CliffordVincentHardingIIIMD

PubMed

• 2531 citations
  B lymphocytes secrete antigen-presenting vesicles.
  Graça Raposo, Hans W. Nijman, Willem Stoorvogel, R Liejendekker, Clifford V. Harding
  The Journal of Experimental Medicine. 1996-03-01
• 1208 citations
  Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
  Clifford V. Harding, John E. Heuser, Philip D. Stahl
  The Journal of Cell Biology. 1983-08-01
• 171 citations
  Mycobacterium tuberculosis LprA Is a Lipoprotein Agonist of TLR2 That Regulates Innate Immunity and APC Function
  Nicole D. Pecora, Adam J. Gehring, David H. Canaday, W. Henry Boom, Clifford V. Harding
  Journal of Immunology. 2006-07-01

Journal Articles

• Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes  
  Mudd, J.C., Murphy, P., Manion, M., Debernardo, R., Hardacre, J., Ammori, J., Hardy, G.A., Harding, C.V., Mahabaleshwar, G.H., Jain, M.K., Jacobson, J.M., Brooks, A.D...., Blood, 1/1/2013
• Interferon-alpha is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers  
  Hardy, G.A.D., Sieg, S., Rodriguez, B., Anthony, D., Asaad, R., Jiang, W., Mudd, J., Schacker, T., Funderburg, N., Pilch, H., Rabin, R.L., Lederman, M.M. and Harding, ..., PLOS One, 1/1/2013
• Type I interferon drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing  
  Simmons, D.P., Wearsch, P.A., Canaday, D.H., Meyerson, H.J., Liu, Y.C., Wang, Y., Boom, W.H. and Harding, C.V., J. Immunol., 1/1/2012
• TLR2 signaling depletes IRAK1 and inhibits induction of type I IFN by TLR7/9  
  Liu, Y.C., Simmons, D.P., Li, X., Abbott, D., Boom, W.H., Harding, C.V., J. Immunol., 1/1/2012
• Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4+ T cell activation via TLR2/1  
  Lancioni CL, Li Q, Thomas JJ, Ding X, Thiel, D, Drage MG, Pecora ND, Ziady AG, Shank SL, Harding CV, Boom WH and Rojas RE, Infect Immun, 1/1/2011
• Mycobacterium tuberculosis promotes HIV trans-infection and suppresses major histocompatibility complex class II antigen processing by dendritic cells  
  Reuter, M.A., Pecora, N.D., Harding, C.V., Canaday, D.H., McDonald, D., J. Virol., 1/1/2010
• CpG-B oligodeoxynucleotides inhibit Toll-like receptor-dependent and independent induction of type I IFN in dendritic cells  
  Liu, Y, Gray, RC, Hardy, GAD, Kuchtey, J, Abbott, DW, Emancipator, SN and Harding, CV, J. Immunol., 1/1/2010
• Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and MHC-I antigen cross processing by TLR9  
  Simmons, D.P., Canaday, D.H., Liu, Y., Li, Q., Huang, A., Boom, W.H. and Harding, C.V., J. Immunol., 1/1/2010
• Regulation of antigen processing by Mycobacterium tuberculosis: a role for Toll-like receptors  
  Harding, C.V. and Boom, W.H., Nature Rev Microbiol, 1/1/2010
• Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2  
  Drage, M.G., Tsai, H.-C., Pecora, N.D., Cheng, T.-Y., Arida, A.R., Shukla, S., Rojas, R.E., Moody, D.B., Boom, W.H., Sacchettini, J.C., and Harding, C.V., Nature Struct Mol Biol, 1/1/2010
• Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing MHC-II molecules capable of antigen presentation  
  Ramachandra, L., Qu, Y., Wang, Y., Cobb, B., Takatsu, K., Boom, W.H., Dubyak, G.R. and Harding, C.V., Infect Immun, 1/1/2010
• Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T cell activation by interfering with proximal TCR signaling  
  Mahon, R.N., Rojas, R.E., Fulton, S.A., Franko, J., Harding, C.V. and Boom, W.H., Infect. Immun., 1/1/2009
• Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection  
  Pecora, N.D., Fulton, S.A., Reba, S.M., Drage, M.G., Simmons, D.P., Urankar-Nagy, N.J., Boom, W.H. and Harding, C.V., Cell. Immunol., 1/1/2009
• TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis  
  Drage, M.G., Pecora, N.D., Hise, A.G., Febbraio, M., Silverstein, R.L., Golenbock, D.T., Boom, W.H. and Harding, C.V., Cell. Immunol., 1/1/2009
• P2X7 receptor-stimulated secretion of MHC-II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1  
  Qu, Y., Ramachandra, L., Mohr, S., Franchi, L., Harding, C.V., Nunez, G. and Dubyak, G.R., J. Immunol., 1/1/2008
• Impaired naive and memory B cell responsiveness to TLR9 stimulation in HIV-infection  
  Jiang, W, MM Lederman, RJ Mohner, B Rodriguez, TM Nedrich, CV Harding & SF Sieg, J Virol, 1/1/2008
• Human beta-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2  
  Funderberg, N., Lederman, M.M., Feng, Z., Drage, M.G., Jadlowsky, J. Harding, C.V., Weinberg, A. and Sieg, S.F., Proc. Natl. Acad. Sci. USA, 1/1/2008
• C/EBP-beta binds to CIITA promoters and inhibits CIITA expression in response to M tuberculosis 19-kDa lipoprotein  
  Pennini, ME, Yang, J, Croniger, CM, Boom, WH and Harding, CV, J. Immunol., 1/1/2007
• M tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function  
  Pecora, ND, Gehring, AJ, Canaday, DH, Boom, WH & Harding, CV, J. Immunol., 1/1/2006
• Interferon-alpha differentially rescues CD4+ and CD8+ T cells from apoptosis in HIV infection  
  Rodriguez, B, Lederman, MM, Jiang, W, Bazdar, DA, Garate, K, Harding, CV & Sieg, SF, AIDS, 1/1/2006
• Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-g-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling  
  Pennini, ME, Pai, RK, Schultz, DC, Boom, WH & Harding, CV, J. Immunol., 1/1/2006
• Enhancement of dendritic cell antigen cross presentation by CpG DNA involves type I IFN and stabilization of class I MHC mRNA  
  Kuchtey, J, Chefalo, PJ, Ramachandra, L & Harding, CV, J. Immunol., 1/1/2005
• CpG ODN induces monocyte maturation in cells from healthy individuals and HIV-infected patients  
  Jiang, W, Lederman, MM, Salkowitz, JR, Harding, CV & Sieg, SS, J. Virol., 1/1/2005
• Prolonged Toll-like receptor signaling by Mycobacterium tuberculosis and its 19-kDa lipoprotein inhibits interferon-gammainduced gene regulation in macrophages  
  Pai RK, Pennini ME, Tobian AAR, Canaday DH, Boom WH & Harding CV, Infect Immun, 1/1/2004
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  Pai RK, Convery M, Hamilton TA, Boom WH & Harding CV, J. Immunol., 1/1/2003
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