ClintonHJoinerMDPhD

PubMed

• 311 citations
  Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c
  Robert M. Cohen, Robert S. Franco, Paramjit K. Khera, Eric P. Smith, Christopher J. Lindsell
  Blood. 2008-11-15
• 168 citations
  Discordance between HbA1c and fructosamine: evidence for a glycosylation gap and its relation to diabetic nephropathy
  Robert M. Cohen, Yancey R. Holmes, Thomas C. Chenier, Clinton H. Joiner
  Diabetes Care. 2003-01-01
• 6 citations
  Quantifying the Cerebral Hemometabolic Response to Blood Transfusion in Pediatric Sickle Cell Disease With Diffuse Optical Spectroscopies.
  Seung Yup Lee, Rowan O Brothers, Katherine B Turrentine, Ayesha Quadri, Eashani Sathialingam
  Frontiers in Neurology. 2022-01-01

Journal Articles

• Clinical Outcomes Associated with Sickle Cell Trait: A Systematic Review  
  Kathryn L Hassell, Rakhi P Naik, Puneet Sahota, Gregory J Kato, Clinton H Joiner, Annals of Internal Medicine
• Use of an oral stable isotope label to confirm variation in red blood cell mean age that influences HbA1c interpretation  
  Khera PK1, Smith EP, Lindsell CJ, Rogge MC, Haggerty S, Wagner DA, Palascak MB, Mehta S, Hibbert JM, Joiner CH, Franco RS, Cohen RM, Am J Hematol, 1/1/2015
• Activationof Protein Kinase C by Phorbol Ester Increases Red Blood Cell Scramblase Activity and External Phosphatidylserine  
  Barber LA1, Palascak MB, Qi X, Joiner CH, Franco RS, Eur J Haematol, 1/1/2015
• Framing the Research Agenda for sickle cell trait: Building on the current understand of clinical events and their potential implications  
  Goldsmith JC, Bonham VL, Joiner, CH, Kato, GJ, Noonan, AS, and Steinberg, MH, Am J Hematol, 1/1/2012
• Engaging patients with sickle cell disease and their families in disease education, research, and community awareness  
  Hines, J, Mitchell, M, Crosby L, Johnson, A, Valenzuela, Kalinyak, K, and Joiner, CH, J Prevent Interven Community, 1/1/2011
• Sickle cell disease due to uniparental disomy in a child who inherited sickle cell trait  
  Swensen, J, Agarwal A, Esquilin J, Swierczek S, Perumbeti A, Hussey D, Joiner CH, Pont-Kingdon G, Lyon Elaine, and Prchal J, Blood, 1/1/2010
• Aminophospholipid Translocase and Phospholipid Scramblase Activities in Sickle Erythrocyte Subpopulations  
  Barber LA, Palascak MB, Joiner CH, Franco RS, Brit J Haematol, 1/1/2009
• Sites of regulated phosphorylation that control KCl cotransporter activity  
  Rinehart J, Maksimova YD, Tanis JE, Stone KL, Hodson CA, Zhang J, Risinger M, Pan W, Wu D, Colangelo CM, Forbush B, Joiner CH, Gulcicek EE, Gallagher PG, Lifton RP, Cell, 1/1/2009
• Red cell lifespan heterogeneity in hematologically normal people is sufficient to alter HbA1c  
  Cohen RM, Franco RS, Khera PK, Smith EP, Lindsell CJ, Ciraolo PJ, Palascak MB, Joiner CH, Blood, 1/1/2008
• Gardos pathway to sickle cell therapies? Inside Blood commentary  
  Joiner CH, Blood, 1/1/2008
• Evidence for inter-individual heterogeneity in the glucose gradient across the human RBC membrane and its relationship to hemoglobin glycation  
  Khera PK, Joiner CH, Carruthers A, Lindsell CJ, Smith EP, Franco RS, Holmes YR, Cohen RM, Diabetes, 1/1/2008
• Discordant HbA1c Results: The Hoofbeats Increase  
  Cohen RM, Joiner CH, Franco RS, J Pediatrics, 1/1/2008
• Effect of Fetal Hemoglobin on the Survival Characteristics of Sickle Cell  
  Franco RS, Yasin Z, Palascak MB, Ciraolo P, Joiner CH, Rucknagel DL, Blood, 1/1/2006
• Multiple isoforms of the KCI cotransporter are expressed in sickle and normal erythroid cells  
  Crable SC, Hammond SM, Papes R, Rettig RK, Zhou GP, Gallagher PG, Joiner CH, Anderson KP, Exp Hematology, 1/1/2005
• KCl Cotransport Mediates Abnormal, Sulfhydryl-Dependent Volume Regulation in Sickle Reticulocytes  
  Joiner CH, Rettig RK, Jiang M, Franco RS, Blood, 1/1/2004
• Is poor glycemic control associated with reduced red blood cell lifespan? Invited Editorial  
  Cohen RM, Franco RS, Joiner CH, Diabetes Care, 1/1/2004
• Discordance between HbA1c and Fructosamine: Evidence for a glycosylation gap and its relation to diabetic retinopathy  
  Cohen RM, Holmes YR, Chenier TC, Joiner CH, Diabetes Care, 1/1/2003
• Regulation of K-Cl Cotransport by Syk and Src protein tyrosine kinase  
  Merciris P, Claussen WJ, Joiner CH, Giraud F, Eur J Physiol, 1/1/2003
• The activation of KCl cotransport by deoxygenation and its role in sickle cell dehydration  
  Joiner CH and Franco RS, Blood Cells, Mol Dis, 1/1/2001
• Modification of erythrocyte hydration in the treatment of sickle cell disease  
  Zhou GP, Anderson KP, Joiner CH, Gallagher PG, Blood Cells, Mol Dis, 1/1/2001
• Universal newborn screening for hemoglobinopathies  
  Joiner CH, J Pediatrics, 1/1/2000
• NHE-1 is the sodium hydrogen exchanger present in erythroid cells  
  Sarangarajan R, Dabhia N, Soleimani M, Baird N, Joiner CH, Biochim Biophysic Acta, 1/1/1998
• Deoxygenation of Sickle Red Blood Cells Stimulates KCl Cotransport Without Affecting Na/H Exchange  
  Joiner CH, Jiang M, Fathallah H, Giraud F, Franco RS, Am J Physiol, 1/1/1997
• Should children with hemoglobinopathies be offered unrelated-donor cord blood stem cell transplantation? [Editorial]  
  Harris RE and Joiner CH, J Pediatrics, 1/1/1997
• The Formation of Transferrin Receptor-positive Sickle Reticulocytes with Intermediate Density is Not determined by HbF Content  
  Franco RS, Thompson H, Palascak M, Joiner CH, Blood, 1/1/1996
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Books/Book Chapters

• Disorders of Hemoglobin. 
  Chapter: Red Cell Membrane in Sickle Cell Disease. 
  Page 158 - 184Gallagher PG and Joiner CHEditors: M.H. Steinberg, B.G. Forget, D.R. Higgs, and R.L. Nagel.Cambridge University Press, United Kingdom2009
• The Renaissance of Sickle Cell Disease in the Human Genome Era 
  Chapter: Damage to the RBC Membrane in Sickle Cell Disease. 
  Goodman SR and Joiner CHEditors: B Pace.Imperial College Press, United Kingdom2007
• Pediatrics and Perinatology: The Scientific Basis. 
  Chapter: Membrane function, Ion Transport and Cellular Ion Regulation 
  Page 40 - 53Joiner CHEditors: P.D. Gluckman and M. Heyman.Edward Arnold Ltd, London, United Kingdom1996
• New Trends in Therapies for Hemoglobinopathies and Thalassemias. 
  Chapter: Dipyridamole inhibits deoxygenation-induced cation fluxes in sickle cells. 
  Page 525 - 542Joiner CH and Jiang MEditors: J Rosa, Y Beuzard, and B Lubin.INSERM/John Libbey, Paris, France1995
• Developmental Physiology: A Pediatric Perspective. 
  Chapter: Membrane Transport and Cellular Ion Regulation 
  Page 3 - 17Joiner CHEditors: P. Gluckman and M. Heymann et al.Edward Arnold Ltd, London, United Kingdom1993
• Pathophysiologic Aspects of Sickle Cell Vasocclusion 
  Chapter: Studies on the Mechanism of Passive Cation Fluxes Activated by Deoxygenation of Sickle Cells. 
  Page 229 - 235Joiner CHEditors: R Nagel.Alan R. Liss, New York, NY1987
• Manual of Newborn Care 
  Chapter: Anemia 
  Joiner CH and Cloherty JPEditors: JP Cloherty and A Stark.Little Brown and Company1985
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Abstracts/Posters

• Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease
  Clinton H. Joiner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• The Novel PIEZO1 Mutation p.L2023V Is Causal for Hereditary Xerocytosis Resulting in Delayed Channel Inactivation and a Dehydrated Red Blood Cell Phenotype.
  Mary A Risinger, Edyta Glogowska, Amber Ht Begtrup, Neha Dagaonkar, Satheesh Chonat, Clinton H Joiner, Charles T. Quinn, Theodosia A. Kalfa, and Patrick G Gallagher, Blood; ASH, San Francisco, CA, 1/1/2014
• Development of a Comprehensive Rapid Next-Generation Sequencing Assay For The Diagnosis Of Inherited Hemolytic Anemia.
  Amber Hogart Begtrup, Neha Dagaonkar, Suvarnamala Pushkaran, Katie M. Giger, Ammar Husami, Diane Kissell, Clinton H. Joiner, Mehdi Keddache, Kejian Zhang, Theodosia A...., Blood; ASH, New Orleans, LA, 1/1/2013
• Measurement Of Erythrocyte Survival In Vivo using a Stable Isotope Label In Sickle Cell Anemia.
  Charles T. Quinn, Paramjit K Khera, Christopher J Lindsell, Clinton H Joiner, Robert M Cohen, Robert S. Franco, Blood; ASH, New Orleans, LA, 1/1/2013
• Impact Of Use Of a Disease-Specific Patient Portal On Transition Readiness and Quality Of Life In Adolescents With Sickle Cell Disease.
  Crosby, LE, Hudepohl, M, Kalinyak, K, Britto, M, Goldstein, A, Brown, K, Culp, A, and Joiner, CH, Blood; ASH, New Orleans, LA, 1/1/2013
• Six-Month Data from a Pilot Self-Management Intervention ForAdolescents With Sickle Cell Disease.
  Lori E Crosby, Naomi Joffe, Karen Kalinyak, Alex Bruck, Clinton H Joiner, Blood; ASH, New Orleans, LA, 1/1/2013
• A phase I trial of Zileuton in sickle cell disease.
  Marthe-Sandrine Eiymo Mwa Mpollo, Maa-Ohui Quarmyne, Omar Rayes, Caryn S. Gonsalves, Laurie Vanderah, Christina Canter, Johnson Haynes Jr., Claudia Fernanda Clavijio, ..., Blood; ASH, New Orleans, LA, 1/1/2013
• Next Generation Sequencing for Diagnostic Testing of Erythrocyte Cytoskeleton Disorders.
  Theodosia A Kalfa, Mary A. Risinger, Suvarnamala Pushkaran, Phillip Dexheimer, Ammar Husami, Diane Kissell, Clinton H. Joiner, Mehdi Keddache, and Kejian Zhang, Blood; ASH, San Francisco, CA, 1/1/2012
• VEGF Mediated Regulation of KCl Cotransporters Gene Expression in Erythroid Cells.
  Gonsalves, CS, Crable, SC, Chandra, S and Joiner, CH, ASH, San Francisco, CA, 1/1/2011
• Vascular Endothelial Growth Factor (VEGF) Increases KCC4 Expression in Erythroid Cells via Signaling Pathways Involving HIF-1a.
  Gonsalves CS, and CH Joiner, Blood; ASH, Orlando, FL, 1/1/2010
• Structural Interactions of KCl Cotransport Proteins KCC1 and KCC3 in Sickle and Normal Erythrocyte Membranes Have Potential Functional Implications.
  Joiner, CH, Risinger M, Rinehart J, Crable S, Ottlinger A, Winkelmann R, Pan D, Huebner C, Gallagher PG, National Sickle Cell Disease Meetings, Fort Lauderdale, FL, 1/1/2009
• Sickle red blood cells have increased phosphorylation of adducin and increased ROS production mediated by signaling pathways involving Rac GTPases.
  Kalfa TA, Pushkaran S, An X, Collias N, Joiner CH, Mohandas N, Zheng Y, National Sickle Cell Disease Meetings, Fort Lauderdale, FL, 1/1/2009
• Sickle Erythrocytes Have Increased Adducin Phosphorylation and Increased ROS Production Mediated by Signaling Pathways Involving Protein Kinase C and Rac GTPases.
  Kalfa TA, George A, Pushkaran S, An X, Joiner CH, Mohandas N, Zheng Y, Blood; American Society of Hematology National Meeting, New Orleans, LA, 1/1/2009
• Effects of Hydroxyurea (HU) and Magnesium Pidolate (Mg) in Hemoglobin SC Disease (HbSC): the “CHAMPS” Trial.
  Wang WC MD, Snyder C, Brugnara C, Telen MJ, Steinberg MH,Wynn LW, McAfee J, Rogers ZR, Kalinyak K, Joiner CH, Kesler K, Blood; American Society of Hematology National Meeting, New Orleans, LA, 1/1/2009
• Red Blood Cell Scramblase Activation Is Induced by Phorbol Ester and Prevented by Inhibition of Protein Kinase C.
  Barber LA, Palascak MB, Joiner CH, Franco RS, American Society of Hematology National Meeting, San Francisco, CA, 1/1/2008
• Correction of Sickle Cell Anemia with -Globin Gene Delivered by Lentivirus Vector in the Setting of Myeloablative or Reduced Intensity Conditioning, and Establishing C...
  Perumbeti A, Higashimoto T, Urbinati F, Lauderback K, Loberg A, Estevez-Pagani G, Meiselman H, Franco R, Witte D, Joiner CH, Malik P, American Society of Hematology National Meeting, San Francisco, CA, 1/1/2008
• Structural and Functional Interactions of KCl Cotransport Proteins KCC1 and KCC3 in Sickle and Normal Erythrocyte Membranes.
  Risinger M, Rinehart J, Crable S, Ottlinger A, Winkelmann R, Pan D, Huebner C, Gallagher PG, Joiner CH, American Society of Hematology National Meeting, San Francisco, CA, 1/1/2008
• Aminophospholipid Translocase Activity is Markedly Decreased in Dehydrated Sickle Red Blood Cells.
  Arnold L, Palsacek M, Ciraolo P, Joiner CH, Franco RS, National Sickle Cell Meetings, Washington, DC, 1/1/2007
• Novel Transcripts of the KCl Cotransporter-3 (KCC3) gene in erythroid cells are derived from alternate splicing within exon 1.
  Crable S, Joiner CH, Gallagher PG, National Sickle Cell Meetings, Washington, DC, 1/1/2007
• Expressional profile of KCl cotransporters in human erythroid differentiation.
  Pan D, Wang D, Crable S, Risinger M, Franco RS, Joiner CH, National Sickle Cell Meetings, Washington, DC, 1/1/2007
• A GC box element is critical for transcriptional regulation of the K-Cl cotransporter isoform KCC3a in hematopoietic cells.
  Crable S, Joiner CH, Gallagher PG, American Society of Hematology National Meeting, Atlanta, GA, 1/1/2007
• KCl Cotransporter Genes KCC1, KCC3a, and KCC4 are Expressed in Human Erythroid Differentiation.
  Pan D, Kalfa T, Wang D, Risinger M, Crable S, Ciraolo P, Franco RS, Joiner CH, American Society of Hematology National Meeting, Atlanta, GA, 1/1/2007
• Expression of a KCl Cotransporter (KCC1) Splice Variant is Suppressed by TNFalpha and NF-B in Erythroid Cells.
  Joiner CH, Crable S, Anderson K, Hammond S, Gallagher P, National Sickle Cell Meetings, Memphis, TN, 1/1/2006
• Kinetic characteristics of KCl Cotransporter isoforms, KCC1, KCC3, and KCC4, expressed in HEK 293 cells.
  Joiner CH, Papes R, Jiang M, Crable S, National Sickle Cell Meetings, Memphis, TN, 1/1/2006
• KCl Cotransport Mediates Abnormal Volume Regulation in Sickle Reticulocytes.
  Joiner CH, Rettig RK, Jiang M, Franco RS, National Sickle Cell Meetings, Memphis, TN, 1/1/2006
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Lectures

• Moving the Clinical Research Agenda Forward 
  Baltimore, MD - 1/1/2013
• Regulation of Erythroid Expression of KCl Cotransporter Genes 
  Bethesda, MD - 1/1/2013
• Basic Genetics and Hematology 
  Cincinnati Children’s Hospital Medical Center - 1/1/2012
• Genetics and Hematologic Manifestations of Sickle Cell Disease 
  Cincinnati Children’s Hospital Medical Center - 1/1/2012
• History of Sickle Cell Disease 
  Cincinnati Children’s Hospital Medical Center - 1/1/2012
• Sickle Cell Trait. 
  Cincinnati Children’s Hospital Medical Center - 1/1/2012
• Beyond Red Cell Sickling: Cellular and Humoral Mechanisms that Contribute to Sickle Cell Pathology 
  Fort Lauderdale, FL - 1/1/2012
• Newborn Screening for Hemoglobinopathies 
  1/1/2012
• Sickle Cell Disease Pathophysiology 
  1/1/2012
• Global Perspective in Sickle Cell Disease. 
  Cincinnati Children's Hospital Medical Center - 1/1/2011
• Progress in Research and Medical Care for Sickle Cell Disease since 1910. 
  Accra, Ghana - 1/1/2010
• Sickle Cell Disease: A Complex Phenotype from the Simplest Mutation. 
  Cincinnati Children's Hospital Medical Center - 1/1/2010
• Sickle Cell Research Workshop 
  Washington, DC - 1/1/2010
• New Paradigms for Sickle Cell Disease - From Pathophysiology to Therapy 
  Cornell-Weill Medical Center, New York, NY - 1/1/2009
• Research in Sickle Cell Disease. 
  1/1/2009
• A vision of a sickle cell disease clinical research network. 
  Bethesda, MD - 1/24/2008
• New Horizons in Sickle Cell Disease 
  Cincinnati Children's Hospital Medical Center - 1/1/2008
• A new pathophysiological paradigm for sickle cell disease” and “Research in sickle cell disease. 
  Fort Lauderdale, FL - 1/1/2008
• New Knowledge, New Concepts, New Therapies in Sickle Cell Disease 
  Dallas, TX - 1/1/2006
• KCC1, KCC3, and KCC4 Are Expressed in Human Red Cells. 
  Yale University, New Haven, CT - 1/1/2006
• New Therapies for Sickle Cell Disease 
  Cincinnati Children's Hospital Medical Center - 1/1/2005
• New Therapies in Sickle Cell Disease. 
  Dayton VA Hospital - 1/1/2005
• Research in Sickle Cell Disease: NIH Clinical Trials Consortium of the Comprehensive Sickle Cell Centers. 
  Los Angeles, CA - 1/1/2005
• Regulatory volume decrease mediated by KCl cotransport in normal and sickle reticulocytes. 
  University of Illinois, Chicago, IL - 1/1/2005
• Perinatal Screening for Hemoglobinopathies. 
  Christ Hospital, Cincinnati, OH - 1/6/2003
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Other

• Global Burden of Sickle Cell Disease. Commentary 
  Joiner CH, and Frederickson, ME, HemeOnc Today
  1/1/2013
• Genetic screening in NCAA has the potential to be discriminatory. Guest editorial. 
  Joiner CH, and Frederickson, ME, Cincinnati Enquirer
  1/9/2010
• What is Sickle Cell Trait? 
  Joiner CH, Sickle Cell News and Views, Sickle Cell Disease Association of America
  1/1/2008
• New hope for people living with sickle cell disease. 
  Joiner CH, Living Longer: Expert Advice for Healthy Living
  http://www.livinglonger.com
  1/6/2004
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