr Psychiatry., 2/1/2013
• 12-month Incidence, Prevalence, Persistence and Treatment of Mental Disorders among Individuals Recently Admitted to Assisted Living Facilities in Maryland  
  Samus QM, Onyike CU, Johnston D, Mayer L, McNabney M, Baker A, Brandt J, Rabins PV, Lyketsos CG, Rosenblatt A, International Psychogeriatrics, Int Psychogeriatr, 1/1/2013
• Systematic Review of the Effectiveness of Pharmacologic Interventions to Improve Quality of Life and Well-being in People With Dementia  
  Cooper C, Mukadam N, Katona C, Lyketsos CG, Blazer D, Ames D, Rabins P, Brodaty H, de Mendonca Lima C, Livingston G, Am J Geriatr Psychiatry, 1/1/2013
• A systematic review of treatment for Mild Cognitive Impairment  
  Cooper C, Li R, Lyketsos C, Livingston G, British Journal of Psychiatry, 1/1/2013
• Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease  
  European Alzheimer's Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer's Disease; Alzheimer's Disease Genetic Consortium; Cohorts for Heart and Ag..., Nat Genet, 1/1/2013
• Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer's disease  
  Trzepacz PT, Cummings J, Konechnik T, Forrester TD, Chang C, Dennehy EB, Willis BA, Shuler C, Tabas LB, Lyketsos C, Int Psychogeriatr, 12/1/2012
• Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis  
  Whitcomb DC,… Lyketsos CG, …Devlin B, Nat Genet, 11/11/2012
• Cognitive outcomes after sertraline treatment in patients with depression of Alzheimer’s disease  
  Munro CA, Longmire CF, Drye LT, Martin BK, Frangakis CE, Meinert CL, MintzerJE, Porsteinsson AP, Rabins PV, Rosenberg PB, Schneider LZ, Weintraub D, Lyketsos CG, for t..., Am J Geriatr Psychiatry, 10/1/2012
• Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study  
  Peters ME, Rosenberg PB, Steinberg M, Norton MC, Welsh-Bohmer KA, Hayden KM, Breitner J, Tschanz JT, Lyketsos CG; the Cache County Investigators, Am J Geriatr Psychiatry, 9/12/2012
• Atypical antipsychotic use in patients with dementia: managing safety concerns  
  Steinberg M, Lyketsos CG, Am J Psychiatry, 9/1/2012
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Books/Book Chapters

• Gabbard’s Treatments of Psychiatric Disorders 
  Chapter: Chapter 64: Neurocognitive disorder due to Alzheimer’s disease. 
  Page 957 - 966Marano C, Rabins PV, Lyketsos CGAPPI Press2014
• Designing and Delivering Dementia Services. 
  De Waal H, Lyketsos C, Ames D, O’Brien JWiley Blackwell, London2013
• Systematic Psychiatric Evaluation. 
  Chisolm MC, Lyketsos CGJohns Hopkins University Press, Baltimore, MD2012
• Handbook of Alzheimer’s Disease 
  Chapter: DTI analyses and clinical applications in Alzheimer’s Disease. 
  Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori SEditors: M. Smith, G. Perry, J. W. Ashford, A. Rosen, M. Adamson, O. Sabri, S. Black, G. B. Frisoni, C. R. Jack and M. W. Weiner.2011
• Imaging the Alzheimer’s Disease Brain, Volume 2 
  Chapter: Chapter 7: DTI analyses and clinical applications in Alzheimer’s Disease. 
  Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori SEditors: M. Smith, G. Perry, J. W. Ashford, A. Rosen, M. Adamson, O. Sabri, S. Black, G. B. Frisoni, C. R. Jack and M. W. Weiner.2011
• Principles and Practice of Geriatric Psychiatry 
  Chapter: Chapter 52: Pharmacologic therapies in Alzheimer’s disease. 
  Page 304 - 311Steinberg M, Lyketsos CGEditors: Abou Saleh, Katona, Kumar.Wiley BlackwellEdition 3rd,2011
• Principles and Practice of Geriatric Psychiatry 
  Chapter: Chapter 44: Mouse models of Alzheimer’s disease. 
  Page 252 - 256Oh E, Lyketsos CG, Wong PEditors: Abou Saleh, Katona, Kumar.Wiley BlackwellEdition 3rd,2011
• Principles and Practice of Geriatric Psychiatry 
  Chapter: Chapter 41: Clinical features of Alzheimer’s disease: cognitive and non-cognitive. 
  Page 226 - 231Salami O, Lyketsos CGEditors: Abou Saleh, Katona, Kumar.Wiley BlackwellEdition 3rd,2011
• Dementia 
  Chapter: Chapter 8: Neuropsychiatric aspects of dementia. 
  Page 70 - 74Leroi I, Lyketsos CGEditors: Ames, Burns, and O’Brien.Hodder Arnold, London2010
• Textbook of Geriatric Psychiatry 
  Chapter: Chapter 13: Dementia and Milder Cognitive Syndromes. 
  Page 243 - 260Lyketsos CGEditors: Blazer and Steffens.APPI2009
• Treating dementia: do we have a pill for it? 
  Ballenger JF, Whitehouse PJ, Lyketsos CG, Rabins PV, Karlawish JHTJohns Hopkins University Press, Baltimore, MD2009
• Psychiatric aspects of neurological diseases. 
  Editors: Lyketsos CG, Rabins PV, Lipsey J, Slavney PR.Oxford University Press, New York2008
• Dementia 
  Chapter: Chapter 6: Neuropsychiatric aspects of dementia. 
  Page 55 - 63Leroi I, Lyketsos CGEditors: Burns, O’Brien, and Ames.Cambridge Press, Cambridge, MA2005
• Comprehensive Textbook of Psychiatry 
  Chapter: Neuropsychiatric aspects of HIV infection and AIDS. 
  Page 426 - 451Treisman GJ, Angelino AF, Hutton HE, Hsu J, Lyketsos CGEditors: Sadock and Sadock.Lippincott, Williams, and Wilkins, Philadelphia, PAEdition 8th,2004
• Textbook of Psychosomatic Medicine 
  Chapter: Aggression and violence. 
  Page 171 - 191Onyike CU, Lyketsos CGEditors: Levenson et al.American Psychiatric Press Inc., Washington, DC2004
• Psychiatry in the Medically Ill. 
  Editors: Levenson J, Lyketsos CG, Trzepacz PT.Psychiatric Clinics of North America, Saunders, Philadelphia, PA2002
• Research and Practice in Alzheimer’s disease (Volume 6) 
  Chapter: Sertraline for major depression in Alzheimer’s disease: the DIADS study. 
  Page 223 - 231Lyketsos CG, Rabins PVSerdi/Springer, Paris2002
• En Tratado de Neurologia Clinica 
  Chapter: Trastornos de la conducta en la demencia. 
  Page 753 - 762Taragano F, Lyketsos CEditors: Federico Michelli et al.Medica Panamericana, Buenos Aires, Argentina2002
• Geriatrics Review Syllabus 
  Chapter: Neuropsychiatric and behavioral disturbances in dementia (Chapter 18) 
  Page 125 - 131Lyketsos CGBlackwell PublishingEdition 5th,2002
• Psychiatric Clinics of North America 
  Chapter: Psychiatric aspects of traumatic brain injury. 
  Page 43 - 69Rao V, Lyketsos CGEditors: Levenson, Lyketsos, Trzepacz.Saunders Publishing2002
• Research and Practice in Alzheimer’s disease (Volume 5) 
  Chapter: Mental and Behavioral Disturbances in Dementia: Findings from the Cache County Study of Memory in Aging. 
  Page 144 - 150Lyketsos CG, Breitner JCSSerdi/Springer, Paris2001
• Textbook of Geriatric Neuropsychiatry 
  Chapter: Neuropsychiatry in the Nursing Home. 
  Page 891 - 903Rovner B, Katz I, Lyketsos CGEditors: Coffey and Cummings.American Psychiatric Press Inc., Washington, DC2000
• Textbook of Geriatric Neuropsychiatry 
  Chapter: Aggression. 
  Page 477 - 488Lyketsos CGEditors: Coffey and Cummings.American Psychiatric Press Inc., Washington, DC2000
• Handbook of Psychiatric Measures. 
  Chapter: Behavioral measures for cognitive disorders. 
  Page 393 - 416Lyketsos CG, Steinberg MAmerican Psychiatric Association, Washington, DC2000
• Research and Practice in Alzheimer’s disease (Volume 3) 
  Chapter: Aggression in patients with dementia. 
  Page 169 - 177Lyketsos CGSerdi/Springer, Paris2000
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Abstracts/Posters

• Depression in HIV infection: recognition, assessment, and management.
  Lyketsos CG, AIDS: Healthcare Professionals' Conference, Medical University of South Carolina, Charleston, SC, 2/4/1994
• HIV, AIDS and Mania.
  Lyketsos CG, The AIDS Dementia Conference, Institute of Pennsylvania Hospital, Philadelphia, PA, 1/26/1994
• The Impact of HIV Infection on Psychiatric Services.
  Lyketsos CG, Treisman GJ, Fishman M, 45th Institute on Hospital and Community Psychiatry, Baltimore, MD, 10/1/1993
• Depression does not affect medical outcomes in HIV infection.
  Lyketsos CG, 5th B. Frank Polk Symposium, Center for AIDS Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD, 4/1/1993
• Dementia and secondary mood disorders in AIDS (Plenary Presentation).
  Lyketsos CG, Lyketsos GC, Fishman M, Treisman GJ, Xth Southeastern European Neuropsychiatric Congress, Thessaloniki, Greece, 9/1/1992
• Mood disorders in temporal lobe epilepsy (Plenary Presentation).
  Lyketsos CG, 4th Annual Conference of the American Neuropsychiatric Association, Washington, DC, 5/1/1992
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Lectures

• Dementia Care: background, evidence, and practice. Keynote Lecture 
  Towson, MD - 5/14/2014
• Progress in treatment development for Alzheimer's disease: where are we in 2014? Plenary Lecture 
  Sani, Halkidiki, Greece - 4/26/2014
• All things remembered. Plenary Lecture 
  West Palm Beach, FL - 1/23/2014
• Agitation as a target for treatment development. Plenary Lecture 
  San Diego, CA - 11/15/2013
• Neuropsychiatric Symptoms in Dementia: Where are we headed? 
  Boston University, Boston, MA - 11/6/2013
• Dementia Care at Home: State of the Art in 2013. 
  Boston, Waltham - 11/6/2013
• Treatment development for Alzheimer’s Disease: how are we doing? 
  Aiginition Hospital, University of Athens, Athens, Greece - 10/8/2013
• Agitation definition in AD citalopram trials. 
  Boston, MA - 7/12/2013
• Care for People with Alzheimer's and Related Dementia and their Families: State of the Art 2013. Keynote Lecture 
  Annapolis, MD - 4/9/2013
• Care for People with Alzheimer's and Related Dementia and their Families: State of the Art 2012. 
  Baltimore, MD - 11/27/2012
• Balancing care with cure in Alzheimer’s disease. Plenary Symposium 
  Baltimore, MD - 9/6/2012
• Tackling overlap of neuropsychiatric symptoms in Alzheimer’s and other dementias: Toward a unified approach to evaluation and treatment. Chair and Speaker 
  Vancouver, British Columbia, Canada - 7/15/2012
• Discussant: Session IV: Drug Repurposing and Combinatorial Therapy. 
  Washington, DC - 5/15/2012
• Who are responders to treatment with ELND0005 treatment? Plenary Panel Presentation 
  Stockholm, Sweden - 5/12/2012
• Using antipsychotics in patients with dementia. Invited Plenary 
  Sao Paulo, Brazil - 3/24/2012
• Neuropsychiatric symptoms in dementia: where are we headed? Invited Plenary 
  Sao Paulo, Brazil - 3/23/2012
• Managing the cure versus care conundrum in dementia. Distinguished Scientist Award Lecture 
  Washington, DC - 3/18/2012
• Neuropsychiatric Syndromes in Dementia and MCI: Where are we heading? Invited Lecture 
  Montreal, Canada - 1/26/2012
• Neuropsychiatric Syndromes in Dementia and MCI: Where are we heading? Plenary Presentation 
  Porte de Versailles, Paris, France - 7/18/2011
• Depression and psychosis in dementia: therapeutic perspectives. Invited Lecture 
  New York, NY - 3/10/2011
• Providing dementia care in the community on a large scale. Invited Lecture 
  Boston, MA - 10/15/2010
• Current issues in the diagnosis and treatment of dementia. Keynote Address 
  Holy Cross Hospital, Silver Spring, MD - 10/2/2010
• How to diagnose and treat “Mild Cognitive Impairment” AND “How to manage co-morbid depression in cognitively impaired patients” [In Greek]. Invited Workshop 
  Athens, Greece - 9/15/2010
• Epidemiology of Neuropsychiatric Disorders in Dementia Keynote Presentation 
  Washington, DC - 4/29/2010
• Executive Dysfunction. Plenary Presentation 
  Washington, DC - 4/29/2010
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Other

• The Copper Ridge Institute Dementia Care Certification Course (electronic media). 
  Steele CD, Brandt J, Baker A, Vozella S, Hovanec L, Lyketsos CG, Lippincott Williams and Wilkins Press, Philadelphia
  1/1/2004